Company · CIK 0000944809 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

OPKO HEALTH, INC. · OPK

Insider activity reported against this company. All insider holders · Files at: ELOX, VBIV. On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market activity at this companybuys $105.0M · 493sales $1.9M · 3net $103.1M

Open-market trades as an insider elsewherebuys $2.0M · 1sales $0 · 0net $2.0M

Reported at this company — common stock

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Dec 31, 2015 PForm 4 →	Jan 4, 2016, 7:11 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	19,600	$10.09	$197,675	158,443,843	+0.01%	plan?
Dec 30, 2015 PForm 4 →	Dec 31, 9:17 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$10.12	$202,378	158,424,243	+0.01%	plan?
Dec 24, 2015 PForm 4 →	Dec 28, 8:06 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	9,900	$10.16	$100,615	158,404,243	+0.01%	plan?
Dec 23, 2015 PForm 4 →	Dec 24, 7:30 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	18,000	$10.11	$182,065	158,394,343	+0.01%	plan?
Dec 22, 2015 PForm 4 →	Dec 23, 7:28 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$9.99	$199,878	158,376,343	+0.01%	plan?
Dec 18, 2015 PForm 4 →	Dec 21, 6:36 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	21,800	$10.00	$218,013	158,356,343	+0.01%	plan?
Dec 14, 2015 PForm 4 →	Dec 15, 8:23 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	106,000	$9.72	$1,029,811	158,334,543	+0.07%	plan?
Dec 11, 2015 GForm 4 →	Dec 23, 7:27 am EST	John A PaganelliDirector	1,500	—	—	329,708	—	plan? late
Dec 11, 2015 PForm 4 →	Dec 14, 7:24 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$10.47	$209,380	158,228,543	+0.01%	plan?
Dec 9, 2015 PForm 4 →	Dec 10, 7:10 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	30,000	$10.86	$325,926	158,208,543	+0.02%	plan?
Dec 7, 2015 PForm 4 →	Dec 8, 7:10 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$10.99	$219,793	158,178,543	+0.01%	plan?
Nov 30, 2015 PForm 4 →	Dec 1, 7:42 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,000	$10.94	$54,696	158,158,543	+0.00%	plan?
Nov 27, 2015 PForm 4 →	Nov 30, 9:09 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$11.06	$19,911	158,153,543	+0.00%	plan?
Nov 25, 2015 PForm 4 →	Nov 27, 9:27 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	17,000	$11.03	$187,432	158,151,743	+0.01%	plan?
Nov 24, 2015 PForm 4 →	Nov 25, 7:03 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	18,000	$10.76	$193,706	158,134,743	+0.01%	plan?
Nov 20, 2015 PForm 4 →	Nov 23, 7:36 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	2,300	$10.89	$25,048	158,116,743	+0.00%	plan?
Nov 19, 2015 PForm 4 →	Nov 20, 6:56 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	30,000	$10.73	$321,819	158,114,443	+0.02%	plan?
Nov 16, 2015 PForm 4 →	Nov 17, 7:05 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	30,000	$10.52	$315,637	158,084,443	+0.02%	plan?
Nov 6, 2015 PForm 4 →	Nov 9, 7:40 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	25,000	$9.83	$245,813	158,054,443	+0.02%	plan?
Nov 5, 2015 PForm 4 →	Nov 6, 7:26 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$9.63	$144,459	158,029,443	+0.01%	plan?
Nov 4, 2015 PForm 4 →	Nov 5, 8:43 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$9.68	$145,200	158,014,443	+0.01%	plan?
Nov 3, 2015 PForm 4 →	Nov 4, 7:27 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$9.76	$146,442	157,999,443	+0.01%	plan?
Nov 2, 2015 PForm 4 →	Nov 3, 8:27 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$9.76	$146,399	157,984,443	+0.01%	plan?
Oct 30, 2015 PForm 4 →	Nov 2, 7:05 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$9.39	$187,754	157,969,443	+0.01%	plan?
Oct 29, 2015 PForm 4 →	Oct 30, 8:35 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	25,000	$9.42	$235,449	157,949,443	+0.02%	plan?
