Company · CIK 0000944809 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

OPKO HEALTH, INC. · OPK

Insider activity reported against this company. All insider holders · Files at: ELOX, VBIV. On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market activity at this companybuys $105.0M · 493sales $1.9M · 3net $103.1M

Open-market trades as an insider elsewherebuys $2.0M · 1sales $0 · 0net $2.0M

Reported at this company — common stock

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Sep 12, 2016 PForm 4 →	Sep 13, 6:04 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.79	$97,869	160,135,143	+0.01%	plan?
Sep 9, 2016 PForm 4 →	Sep 12, 6:06 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,600	$9.87	$35,535	160,125,143	+0.00%	plan?
Sep 2, 2016 PForm 4 →	Sep 6, 11:00 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.28	$92,800	160,121,543	+0.01%	plan?
Aug 25, 2016 PForm 4 →	Aug 26, 6:26 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	48,400	$9.06	$438,293	160,111,543	+0.03%	plan?
Aug 24, 2016 PForm 4 →	Aug 25, 6:26 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$9.24	$138,586	160,063,143	+0.01%	plan?
Aug 23, 2016 PForm 4 →	Aug 24, 7:31 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	29,000	$9.53	$276,464	160,048,143	+0.02%	plan?
Aug 22, 2016 PForm 4 →	Aug 23, 7:06 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	11,800	$9.76	$115,214	160,019,143	+0.01%	plan?
Aug 19, 2016 PForm 4 →	Aug 22, 7:09 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$9.82	$147,236	160,007,343	+0.01%	plan?
Aug 18, 2016 PForm 4 →	Aug 19, 7:23 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.87	$98,717	159,992,343	+0.01%	plan?
Aug 17, 2016 PForm 4 →	Aug 18, 6:07 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.90	$98,953	159,982,343	+0.01%	plan?
Aug 16, 2016 PForm 4 →	Aug 17, 6:29 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$10.02	$100,183	159,972,343	+0.01%	plan?
Aug 15, 2016 PForm 4 →	Aug 16, 6:23 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$10.07	$100,665	159,962,343	+0.01%	plan?
Aug 10, 2016 PForm 4 →	Aug 11, 6:29 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.98	$99,763	159,952,343	+0.01%	plan?
Aug 9, 2016 PForm 4 →	Aug 10, 6:28 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$10.21	$102,140	159,942,343	+0.01%	plan?
Aug 2, 2016 PForm 4 →	Aug 3, 7:21 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.88	$98,802	159,932,343	+0.01%	plan?
Jul 27, 2016 PForm 4 →	Jul 28, 6:22 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.91	$99,142	159,922,343	+0.01%	plan?
Jul 13, 2016 PForm 4 →	Jul 14, 6:05 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,800	$9.65	$152,453	159,912,343	+0.01%	plan?
Jul 11, 2016 PForm 4 →	Jul 12, 6:18 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.82	$98,182	159,896,543	+0.01%	plan?
Jun 30, 2016 PForm 4 →	Jul 1, 10:34 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	18,000	$9.27	$166,844	159,886,543	+0.01%	plan?
Jun 29, 2016 PForm 4 →	Jun 30, 7:11 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	12,800	$9.24	$118,304	159,868,543	+0.01%	plan?
Jun 27, 2016 PForm 4 →	Jun 28, 6:55 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	21,000	$8.88	$186,384	159,855,743	+0.01%	plan?
Jun 24, 2016 PForm 4 →	Jun 27, 6:46 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	18,000	$9.40	$169,245	159,834,743	+0.01%	plan?
Jun 22, 2016 PForm 4 →	Jun 23, 6:31 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	18,000	$9.42	$169,581	159,816,743	+0.01%	plan?
Jun 20, 2016 PForm 4 →	Jun 21, 6:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.19	$91,892	159,798,743	+0.01%	plan?
Jun 17, 2016 PForm 4 →	Jun 20, 6:02 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	18,000	$9.07	$163,231	159,788,743	+0.01%	plan?
Jun 16, 2016 PForm 4 →	Jun 17, 6:14 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.23	$92,335	159,770,743	+0.01%	plan?
