Company · CIK 0000944809 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

OPKO HEALTH, INC. · OPK

Insider activity reported against this company. All insider holders · Files at: ELOX, VBIV. On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market activity at this companybuys $105.0M · 493sales $1.9M · 3net $103.1M

Open-market trades as an insider elsewherebuys $2.0M · 1sales $0 · 0net $2.0M

Reported at this company — common stock

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Mar 2, 2018 PForm 4 →	Mar 5, 6:29 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	364,800	$2.94	$1,073,716	1,875,300	+24.2%	plan?
Feb 21, 2018 PForm 4 →	Feb 22, 6:12 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	172,500	$3.63	$625,955	1,510,500	+12.9%	plan?
Feb 9, 2018 PForm 4 →	Feb 12, 6:24 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	185,000	$3.83	$708,291	1,338,000	+16.0%	plan?
Feb 8, 2018 PForm 4 →	Feb 9, 6:09 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$4.04	$80,832	1,153,000	+1.77%	plan?
Feb 7, 2018 PForm 4 →	Feb 8, 7:55 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	78,000	$4.22	$329,251	1,133,000	+7.39%	plan?
Feb 6, 2018 PForm 4 →	Feb 7, 7:16 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	60,000	$4.22	$252,941	1,055,000	+6.03%	plan?
Feb 5, 2018 PForm 4 →	Feb 6, 6:04 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	50,000	$4.14	$206,836	995,000	+5.29%	plan?
Feb 2, 2018 PForm 4 →	Feb 5, 7:09 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	55,000	$4.30	$236,680	945,000	+6.18%	plan?
Jan 31, 2018 PForm 4 →	Feb 1, 6:10 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	65,000	$4.47	$290,416	890,000	+7.88%	plan?
Jan 26, 2018 PForm 4 →	Jan 29, 6:37 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	55,000	$4.90	$269,712	825,000	+7.14%	plan?
Jan 25, 2018 PForm 4 →	Jan 26, 6:55 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	75,000	$4.99	$374,204	770,000	+10.8%	plan?
Jan 24, 2018 PForm 4 →	Jan 25, 7:23 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	100,000	$4.89	$488,829	695,000	+16.8%	plan?
Jan 23, 2018 PForm 4 →	Jan 24, 7:24 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	100,000	$4.76	$476,070	595,000	+20.2%	plan?
Jan 22, 2018 PForm 4 →	Jan 23, 7:39 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	100,000	$4.40	$439,675	495,000	+25.3%	plan?
Sep 19, 2017 PForm 4 →	Sep 20, 6:12 am EDT	Phillip Md Et Al Frost +2CEO & Chairman, Director, 10% Owner	15,000	$6.01	$90,099	395,000	+3.95%	plan?
Sep 18, 2017 PForm 4 →	Sep 19, 6:26 am EDT	Phillip Md Et Al Frost +2CEO & Chairman, Director, 10% Owner	40,000	$6.00	$240,000	380,000	+11.8%	plan?
Sep 15, 2017 PForm 4 →	Sep 18, 6:09 am EDT	Adam LogalSr. Vice President, CFO	1,500	$6.03	$9,045	162,793	+0.93%	plan?
Sep 15, 2017 PForm 4 →	Sep 18, 6:08 am EDT	Phillip Md Et Al Frost +2CEO & Chairman, Director, 10% Owner	80,000	$6.01	$480,411	340,000	+30.8%	plan?
Sep 14, 2017 PForm 4 →	Sep 15, 8:30 am EDT	Phillip Md Et Al Frost +2CEO & Chairman, Director, 10% Owner	260,000	$5.98	$1,555,624	260,000	—	plan?
Aug 25, 2017 PForm 4 →	Aug 28, 6:06 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	25,000	$6.17	$154,236	164,234,443	+0.02%	plan?
Aug 24, 2017 PForm 4 →	Aug 25, 6:02 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$6.24	$62,353	164,209,443	+0.01%	plan?
Aug 23, 2017 PForm 4 →	Aug 24, 7:12 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	12,000	$6.13	$73,554	164,199,443	+0.01%	plan?
Aug 22, 2017 PForm 4 →	Aug 23, 6:03 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$6.13	$11,034	164,187,443	+0.00%	plan?