Oct 28, 2015 PForm 4 →	Oct 29, 9:01 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	25,000	$9.46	$236,491	157,924,443	+0.02%	plan?
Oct 22, 2015 PForm 4 →	Oct 23, 7:05 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	31,800	$8.90	$283,101	157,899,443	+0.02%	plan?
Oct 13, 2015 PForm 4 →	Oct 14, 7:16 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$8.54	$170,866	157,867,643	+0.01%	plan?
Oct 8, 2015 MForm 4 →	Oct 9, 4:23 pm EDT	Alice Lin-Tsing YuDirector	20,000	$3.43	$68,600	80,000	—	plan?
Oct 2, 2015 PForm 4 →	Oct 5, 8:52 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$8.40	$15,127	157,847,643	+0.00%	plan?
Oct 1, 2015 PForm 4 →	Oct 2, 7:19 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	52,500	$8.33	$437,153	157,845,843	+0.03%	plan?
Sep 30, 2015 PForm 4 →	Oct 1, 7:14 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	70,000	$8.35	$584,204	157,793,343	+0.04%	plan?
Sep 29, 2015 PForm 4 →	Sep 30, 7:37 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	30,000	$8.38	$251,442	157,723,343	+0.02%	plan?
Sep 25, 2015 PForm 4 →	Sep 28, 8:42 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	202,900	$9.08	$1,841,480	157,693,343	+0.13%	plan?
Sep 23, 2015 PForm 4 →	Sep 24, 6:54 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	50,000	$9.56	$478,172	157,490,443	+0.03%	plan?
Sep 22, 2015 PForm 4 →	Sep 23, 6:35 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	43,200	$9.74	$420,819	157,440,443	+0.03%	plan?
Sep 21, 2015 PForm 4 →	Sep 22, 6:04 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	27,000	$10.02	$270,550	157,397,243	+0.02%	plan?
Sep 18, 2015 FMForm 4 →	Sep 22, 6:03 am EDT	John A PaganelliDirector	38,517	$1.91	$73,708	331,208	—	plan?
Sep 18, 2015 PForm 4 →	Sep 21, 6:04 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	12,600	$10.41	$131,192	157,370,243	+0.01%	plan?
Sep 17, 2015 PForm 4 →	Sep 18, 7:36 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,400	$10.34	$55,833	157,357,643	+0.00%	plan?
Sep 16, 2015 PForm 4 →	Sep 17, 7:52 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	32,400	$10.16	$329,102	157,352,243	+0.02%	plan?
Sep 14, 2015 PForm 4 →	Sep 15, 7:07 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$10.03	$150,400	157,319,843	+0.01%	plan?
Sep 14, 2015 PForm 4 →	Sep 15, 7:05 am EDT	Adam LogalSr. Vice President, CFO	1,000	$9.95	$9,950	45,789	+2.23%	plan?
Sep 11, 2015 PForm 4 →	Sep 14, 7:09 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	110,600	$10.03	$1,109,628	157,304,843	+0.07%	plan?
Sep 9, 2015 PForm 4 →	Sep 10, 7:01 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	27,200	$10.46	$284,541	157,194,243	+0.02%	plan?
Sep 8, 2015 PForm 4 →	Sep 9, 8:07 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	7,200	$10.64	$76,590	157,167,043	+0.00%	plan?
Sep 4, 2015 PForm 4 →	Sep 8, 8:51 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	16,200	$10.67	$172,887	157,159,843	+0.01%	plan?
Sep 3, 2015 PForm 4 →	Sep 4, 7:08 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	9,000	$10.96	$98,621	157,143,643	+0.01%	plan?
Aug 31, 2015 PForm 4 →	Sep 1, 7:12 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	73,200	$10.83	$792,544	157,134,643	+0.05%	plan?
Aug 28, 2015 PForm 4 →	Aug 31, 7:21 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	12,600	$11.32	$142,637	157,061,443	+0.01%	plan?
Aug 27, 2015 PForm 4 →	Aug 28, 7:20 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	46,800	$11.05	$517,325	157,048,843	+0.03%	plan?
Aug 25, 2015 PForm 4 →	Aug 26, 7:19 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	20,000	$10.82	$216,325	24,591,033	+0.08%	plan?
