Company · CIK 0000874015 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

IONIS PHARMACEUTICALS INC · IONS

Insider activity reported against this company. All insider holders · Files at: AKCA, RGLS. On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market activity at this companybuys $1.1M · 1sales $99.1M · 181net −$98.0M

Open-market trades as an insider elsewherebuys $225.0M · 2sales $3.8M · 2net $221.2M

Reported at this company — common stock

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Apr 6, 2016 MForm 4 →	Apr 7, 6:18 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	$10.82	$10,820	10,124	—	plan?
Apr 6, 2016 SForm 4 →	Apr 7, 6:18 pm EDT	Stanley T CrookeChairman and CEO, Director	11,000	$46.13	$507,375	2,170	−83.5%	plan?
Apr 6, 2016 MForm 4 →	Apr 7, 6:18 pm EDT	Stanley T CrookeChairman and CEO, Director	11,000	$10.29	$113,190	2,670	—	plan?
Mar 31, 2016 SForm 4 →	Apr 1, 6:18 pm EDT	Stanley T CrookeChairman and CEO, Director	11,000	$40.74	$448,085	2,170	−83.5%	plan?
Mar 31, 2016 MForm 4 →	Apr 1, 6:18 pm EDT	Stanley T CrookeChairman and CEO, Director	11,000	$10.24	$112,655	2,670	—	plan?
Mar 23, 2016 SForm 4 →	Mar 24, 7:13 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	$45.40	$45,400	9,124	−9.88%	plan?
Mar 23, 2016 MForm 4 →	Mar 24, 7:13 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	$10.82	$10,820	10,124	—	plan?
Feb 19, 2016 MForm 4 →	Feb 22, 4:10 pm EST	Spencer R BerthelsenDirector	12,500	$5.93	$74,125	74,343	—	plan?
Feb 3, 2016 MForm 4 →	Feb 4, 11:54 am EST	Joseph LoscalzoDirector	938	—	—	2,543	—	plan?
Jan 19, 2016 SForm 4 →	Jan 19, 8:27 pm EST	Stanley T CrookeChairman and CEO, Director	13,401	$41.46	$555,598	2,170	−86.1%	plan?
Jan 19, 2016 SForm 4 →	Jan 19, 8:27 pm EST	Elizabeth L HougenSVP, Finance & CFO	1,899	$41.46	$78,742	6,331	−23.1%	plan?
Jan 19, 2016 SForm 4 →	Jan 19, 8:12 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	1,871	$41.46	$77,574	9,124	−17.0%	plan?
Jan 19, 2016 SForm 4 →	Jan 19, 8:11 pm EST	B Lynne ParshallCOO & Secretary, Director	5,192	$41.46	$215,257	16,290	−24.2%	plan?
Jan 19, 2016 SForm 4 →	Jan 19, 8:09 pm EST	Richard S GearySVP, Development	2,162	$41.46	$89,634	8,354	−20.6%	plan?
Jan 19, 2016 SForm 4 →	Jan 19, 8:09 pm EST	Brett P MoniaSVP, Antisense Drug Discovery	2,208	$41.46	$91,541	7,693	−22.3%	plan?
Jan 19, 2016 SForm 4 →	Jan 19, 8:08 pm EST	Sarah BoyceChief Business Officer	872	$41.46	$36,151	1,735	−33.4%	plan?
Jan 19, 2016 SForm 4 →	Jan 19, 8:08 pm EST	C Frank BennettSVP, Antisense Research	2,110	$41.46	$87,474	10,590	−16.6%	plan?
Jan 15, 2016 MForm 4 →	Jan 19, 8:27 pm EST	Stanley T CrookeChairman and CEO, Director	24,661	—	—	2,315	—	plan?
Jan 15, 2016 MForm 4 →	Jan 19, 8:27 pm EST	Elizabeth L HougenSVP, Finance & CFO	4,762	—	—	6,881	—	plan?
Jan 15, 2016 MForm 4 →	Jan 19, 8:12 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	4,693	—	—	9,646	—	plan?
Jan 15, 2016 MForm 4 →	Jan 19, 8:11 pm EST	B Lynne ParshallCOO & Secretary, Director	13,267	—	—	18,593	—	plan?
Jan 15, 2016 MForm 4 →	Jan 19, 8:09 pm EST	Richard S GearySVP, Development	5,427	—	—	8,904	—	plan?
