Company · CIK 0000944809 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

OPKO HEALTH, INC. · OPK

Insider activity reported against this company. All insider holders · Files at: ELOX, VBIV. On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market activity at this companybuys $105.0M · 493sales $1.9M · 3net $103.1M

Open-market trades as an insider elsewherebuys $2.0M · 1sales $0 · 0net $2.0M

Reported at this company — common stock

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Jul 24, 2026 FForm 4 →	Jul 28, 4:24 pm EDT	Adam LogalSr. Vice President, CFO	53,266	$1.22	$64,985	563,396	—
Jul 24, 2026 FForm 4 →	Jul 28, 4:21 pm EDT	Steven D RubinExecutive VP-Administration, Director	53,266	$1.22	$64,985	6,571,966	—
Mar 6, 2019 PForm 4 →	Mar 7, 9:45 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	50,000	$2.57	$128,622	25,185,177	+0.20%	plan?
Mar 6, 2019 PForm 4 →	Mar 7, 9:45 am EST	Steven D RubinExecutive VP-Administration, Director	8,000	$2.56	$20,452	5,719,147	+0.14%	plan?
Feb 28, 2019 PForm 4 →	Mar 1, 7:38 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	200,000	$2.48	$495,947	25,135,177	+0.80%	plan?
Feb 1, 2019 FMForm 4 →	Feb 5, 4:33 pm EST	Steven D RubinExecutive VP-Administration, Director	30,522	$1.20	$36,684	5,711,147	—	plan?
Jan 17, 2019 PForm 4 →	Jan 18, 6:55 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$3.67	$55,031	24,935,177	+0.06%	plan?
Jan 16, 2019 PForm 4 →	Jan 17, 6:52 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$3.74	$37,369	24,920,177	+0.04%	plan?
Jan 14, 2019 PForm 4 →	Jan 15, 6:16 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$3.74	$56,055	24,910,177	+0.06%	plan?
Jan 11, 2019 PForm 4 →	Jan 14, 6:51 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$3.83	$38,325	24,895,177	+0.04%	plan?
Jan 10, 2019 PForm 4 →	Jan 11, 6:59 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$3.69	$36,908	24,885,177	+0.04%	plan?
Jan 9, 2019 PForm 4 →	Jan 10, 7:11 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$3.65	$36,501	24,875,177	+0.04%	plan?
Jan 8, 2019 PForm 4 →	Jan 9, 7:11 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	35,000	$3.61	$126,376	24,865,177	+0.14%	plan?
Jan 7, 2019 PForm 4 →	Jan 8, 7:32 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	55,000	$3.56	$195,922	24,830,177	+0.22%	plan?
Jan 4, 2019 PForm 4 →	Jan 7, 7:11 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	30,000	$3.43	$102,914	24,775,177	+0.12%	plan?
Jan 3, 2019 PForm 4 →	Jan 4, 6:55 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	50,000	$3.25	$162,693	24,745,177	+0.20%	plan?
Jan 2, 2019 PForm 4 →	Jan 3, 7:51 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	40,000	$3.24	$129,713	24,695,177	+0.16%	plan?
Dec 31, 2018 PForm 4 →	Jan 2, 2019, 8:44 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	135,000	$2.97	$401,068	24,655,177	+0.55%	plan?
Dec 28, 2018 PForm 4 →	Dec 31, 7:07 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	100,000	$3.13	$312,898	24,520,177	+0.41%	plan?
Nov 8, 2018 AForm 4 →	Nov 13, 7:43 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,057,307	$3.49	$70,000,001	24,420,177	—	plan? late
Nov 8, 2018 AForm 4 →	Nov 13, 7:42 am EST	Jane Ph D HsiaoVice Chairman & CTO, Director	573,066	$3.49	$2,000,000	25,346,199	—	plan? late
Sep 7, 2018 PForm 4 →	Sep 10, 6:30 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$5.57	$55,705	4,362,870	+0.23%	plan?
Sep 7, 2018 PForm 4 →	Sep 10, 6:30 am EDT	Robert Scott FishelDirector	10,000	$4.63	$46,300	4,070,728	+0.25%	plan?
Sep 5, 2018 PForm 4 →	Sep 6, 7:40 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$5.79	$57,943	4,352,870	+0.23%	plan?
Aug 30, 2018 PForm 4 →	Aug 31, 6:24 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,000	$5.90	$29,475	4,342,870	+0.12%	plan?
