Company · CIK 0000944809 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

OPKO HEALTH, INC. · OPK

Insider activity reported against this company. All insider holders · Files at: ELOX, VBIV. On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market activity at this companybuys $105.0M · 493sales $1.9M · 3net $103.1M

Open-market trades as an insider elsewherebuys $2.0M · 1sales $0 · 0net $2.0M

Reported at this company — common stock

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Apr 4, 2017 PForm 4 →	Apr 5, 7:10 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	7,400	$7.69	$56,943	160,839,343	+0.00%	plan?
Apr 3, 2017 PForm 4 →	Apr 4, 7:36 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	21,600	$7.82	$168,908	160,831,943	+0.01%	plan?
Mar 31, 2017 PForm 4 →	Apr 3, 7:34 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$8.00	$14,400	160,810,343	+0.00%	plan?
Mar 30, 2017 PForm 4 →	Mar 31, 7:40 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,600	$8.02	$85,043	160,808,543	+0.01%	plan?
Mar 29, 2017 PForm 4 →	Mar 30, 7:14 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	9,200	$8.14	$74,847	160,797,943	+0.01%	plan?
Mar 28, 2017 PForm 4 →	Mar 29, 8:01 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,600	$8.03	$28,895	160,788,743	+0.00%	plan?
Mar 24, 2017 PForm 4 →	Mar 27, 6:26 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,600	$7.75	$27,917	160,785,143	+0.00%	plan?
Mar 23, 2017 PForm 4 →	Mar 24, 7:25 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	12,200	$7.71	$94,024	160,781,543	+0.01%	plan?
Mar 21, 2017 PForm 4 →	Mar 22, 7:28 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,800	$7.85	$45,531	160,769,343	+0.00%	plan?
Mar 20, 2017 PForm 4 →	Mar 21, 7:32 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	11,000	$7.99	$87,924	160,763,543	+0.01%	plan?
Mar 17, 2017 PForm 4 →	Mar 20, 7:30 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	9,000	$8.19	$73,710	160,752,543	+0.01%	plan?
Mar 15, 2017 PForm 4 →	Mar 16, 7:10 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$8.03	$14,453	160,743,543	+0.00%	plan?
Mar 14, 2017 SForm 4 →	Mar 15, 6:31 pm EDT	Adam LogalSr. Vice President, CFO	112,975	$8.07	$911,674	161,293	−41.2%	plan?
Mar 13, 2017 FMForm 4 →	Mar 15, 6:31 pm EDT	Adam LogalSr. Vice President, CFO	299,935	$1.89	$565,922	274,268	—	plan?
Mar 13, 2017 FGMForm 4 →	Mar 15, 6:30 pm EDT	Richard A LernerDirector	114,823	$3.26	$82,002	156,172	—	plan?
Mar 10, 2017 PForm 4 →	Mar 13, 7:22 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$7.97	$14,345	160,741,743	+0.00%	plan?
Mar 9, 2017 PForm 4 →	Mar 10, 7:22 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,600	$7.84	$28,209	160,739,943	+0.00%	plan?
Mar 8, 2017 PForm 4 →	Mar 9, 7:07 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$7.92	$14,256	160,736,343	+0.00%	plan?
Mar 6, 2017 FMForm 4 →	Mar 7, 5:08 pm EST	John A PaganelliDirector	29,015	$4.73	$137,204	350,340	—	plan?
Mar 3, 2017 PForm 4 →	Mar 6, 7:03 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	8,600	$7.43	$63,895	160,734,543	+0.01%	plan?
Mar 2, 2017 PForm 4 →	Mar 3, 8:05 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	94,800	$7.53	$713,787	160,725,943	+0.06%	plan?
Feb 24, 2017 PForm 4 →	Feb 27, 7:01 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,600	$8.45	$30,436	160,631,143	+0.00%	plan?
Feb 23, 2017 PForm 4 →	Feb 24, 6:11 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$8.39	$15,102	160,627,543	+0.00%	plan?
Feb 22, 2017 FMForm 4 →	Feb 28, 6:27 pm EST	John A PaganelliDirector	24,853	$3.30	$82,008	339,355	—	plan? late
Feb 22, 2017 PForm 4 →	Feb 23, 7:08 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$8.54	$15,371	160,625,743	+0.00%	plan?