Jan 15, 2016 MForm 4 →	Jan 19, 8:09 pm EST	Brett P MoniaSVP, Antisense Drug Discovery	5,543	—	—	8,297	—	plan?
Jan 15, 2016 MForm 4 →	Jan 19, 8:08 pm EST	Sarah BoyceChief Business Officer	2,188	—	—	2,607	—	plan?
Jan 15, 2016 MForm 4 →	Jan 19, 8:08 pm EST	C Frank BennettSVP, Antisense Research	5,295	—	—	11,112	—	plan?
Jan 5, 2016 SForm 4 →	Jan 7, 6:52 pm EST	Stanley T CrookeChairman and CEO, Director	5,500	$62.10	$341,550	1,297	−80.9%	plan?
Jan 5, 2016 MForm 4 →	Jan 7, 6:52 pm EST	Stanley T CrookeChairman and CEO, Director	5,500	$10.19	$56,060	1,797	—	plan?
Jan 4, 2016 SForm 4 →	Jan 4, 9:26 pm EST	B Lynne ParshallCOO & Secretary, Director	809	$61.05	$49,389	8,215	−8.96%	plan?
Jan 4, 2016 SForm 4 →	Jan 4, 9:25 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	$61.10	$61,100	6,302	−13.7%	plan?
Jan 4, 2016 SForm 4 →	Jan 4, 9:24 pm EST	Brett P MoniaSVP, Antisense Drug Discovery	127	$61.00	$7,747	4,358	−2.83%	plan?
Jan 4, 2016 SForm 4 →	Jan 4, 9:22 pm EST	Stanley T CrookeChairman and CEO, Director	11,000	$61.05	$671,550	1,297	−89.5%	plan?
Jan 4, 2016 MForm 4 →	Jan 4, 9:22 pm EST	Stanley T CrookeChairman and CEO, Director	11,000	$10.19	$112,120	2,297	—	plan?
Jan 1, 2016 JMForm 4 →	Jan 4, 9:26 pm EST	B Lynne ParshallCOO & Secretary, Director	881	$17.39	$15,319	9,024	—	plan?
Jan 1, 2016 JMForm 4 →	Jan 4, 9:25 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	1,043	$9.44	$9,844	7,150	—	plan?
Jan 1, 2016 JForm 4 →	Jan 4, 9:24 pm EST	Brett P MoniaSVP, Antisense Drug Discovery	130	$47.71	$6,202	4,485	—	plan?
Jan 1, 2016 JForm 4 →	Jan 4, 9:23 pm EST	Elizabeth L HougenSVP, Finance & CFO	41	$47.71	$1,956	3,468	—	plan?
Jan 1, 2016 JForm 4 →	Jan 4, 9:23 pm EST	Richard S GearySVP, Development	269	$47.71	$12,834	5,089	—	plan?
Jan 1, 2016 JForm 4 →	Jan 4, 9:21 pm EST	Sarah BoyceChief Business Officer	419	$47.71	$19,991	419	—	plan?
Jan 1, 2016 JForm 4 →	Jan 4, 9:19 pm EST	C Frank BennettSVP, Antisense Research	89	$47.71	$4,246	7,405	—	plan?
Dec 15, 2015 SForm 4 →	Dec 17, 7:23 pm EST	C Frank BennettSVP, Antisense Research	7,909	$57.41	$454,045	7,316	−51.9%	plan?
Dec 15, 2015 MForm 4 →	Dec 17, 7:23 pm EST	C Frank BennettSVP, Antisense Research	7,909	$14.47	$114,443	11,225	—	plan?
Dec 1, 2015 SForm 4 →	Dec 2, 6:49 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	$61.50	$61,500	6,259	−13.8%	plan?
Dec 1, 2015 MForm 4 →	Dec 2, 6:49 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	$7.25	$7,250	7,259	—	plan?
Nov 11, 2015 SForm 4 →	Nov 12, 7:02 pm EST	Joseph Klein IIIDirector	6,875	$64.18	$441,234	5,543	−55.4%	plan?
Nov 11, 2015 MForm 4 →	Nov 12, 7:02 pm EST	Joseph Klein IIIDirector	6,875	$10.95	$75,313	8,668	—	plan?
Nov 10, 2015 SForm 4 →	Nov 12, 7:03 pm EST	C Frank BennettSVP, Antisense Research	5,000	$64.00	$320,000	7,316	−40.6%	plan?