Aug 24, 2015 PForm 4 →	Aug 25, 7:04 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	223,600	$10.99	$2,458,078	157,002,043	+0.14%	plan?
Aug 21, 2015 PForm 4 →	Aug 24, 7:53 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	185,000	$12.24	$2,264,345	156,778,443	+0.12%	plan?
Aug 20, 2015 AForm 4 →	Aug 24, 7:53 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	34,375	—	—	156,593,443	—	plan?
Aug 20, 2015 PForm 4 →	Aug 20, 5:09 pm EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	544,000	$12.32	$6,702,134	156,559,068	+0.35%	plan?
Aug 20, 2015 PForm 4 →	Aug 20, 5:09 pm EDT	Steven D RubinExecutive VP-Administration, Director	2,000	$12.40	$24,799	5,441,407	+0.04%	plan?
Aug 18, 2015 MForm 4 →	Aug 19, 10:28 am EDT	Alice Lin-Tsing YuDirector	20,000	$2.05	$41,000	60,000	—	plan?
Aug 12, 2015 FMForm 4 →	Aug 13, 2:55 pm EDT	Robert A BaronDirector	5,153	$0.7972	$4,108	295,812	—	plan?
Aug 7, 2015 MForm 4 →	Aug 10, 8:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,056,574	$5.56	$5,878,686	3,068,951	—	plan?
Aug 7, 2015 MForm 4 →	Aug 10, 8:48 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	200,000	$7.94	$1,588,500	24,571,033	—	plan?
Aug 6, 2015 CForm 4 →	Aug 7, 8:50 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	144,823	$7.07	$1,023,899	4,617,404	—	plan?
Aug 6, 2015 CForm 4 →	Aug 7, 8:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,049,971	$7.07	$7,423,295	156,015,068	—	plan?
Jul 10, 2015 GForm 5 →	Mar 12, 2019, 4:26 pm EDT	Alice Lin-Tsing YuDirector	33,510	—	—	66,490	—	plan?
Jul 8, 2015 PForm 4 →	Jul 9, 7:05 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	7,200	$16.56	$119,197	154,965,097	+0.00%	plan?
Jul 7, 2015 PForm 4 →	Jul 8, 7:01 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,400	$16.64	$89,838	154,957,897	+0.00%	plan?
Jul 6, 2015 PForm 4 →	Jul 7, 6:46 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,600	$16.07	$57,860	154,952,497	+0.00%	plan?
Jul 2, 2015 PForm 4 →	Jul 6, 6:40 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	9,000	$16.13	$145,167	154,948,897	+0.01%	plan?
Jun 30, 2015 GForm 4 →	Jul 1, 5:38 pm EDT	John A PaganelliDirector	100	—	—	299,725	—	plan?
Jun 29, 2015 PForm 4 →	Jun 30, 6:43 am EDT	Robert A BaronDirector	2,000	$15.82	$31,630	290,965	+0.69%	plan?
Jun 29, 2015 PForm 4 →	Jun 30, 6:41 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	7,200	$15.62	$112,471	154,939,897	+0.00%	plan?
Jun 26, 2015 PForm 4 →	Jun 29, 6:58 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,400	$16.07	$86,779	154,932,697	+0.00%	plan?
Jun 25, 2015 PForm 4 →	Jun 26, 9:14 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	7,200	$15.39	$110,774	154,927,297	+0.00%	plan?
Jun 24, 2015 PForm 4 →	Jun 25, 9:00 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	57,200	$15.33	$876,775	154,920,097	+0.04%	plan?
Jun 23, 2015 PForm 4 →	Jun 24, 6:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	9,000	$15.60	$140,428	154,862,897	+0.01%	plan?
Jun 22, 2015 PForm 4 →	Jun 23, 8:55 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	23,400	$15.53	$363,351	154,853,897	+0.02%	plan?
Jun 19, 2015 PForm 4 →	Jun 22, 6:15 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	7,200	$15.33	$110,363	154,830,497	+0.00%	plan?
Jun 17, 2015 PForm 4 →	Jun 18, 7:13 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,400	$15.35	$236,416	154,823,297	+0.01%	plan?
Jun 16, 2015 PForm 4 →	Jun 17, 6:54 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$15.36	$153,628	154,807,897	+0.01%	plan?