Aug 28, 2018 PForm 4 →	Aug 29, 6:02 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	5,000	$5.80	$28,994	4,337,870	+0.12%	plan?
Aug 24, 2018 PForm 4 →	Aug 27, 7:25 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$5.70	$85,553	4,332,870	+0.35%	plan?
Aug 17, 2018 PForm 4 →	Aug 20, 7:07 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$5.54	$55,358	4,317,870	+0.23%	plan?
Aug 13, 2018 PForm 4 →	Aug 14, 6:10 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$5.33	$79,932	4,307,870	+0.35%	plan?
Aug 9, 2018 PForm 4 →	Aug 10, 7:10 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$5.45	$54,525	4,292,870	+0.23%	plan?
Jul 26, 2018 PForm 4 →	Jul 27, 6:30 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	90,000	$5.06	$455,206	4,282,870	+2.15%	plan?
Jul 25, 2018 PForm 4 →	Jul 26, 6:28 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	60,000	$5.47	$328,248	4,192,870	+1.45%	plan?
Jul 24, 2018 PForm 4 →	Jul 25, 6:52 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	55,000	$5.60	$307,769	4,132,870	+1.35%	plan?
Jul 20, 2018 PForm 4 →	Jul 23, 6:39 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$5.89	$58,900	4,077,870	+0.25%	plan?
Jul 19, 2018 PForm 4 →	Jul 20, 6:22 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$5.95	$59,500	4,067,870	+0.25%	plan?
Jul 18, 2018 PForm 4 →	Jul 19, 6:44 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$6.05	$60,500	4,057,870	+0.25%	plan?
Jul 16, 2018 PForm 4 →	Jul 17, 7:17 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	15,000	$5.68	$85,249	4,047,870	+0.37%	plan?
Jul 11, 2018 PForm 4 →	Jul 12, 7:12 am EDT	Robert Scott FishelDirector	2,500	$6.00	$14,991	4,060,728	+0.06%	plan?
Jul 3, 2018 PForm 4 →	Jul 5, 7:35 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$4.75	$47,501	4,032,870	+0.25%	plan?
Jun 29, 2018 PForm 4 →	Jul 2, 6:23 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	7,720	$4.71	$36,335	4,022,870	+0.19%	plan?
Jun 28, 2018 PForm 4 →	Jun 29, 7:09 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$4.68	$93,600	4,015,150	+0.50%	plan?
Jun 27, 2018 PForm 4 →	Jun 28, 6:54 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$4.75	$47,500	3,995,150	+0.25%	plan?
Jun 22, 2018 PForm 4 →	Jun 25, 6:47 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$4.45	$44,500	3,985,150	+0.25%	plan?
Jun 21, 2018 PForm 4 →	Jun 22, 6:41 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	30,000	$4.54	$136,200	3,975,150	+0.76%	plan?
Jun 19, 2018 PForm 4 →	Jun 20, 6:19 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	20,000	$4.32	$86,300	3,945,150	+0.51%	plan?
Jun 18, 2018 PForm 4 →	Jun 19, 6:25 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	14,299	$4.34	$62,013	3,925,150	+0.37%	plan?
Jun 15, 2018 PForm 4 →	Jun 18, 6:10 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$4.42	$44,200	3,910,851	+0.26%	plan?
Jun 11, 2018 PForm 4 →	Jun 12, 6:17 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$4.22	$42,200	3,900,851	+0.26%	plan?
Jun 8, 2018 FMForm 4 →	Jun 12, 6:05 pm EDT	Adam LogalSr. Vice President, CFO	138,946	$3.81	$529,660	175,912	—	plan?
Jun 7, 2018 PForm 4 →	Jun 8, 7:37 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$4.04	$40,400	3,890,851	+0.26%	plan?
Jun 6, 2018 PForm 4 →	Jun 7, 7:11 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	30,000	$4.05	$121,500	3,880,851	+0.78%	plan?
May 31, 2018 PForm 4 →	Jun 1, 6:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	3,900	$3.76	$14,664	3,850,851	+0.10%	plan?
May 29, 2018 PForm 4 →	May 30, 7:29 am EDT	Robert Scott FishelDirector	2,500	$3.73	$9,333	4,058,228	+0.06%	plan?
May 25, 2018 PForm 4 →	May 29, 6:31 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$3.70	$37,000	3,846,951	+0.26%	plan?