Aug 21, 2017 PForm 4 →	Aug 22, 6:02 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	25,000	$6.10	$152,539	164,185,643	+0.02%	plan?
Aug 17, 2017 PForm 4 →	Aug 18, 7:05 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	50,000	$5.96	$298,048	164,160,643	+0.03%	plan?
Aug 16, 2017 PForm 4 →	Aug 17, 7:19 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	40,000	$6.04	$241,734	164,110,643	+0.02%	plan?
Aug 15, 2017 PForm 4 →	Aug 16, 7:18 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	25,000	$6.08	$152,074	164,070,643	+0.02%	plan?
Aug 14, 2017 PForm 4 →	Aug 15, 7:05 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$6.15	$61,527	164,045,643	+0.01%	plan?
Aug 11, 2017 PForm 4 →	Aug 14, 6:53 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$6.19	$61,895	164,035,643	+0.01%	plan?
Aug 10, 2017 PForm 4 →	Aug 11, 7:03 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	39,000	$6.23	$242,794	164,025,643	+0.02%	plan?
Aug 9, 2017 PForm 4 →	Aug 10, 6:28 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	18,000	$6.35	$114,227	163,986,643	+0.01%	plan?
Aug 8, 2017 PForm 4 →	Aug 9, 6:54 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,000	$6.05	$30,250	163,968,643	+0.00%	plan?
Aug 2, 2017 PForm 4 →	Aug 3, 7:25 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	25,000	$6.15	$153,740	163,963,643	+0.02%	plan?
Aug 1, 2017 PForm 4 →	Aug 2, 7:08 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	46,600	$6.25	$291,046	163,938,643	+0.03%	plan?
Jul 28, 2017 PForm 4 →	Jul 31, 6:18 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	35,100	$6.30	$221,012	163,892,043	+0.02%	plan?
Jul 27, 2017 PForm 4 →	Jul 28, 6:41 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	23,600	$6.34	$149,687	163,856,943	+0.01%	plan?
Jul 26, 2017 PForm 4 →	Jul 27, 6:21 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	36,200	$6.39	$231,214	163,833,343	+0.02%	plan?
Jul 25, 2017 PForm 4 →	Jul 26, 7:10 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	39,800	$6.41	$255,170	163,797,143	+0.02%	plan?
Jul 24, 2017 PForm 4 →	Jul 25, 6:09 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	45,000	$6.42	$289,050	163,757,343	+0.03%	plan?
Jul 20, 2017 PForm 4 →	Jul 21, 6:47 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,400	$6.46	$34,872	163,712,343	+0.00%	plan?
Jul 17, 2017 PForm 4 →	Jul 18, 7:30 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$6.04	$10,871	163,706,943	+0.00%	plan?
Jul 14, 2017 PForm 4 →	Jul 17, 7:14 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	12,600	$6.16	$77,564	163,705,143	+0.01%	plan?
Jul 12, 2017 PForm 4 →	Jul 13, 6:57 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,600	$6.12	$22,050	163,692,543	+0.00%	plan?
Jul 10, 2017 PForm 4 →	Jul 11, 6:38 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	50,000	$6.19	$309,570	163,688,943	+0.03%	plan?
Jul 6, 2017 PForm 4 →	Jul 7, 6:26 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	25,000	$6.29	$157,141	163,638,943	+0.02%	plan?
Jul 3, 2017 PForm 4 →	Jul 5, 6:46 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	60,800	$6.44	$391,396	163,613,943	+0.04%	plan?
Jun 30, 2017 PForm 4 →	Jul 3, 8:09 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,600	$6.58	$23,700	163,553,143	+0.00%	plan?
Jun 28, 2017 PForm 4 →	Jun 29, 6:11 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$6.87	$12,366	163,549,543	+0.00%	plan?
Jun 27, 2017 PForm 4 →	Jun 28, 7:09 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	21,800	$6.77	$147,541	163,547,743	+0.01%	plan?
Jun 26, 2017 PForm 4 →	Jun 27, 7:00 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$6.97	$12,543	163,525,943	+0.00%	plan?
Jun 22, 2017 PForm 4 →	Jun 23, 6:31 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	131,000	$6.72	$880,268	163,524,143	+0.08%	plan?