Jun 12, 2015 PForm 4 →	Jun 15, 6:43 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$15.51	$155,099	154,797,897	+0.01%	plan?
Jun 11, 2015 PForm 4 →	Jun 12, 7:41 am EDT	John A PaganelliDirector	4,175	$15.90	$66,380	4,175	—	plan?
Jun 10, 2015 PForm 4 →	Jun 11, 8:47 am EDT	Robert A BaronDirector	3,000	$16.06	$48,180	288,965	+1.05%	plan?
Jun 9, 2015 PForm 4 →	Jun 10, 7:21 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$15.95	$239,280	154,787,897	+0.01%	plan?
Jun 5, 2015 PForm 4 →	Jun 9, 4:15 pm EDT	Richard A LernerDirector	12,500	$15.90	$198,721	5,600	—	plan?
May 13, 2015 PForm 4 →	May 14, 7:08 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	6,000	$15.55	$93,318	154,772,897	+0.00%	plan?
May 12, 2015 PForm 4 →	May 13, 6:18 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	6,000	$14.76	$88,535	154,766,897	+0.00%	plan?
May 11, 2015 PForm 4 →	May 12, 6:28 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	6,000	$14.30	$85,825	154,760,897	+0.00%	plan?
May 8, 2015 PForm 4 →	May 11, 6:01 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	9,000	$14.14	$127,268	154,754,897	+0.01%	plan?
May 7, 2015 PForm 4 →	May 8, 7:11 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	9,000	$14.06	$126,521	154,745,897	+0.01%	plan?
May 6, 2015 PForm 4 →	May 7, 7:06 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	12,600	$13.93	$175,463	154,736,897	+0.01%	plan?
May 5, 2015 PForm 4 →	May 6, 6:42 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	9,000	$13.93	$125,401	154,724,297	+0.01%	plan?
May 4, 2015 PForm 4 →	May 5, 7:13 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	7,200	$14.27	$102,777	154,715,297	+0.00%	plan?
May 1, 2015 PForm 4 →	May 4, 6:12 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	6,700	$14.03	$94,017	154,708,097	+0.00%	plan?
Apr 30, 2015 PForm 4 →	May 1, 9:40 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	31,300	$13.95	$436,669	154,701,397	+0.02%	plan?
Apr 29, 2015 PForm 4 →	Apr 30, 6:06 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,500	$14.37	$222,680	154,670,097	+0.01%	plan?
Apr 28, 2015 PForm 4 →	Apr 29, 7:04 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	8,000	$14.45	$115,637	154,654,597	+0.01%	plan?
Apr 27, 2015 PForm 4 →	Apr 28, 6:04 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	8,800	$14.47	$127,358	154,646,597	+0.01%	plan?
Apr 24, 2015 PForm 4 →	Apr 27, 6:29 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	4,100	$14.80	$60,696	154,637,797	+0.00%	plan?
Apr 21, 2015 PForm 4 →	Apr 22, 6:50 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,700	$14.30	$81,526	154,633,697	+0.00%	plan?
Apr 17, 2015 PForm 4 →	Apr 20, 6:44 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	19,800	$14.29	$282,973	154,627,997	+0.01%	plan?