Feb 21, 2017 PForm 4 →	Feb 22, 7:21 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,600	$8.80	$31,680	160,623,943	+0.00%	plan?
Feb 17, 2017 PForm 4 →	Feb 21, 6:36 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$8.80	$15,836	160,620,343	+0.00%	plan?
Feb 16, 2017 PForm 4 →	Feb 17, 7:33 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$8.65	$15,570	160,618,543	+0.00%	plan?
Feb 15, 2017 PForm 4 →	Feb 16, 6:25 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$8.46	$15,228	160,616,743	+0.00%	plan?
Feb 14, 2017 PForm 4 →	Feb 15, 7:41 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$8.41	$15,138	160,614,943	+0.00%	plan?
Feb 13, 2017 PForm 4 →	Feb 14, 7:20 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$8.36	$15,046	160,613,143	+0.00%	plan?
Feb 10, 2017 PForm 4 →	Feb 13, 7:27 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$8.14	$14,656	160,611,343	+0.00%	plan?
Feb 9, 2017 PForm 4 →	Feb 10, 7:06 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$8.07	$80,696	160,609,543	+0.01%	plan?
Feb 8, 2017 PForm 4 →	Feb 9, 7:49 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,600	$8.13	$126,891	160,599,543	+0.01%	plan?
Feb 8, 2017 PForm 4 →	Feb 9, 7:46 am EST	Steven D RubinExecutive VP-Administration, Director	2,000	$8.11	$16,214	5,575,251	+0.04%	plan?
Feb 7, 2017 PForm 4 →	Feb 8, 7:36 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,400	$8.27	$44,671	160,583,943	+0.00%	plan?
Feb 6, 2017 PForm 4 →	Feb 7, 10:06 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,600	$8.32	$171,435	160,578,543	+0.01%	plan?
Feb 2, 2017 PForm 4 →	Feb 3, 6:03 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	6,000	$8.53	$51,156	160,557,943	+0.00%	plan?
Feb 1, 2017 PForm 4 →	Feb 2, 6:03 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	9,000	$8.59	$77,341	160,551,943	+0.01%	plan?
Jan 31, 2017 PForm 4 →	Feb 1, 6:02 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	12,000	$8.60	$103,179	160,542,943	+0.01%	plan?
Jan 30, 2017 PForm 4 →	Jan 31, 6:03 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$8.49	$84,860	160,530,943	+0.01%	plan?
Jan 27, 2017 PForm 4 →	Jan 30, 7:02 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	12,000	$8.67	$103,984	160,520,943	+0.01%	plan?
Jan 25, 2017 PForm 4 →	Jan 26, 6:03 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$8.55	$85,507	160,508,943	+0.01%	plan?
Jan 24, 2017 PForm 4 →	Jan 25, 6:03 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$8.46	$84,572	160,498,943	+0.01%	plan?
Jan 23, 2017 PForm 4 →	Jan 24, 6:35 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	12,000	$8.48	$101,779	160,488,943	+0.01%	plan?
Jan 20, 2017 PForm 4 →	Jan 23, 6:03 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	8,600	$8.72	$74,978	160,476,943	+0.01%	plan?
Jan 19, 2017 FMForm 4 →	Jan 23, 7:30 am EST	Robert A BaronDirector	83,315	$4.90	$408,006	320,773	—	plan?
Jan 19, 2017 PForm 4 →	Jan 20, 6:02 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$8.75	$175,038	160,468,343	+0.01%	plan?
Jan 18, 2017 PForm 4 →	Jan 19, 6:03 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,700	$8.87	$94,860	160,448,343	+0.01%	plan?
Jan 13, 2017 MForm 4 →	Jan 17, 4:12 pm EST	Thomas E BeierDirector	20,000	$2.05	$41,000	60,000	—	plan?
Jan 13, 2017 PForm 4 →	Jan 17, 6:09 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$9.15	$137,225	160,437,643	+0.01%	plan?