May 23, 2018 PForm 4 →	May 24, 6:46 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	40,000	$3.73	$149,300	3,836,951	+1.05%	plan?
May 22, 2018 PForm 4 →	May 23, 7:15 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$3.73	$37,300	3,796,951	+0.26%	plan?
May 21, 2018 PForm 4 →	May 22, 7:18 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	90,000	$3.82	$344,096	3,786,951	+2.43%	plan?
May 18, 2018 PForm 4 →	May 21, 6:24 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	100,000	$4.04	$403,789	3,696,951	+2.78%	plan?
May 14, 2018 FGMForm 4 →	May 15, 4:13 pm EDT	Richard A LernerDirector	102,709	$3.99	$308,701	178,881	—	plan?
May 14, 2018 PForm 4 →	May 15, 6:04 am EDT	Robert Scott FishelDirector	1,800	$4.79	$8,622	4,055,728	+0.04%	plan?
May 4, 2018 PForm 4 →	May 7, 6:58 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	26,000	$3.14	$81,540	3,596,951	+0.73%	plan?
May 4, 2018 PForm 4 →	May 7, 6:57 am EDT	Robert Scott FishelDirector	5,000	$3.14	$15,700	4,053,928	+0.12%	plan?
May 3, 2018 PForm 4 →	May 4, 6:57 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	51,800	$3.09	$159,998	3,570,951	+1.47%	plan?
May 2, 2018 PForm 4 →	May 3, 6:02 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	50,330	$3.15	$158,630	3,519,151	+1.45%	plan?
May 1, 2018 PForm 4 →	May 2, 6:28 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	31,222	$3.05	$95,210	3,468,821	+0.91%	plan?
Apr 30, 2018 PForm 4 →	May 1, 6:36 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	75,000	$3.08	$231,126	3,437,599	+2.23%	plan?
Apr 26, 2018 PForm 4 →	Apr 27, 7:20 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	31,800	$3.03	$96,449	3,362,599	+0.95%	plan?
Apr 25, 2018 PForm 4 →	Apr 26, 6:31 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	55,372	$2.99	$165,342	3,330,799	+1.69%	plan?
Apr 25, 2018 PForm 4 →	Apr 26, 6:24 am EDT	Robert Scott FishelDirector	12,500	$2.97	$37,125	4,048,928	+0.31%	plan?
Apr 24, 2018 PForm 4 →	Apr 25, 6:06 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	75,000	$2.97	$222,641	3,275,427	+2.34%	plan?
Apr 23, 2018 PForm 4 →	Apr 24, 6:13 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	75,000	$3.04	$227,655	3,200,427	+2.40%	plan?
Apr 20, 2018 PForm 4 →	Apr 23, 11:20 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	60,000	$3.12	$187,490	3,125,427	+1.96%	plan?
Apr 19, 2018 PForm 4 →	Apr 20, 6:40 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$3.17	$31,700	3,065,427	+0.33%	plan?
Apr 16, 2018 PForm 4 →	Apr 17, 6:53 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	50,000	$3.02	$150,950	3,055,427	+1.66%	plan?
Apr 16, 2018 PForm 4 →	Apr 17, 6:52 am EDT	Robert Scott FishelDirector	15,000	$3.01	$45,100	4,036,428	+0.37%	plan?
Apr 13, 2018 PForm 4 →	Apr 16, 6:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	30,000	$2.99	$89,800	3,005,427	+1.01%	plan?
Apr 13, 2018 PForm 4 →	Apr 16, 6:48 am EDT	Robert Scott FishelDirector	10,000	$3.02	$30,200	4,021,428	+0.25%	plan?
Apr 12, 2018 PForm 4 →	Apr 13, 6:32 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	65,000	$3.04	$197,300	2,975,427	+2.23%	plan?
Apr 11, 2018 PForm 4 →	Apr 12, 6:41 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	43,000	$3.06	$131,727	2,910,427	+1.50%	plan?
Apr 10, 2018 PForm 4 →	Apr 11, 6:23 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	36,527	$3.06	$111,706	2,867,427	+1.29%	plan?
Apr 9, 2018 PForm 4 →	Apr 10, 8:09 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	80,000	$3.04	$243,088	2,830,900	+2.91%	plan?
Apr 6, 2018 PForm 4 →	Apr 9, 6:07 am EDT	Robert Scott FishelDirector	10,000	$3.16	$31,600	4,011,428	+0.25%	plan?