Nov 10, 2015 MForm 4 →	Nov 12, 7:03 pm EST	C Frank BennettSVP, Antisense Research	5,000	$14.47	$72,350	12,316	—	plan?
Nov 6, 2015 SForm 4 →	Nov 9, 7:28 pm EST	C Frank BennettSVP, Antisense Research	5,000	$56.00	$280,000	7,316	−40.6%	plan?
Nov 6, 2015 MForm 4 →	Nov 9, 7:28 pm EST	C Frank BennettSVP, Antisense Research	5,000	$14.47	$72,350	12,316	—	plan?
Nov 3, 2015 SForm 4 →	Nov 4, 7:00 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	$51.95	$51,950	6,259	−13.8%	plan?
Nov 3, 2015 MForm 4 →	Nov 4, 7:00 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	$7.25	$7,250	7,259	—	plan?
Oct 21, 2015 SForm 4 →	Oct 23, 7:35 pm EDT	Stanley T CrookeChairman and CEO, Director	44,000	$43.85	$1,929,355	1,297	−97.1%	plan?
Oct 21, 2015 MForm 4 →	Oct 23, 7:35 pm EDT	Stanley T CrookeChairman and CEO, Director	44,000	$10.67	$469,310	1,797	—	plan?
Oct 1, 2015 SForm 4 →	Oct 5, 7:14 pm EDT	B Lynne ParshallCOO & Secretary, Director	12,436	$40.75	$506,747	8,143	−60.4%	plan?
Oct 1, 2015 MForm 4 →	Oct 5, 7:14 pm EDT	B Lynne ParshallCOO & Secretary, Director	12,436	$12.20	$151,720	11,579	—	plan?
Jul 6, 2015 SForm 4 →	Jul 8, 5:55 pm EDT	B Lynne ParshallCOO & Secretary, Director	6,218	$57.01	$354,470	8,143	−43.3%	plan?
Jul 6, 2015 MForm 4 →	Jul 8, 5:55 pm EDT	B Lynne ParshallCOO & Secretary, Director	6,218	$7.92	$49,261	12,986	—	plan?
Jul 6, 2015 SForm 4 →	Jul 8, 5:54 pm EDT	Stanley T CrookeChairman and CEO, Director	6,175	$57.01	$352,018	1,297	−82.6%	plan?
Jul 6, 2015 MForm 4 →	Jul 8, 5:54 pm EDT	Stanley T CrookeChairman and CEO, Director	6,175	$10.88	$67,184	2,472	—	plan?
Jul 2, 2015 SForm 4 →	Jul 2, 6:05 pm EDT	Brett P MoniaSVP, Antisense Drug Discovery	198	$56.30	$11,147	4,355	−4.35%	plan?
Jul 1, 2015 SForm 4 →	Jul 2, 6:06 pm EDT	B Lynne ParshallCOO & Secretary, Director	6,218	$57.56	$357,914	8,143	−43.3%	plan?
Jul 1, 2015 JMForm 4 →	Jul 2, 6:06 pm EDT	B Lynne ParshallCOO & Secretary, Director	6,289	$10.72	$67,433	14,361	—	plan?
Jul 1, 2015 JForm 4 →	Jul 2, 6:05 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	85	$48.59	$4,130	6,259	—	plan?
Jul 1, 2015 JForm 4 →	Jul 2, 6:05 pm EDT	Brett P MoniaSVP, Antisense Drug Discovery	127	$48.59	$6,170	4,553	—	plan?
Jul 1, 2015 JForm 4 →	Jul 2, 6:04 pm EDT	Elizabeth L HougenSVP, Finance & CFO	40	$48.59	$1,943	3,427	—	plan?
Jul 1, 2015 JForm 4 →	Jul 2, 6:03 pm EDT	Richard S GearySVP, Development	265	$48.59	$12,875	4,820	—	plan?
Jul 1, 2015 SForm 4 →	Jul 2, 6:02 pm EDT	Stanley T CrookeChairman and CEO, Director	6,175	$57.56	$355,439	1,297	−82.6%	plan?
Jul 1, 2015 MForm 4 →	Jul 2, 6:02 pm EDT	Stanley T CrookeChairman and CEO, Director	6,175	$10.88	$67,184	2,472	—	plan?