Jan 4, 2017 MForm 4 →	Jan 5, 11:11 am EST	Jane Ph D HsiaoVice Chairman & CTO, Director	112,500	$7.61	$856,125	24,713,133	—	plan?
Jan 3, 2017 PForm 4 →	Jan 4, 6:02 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$9.04	$180,794	160,422,643	+0.01%	plan?
Dec 30, 2016 PForm 4 →	Jan 3, 2017, 7:56 am EST	Steven D RubinExecutive VP-Administration, Director	2,000	$9.18	$18,353	5,573,251	+0.04%	plan?
Dec 30, 2016 PForm 4 →	Jan 3, 2017, 6:02 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	25,000	$9.42	$235,515	160,402,643	+0.02%	plan?
Dec 19, 2016 GForm 4 →	Dec 22, 4:34 pm EST	John A PaganelliDirector	1,000	—	—	324,208	—	plan? late
Dec 14, 2016 GForm 4 →	Dec 15, 4:15 pm EST	John A PaganelliDirector	500	—	—	325,208	—	plan?
Dec 9, 2016 GForm 4 →	Dec 12, 4:29 pm EST	John A PaganelliDirector	4,000	—	—	325,708	—	plan?
Dec 2, 2016 PForm 4 →	Dec 5, 6:08 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,000	$10.49	$10,488	160,377,643	+0.00%	plan?
Dec 1, 2016 PForm 4 →	Dec 2, 7:46 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,800	$10.27	$39,035	160,376,643	+0.00%	plan?
Nov 30, 2016 PForm 4 →	Dec 1, 6:07 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$10.40	$18,720	160,372,843	+0.00%	plan?
Nov 28, 2016 PForm 4 →	Nov 29, 7:37 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,600	$10.61	$59,411	160,371,043	+0.00%	plan?
Nov 23, 2016 PForm 4 →	Nov 25, 7:06 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	4,300	$10.09	$43,387	160,365,443	+0.00%	plan?
Nov 22, 2016 PForm 4 →	Nov 23, 7:04 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,400	$10.28	$55,523	160,361,143	+0.00%	plan?
Nov 21, 2016 PForm 4 →	Nov 22, 6:43 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,600	$10.41	$37,468	160,355,743	+0.00%	plan?
Nov 18, 2016 PForm 4 →	Nov 21, 7:09 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$10.38	$18,692	160,352,143	+0.00%	plan?
Nov 16, 2016 PForm 4 →	Nov 17, 6:07 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	4,300	$10.13	$43,565	160,350,343	+0.00%	plan?
Nov 10, 2016 PForm 4 →	Nov 14, 6:23 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	14,600	$9.46	$138,143	160,346,043	+0.01%	plan?
Nov 9, 2016 PForm 4 →	Nov 10, 6:06 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,400	$9.33	$50,382	160,331,443	+0.00%	plan?
Nov 8, 2016 PForm 4 →	Nov 9, 6:01 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	23,100	$9.22	$213,054	160,326,043	+0.01%	plan?
Nov 2, 2016 PForm 4 →	Nov 3, 6:19 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.48	$94,845	160,302,943	+0.01%	plan?
Nov 1, 2016 PForm 4 →	Nov 2, 6:13 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.49	$94,878	160,292,943	+0.01%	plan?
Oct 31, 2016 PForm 4 →	Nov 1, 6:10 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	11,800	$9.43	$111,279	160,282,943	+0.01%	plan?
Oct 28, 2016 PForm 4 →	Oct 31, 6:23 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.46	$94,566	160,271,143	+0.01%	plan?
Oct 27, 2016 PForm 4 →	Oct 28, 6:17 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.36	$93,568	160,261,143	+0.01%	plan?
Oct 26, 2016 PForm 4 →	Oct 27, 7:03 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,600	$9.27	$51,940	160,251,143	+0.00%	plan?
Oct 25, 2016 PForm 4 →	Oct 26, 7:57 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,600	$9.38	$33,750	160,245,543	+0.00%	plan?
Oct 24, 2016 PForm 4 →	Oct 25, 6:05 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$9.50	$17,091	160,241,943	+0.00%	plan?
Oct 21, 2016 PForm 4 →	Oct 24, 6:06 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$9.38	$16,884	160,240,143	+0.00%	plan?