Jun 14, 2016 PForm 4 →	Jun 15, 6:13 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	16,000	$9.01	$144,177	159,760,743	+0.01%	plan?
Jun 10, 2016 PForm 4 →	Jun 13, 7:31 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.36	$93,579	159,744,743	+0.01%	plan?
Jun 9, 2016 PForm 4 →	Jun 10, 6:17 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,000	$9.74	$48,677	159,734,743	+0.00%	plan?
Jun 8, 2016 PForm 4 →	Jun 9, 6:18 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	11,200	$9.80	$109,752	159,729,743	+0.01%	plan?
Jun 7, 2016 PForm 4 →	Jun 8, 6:53 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,000	$9.90	$49,499	159,718,543	+0.00%	plan?
Jun 6, 2016 PForm 4 →	Jun 7, 6:01 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	17,800	$9.97	$177,385	159,713,543	+0.01%	plan?
Jun 3, 2016 PForm 4 →	Jun 6, 6:23 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	18,600	$10.07	$187,362	159,695,743	+0.01%	plan?
Jun 1, 2016 PForm 4 →	Jun 2, 6:37 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,800	$10.49	$113,262	159,677,143	+0.01%	plan?
May 27, 2016 PForm 4 →	May 31, 6:06 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$10.35	$207,014	159,666,343	+0.01%	plan?
May 26, 2016 PForm 4 →	May 27, 6:00 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	12,000	$10.45	$125,436	159,646,343	+0.01%	plan?
May 13, 2016 SForm 4 →	May 17, 4:22 pm EDT	Robert A BaronDirector	37,500	$9.83	$368,491	284,088	−11.7%	plan?
May 12, 2016 PForm 4 →	May 13, 6:04 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	30,600	$9.56	$292,656	159,634,343	+0.02%	plan?
May 11, 2016 PForm 4 →	May 12, 7:06 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	19,400	$10.05	$194,980	159,603,743	+0.01%	plan?
May 4, 2016 PForm 4 →	May 5, 6:15 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	29,800	$9.91	$295,333	159,584,343	+0.02%	plan?
May 3, 2016 FForm 4/A →	May 17, 5:08 pm EDT	Steven D RubinExecutive VP-Administration, Director	121,156	$10.34	$1,252,753	5,571,251	—	plan?
May 3, 2016 FMForm 4 →	May 5, 5:20 pm EDT	Steven D RubinExecutive VP-Administration, Director	384,918	$4.38	$1,685,052	5,557,489	—	plan? amended
May 3, 2016 PForm 4 →	May 4, 6:05 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	8,100	$10.25	$83,017	159,554,543	+0.01%	plan?
May 2, 2016 PForm 4 →	May 3, 6:10 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	11,800	$10.33	$121,926	159,546,443	+0.01%	plan?
Apr 29, 2016 PForm 4 →	May 2, 6:06 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$10.70	$107,049	159,534,643	+0.01%	plan?
Apr 28, 2016 PForm 4 →	Apr 29, 6:31 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$10.83	$108,325	159,524,643	+0.01%	plan?
Apr 27, 2016 PForm 4 →	Apr 28, 7:01 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	11,800	$10.95	$129,157	159,514,643	+0.01%	plan?
Apr 25, 2016 PForm 4 →	Apr 26, 6:50 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$11.12	$166,735	159,502,843	+0.01%	plan?
Apr 19, 2016 PForm 4 →	Apr 20, 6:50 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	7,400	$11.00	$81,373	159,487,843	+0.00%	plan?
Apr 15, 2016 PForm 4 →	Apr 18, 6:44 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	7,600	$10.78	$81,926	159,480,443	+0.00%	plan?
Apr 6, 2016 PForm 4 →	Apr 7, 7:10 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$10.61	$212,157	159,472,843	+0.01%	plan?
Apr 5, 2016 PForm 4 →	Apr 6, 7:21 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$10.28	$205,646	159,452,843	+0.01%	plan?
Apr 1, 2016 MForm 4 →	Apr 5, 4:39 pm EDT	Thomas E BeierDirector	20,000	$1.54	$30,800	40,000	—	plan?