Jun 19, 2017 GForm 4 →	Jun 20, 5:05 pm EDT	John A PaganelliDirector	1,000	—	—	349,340	—	plan?
Jun 15, 2017 PForm 4 →	Jun 16, 6:17 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	200,000	$6.43	$1,285,692	163,393,143	+0.12%	plan?
Jun 13, 2017 PForm 4 →	Jun 14, 6:33 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	7,200	$6.51	$46,901	163,193,143	+0.00%	plan?
Jun 12, 2017 PForm 4 →	Jun 13, 6:22 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$6.37	$11,458	163,185,943	+0.00%	plan?
Jun 9, 2017 PForm 4 →	Jun 12, 6:05 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	25,000	$6.39	$159,643	163,184,143	+0.02%	plan?
Jun 7, 2017 PForm 4 →	Jun 8, 7:39 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	55,600	$6.27	$348,785	163,159,143	+0.03%	plan?
Jun 6, 2017 PForm 4 →	Jun 7, 7:26 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	30,000	$6.30	$189,147	163,103,543	+0.02%	plan?
Jun 5, 2017 PForm 4 →	Jun 6, 7:17 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	55,000	$6.31	$347,135	163,073,543	+0.03%	plan?
Jun 5, 2017 PForm 4 →	Jun 6, 7:16 am EDT	Richard A LernerDirector	10,000	$6.31	$63,135	166,172	+6.40%	plan?
Jun 2, 2017 MForm 4 →	Jun 5, 9:49 am EDT	Richard C Pfenniger Jr.Director	20,000	$3.43	$68,600	170,000	—	plan?
Jun 1, 2017 PForm 4 →	Jun 2, 11:36 am EDT	John A PaganelliDirector	5,000	$6.17	$30,840	9,175	+120%	plan?
May 31, 2017 PForm 4 →	Jun 1, 9:27 am EDT	Steven D RubinExecutive VP-Administration, Director	2,000	$6.10	$12,200	5,685,915	+0.04%	plan?
May 31, 2017 PForm 4 →	Jun 1, 6:45 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	207,700	$6.11	$1,269,461	163,018,543	+0.13%	plan?
May 30, 2017 PForm 4 →	May 31, 6:48 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	18,600	$6.28	$116,773	162,810,843	+0.01%	plan?
May 26, 2017 PForm 4 →	May 30, 7:02 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	64,600	$6.31	$407,432	162,792,243	+0.04%	plan?
May 25, 2017 PForm 4 →	May 26, 7:13 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	26,000	$6.38	$165,786	162,727,643	+0.02%	plan?
May 24, 2017 PForm 4 →	May 25, 6:20 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	42,200	$6.42	$270,959	162,701,643	+0.03%	plan?
May 22, 2017 PForm 4 →	May 23, 7:03 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	120,000	$6.43	$772,174	162,659,443	+0.07%	plan?
May 19, 2017 PForm 4 →	May 22, 6:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	9,200	$6.60	$60,685	162,539,443	+0.01%	plan?
May 18, 2017 PForm 4 →	May 19, 6:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$6.59	$131,808	162,530,243	+0.01%	plan?
May 17, 2017 PForm 4 →	May 18, 7:00 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	70,800	$6.54	$463,256	162,510,243	+0.04%	plan?
May 16, 2017 PForm 4 →	May 17, 6:45 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	27,800	$6.61	$183,634	162,439,443	+0.02%	plan?
May 11, 2017 PForm 4/A →	Feb 5, 2019, 4:30 pm EST	Jane Ph D HsiaoVice Chairman & CTO, Director	20,000	$6.93	$138,500	4,677,404	+0.43%	plan?
May 11, 2017 PForm 4 →	May 12, 10:53 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	20,000	$6.93	$138,500	24,773,133	+0.08%	plan? amended
May 11, 2017 PForm 4 →	May 11, 2:17 pm EDT	Steven D RubinExecutive VP-Administration, Director	2,000	$6.91	$13,814	5,683,915	+0.04%	plan?
May 10, 2017 PForm 4/A →	Feb 5, 2019, 4:26 pm EST	Jane Ph D HsiaoVice Chairman & CTO, Director	40,000	$6.97	$278,705	4,657,404	+0.87%	plan?