Oct 20, 2016 PForm 4 →	Oct 21, 6:04 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	2,700	$9.26	$24,989	160,238,343	+0.00%	plan?
Oct 19, 2016 PForm 4 →	Oct 20, 7:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	14,700	$9.26	$136,131	160,235,643	+0.01%	plan?
Oct 18, 2016 PForm 4 →	Oct 19, 7:45 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$9.29	$16,722	160,220,943	+0.00%	plan?
Oct 17, 2016 PForm 4 →	Oct 18, 6:05 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,600	$9.34	$33,642	160,219,143	+0.00%	plan?
Oct 14, 2016 PForm 4 →	Oct 17, 6:01 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$9.48	$17,064	160,215,543	+0.00%	plan?
Oct 13, 2016 PForm 4 →	Oct 14, 6:17 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,400	$9.52	$51,432	160,213,743	+0.00%	plan?
Oct 11, 2016 PForm 4 →	Oct 12, 6:07 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	7,200	$9.78	$70,432	160,208,343	+0.00%	plan?
Oct 7, 2016 PForm 4 →	Oct 11, 6:02 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	24,800	$9.82	$243,597	160,201,143	+0.02%	plan?
Oct 6, 2016 PForm 4 →	Oct 7, 6:06 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	4,200	$10.53	$44,242	160,176,343	+0.00%	plan?
Oct 4, 2016 PForm 4 →	Oct 5, 6:10 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,600	$10.57	$38,056	160,172,143	+0.00%	plan?
Sep 30, 2016 PForm 4 →	Oct 3, 6:00 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$10.54	$18,972	160,168,543	+0.00%	plan?
Sep 29, 2016 PForm 4 →	Sep 30, 6:03 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,600	$10.67	$38,418	160,166,743	+0.00%	plan?
Sep 28, 2016 PForm 4 →	Sep 29, 6:30 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,400	$11.01	$59,448	160,163,143	+0.00%	plan?
Sep 27, 2016 PForm 4 →	Sep 28, 6:17 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$11.16	$20,086	160,157,743	+0.00%	plan?
Sep 26, 2016 PForm 4 →	Sep 27, 6:02 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$11.04	$19,880	160,155,943	+0.00%	plan?
Sep 23, 2016 PForm 4 →	Sep 26, 6:07 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$10.95	$19,710	160,154,143	+0.00%	plan?
Sep 22, 2016 PForm 4 →	Sep 23, 6:04 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$10.63	$19,131	160,152,343	+0.00%	plan?
Sep 21, 2016 PForm 4 →	Sep 22, 7:27 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$10.46	$18,828	160,150,543	+0.00%	plan?
Sep 20, 2016 PForm 4 →	Sep 21, 6:26 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$10.36	$18,648	160,148,743	+0.00%	plan?
Sep 19, 2016 PForm 4 →	Sep 20, 6:52 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,800	$10.18	$18,324	160,146,943	+0.00%	plan?
Sep 13, 2016 PForm 4 →	Sep 14, 6:05 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$9.95	$99,530	160,145,143	+0.01%	plan?