Apr 1, 2016 PForm 4 →	Apr 1, 5:55 pm EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	23,600	$10.35	$244,254	159,432,843	+0.01%	plan?
Mar 31, 2016 PForm 4 →	Apr 1, 8:11 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	25,000	$10.26	$256,498	159,409,243	+0.02%	plan?
Mar 30, 2016 PForm 4 →	Mar 31, 6:05 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	85,600	$10.10	$864,320	159,384,243	+0.05%	plan?
Mar 30, 2016 PForm 4 →	Mar 31, 6:04 am EDT	Steven D RubinExecutive VP-Administration, Director	1,000	$10.17	$10,166	5,442,407	+0.02%	plan?
Mar 24, 2016 PForm 4 →	Mar 25, 8:42 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$11.14	$222,787	159,298,643	+0.01%	plan?
Mar 17, 2016 PForm 4 →	Mar 18, 7:31 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	1,200	$10.65	$12,785	24,600,633	+0.00%	plan?
Mar 16, 2016 PForm 4 →	Mar 17, 4:19 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	1,200	$9.99	$11,988	24,599,433	+0.00%	plan?
Mar 15, 2016 PForm 4 →	Mar 16, 6:06 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	30,000	$9.96	$298,762	159,278,643	+0.02%	plan?
Mar 14, 2016 PForm 4 →	Mar 16, 6:06 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	2,400	$10.06	$24,143	24,598,233	+0.01%	plan?
Mar 11, 2016 PForm 4 →	Mar 15, 4:22 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	1,200	$10.21	$12,252	24,595,833	+0.00%	plan?
Mar 10, 2016 PForm 4 →	Mar 11, 6:49 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	23,600	$9.89	$233,396	159,248,643	+0.01%	plan?
Mar 8, 2016 PForm 4 →	Mar 15, 4:20 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	3,600	$9.94	$35,787	24,594,633	+0.01%	plan? late
Mar 8, 2016 PForm 4 →	Mar 9, 6:55 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,400	$10.00	$53,997	159,225,043	+0.00%	plan?
Mar 4, 2016 PForm 4 →	Mar 7, 6:46 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	11,900	$9.66	$114,906	159,219,643	+0.01%	plan?
Mar 3, 2016 PForm 4 →	Mar 4, 7:04 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	7,200	$9.61	$69,198	159,207,743	+0.00%	plan?
Mar 1, 2016 PForm 4 →	Mar 2, 7:14 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	64,800	$9.08	$588,125	159,200,543	+0.04%	plan?
Feb 26, 2016 PForm 4 →	Feb 29, 7:28 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	4,800	$9.27	$44,507	159,135,743	+0.00%	plan?
Feb 24, 2016 PForm 4 →	Feb 25, 6:51 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	7,200	$8.70	$62,607	159,130,943	+0.00%	plan?
Feb 23, 2016 PForm 4 →	Feb 24, 6:07 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	27,800	$8.92	$248,096	159,123,743	+0.02%	plan?
Feb 18, 2016 PForm 4 →	Feb 19, 7:21 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	13,000	$8.74	$113,652	159,095,943	+0.01%	plan?
Feb 17, 2016 PForm 4 →	Feb 18, 6:54 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	2,000	$8.01	$16,030	159,082,943	+0.00%	plan?
Feb 16, 2016 PForm 4 →	Feb 17, 6:10 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$7.92	$118,731	159,080,943	+0.01%	plan?
Feb 12, 2016 PForm 4 →	Feb 16, 6:04 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	11,000	$7.88	$86,706	159,065,943	+0.01%	plan?
Feb 11, 2016 PForm 4 →	Feb 12, 7:05 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	21,800	$7.92	$172,671	159,054,943	+0.01%	plan?
Feb 8, 2016 PForm 4 →	Feb 9, 6:44 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	45,300	$7.68	$348,123	159,033,143	+0.03%	plan?
Feb 5, 2016 PForm 4 →	Feb 8, 7:00 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	18,000	$8.24	$148,233	158,987,843	+0.01%	plan?
Feb 4, 2016 PForm 4 →	Feb 5, 8:04 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,400	$7.91	$42,739	158,969,843	+0.00%	plan?