May 10, 2017 PForm 4 →	May 11, 6:50 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	40,000	$6.97	$278,705	24,753,133	+0.16%	plan? amended
May 10, 2017 PForm 4 →	May 11, 6:41 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,125,000	$6.96	$7,829,775	162,411,643	+0.70%	plan?
May 8, 2017 PForm 4 →	May 9, 6:46 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	100,000	$7.22	$722,248	161,286,643	+0.06%	plan?
May 5, 2017 PForm 4 →	May 8, 6:54 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$7.52	$75,234	161,186,643	+0.01%	plan?
May 4, 2017 PForm 4 →	May 5, 6:41 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	11,800	$7.51	$88,592	161,176,643	+0.01%	plan?
May 3, 2017 PForm 4 →	May 4, 6:41 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	11,000	$7.53	$82,784	161,164,843	+0.01%	plan?
May 2, 2017 PForm 4 →	May 2, 6:56 pm EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$7.58	$113,760	161,153,843	+0.01%	plan?
May 1, 2017 PForm 4 →	May 2, 7:03 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	4,700	$7.68	$36,104	161,138,843	+0.00%	plan?
Apr 28, 2017 PForm 4 →	May 1, 7:10 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	9,000	$7.78	$70,010	161,134,143	+0.01%	plan?
Apr 27, 2017 PForm 4 →	Apr 28, 7:05 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	22,500	$7.81	$175,787	161,125,143	+0.01%	plan?
Apr 26, 2017 PForm 4 →	Apr 27, 7:12 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,000	$7.84	$39,196	161,102,643	+0.00%	plan?
Apr 21, 2017 PForm 4 →	Apr 24, 7:32 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	19,000	$7.48	$142,197	161,097,643	+0.01%	plan?
Apr 19, 2017 PForm 4 →	Apr 20, 7:27 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$7.49	$112,291	161,078,643	+0.01%	plan?
Apr 18, 2017 PForm 4 →	Apr 19, 7:32 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	27,800	$7.26	$201,790	161,063,643	+0.02%	plan?
Apr 17, 2017 PForm 4 →	Apr 18, 7:04 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	13,600	$7.48	$101,676	161,035,843	+0.01%	plan?
Apr 13, 2017 PForm 4 →	Apr 14, 7:45 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	30,800	$7.58	$233,400	161,022,243	+0.02%	plan?
Apr 12, 2017 FMForm 4 →	Apr 13, 4:25 pm EDT	Steven D RubinExecutive VP-Administration, Director	423,336	$4.34	$1,838,254	5,681,915	—	plan?
Apr 11, 2017 PForm 4 →	Apr 12, 6:12 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	18,000	$7.49	$134,909	160,991,443	+0.01%	plan?
Apr 10, 2017 MForm 4 →	Apr 11, 4:14 pm EDT	Alice Lin-Tsing YuDirector	20,000	$4.72	$94,400	100,000	—	plan?
Apr 10, 2017 PForm 4 →	Apr 11, 7:00 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	33,000	$7.60	$250,842	160,973,443	+0.02%	plan?
Apr 7, 2017 PForm 4 →	Apr 10, 8:23 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	28,000	$7.58	$212,220	160,940,443	+0.02%	plan?
Apr 6, 2017 PForm 4 →	Apr 7, 8:28 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	28,600	$7.58	$216,881	160,912,443	+0.02%	plan?
Apr 5, 2017 PForm 4 →	Apr 6, 7:31 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	44,500	$7.69	$342,042	160,883,843	+0.03%	plan?