Reported at this company — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Jun 18, 2026 AForm 4 →	Jun 22, 5:38 pm EDT	Prem A LachmanDirector	30,000	—	—	30,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:37 pm EDT	Roger Medel M.D.Director	30,000	—	—	30,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:36 pm EDT	John A PaganelliDirector	30,000	—	—	30,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:34 pm EDT	Richard C Pfenniger Jr.Director	60,000	—	—	60,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:33 pm EDT	Subbarao V UppaluriDirector	80,000	—	—	80,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:32 pm EDT	Alice Lin-Tsing YuDirector	30,000	—	—	30,000	—
Feb 1, 2019 MForm 4 →	Feb 5, 4:33 pm EST	Steven D RubinExecutive VP-Administration, Director	24,877	—	—	0	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:16 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:16 pm EDT	Richard C Pfenniger Jr.Director	30,000	—	—	30,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:15 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:15 pm EDT	Richard M KrasnoDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:14 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:14 pm EDT	Robert Scott FishelDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:13 pm EDT	Adam LogalSr. Vice President, CFO	300,000	—	—	300,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:13 pm EDT	Steven D RubinExecutive VP-Administration, Director	300,000	—	—	300,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:12 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	500,000	—	—	500,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:11 pm EDT	Phillip Md Et Al FrostCEO & Chairman, Director, 10% Owner	500,000	—	—	500,000	—
Jun 8, 2018 MForm 4 →	Jun 12, 6:05 pm EDT	Adam LogalSr. Vice President, CFO	75,000	—	—	0	—
May 14, 2018 MForm 4 →	May 15, 4:13 pm EDT	Richard A LernerDirector	45,000	—	—	0	—
Apr 3, 2018 AForm 4 →	Apr 4, 4:13 pm EDT	Robert Scott FishelDirector	40,000	—	—	40,000	—
Feb 27, 2018 AForm 4 →	Mar 1, 4:11 pm EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	—	—	—	—	—
Feb 27, 2018 AForm 4 →	Mar 1, 4:10 pm EST	Jane Ph D HsiaoVice Chairman & CTO, Director	—	—	—	—	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:22 pm EDT	Richard M KrasnoDirector	20,000	—	—	20,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:21 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:19 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:18 pm EDT	Richard C Pfenniger Jr.Director	30,000	—	—	30,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:17 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
Jun 2, 2017 MForm 4 →	Jun 5, 9:49 am EDT	Richard C Pfenniger Jr.Director	20,000	—	—	0	—
Apr 12, 2017 MForm 4 →	Apr 13, 4:25 pm EDT	Steven D RubinExecutive VP-Administration, Director	265,000	—	—	0	—
Apr 10, 2017 MForm 4 →	Apr 11, 4:14 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	0	—
Mar 13, 2017 MForm 4 →	Mar 15, 6:31 pm EDT	Adam LogalSr. Vice President, CFO	264,207	—	—	0	—
Mar 13, 2017 MForm 4 →	Mar 15, 6:30 pm EDT	Richard A LernerDirector	20,000	—	—	0	—
Mar 6, 2017 MForm 4 →	Mar 7, 5:08 pm EST	John A PaganelliDirector	20,000	—	—	0	—
Feb 22, 2017 MForm 4 →	Feb 28, 6:27 pm EST	John A PaganelliDirector	20,000	—	—	0	—	late
Feb 9, 2017 AForm 4 →	Feb 10, 4:35 pm EST	Richard M KrasnoDirector	40,000	—	—	40,000	—
Jan 19, 2017 MForm 4 →	Jan 23, 7:30 am EST	Robert A BaronDirector	60,000	—	—	0	—
Jan 13, 2017 MForm 4 →	Jan 17, 4:12 pm EST	Thomas E BeierDirector	20,000	—	—	0	—
Jan 4, 2017 MForm 4 →	Jan 5, 11:11 am EST	Jane Ph D HsiaoVice Chairman & CTO, Director	112,500	—	—	112,500	—
Jun 2, 2016 AForm 4 →	Jun 3, 4:47 pm EDT	Richard C Pfenniger Jr.Director	10,000	—	—	10,000	—
May 5, 2016 AForm 4 →	May 5, 5:21 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:20 pm EDT	Richard C Pfenniger Jr.Director	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:19 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:18 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:17 pm EDT	Dmitry KolosovDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:16 pm EDT	Thomas E BeierDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:15 pm EDT	Robert A BaronDirector	20,000	—	—	20,000	—