Feb 3, 2016 PForm 4 →	Feb 4, 7:15 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,400	$7.70	$118,592	158,964,443	+0.01%	plan?
Feb 2, 2016 PForm 4 →	Feb 3, 9:24 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	35,800	$7.74	$277,135	158,949,043	+0.02%	plan?
Feb 1, 2016 PForm 4 →	Feb 2, 8:45 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	16,200	$7.86	$127,288	158,913,243	+0.01%	plan?
Jan 28, 2016 PForm 4 →	Jan 29, 7:24 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	32,800	$7.71	$252,797	158,897,043	+0.02%	plan?
Jan 27, 2016 PForm 4 →	Jan 28, 7:25 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	39,800	$7.85	$312,267	158,864,243	+0.03%	plan?
Jan 26, 2016 PForm 4 →	Jan 27, 7:09 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$7.83	$117,513	158,824,443	+0.01%	plan?
Jan 25, 2016 PForm 4 →	Jan 26, 7:37 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	25,200	$7.99	$201,278	158,809,443	+0.02%	plan?
Jan 22, 2016 FMForm 4 →	Jan 26, 8:35 pm EST	Robert A BaronDirector	34,224	$2.03	$69,606	321,588	—	plan?
Jan 21, 2016 PForm 4 →	Jan 22, 7:47 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$7.85	$156,994	158,784,243	+0.01%	plan?
Jan 20, 2016 PForm 4 →	Jan 21, 7:12 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	58,600	$7.55	$442,250	158,764,243	+0.04%	plan?
Jan 19, 2016 PForm 4 →	Jan 20, 7:46 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	23,400	$7.80	$182,589	158,705,643	+0.01%	plan?
Jan 15, 2016 PForm 4 →	Jan 19, 8:56 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	65,400	$7.87	$515,020	158,682,243	+0.04%	plan?
Jan 14, 2016 PForm 4 →	Jan 15, 7:02 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$7.93	$79,314	158,616,843	+0.01%	plan?
Jan 13, 2016 PForm 4 →	Jan 14, 9:45 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	18,000	$8.29	$149,173	158,606,843	+0.01%	plan?
Jan 12, 2016 PForm 4 →	Jan 13, 7:45 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$8.58	$171,535	158,588,843	+0.01%	plan?
Jan 11, 2016 PForm 4 →	Jan 12, 6:57 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$8.51	$85,104	158,568,843	+0.01%	plan?
Jan 8, 2016 PForm 4 →	Jan 11, 7:27 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$8.79	$87,897	158,558,843	+0.01%	plan?
Jan 7, 2016 PForm 4 →	Jan 8, 7:30 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	25,000	$8.86	$221,495	158,548,843	+0.02%	plan?
Jan 6, 2016 PForm 4 →	Jan 7, 7:27 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	50,000	$9.23	$461,607	158,523,843	+0.03%	plan?
Jan 5, 2016 PForm 4 →	Jan 6, 7:22 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	30,000	$9.83	$294,920	158,473,843	+0.02%	plan?