Jul 1, 2015 JForm 4 →	Jul 2, 6:01 pm EDT	C Frank BennettSVP, Antisense Research	87	$48.59	$4,227	7,316	—	plan?
Jul 1, 2015 MForm 4 →	Jul 2, 6:00 pm EDT	Joseph H WenderDirector	1,448	—	—	31,665	—	plan?
Jul 1, 2015 MForm 4 →	Jul 2, 6:00 pm EDT	Frederick T MutoDirector	1,448	—	—	2,543	—	plan?
Jul 1, 2015 MForm 4 →	Jul 2, 5:59 pm EDT	Joseph LoscalzoDirector	667	—	—	1,605	—	plan?
Jul 1, 2015 MForm 4 →	Jul 2, 5:58 pm EDT	Joseph Klein IIIDirector	1,448	—	—	5,543	—	plan?
Jul 1, 2015 MForm 4 →	Jul 2, 5:57 pm EDT	Breaux CastlemanDirector	2,074	—	—	3,481	—	plan?
Jul 1, 2015 MForm 4 →	Jul 2, 5:57 pm EDT	Spencer R BerthelsenDirector	1,448	—	—	61,843	—	plan?
Jun 8, 2015 SForm 4 →	Jun 10, 6:36 pm EDT	Brett P MoniaSVP, Antisense Drug Discovery	7,600	$66.22	$503,280	4,426	−63.2%	plan?
Jun 8, 2015 MForm 4 →	Jun 10, 6:36 pm EDT	Brett P MoniaSVP, Antisense Drug Discovery	7,600	$10.29	$78,204	12,026	—	plan?
Jun 1, 2015 SForm 4 →	Jun 3, 5:29 pm EDT	Frederick T MutoDirector	10,000	$66.91	$669,110	1,095	−90.1%	plan?
Jun 1, 2015 MForm 4 →	Jun 3, 5:29 pm EDT	Frederick T MutoDirector	10,000	$3.95	$39,500	11,095	—	plan?
Apr 17, 2015 MForm 4 →	Apr 17, 6:13 pm EDT	Spencer R BerthelsenDirector	10,000	$3.95	$39,500	60,395	—	plan?
Apr 7, 2015 SForm 4 →	Apr 8, 5:12 pm EDT	B Lynne ParshallCOO & Secretary, Director	5,565	$63.07	$350,990	8,072	−40.8%	plan?
Apr 7, 2015 MForm 4 →	Apr 8, 5:12 pm EDT	B Lynne ParshallCOO & Secretary, Director	5,565	$14.69	$81,750	13,637	—	plan?
Apr 7, 2015 SForm 4 →	Apr 8, 5:11 pm EDT	Stanley T CrookeChairman and CEO, Director	22,377	$63.07	$1,411,340	1,297	−94.5%	plan?
Apr 7, 2015 MForm 4 →	Apr 8, 5:11 pm EDT	Stanley T CrookeChairman and CEO, Director	22,377	$11.08	$248,019	3,331	—	plan?
Apr 1, 2015 SForm 4 →	Apr 6, 11:51 am EDT	B Lynne ParshallCOO & Secretary, Director	5,377	$61.93	$333,009	8,072	−40.0%	plan?
Apr 1, 2015 MForm 4 →	Apr 6, 11:51 am EDT	B Lynne ParshallCOO & Secretary, Director	5,377	$14.69	$78,988	13,449	—	plan?
Apr 1, 2015 SForm 4 →	Apr 6, 11:50 am EDT	Stanley T CrookeChairman and CEO, Director	21,623	$61.93	$1,339,158	1,297	−94.3%	plan?
Apr 1, 2015 MForm 4 →	Apr 6, 11:50 am EDT	Stanley T CrookeChairman and CEO, Director	21,623	$11.08	$239,661	3,263	—	plan?
Mar 23, 2015 SForm 4 →	Mar 25, 4:23 pm EDT	C Frank BennettSVP, Antisense Research	15,000	$70.61	$1,059,110	7,229	−67.5%	plan?
Mar 23, 2015 MForm 4 →	Mar 25, 4:23 pm EDT	C Frank BennettSVP, Antisense Research	15,000	$14.47	$217,050	16,229	—	plan?
Mar 19, 2015 SForm 4 →	Mar 20, 6:58 pm EDT	Elizabeth L HougenSVP, Finance & CFO	10,000	$73.33	$733,260	3,387	−74.7%	plan?