May 3, 2016 MForm 4 →	May 5, 5:20 pm EDT	Steven D RubinExecutive VP-Administration, Director	250,000	—	—	0	—	amended
Apr 1, 2016 MForm 4 →	Apr 5, 4:39 pm EDT	Thomas E BeierDirector	20,000	—	—	0	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:55 pm EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	500,000	—	—	500,000	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:55 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	450,000	—	—	450,000	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:54 pm EDT	Steven D RubinExecutive VP-Administration, Director	450,000	—	—	450,000	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:54 pm EDT	Adam LogalSr. Vice President, CFO	250,000	—	—	250,000	—
Jan 22, 2016 MForm 4 →	Jan 26, 8:35 pm EST	Robert A BaronDirector	30,000	—	—	0	—
Oct 8, 2015 MForm 4 →	Oct 9, 4:23 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	0	—
Sep 18, 2015 MForm 4 →	Sep 22, 6:03 am EDT	John A PaganelliDirector	35,000	—	—	0	—
Aug 18, 2015 MForm 4 →	Aug 19, 10:28 am EDT	Alice Lin-Tsing YuDirector	20,000	—	—	0	—
Aug 12, 2015 MForm 4 →	Aug 13, 2:55 pm EDT	Robert A BaronDirector	5,000	—	—	0	—
Aug 7, 2015 MForm 4 →	Aug 10, 8:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,056,574	—	—	300,000	—
Aug 7, 2015 MForm 4 →	Aug 10, 8:48 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	200,000	—	—	262,500	—
Aug 6, 2015 CForm 4 →	Aug 7, 8:50 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	—	—	—	0	—
Aug 6, 2015 CForm 4 →	Aug 7, 8:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	—	—	—	0	—
Jul 17, 2015 MForm 4 →	Jul 20, 4:21 pm EDT	Thomas E BeierDirector	20,000	—	—	0	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:35 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:34 pm EDT	Richard C Pfenniger Jr.Director	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:33 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:32 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:30 pm EDT	Dmitry KolosovDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:29 pm EDT	Thomas E BeierDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:28 pm EDT	Robert A BaronDirector	20,000	—	—	20,000	—
Mar 18, 2015 AForm 4 →	Mar 27, 6:16 pm EDT	Dmitry KolosovDirector	10,000	—	—	10,000	—	late
Mar 18, 2015 AForm 4 →	Mar 19, 4:18 pm EDT	Adam LogalSr. Vice President, CFO	250,000	—	—	250,000	—
Mar 18, 2015 AForm 4 →	Mar 19, 4:17 pm EDT	Steven D RubinExecutive VP-Administration, Director	450,000	—	—	450,000	—
Mar 18, 2015 AForm 4 →	Mar 19, 4:16 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	450,000	—	—	450,000	—
Mar 18, 2015 AForm 4 →	Mar 19, 4:16 pm EDT	Phillip Md Et Al FrostCEO & Chairman, Director, 10% Owner	500,000	—	—	500,000	—
Mar 12, 2015 MForm 4 →	Mar 13, 5:12 pm EDT	Adam LogalSr. Vice President, CFO	95,000	—	—	0	—
Jan 31, 2015 MForm 4 →	Feb 2, 6:02 am EST	Steven D RubinExecutive VP-Administration, Director	5,190,385	—	—	0	—
Jan 31, 2015 MForm 4 →	Feb 2, 6:01 am EST	Jane Ph D HsiaoVice Chairman & CTO, Director	7,090,525	—	—	0	—
Jan 31, 2015 MForm 4 →	Feb 2, 6:00 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	14,144,217	$0.7181	$399,259	0	—

Filed by this entity as an insider elsewhere — common stock

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Dec 19, 2017 AForm 4 →	Dec 21, 6:27 pm EST	Sevion Therapeutics, Inc.SVOND	495,126	—	—	1,289,818	—	plan?
Oct 30, 2017 PForm 4 →	Nov 1, 4:11 pm EDT	VBI Vaccines Inc/BCVBIV	655,738	$3.05	$2,000,001	6,678,752	+10.9%	plan?
Sep 19, 2017 CForm 4 →	Nov 7, 4:00 pm EST	Sevion Therapeutics, Inc.SVON	1,250,006	—	—	15,893,844	—	plan? late
Aug 10, 2017 CForm 4 →	Aug 14, 5:15 pm EDT	Sevion Therapeutics, Inc.SVON	4,126,822	$0.10	$412,682	14,643,838	—	plan?

Filed by this entity as an insider elsewhere — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Sep 19, 2017 CForm 4 →	Nov 7, 4:00 pm EST	Sevion Therapeutics, Inc.SVON	66,667	—	—	0	—	late
Aug 10, 2017 CForm 4 →	Aug 14, 5:15 pm EDT	Sevion Therapeutics, Inc.SVON	—	—	—	0	—