Reported at this company — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Jun 18, 2026 AForm 4 →	Jun 22, 5:38 pm EDT	Prem A LachmanDirector	30,000	—	—	30,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:37 pm EDT	Roger Medel M.D.Director	30,000	—	—	30,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:36 pm EDT	John A PaganelliDirector	30,000	—	—	30,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:34 pm EDT	Richard C Pfenniger Jr.Director	60,000	—	—	60,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:33 pm EDT	Subbarao V UppaluriDirector	80,000	—	—	80,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:32 pm EDT	Alice Lin-Tsing YuDirector	30,000	—	—	30,000	—
Feb 1, 2019 MForm 4 →	Feb 5, 4:33 pm EST	Steven D RubinExecutive VP-Administration, Director	24,877	—	—	0	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:16 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:16 pm EDT	Richard C Pfenniger Jr.Director	30,000	—	—	30,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:15 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:15 pm EDT	Richard M KrasnoDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:14 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:14 pm EDT	Robert Scott FishelDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:13 pm EDT	Adam LogalSr. Vice President, CFO	300,000	—	—	300,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:13 pm EDT	Steven D RubinExecutive VP-Administration, Director	300,000	—	—	300,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:12 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	500,000	—	—	500,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:11 pm EDT	Phillip Md Et Al FrostCEO & Chairman, Director, 10% Owner	500,000	—	—	500,000	—
Jun 8, 2018 MForm 4 →	Jun 12, 6:05 pm EDT	Adam LogalSr. Vice President, CFO	75,000	—	—	0	—
May 14, 2018 MForm 4 →	May 15, 4:13 pm EDT	Richard A LernerDirector	45,000	—	—	0	—
Apr 3, 2018 AForm 4 →	Apr 4, 4:13 pm EDT	Robert Scott FishelDirector	40,000	—	—	40,000	—
Feb 27, 2018 AForm 4 →	Mar 1, 4:11 pm EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	—	—	—	—	—
Feb 27, 2018 AForm 4 →	Mar 1, 4:10 pm EST	Jane Ph D HsiaoVice Chairman & CTO, Director	—	—	—	—	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:22 pm EDT	Richard M KrasnoDirector	20,000	—	—	20,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:21 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:19 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:18 pm EDT	Richard C Pfenniger Jr.Director	30,000	—	—	30,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:17 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
Jun 2, 2017 MForm 4 →	Jun 5, 9:49 am EDT	Richard C Pfenniger Jr.Director	20,000	—	—	0	—
Apr 12, 2017 MForm 4 →	Apr 13, 4:25 pm EDT	Steven D RubinExecutive VP-Administration, Director	265,000	—	—	0	—
Apr 10, 2017 MForm 4 →	Apr 11, 4:14 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	0	—
Mar 13, 2017 MForm 4 →	Mar 15, 6:31 pm EDT	Adam LogalSr. Vice President, CFO	264,207	—	—	0	—
Mar 13, 2017 MForm 4 →	Mar 15, 6:30 pm EDT	Richard A LernerDirector	20,000	—	—	0	—
Mar 6, 2017 MForm 4 →	Mar 7, 5:08 pm EST	John A PaganelliDirector	20,000	—	—	0	—
Feb 22, 2017 MForm 4 →	Feb 28, 6:27 pm EST	John A PaganelliDirector	20,000	—	—	0	—	late
Feb 9, 2017 AForm 4 →	Feb 10, 4:35 pm EST	Richard M KrasnoDirector	40,000	—	—	40,000	—
Jan 19, 2017 MForm 4 →	Jan 23, 7:30 am EST	Robert A BaronDirector	60,000	—	—	0	—
Jan 13, 2017 MForm 4 →	Jan 17, 4:12 pm EST	Thomas E BeierDirector	20,000	—	—	0	—
Jan 4, 2017 MForm 4 →	Jan 5, 11:11 am EST	Jane Ph D HsiaoVice Chairman & CTO, Director	112,500	—	—	112,500	—
Jun 2, 2016 AForm 4 →	Jun 3, 4:47 pm EDT	Richard C Pfenniger Jr.Director	10,000	—	—	10,000	—
May 5, 2016 AForm 4 →	May 5, 5:21 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:20 pm EDT	Richard C Pfenniger Jr.Director	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:19 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:18 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:17 pm EDT	Dmitry KolosovDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:16 pm EDT	Thomas E BeierDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:15 pm EDT	Robert A BaronDirector	20,000	—	—	20,000	—