Apr 6, 2018 PForm 4 →	Apr 9, 6:04 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	60,000	$3.10	$186,152	2,750,900	+2.23%	plan?
Apr 5, 2018 PForm 4 →	Apr 6, 7:28 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	10,000	$3.25	$32,500	2,690,900	+0.37%	plan?
Apr 3, 2018 PForm 4 →	Apr 4, 6:03 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	153,000	$3.00	$458,790	2,680,900	+6.05%	plan?
Mar 28, 2018 PForm 4 →	Mar 29, 6:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	80,000	$3.07	$245,868	2,527,900	+3.27%	plan?
Mar 27, 2018 PForm 4 →	Mar 28, 6:19 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	86,100	$3.25	$279,689	2,447,900	+3.65%	plan?
Mar 26, 2018 PForm 4 →	Mar 27, 7:14 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	26,000	$3.19	$83,055	2,361,800	+1.11%	plan?
Mar 23, 2018 PForm 4 →	Mar 26, 7:11 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	25,000	$3.27	$81,700	2,335,800	+1.08%	plan?
Mar 22, 2018 PForm 4 →	Mar 23, 6:45 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	30,000	$3.32	$99,480	2,310,800	+1.32%	plan?
Mar 21, 2018 PForm 4 →	Mar 22, 6:47 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	30,000	$3.38	$101,384	2,280,800	+1.33%	plan?
Mar 20, 2018 PForm 4 →	Mar 21, 6:34 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	75,000	$3.32	$249,365	2,250,800	+3.45%	plan?
Mar 19, 2018 PForm 4 →	Mar 20, 6:21 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	40,000	$3.51	$140,240	2,175,800	+1.87%	plan?
Mar 15, 2018 PForm 4 →	Mar 16, 6:54 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	61,000	$3.32	$202,524	2,135,800	+2.94%	plan?
Mar 13, 2018 PForm 4 →	Mar 14, 4:07 pm EDT	Adam LogalSr. Vice President, CFO	2,065	$3.40	$7,011	164,858	+1.27%	plan?
Mar 13, 2018 PForm 4 →	Mar 14, 7:10 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	67,500	$3.36	$227,007	2,074,800	+3.36%	plan?
Mar 12, 2018 PForm 4 →	Mar 13, 6:10 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	25,000	$3.48	$86,995	2,007,300	+1.26%	plan?
Mar 8, 2018 PForm 4 →	Mar 9, 6:43 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	32,000	$3.28	$104,835	1,982,300	+1.64%	plan?
Mar 7, 2018 PForm 4 →	Mar 8, 6:51 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	75,000	$3.29	$246,946	1,950,300	+4.00%	plan?
Mar 7, 2018 PForm 4 →	Mar 8, 6:49 am EST	Steven D RubinExecutive VP-Administration, Director	6,000	$3.25	$19,500	5,691,915	+0.11%	plan?

Reported at this company — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Jun 18, 2026 AForm 4 →	Jun 22, 5:38 pm EDT	Prem A LachmanDirector	30,000	—	—	30,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:37 pm EDT	Roger Medel M.D.Director	30,000	—	—	30,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:36 pm EDT	John A PaganelliDirector	30,000	—	—	30,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:34 pm EDT	Richard C Pfenniger Jr.Director	60,000	—	—	60,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:33 pm EDT	Subbarao V UppaluriDirector	80,000	—	—	80,000	—
Jun 18, 2026 AForm 4 →	Jun 22, 5:32 pm EDT	Alice Lin-Tsing YuDirector	30,000	—	—	30,000	—
Feb 1, 2019 MForm 4 →	Feb 5, 4:33 pm EST	Steven D RubinExecutive VP-Administration, Director	24,877	—	—	0	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:16 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:16 pm EDT	Richard C Pfenniger Jr.Director	30,000	—	—	30,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:15 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:15 pm EDT	Richard M KrasnoDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:14 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:14 pm EDT	Robert Scott FishelDirector	20,000	—	—	20,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:13 pm EDT	Adam LogalSr. Vice President, CFO	300,000	—	—	300,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:13 pm EDT	Steven D RubinExecutive VP-Administration, Director	300,000	—	—	300,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:12 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	500,000	—	—	500,000	—