Mar 19, 2015 MForm 4 →	Mar 20, 6:58 pm EDT	Elizabeth L HougenSVP, Finance & CFO	10,000	$11.27	$112,700	13,387	—	plan?
Mar 19, 2015 SForm 4 →	Mar 20, 6:56 pm EDT	Richard S GearySVP, Development	8,000	$75.00	$600,032	4,555	−63.7%	plan?
Mar 19, 2015 MForm 4 →	Mar 20, 6:56 pm EDT	Richard S GearySVP, Development	8,000	$14.69	$117,520	12,555	—	plan?
Mar 19, 2015 SForm 4 →	Mar 20, 6:55 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	30,525	$74.85	$2,284,757	6,174	−83.2%	plan?
Mar 19, 2015 MForm 4 →	Mar 20, 6:55 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	30,525	$22.62	$690,416	16,699	—	plan?
Mar 18, 2015 SForm 4 →	Mar 20, 6:57 pm EDT	Joseph H WenderDirector	12,500	$71.41	$892,586	30,217	−29.3%	plan?
Mar 18, 2015 MForm 4 →	Mar 20, 6:57 pm EDT	Joseph H WenderDirector	12,500	$5.93	$74,125	36,617	—	plan?
Mar 5, 2015 MForm 4 →	Mar 9, 7:45 pm EDT	Richard S GearySVP, Development	15,080	$8.88	$133,972	11,555	—	plan?
Mar 5, 2015 SForm 4 →	Mar 9, 7:45 pm EDT	Richard S GearySVP, Development	18,095	$71.15	$1,287,382	4,555	−79.9%	plan?

Reported at this company — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake
Dec 15, 2015 MForm 4 →	Dec 17, 7:23 pm EST	C Frank BennettSVP, Antisense Research	7,909	—	—	0	—
Dec 1, 2015 MForm 4 →	Dec 2, 6:49 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	—	—	2,067	—
Nov 11, 2015 MForm 4 →	Nov 12, 7:02 pm EST	Joseph Klein IIIDirector	6,875	—	—	2,812	—
Nov 10, 2015 MForm 4 →	Nov 12, 7:03 pm EST	C Frank BennettSVP, Antisense Research	5,000	—	—	7,909	—
Nov 9, 2015 GForm 4 →	Nov 9, 7:45 pm EST	B Lynne ParshallCOO & Secretary, Director	8,000	—	—	1,000	—
Nov 6, 2015 MForm 4 →	Nov 9, 7:28 pm EST	C Frank BennettSVP, Antisense Research	5,000	—	—	12,909	—
Nov 3, 2015 MForm 4 →	Nov 4, 7:00 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	—	—	3,067	—
Oct 21, 2015 MForm 4 →	Oct 23, 7:35 pm EDT	Stanley T CrookeChairman and CEO, Director	44,000	—	—	2,000	—
Oct 1, 2015 MForm 4 →	Oct 5, 7:14 pm EDT	B Lynne ParshallCOO & Secretary, Director	12,436	—	—	29,354	—
Jul 6, 2015 MForm 4 →	Jul 8, 5:55 pm EDT	B Lynne ParshallCOO & Secretary, Director	6,218	—	—	17,027	—
Jul 6, 2015 MForm 4 →	Jul 8, 5:54 pm EDT	Stanley T CrookeChairman and CEO, Director	6,175	—	—	5,000	—
Jul 1, 2015 MForm 4 →	Jul 2, 6:06 pm EDT	B Lynne ParshallCOO & Secretary, Director	6,218	—	—	1,375	—
Jul 1, 2015 MForm 4 →	Jul 2, 6:02 pm EDT	Stanley T CrookeChairman and CEO, Director	6,175	—	—	6,175	—
Jul 1, 2015 AMForm 4 →	Jul 2, 6:00 pm EDT	Joseph H WenderDirector	20,115	—	—	16,000	—
Jul 1, 2015 AMForm 4 →	Jul 2, 6:00 pm EDT	Frederick T MutoDirector	20,115	—	—	16,000	—
Jul 1, 2015 AMForm 4 →	Jul 2, 5:59 pm EDT	Joseph LoscalzoDirector	19,334	—	—	16,000	—