Reported at this company — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Jun 18, 2026 AForm 4 →	Jun 22, 5:38 pm EDT	Prem A LachmanDirector	30,000	—	—	30,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:37 pm EDT	Roger Medel M.D.Director	30,000	—	—	30,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:36 pm EDT	John A PaganelliDirector	30,000	—	—	30,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:34 pm EDT	Richard C Pfenniger Jr.Director	60,000	—	—	60,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:33 pm EDT	Subbarao V UppaluriDirector	80,000	—	—	80,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:32 pm EDT	Alice Lin-Tsing YuDirector	30,000	—	—	30,000	—
Feb 1, 2019 MForm 4 →	Feb 5, 4:33 pm EST	Steven D RubinExecutive VP-Administration, Director	24,877	—	—	0	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:16 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:16 pm EDT	Richard C Pfenniger Jr.Director	30,000	—	—	30,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:15 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:15 pm EDT	Richard M KrasnoDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:14 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:14 pm EDT	Robert Scott FishelDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:13 pm EDT	Adam LogalSr. Vice President, CFO	300,000	—	—	300,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:13 pm EDT	Steven D RubinExecutive VP-Administration, Director	300,000	—	—	300,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:12 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	500,000	—	—	500,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:11 pm EDT	Phillip Md Et Al FrostCEO & Chairman, Director, 10% Owner	500,000	—	—	500,000	—
Jun 8, 2018 MForm 4 →	Jun 12, 6:05 pm EDT	Adam LogalSr. Vice President, CFO	75,000	—	—	0	—
May 14, 2018 MForm 4 →	May 15, 4:13 pm EDT	Richard A LernerDirector	45,000	—	—	0	—
Apr 3, 2018 AForm 4 →	Apr 4, 4:13 pm EDT	Robert Scott FishelDirector	40,000	—	—	40,000	—
Feb 27, 2018 AForm 4 →	Mar 1, 4:11 pm EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	—	—	—	—	—
Feb 27, 2018 AForm 4 →	Mar 1, 4:10 pm EST	Jane Ph D HsiaoVice Chairman & CTO, Director	—	—	—	—	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:22 pm EDT	Richard M KrasnoDirector	20,000	—	—	20,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:21 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:19 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:18 pm EDT	Richard C Pfenniger Jr.Director	30,000	—	—	30,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:17 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
Jun 2, 2017 MForm 4 →	Jun 5, 9:49 am EDT	Richard C Pfenniger Jr.Director	20,000	—	—	0	—
Apr 12, 2017 MForm 4 →	Apr 13, 4:25 pm EDT	Steven D RubinExecutive VP-Administration, Director	265,000	—	—	0	—
Apr 10, 2017 MForm 4 →	Apr 11, 4:14 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	0	—
Mar 13, 2017 MForm 4 →	Mar 15, 6:31 pm EDT	Adam LogalSr. Vice President, CFO	264,207	—	—	0	—
Mar 13, 2017 MForm 4 →	Mar 15, 6:30 pm EDT	Richard A LernerDirector	20,000	—	—	0	—
Mar 6, 2017 MForm 4 →	Mar 7, 5:08 pm EST	John A PaganelliDirector	20,000	—	—	0	—
Feb 22, 2017 MForm 4 →	Feb 28, 6:27 pm EST	John A PaganelliDirector	20,000	—	—	0	—	late
Feb 9, 2017 AForm 4 →	Feb 10, 4:35 pm EST	Richard M KrasnoDirector	40,000	—	—	40,000	—
Jan 19, 2017 MForm 4 →	Jan 23, 7:30 am EST	Robert A BaronDirector	60,000	—	—	0	—
Jan 13, 2017 MForm 4 →	Jan 17, 4:12 pm EST	Thomas E BeierDirector	20,000	—	—	0	—
Jan 4, 2017 MForm 4 →	Jan 5, 11:11 am EST	Jane Ph D HsiaoVice Chairman & CTO, Director	112,500	—	—	112,500	—
Jun 2, 2016 AForm 4 →	Jun 3, 4:47 pm EDT	Richard C Pfenniger Jr.Director	10,000	—	—	10,000	—
May 5, 2016 AForm 4 →	May 5, 5:21 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:20 pm EDT	Richard C Pfenniger Jr.Director	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:19 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:18 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:17 pm EDT	Dmitry KolosovDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:16 pm EDT	Thomas E BeierDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:15 pm EDT	Robert A BaronDirector	20,000	—	—	20,000	—