Jun 21, 2018 AForm 4 →	Jun 22, 4:11 pm EDT	Phillip Md Et Al FrostCEO & Chairman, Director, 10% Owner	500,000	—	—	500,000	—
Jun 8, 2018 MForm 4 →	Jun 12, 6:05 pm EDT	Adam LogalSr. Vice President, CFO	75,000	—	—	0	—
May 14, 2018 MForm 4 →	May 15, 4:13 pm EDT	Richard A LernerDirector	45,000	—	—	0	—
Apr 3, 2018 AForm 4 →	Apr 4, 4:13 pm EDT	Robert Scott FishelDirector	40,000	—	—	40,000	—
Feb 27, 2018 AForm 4 →	Mar 1, 4:11 pm EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	—	—	—	—	—
Feb 27, 2018 AForm 4 →	Mar 1, 4:10 pm EST	Jane Ph D HsiaoVice Chairman & CTO, Director	—	—	—	—	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:22 pm EDT	Richard M KrasnoDirector	20,000	—	—	20,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:21 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:19 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:18 pm EDT	Richard C Pfenniger Jr.Director	30,000	—	—	30,000	—
Jun 15, 2017 AForm 4 →	Jun 16, 4:17 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
Jun 2, 2017 MForm 4 →	Jun 5, 9:49 am EDT	Richard C Pfenniger Jr.Director	20,000	—	—	0	—
Apr 12, 2017 MForm 4 →	Apr 13, 4:25 pm EDT	Steven D RubinExecutive VP-Administration, Director	265,000	—	—	0	—
Apr 10, 2017 MForm 4 →	Apr 11, 4:14 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	0	—
Mar 13, 2017 MForm 4 →	Mar 15, 6:31 pm EDT	Adam LogalSr. Vice President, CFO	264,207	—	—	0	—
Mar 13, 2017 MForm 4 →	Mar 15, 6:30 pm EDT	Richard A LernerDirector	20,000	—	—	0	—
Mar 6, 2017 MForm 4 →	Mar 7, 5:08 pm EST	John A PaganelliDirector	20,000	—	—	0	—
Feb 22, 2017 MForm 4 →	Feb 28, 6:27 pm EST	John A PaganelliDirector	20,000	—	—	0	—	late
Feb 9, 2017 AForm 4 →	Feb 10, 4:35 pm EST	Richard M KrasnoDirector	40,000	—	—	40,000	—
Jan 19, 2017 MForm 4 →	Jan 23, 7:30 am EST	Robert A BaronDirector	60,000	—	—	0	—
Jan 13, 2017 MForm 4 →	Jan 17, 4:12 pm EST	Thomas E BeierDirector	20,000	—	—	0	—
Jan 4, 2017 MForm 4 →	Jan 5, 11:11 am EST	Jane Ph D HsiaoVice Chairman & CTO, Director	112,500	—	—	112,500	—
Jun 2, 2016 AForm 4 →	Jun 3, 4:47 pm EDT	Richard C Pfenniger Jr.Director	10,000	—	—	10,000	—
May 5, 2016 AForm 4 →	May 5, 5:21 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:20 pm EDT	Richard C Pfenniger Jr.Director	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:19 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:18 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:17 pm EDT	Dmitry KolosovDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:16 pm EDT	Thomas E BeierDirector	20,000	—	—	20,000	—
May 5, 2016 AForm 4 →	May 5, 5:15 pm EDT	Robert A BaronDirector	20,000	—	—	20,000	—
May 3, 2016 MForm 4 →	May 5, 5:20 pm EDT	Steven D RubinExecutive VP-Administration, Director	250,000	—	—	0	—	amended
Apr 1, 2016 MForm 4 →	Apr 5, 4:39 pm EDT	Thomas E BeierDirector	20,000	—	—	0	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:55 pm EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	500,000	—	—	500,000	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:55 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	450,000	—	—	450,000	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:54 pm EDT	Steven D RubinExecutive VP-Administration, Director	450,000	—	—	450,000	—