Jul 1, 2015 AMForm 4 →	Jul 2, 5:58 pm EDT	Joseph Klein IIIDirector	20,115	—	—	16,000	—
Jul 1, 2015 AMForm 4 →	Jul 2, 5:57 pm EDT	Breaux CastlemanDirector	20,741	—	—	16,000	—
Jul 1, 2015 AMForm 4 →	Jul 2, 5:57 pm EDT	Spencer R BerthelsenDirector	20,115	—	—	16,000	—
Jun 8, 2015 MForm 4 →	Jun 10, 6:36 pm EDT	Brett P MoniaSVP, Antisense Drug Discovery	7,600	—	—	0	—
Jun 1, 2015 MForm 4 →	Jun 3, 5:29 pm EDT	Frederick T MutoDirector	10,000	—	—	0	—
Apr 17, 2015 MForm 4 →	Apr 17, 6:13 pm EDT	Spencer R BerthelsenDirector	10,000	—	—	0	—
Apr 7, 2015 MForm 4 →	Apr 8, 5:12 pm EDT	B Lynne ParshallCOO & Secretary, Director	5,565	—	—	37,628	—
Apr 7, 2015 MForm 4 →	Apr 8, 5:11 pm EDT	Stanley T CrookeChairman and CEO, Director	22,377	—	—	7,350	—
Apr 1, 2015 MForm 4 →	Apr 6, 11:51 am EDT	B Lynne ParshallCOO & Secretary, Director	5,377	—	—	43,193	—
Apr 1, 2015 MForm 4 →	Apr 6, 11:50 am EDT	Stanley T CrookeChairman and CEO, Director	21,623	—	—	9,384	—
Mar 23, 2015 MForm 4 →	Mar 25, 4:23 pm EDT	C Frank BennettSVP, Antisense Research	15,000	—	—	17,909	—
Mar 19, 2015 MForm 4 →	Mar 20, 6:58 pm EDT	Elizabeth L HougenSVP, Finance & CFO	10,000	—	—	10,000	—
Mar 19, 2015 MForm 4 →	Mar 20, 6:56 pm EDT	Richard S GearySVP, Development	8,000	—	—	17,240	—
Mar 19, 2015 MForm 4 →	Mar 20, 6:55 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	30,525	—	—	31,875	—
Mar 18, 2015 MForm 4 →	Mar 20, 6:57 pm EDT	Joseph H WenderDirector	12,500	—	—	0	—
Mar 5, 2015 MForm 4 →	Mar 9, 7:45 pm EDT	Richard S GearySVP, Development	15,080	—	—	7,035	—
Mar 5, 2015 MForm 4 →	Mar 9, 7:27 pm EDT	Elizabeth L HougenSVP, Finance & CFO	28,094	—	—	4,063	—
Mar 5, 2015 MForm 4 →	Mar 9, 7:27 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	5,800	—	—	1,617	—
Mar 5, 2015 MForm 4 →	Mar 9, 7:26 pm EDT	Joseph H WenderDirector	12,500	—	—	0	—
Mar 5, 2015 MForm 4 →	Mar 9, 7:25 pm EDT	Joseph Klein IIIDirector	10,000	—	—	5,937	—
Feb 12, 2015 MForm 4 →	Feb 17, 5:39 pm EST	Joseph H WenderDirector	10,000	—	—	0	—
Feb 3, 2015 MForm 4 →	Feb 5, 6:08 pm EST	Joseph LoscalzoDirector	938	—	—	2,812	—
Jan 27, 2015 MForm 4 →	Jan 29, 7:03 pm EST	Stanley T CrookeChairman and CEO, Director	11,000	—	—	11,350	—
Jan 15, 2015 AMForm 4 →	Jan 20, 8:00 pm EST	Stanley T CrookeChairman and CEO, Director	46,375	—	—	1,062	—
Jan 15, 2015 AForm 4 →	Jan 20, 7:59 pm EST	Sarah BoyceChief Business Officer	8,750	—	—	8,750	—
Jan 15, 2015 AMForm 4 →	Jan 20, 7:58 pm EST	B Lynne ParshallCOO & Secretary, Director	29,824	—	—	10,312	—
Jan 15, 2015 AMForm 4 →	Jan 20, 7:57 pm EST	Brett P MoniaSVP, Antisense Drug Discovery	10,095	—	—	5,625	—
Jan 15, 2015 AMForm 4 →	Jan 20, 7:57 pm EST	Elizabeth L HougenSVP, Finance & CFO	8,901	—	—	5,625	—