Reported at this company — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Jun 18, 2026 AForm 4 →	Jun 22, 5:38 pm EDT	Prem A LachmanDirector	30,000	—	—	30,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:37 pm EDT	Roger Medel M.D.Director	30,000	—	—	30,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:36 pm EDT	John A PaganelliDirector	30,000	—	—	30,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:34 pm EDT	Richard C Pfenniger Jr.Director	60,000	—	—	60,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:33 pm EDT	Subbarao V UppaluriDirector	80,000	—	—	80,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:32 pm EDT	Alice Lin-Tsing YuDirector	30,000	—	—	30,000	—
Feb 1, 2019 MForm 4 →	Feb 5, 4:33 pm EST	Steven D RubinExecutive VP-Administration, Director	24,877	—	—	0	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:16 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:16 pm EDT	Richard C Pfenniger Jr.Director	30,000	—	—	30,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:15 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:15 pm EDT	Richard M KrasnoDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:14 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:14 pm EDT	Robert Scott FishelDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:13 pm EDT	Adam LogalSr. Vice President, CFO	300,000	—	—	300,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:13 pm EDT	Steven D RubinExecutive VP-Administration, Director	300,000	—	—	300,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:12 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	500,000	—	—	500,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:11 pm EDT	Phillip Md Et Al FrostCEO & Chairman, Director, 10% Owner	500,000	—	—	500,000	—
Jun 8, 2018 MForm 4 →	Jun 12, 6:05 pm EDT	Adam LogalSr. Vice President, CFO	75,000	—	—	0	—
May 14, 2018 MForm 4 →	May 15, 4:13 pm EDT	Richard A LernerDirector	45,000	—	—	0	—
Apr 3, 2018 AForm 4 →	Apr 4, 4:13 pm EDT	Robert Scott FishelDirector	40,000	—	—	40,000	—
Feb 27, 2018 AForm 4 →	Mar 1, 4:11 pm EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	—	—	—	—	—
Feb 27, 2018 AForm 4 →	Mar 1, 4:10 pm EST	Jane Ph D HsiaoVice Chairman & CTO, Director	—	—	—	—	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:22 pm EDT	Richard M KrasnoDirector	20,000	—	—	20,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:21 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:19 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:18 pm EDT	Richard C Pfenniger Jr.Director	30,000	—	—	30,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:17 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
Jun 2, 2017 MForm 4 →	Jun 5, 9:49 am EDT	Richard C Pfenniger Jr.Director	20,000	—	—	0	—
Apr 12, 2017 MForm 4 →	Apr 13, 4:25 pm EDT	Steven D RubinExecutive VP-Administration, Director	265,000	—	—	0	—
Apr 10, 2017 MForm 4 →	Apr 11, 4:14 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	0	—
Mar 13, 2017 MForm 4 →	Mar 15, 6:31 pm EDT	Adam LogalSr. Vice President, CFO	264,207	—	—	0	—
Mar 13, 2017 MForm 4 →	Mar 15, 6:30 pm EDT	Richard A LernerDirector	20,000	—	—	0	—
Mar 6, 2017 MForm 4 →	Mar 7, 5:08 pm EST	John A PaganelliDirector	20,000	—	—	0	—
Feb 22, 2017 MForm 4 →	Feb 28, 6:27 pm EST	John A PaganelliDirector	20,000	—	—	0	—	late
Feb 9, 2017 AForm 4 →	Feb 10, 4:35 pm EST	Richard M KrasnoDirector	40,000	—	—	40,000	—
Jan 19, 2017 MForm 4 →	Jan 23, 7:30 am EST	Robert A BaronDirector	60,000	—	—	0	—
Jan 13, 2017 MForm 4 →	Jan 17, 4:12 pm EST	Thomas E BeierDirector	20,000	—	—	0	—
Jan 4, 2017 MForm 4 →	Jan 5, 11:11 am EST	Jane Ph D HsiaoVice Chairman & CTO, Director	112,500	—	—	112,500	—
Jun 2, 2016 AForm 4 →	Jun 3, 4:47 pm EDT	Richard C Pfenniger Jr.Director	10,000	—	—	10,000	—
May 5, 2016 AForm 4 →	May 5, 5:21 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:20 pm EDT	Richard C Pfenniger Jr.Director	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:19 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:18 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:17 pm EDT	Dmitry KolosovDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:16 pm EDT	Thomas E BeierDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:15 pm EDT	Robert A BaronDirector	20,000	—	—	20,000	—