May 3, 2016 MForm 4 →	May 5, 5:20 pm EDT	Steven D RubinExecutive VP-Administration, Director	250,000	—	—	0	—	amended
Apr 1, 2016 MForm 4 →	Apr 5, 4:39 pm EDT	Thomas E BeierDirector	20,000	—	—	0	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:55 pm EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	500,000	—	—	500,000	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:55 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	450,000	—	—	450,000	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:54 pm EDT	Steven D RubinExecutive VP-Administration, Director	450,000	—	—	450,000	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:54 pm EDT	Adam LogalSr. Vice President, CFO	250,000	—	—	250,000	—
Jan 22, 2016 MForm 4 →	Jan 26, 8:35 pm EST	Robert A BaronDirector	30,000	—	—	0	—
Oct 8, 2015 MForm 4 →	Oct 9, 4:23 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	0	—
Sep 18, 2015 MForm 4 →	Sep 22, 6:03 am EDT	John A PaganelliDirector	35,000	—	—	0	—
Aug 18, 2015 MForm 4 →	Aug 19, 10:28 am EDT	Alice Lin-Tsing YuDirector	20,000	—	—	0	—
Aug 12, 2015 MForm 4 →	Aug 13, 2:55 pm EDT	Robert A BaronDirector	5,000	—	—	0	—
Aug 7, 2015 MForm 4 →	Aug 10, 8:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,056,574	—	—	300,000	—
Aug 7, 2015 MForm 4 →	Aug 10, 8:48 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	200,000	—	—	262,500	—
Aug 6, 2015 CForm 4 →	Aug 7, 8:50 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	—	—	—	0	—
Aug 6, 2015 CForm 4 →	Aug 7, 8:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	—	—	—	0	—
Jul 17, 2015 MForm 4 →	Jul 20, 4:21 pm EDT	Thomas E BeierDirector	20,000	—	—	0	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:35 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:34 pm EDT	Richard C Pfenniger Jr.Director	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:33 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:32 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:30 pm EDT	Dmitry KolosovDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:29 pm EDT	Thomas E BeierDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:28 pm EDT	Robert A BaronDirector	20,000	—	—	20,000	—
Mar 18, 2015 AForm 4 →	Mar 27, 6:16 pm EDT	Dmitry KolosovDirector	10,000	—	—	10,000	—	late
Mar 18, 2015 AForm 4 →	Mar 19, 4:18 pm EDT	Adam LogalSr. Vice President, CFO	250,000	—	—	250,000	—
Mar 18, 2015 AForm 4 →	Mar 19, 4:17 pm EDT	Steven D RubinExecutive VP-Administration, Director	450,000	—	—	450,000	—
Mar 18, 2015 AForm 4 →	Mar 19, 4:16 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	450,000	—	—	450,000	—
Mar 18, 2015 AForm 4 →	Mar 19, 4:16 pm EDT	Phillip Md Et Al FrostCEO & Chairman, Director, 10% Owner	500,000	—	—	500,000	—
Mar 12, 2015 MForm 4 →	Mar 13, 5:12 pm EDT	Adam LogalSr. Vice President, CFO	95,000	—	—	0	—
Jan 31, 2015 MForm 4 →	Feb 2, 6:02 am EST	Steven D RubinExecutive VP-Administration, Director	5,190,385	—	—	0	—
Jan 31, 2015 MForm 4 →	Feb 2, 6:01 am EST	Jane Ph D HsiaoVice Chairman & CTO, Director	7,090,525	—	—	0	—
Jan 31, 2015 MForm 4 →	Feb 2, 6:00 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	14,144,217	$0.7181	$399,259	0	—

Filed by this entity as an insider elsewhere — common stock

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Dec 19, 2017 AForm 4 →	Dec 21, 6:27 pm EST	Sevion Therapeutics, Inc.SVOND	495,126	—	—	1,289,818	—	plan?
Oct 30, 2017 PForm 4 →	Nov 1, 4:11 pm EDT	VBI Vaccines Inc/BCVBIV	655,738	$3.05	$2,000,001	6,678,752	+10.9%	plan?
Sep 19, 2017 CForm 4 →	Nov 7, 4:00 pm EST	Sevion Therapeutics, Inc.SVON	1,250,006	—	—	15,893,844	—	plan? late
Aug 10, 2017 CForm 4 →	Aug 14, 5:15 pm EDT	Sevion Therapeutics, Inc.SVON	4,126,822	$0.10	$412,682	14,643,838	—	plan?

Filed by this entity as an insider elsewhere — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Sep 19, 2017 CForm 4 →	Nov 7, 4:00 pm EST	Sevion Therapeutics, Inc.SVON	66,667	—	—	0	—	late
Aug 10, 2017 CForm 4 →	Aug 14, 5:15 pm EDT	Sevion Therapeutics, Inc.SVON	—	—	—	0	—