Jan 15, 2015 AMForm 4 →	Jan 20, 7:56 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	8,625	—	—	5,625	—
Jan 15, 2015 AMForm 4 →	Jan 20, 7:55 pm EST	C Frank BennettSVP, Antisense Research	9,226	—	—	5,625	—
Jan 15, 2015 AMForm 4 →	Jan 20, 7:53 pm EST	Richard S GearySVP, Development	9,567	—	—	5,625	—
Jan 9, 2015 MForm 4 →	Jan 13, 6:51 pm EST	Stanley T CrookeChairman and CEO, Director	11,000	—	—	12,350	—
Jan 6, 2015 MForm 4 →	Jan 8, 7:15 pm EST	Stanley T CrookeChairman and CEO, Director	22,000	—	—	13,350	—
Jan 2, 2015 AMForm 4 →	Jan 5, 8:04 pm EST	B Lynne ParshallCOO & Secretary, Director	143,658	—	—	48,570	—
Jan 2, 2015 AMForm 4 →	Jan 5, 8:03 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	32,957	—	—	9,750	—
Jan 2, 2015 AMForm 4 →	Jan 5, 8:02 pm EST	Stanley T CrookeChairman and CEO, Director	173,700	—	—	8,700	—
Jan 2, 2015 AForm 4 →	Jan 5, 8:01 pm EST	Elizabeth L HougenSVP, Finance & CFO	33,112	—	—	33,112	—
Jan 2, 2015 AForm 4 →	Jan 5, 7:59 pm EST	C Frank BennettSVP, Antisense Research	31,457	—	—	31,457	—
Jan 2, 2015 AForm 4 →	Jan 5, 7:57 pm EST	Richard S GearySVP, Development	33,112	—	—	33,112	—
Jan 2, 2015 AForm 4 →	Jan 5, 7:56 pm EST	Brett P MoniaSVP, Antisense Drug Discovery	36,423	—	—	36,423	—
Jan 1, 2015 AForm 4 →	Jan 5, 8:31 pm EST	Sarah BoyceChief Business Officer	52,500	—	—	52,500	—

Filed by this entity as an insider elsewhere — common stock

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Oct 17, 2018 JForm 4 →	Oct 18, 8:05 pm EDT	AKCEA THERAPEUTICS, INC.AKCA	1,671,849	—	—	67,383,965	—	plan?
Aug 3, 2018 JForm 4 →	Aug 6, 5:17 pm EDT	AKCEA THERAPEUTICS, INC.AKCA	1,597,571	—	—	65,712,116	—	plan?
Apr 17, 2018 PForm 4 →	Apr 19, 6:48 pm EDT	AKCEA THERAPEUTICS, INC.AKCA	10,666,666	$18.75	$199,999,988	64,114,545	+20.0%	plan?
Apr 17, 2018 JForm 4 →	Apr 19, 6:48 pm EDT	AKCEA THERAPEUTICS, INC.AKCA	8,000,000	—	—	53,447,879	—	plan?
Jul 19, 2017 PForm 4 →	Jul 21, 4:04 pm EDT	AKCEA THERAPEUTICS, INC.AKCA	3,125,000	$8.00	$25,000,000	45,447,879	+7.38%	plan?
Jul 19, 2017 CJForm 4 →	Jul 21, 4:04 pm EDT	AKCEA THERAPEUTICS, INC.AKCA	42,322,879	—	—	42,322,879	—	plan?
Jul 15, 2015 SForm 4 →	Jul 17, 6:08 pm EDT	Regulus Therapeutics Inc.RGLS	343,133	$10.60	$3,636,078	5,173,172	−6.22%	plan?
Jun 30, 2015 SForm 4 →	Jul 2, 4:28 pm EDT	Regulus Therapeutics Inc.RGLS	13,248	$10.79	$143,010	5,516,305	−0.24%	plan?
Jun 23, 2015 GForm 4 →	Jul 2, 4:28 pm EDT	Regulus Therapeutics Inc.RGLS	13,248	—	—	5,529,553	—	plan? late

Filed by this entity as an insider elsewhere — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Jul 19, 2017 CForm 4 →	Jul 21, 4:04 pm EDT	AKCEA THERAPEUTICS, INC.AKCA	28,884,540	—	—	0	—