May 3, 2016 MForm 4 →	May 5, 5:20 pm EDT	Steven D RubinExecutive VP-Administration, Director	250,000	—	—	0	—	amended
Apr 1, 2016 MForm 4 →	Apr 5, 4:39 pm EDT	Thomas E BeierDirector	20,000	—	—	0	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:55 pm EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	500,000	—	—	500,000	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:55 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	450,000	—	—	450,000	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:54 pm EDT	Steven D RubinExecutive VP-Administration, Director	450,000	—	—	450,000	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:54 pm EDT	Adam LogalSr. Vice President, CFO	250,000	—	—	250,000	—
Jan 22, 2016 MForm 4 →	Jan 26, 8:35 pm EST	Robert A BaronDirector	30,000	—	—	0	—
Oct 8, 2015 MForm 4 →	Oct 9, 4:23 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	0	—
Sep 18, 2015 MForm 4 →	Sep 22, 6:03 am EDT	John A PaganelliDirector	35,000	—	—	0	—
Aug 18, 2015 MForm 4 →	Aug 19, 10:28 am EDT	Alice Lin-Tsing YuDirector	20,000	—	—	0	—
Aug 12, 2015 MForm 4 →	Aug 13, 2:55 pm EDT	Robert A BaronDirector	5,000	—	—	0	—
Aug 7, 2015 MForm 4 →	Aug 10, 8:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,056,574	—	—	300,000	—
Aug 7, 2015 MForm 4 →	Aug 10, 8:48 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	200,000	—	—	262,500	—
Aug 6, 2015 CForm 4 →	Aug 7, 8:50 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	—	—	—	0	—
Aug 6, 2015 CForm 4 →	Aug 7, 8:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	—	—	—	0	—
Jul 17, 2015 MForm 4 →	Jul 20, 4:21 pm EDT	Thomas E BeierDirector	20,000	—	—	0	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:35 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:34 pm EDT	Richard C Pfenniger Jr.Director	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:33 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:32 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:30 pm EDT	Dmitry KolosovDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:29 pm EDT	Thomas E BeierDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:28 pm EDT	Robert A BaronDirector	20,000	—	—	20,000	—
Mar 18, 2015 AForm 4 →	Mar 27, 6:16 pm EDT	Dmitry KolosovDirector	10,000	—	—	10,000	—	late
Mar 18, 2015 AForm 4 →	Mar 19, 4:18 pm EDT	Adam LogalSr. Vice President, CFO	250,000	—	—	250,000	—
Mar 18, 2015 AForm 4 →	Mar 19, 4:17 pm EDT	Steven D RubinExecutive VP-Administration, Director	450,000	—	—	450,000	—
Mar 18, 2015 AForm 4 →	Mar 19, 4:16 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	450,000	—	—	450,000	—
Mar 18, 2015 AForm 4 →	Mar 19, 4:16 pm EDT	Phillip Md Et Al FrostCEO & Chairman, Director, 10% Owner	500,000	—	—	500,000	—
Mar 12, 2015 MForm 4 →	Mar 13, 5:12 pm EDT	Adam LogalSr. Vice President, CFO	95,000	—	—	0	—
Jan 31, 2015 MForm 4 →	Feb 2, 6:02 am EST	Steven D RubinExecutive VP-Administration, Director	5,190,385	—	—	0	—
Jan 31, 2015 MForm 4 →	Feb 2, 6:01 am EST	Jane Ph D HsiaoVice Chairman & CTO, Director	7,090,525	—	—	0	—
Jan 31, 2015 MForm 4 →	Feb 2, 6:00 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	14,144,217	$0.7181	$399,259	0	—

Filed by this entity as an insider elsewhere — common stock

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Dec 19, 2017 AForm 4 →	Dec 21, 6:27 pm EST	Sevion Therapeutics, Inc.SVOND	495,126	—	—	1,289,818	—	plan?
Oct 30, 2017 PForm 4 →	Nov 1, 4:11 pm EDT	VBI Vaccines Inc/BCVBIV	655,738	$3.05	$2,000,001	6,678,752	+10.9%	plan?
Sep 19, 2017 CForm 4 →	Nov 7, 4:00 pm EST	Sevion Therapeutics, Inc.SVON	1,250,006	—	—	15,893,844	—	plan? late
Aug 10, 2017 CForm 4 →	Aug 14, 5:15 pm EDT	Sevion Therapeutics, Inc.SVON	4,126,822	$0.10	$412,682	14,643,838	—	plan?

Filed by this entity as an insider elsewhere — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Sep 19, 2017 CForm 4 →	Nov 7, 4:00 pm EST	Sevion Therapeutics, Inc.SVON	66,667	—	—	0	—	late
Aug 10, 2017 CForm 4 →	Aug 14, 5:15 pm EDT	Sevion Therapeutics, Inc.SVON	—	—	—	0	—