May 3, 2016 MForm 4 →	May 5, 5:20 pm EDT	Steven D RubinExecutive VP-Administration, Director	250,000	—	—	0	—	amended
Apr 1, 2016 MForm 4 →	Apr 5, 4:39 pm EDT	Thomas E BeierDirector	20,000	—	—	0	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:55 pm EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	500,000	—	—	500,000	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:55 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	450,000	—	—	450,000	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:54 pm EDT	Steven D RubinExecutive VP-Administration, Director	450,000	—	—	450,000	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:54 pm EDT	Adam LogalSr. Vice President, CFO	250,000	—	—	250,000	—
Jan 22, 2016 MForm 4 →	Jan 26, 8:35 pm EST	Robert A BaronDirector	30,000	—	—	0	—
Oct 8, 2015 MForm 4 →	Oct 9, 4:23 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	0	—
Sep 18, 2015 MForm 4 →	Sep 22, 6:03 am EDT	John A PaganelliDirector	35,000	—	—	0	—
Aug 18, 2015 MForm 4 →	Aug 19, 10:28 am EDT	Alice Lin-Tsing YuDirector	20,000	—	—	0	—
Aug 12, 2015 MForm 4 →	Aug 13, 2:55 pm EDT	Robert A BaronDirector	5,000	—	—	0	—
Aug 7, 2015 MForm 4 →	Aug 10, 8:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,056,574	—	—	300,000	—
Aug 7, 2015 MForm 4 →	Aug 10, 8:48 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	200,000	—	—	262,500	—
Aug 6, 2015 CForm 4 →	Aug 7, 8:50 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	—	—	—	0	—
Aug 6, 2015 CForm 4 →	Aug 7, 8:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	—	—	—	0	—
Jul 17, 2015 MForm 4 →	Jul 20, 4:21 pm EDT	Thomas E BeierDirector	20,000	—	—	0	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:35 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:34 pm EDT	Richard C Pfenniger Jr.Director	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:33 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:32 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:30 pm EDT	Dmitry KolosovDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:29 pm EDT	Thomas E BeierDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:28 pm EDT	Robert A BaronDirector	20,000	—	—	20,000	—
Mar 18, 2015 AForm 4 →	Mar 27, 6:16 pm EDT	Dmitry KolosovDirector	10,000	—	—	10,000	—	late
Mar 18, 2015 AForm 4 →	Mar 19, 4:18 pm EDT	Adam LogalSr. Vice President, CFO	250,000	—	—	250,000	—
Mar 18, 2015 AForm 4 →	Mar 19, 4:17 pm EDT	Steven D RubinExecutive VP-Administration, Director	450,000	—	—	450,000	—
Mar 18, 2015 AForm 4 →	Mar 19, 4:16 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	450,000	—	—	450,000	—
Mar 18, 2015 AForm 4 →	Mar 19, 4:16 pm EDT	Phillip Md Et Al FrostCEO & Chairman, Director, 10% Owner	500,000	—	—	500,000	—
Mar 12, 2015 MForm 4 →	Mar 13, 5:12 pm EDT	Adam LogalSr. Vice President, CFO	95,000	—	—	0	—
Jan 31, 2015 MForm 4 →	Feb 2, 6:02 am EST	Steven D RubinExecutive VP-Administration, Director	5,190,385	—	—	0	—
Jan 31, 2015 MForm 4 →	Feb 2, 6:01 am EST	Jane Ph D HsiaoVice Chairman & CTO, Director	7,090,525	—	—	0	—
Jan 31, 2015 MForm 4 →	Feb 2, 6:00 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	14,144,217	$0.7181	$399,259	0	—

Filed by this entity as an insider elsewhere — common stock

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Dec 19, 2017 AForm 4 →	Dec 21, 6:27 pm EST	Sevion Therapeutics, Inc.SVOND	495,126	—	—	1,289,818	—	plan?
Oct 30, 2017 PForm 4 →	Nov 1, 4:11 pm EDT	VBI Vaccines Inc/BCVBIV	655,738	$3.05	$2,000,001	6,678,752	+10.9%	plan?
Sep 19, 2017 CForm 4 →	Nov 7, 4:00 pm EST	Sevion Therapeutics, Inc.SVON	1,250,006	—	—	15,893,844	—	plan? late
Aug 10, 2017 CForm 4 →	Aug 14, 5:15 pm EDT	Sevion Therapeutics, Inc.SVON	4,126,822	$0.10	$412,682	14,643,838	—	plan?

Filed by this entity as an insider elsewhere — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Sep 19, 2017 CForm 4 →	Nov 7, 4:00 pm EST	Sevion Therapeutics, Inc.SVON	66,667	—	—	0	—	late
Aug 10, 2017 CForm 4 →	Aug 14, 5:15 pm EDT	Sevion Therapeutics, Inc.SVON	—	—	—	0	—