Apr 1, 2016 AForm 4 →	Apr 1, 5:54 pm EDT	Adam LogalSr. Vice President, CFO	250,000	—	—	250,000	—
Jan 22, 2016 MForm 4 →	Jan 26, 8:35 pm EST	Robert A BaronDirector	30,000	—	—	0	—
Oct 8, 2015 MForm 4 →	Oct 9, 4:23 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	0	—
Sep 18, 2015 MForm 4 →	Sep 22, 6:03 am EDT	John A PaganelliDirector	35,000	—	—	0	—
Aug 18, 2015 MForm 4 →	Aug 19, 10:28 am EDT	Alice Lin-Tsing YuDirector	20,000	—	—	0	—
Aug 12, 2015 MForm 4 →	Aug 13, 2:55 pm EDT	Robert A BaronDirector	5,000	—	—	0	—
Aug 7, 2015 MForm 4 →	Aug 10, 8:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	1,056,574	—	—	300,000	—
Aug 7, 2015 MForm 4 →	Aug 10, 8:48 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	200,000	—	—	262,500	—
Aug 6, 2015 CForm 4 →	Aug 7, 8:50 am EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	—	—	—	0	—
Aug 6, 2015 CForm 4 →	Aug 7, 8:49 am EDT	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	—	—	—	0	—
Jul 17, 2015 MForm 4 →	Jul 20, 4:21 pm EDT	Thomas E BeierDirector	20,000	—	—	0	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:35 pm EDT	Alice Lin-Tsing YuDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:34 pm EDT	Richard C Pfenniger Jr.Director	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:33 pm EDT	John A PaganelliDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:32 pm EDT	Richard A LernerDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:30 pm EDT	Dmitry KolosovDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:29 pm EDT	Thomas E BeierDirector	20,000	—	—	20,000	—
Jun 18, 2015 AForm 4 →	Jun 19, 4:28 pm EDT	Robert A BaronDirector	20,000	—	—	20,000	—
Mar 18, 2015 AForm 4 →	Mar 27, 6:16 pm EDT	Dmitry KolosovDirector	10,000	—	—	10,000	—	late
Mar 18, 2015 AForm 4 →	Mar 19, 4:18 pm EDT	Adam LogalSr. Vice President, CFO	250,000	—	—	250,000	—
Mar 18, 2015 AForm 4 →	Mar 19, 4:17 pm EDT	Steven D RubinExecutive VP-Administration, Director	450,000	—	—	450,000	—
Mar 18, 2015 AForm 4 →	Mar 19, 4:16 pm EDT	Jane Ph D HsiaoVice Chairman & CTO, Director	450,000	—	—	450,000	—
Mar 18, 2015 AForm 4 →	Mar 19, 4:16 pm EDT	Phillip Md Et Al FrostCEO & Chairman, Director, 10% Owner	500,000	—	—	500,000	—
Mar 12, 2015 MForm 4 →	Mar 13, 5:12 pm EDT	Adam LogalSr. Vice President, CFO	95,000	—	—	0	—
Jan 31, 2015 MForm 4 →	Feb 2, 6:02 am EST	Steven D RubinExecutive VP-Administration, Director	5,190,385	—	—	0	—
Jan 31, 2015 MForm 4 →	Feb 2, 6:01 am EST	Jane Ph D HsiaoVice Chairman & CTO, Director	7,090,525	—	—	0	—
Jan 31, 2015 MForm 4 →	Feb 2, 6:00 am EST	Phillip Md Et Al Frost +1CEO & Chairman, Director, 10% Owner	14,144,217	$0.7181	$399,259	0	—

Filed by this entity as an insider elsewhere — common stock

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Dec 19, 2017 AForm 4 →	Dec 21, 6:27 pm EST	Sevion Therapeutics, Inc.SVOND	495,126	—	—	1,289,818	—	plan?
Oct 30, 2017 PForm 4 →	Nov 1, 4:11 pm EDT	VBI Vaccines Inc/BCVBIV	655,738	$3.05	$2,000,001	6,678,752	+10.9%	plan?
Sep 19, 2017 CForm 4 →	Nov 7, 4:00 pm EST	Sevion Therapeutics, Inc.SVON	1,250,006	—	—	15,893,844	—	plan? late
Aug 10, 2017 CForm 4 →	Aug 14, 5:15 pm EDT	Sevion Therapeutics, Inc.SVON	4,126,822	$0.10	$412,682	14,643,838	—	plan?

Filed by this entity as an insider elsewhere — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Sep 19, 2017 CForm 4 →	Nov 7, 4:00 pm EST	Sevion Therapeutics, Inc.SVON	66,667	—	—	0	—	late
Aug 10, 2017 CForm 4 →	Aug 14, 5:15 pm EDT	Sevion Therapeutics, Inc.SVON	—	—	—	0	—