Form4insider filings, from the source

Company · CIK 0000874015 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

IONIS PHARMACEUTICALS INC · IONS

Insider activity reported against this company. All insider holders · Files at: AKCA, RGLS. On EDGAR ↗

1M3M6M1Y2YAll datashares as filed — not split-adjusted
Open-market activity at this companybuys $1.1M · 1sales $3.5M · 4net −$2.5M
$10k$10k$100k$100k$1M$1M$10M$10MbuyssalesJun 28Jul 13Jul 28Aug 13Aug 28Sep 13Sep 28

Reported at this company — common stock

TradeReported (ET)InsiderSharesAvg priceTotalOwned afterΔ stakeFlags
Aug 31, 2026 JForm 4 →Sep 2, 8:32 pm EDTC Frank BennettEVP, Chief Scientific Officer110$51.31$5,64460,128—
Aug 31, 2026 JForm 4 →Sep 2, 8:22 pm EDTPatrick R. O'NeilEVP CLO & General Counsel63$51.31$3,23259,205—
Aug 31, 2026 JForm 4 →Sep 2, 8:22 pm EDTBrett P MoniaChief Executive Officer, Director98$51.31$5,028242,760—
Aug 31, 2026 JForm 4 →Sep 2, 8:22 pm EDTBrian BirchlerEVP, Corp and Development Ops58$51.31$2,976102,883—
Jul 30, 2026 PForm 4 →Jul 31, 4:42 pm EDTMichael R HaydenDirector20,000$52.94$1,058,70024,000+500%
Jul 15, 2026 MForm 4 →Jul 17, 5:12 pm EDTJoan E HermanDirector5,220——51,306—
Jul 15, 2026 MForm 4 →Jul 17, 5:12 pm EDTSpencer R BerthelsenDirector5,220——161,233—
Jul 7, 2026 JForm 4 →Jul 9, 7:26 pm EDTC Frank BennettEVP, Chief Scientific Officer15,000——15,000—10b5-1
Jul 7, 2026 SForm 4 →Jul 9, 7:26 pm EDTC Frank BennettEVP, Chief Scientific Officer20,536$84.95$1,744,6230−100%10b5-1
Jul 7, 2026 SForm 4 →Jul 9, 6:07 pm EDTAllene M. DiazDirector10,111$85.42$863,6373,811−72.6%10b5-1
Jul 7, 2026 MForm 4 →Jul 9, 6:07 pm EDTAllene M. DiazDirector10,111$47.11$476,32913,922—10b5-1
Jul 7, 2026 SForm 4 →Jul 9, 6:07 pm EDTHolly B. KordasiewiczEVP, Chief Development Officer362$84.30$30,51722,096−1.61%10b5-1
Jul 1, 2026 SForm 4 →Jul 6, 6:49 pm EDTJoseph Klein IIIDirector11,518$79.04$910,41611,014−51.1%10b5-1
Jul 1, 2026 MForm 4 →Jul 6, 6:49 pm EDTJoseph Klein IIIDirector11,518$39.94$460,02922,532—10b5-1

Reported at this company — derivatives (options, RSUs, warrants)

TradeReported (ET)InsiderSharesAvg priceTotalOwned afterΔ stakeFlags
Jul 15, 2026 AForm 4 →Jul 17, 5:13 pm EDTPeter N ReikesDirector3,399——3,399—
Jul 15, 2026 AForm 4 →Jul 17, 5:13 pm EDTLudwig HantsonDirector3,399——3,399—
Jul 15, 2026 MForm 4 →Jul 17, 5:12 pm EDTJoan E HermanDirector5,220——2,301—
Jul 15, 2026 MForm 4 →Jul 17, 5:12 pm EDTSpencer R BerthelsenDirector5,220——2,301—
Jul 7, 2026 JForm 4 →Jul 9, 7:26 pm EDTC Frank BennettEVP, Chief Scientific Officer15,000——12,109—10b5-1
Jul 7, 2026 MForm 4 →Jul 9, 6:07 pm EDTAllene M. DiazDirector10,111——0—10b5-1
Jul 1, 2026 AForm 4 →Jul 6, 6:50 pm EDTMichael J. YangDirector7,670——9,451—
Jul 1, 2026 AForm 4 →Jul 6, 6:50 pm EDTJoseph LoscalzoDirector7,670——7,521—
Jul 1, 2026 AForm 4 →Jul 6, 6:49 pm EDTJoan E HermanDirector7,670——7,521—
Jul 1, 2026 AMForm 4 →Jul 6, 6:49 pm EDTJoseph Klein IIIDirector19,188——16,277—10b5-1
Jul 1, 2026 AForm 4 →Jul 6, 6:45 pm EDTMichael R HaydenDirector7,670——12,198—
Jul 1, 2026 AForm 4 →Jul 6, 6:44 pm EDTAllene M. DiazDirector7,670——7,521—
Jul 1, 2026 AForm 4 →Jul 6, 6:44 pm EDTSpencer R BerthelsenDirector7,670——7,521—

Filed by this entity as an insider elsewhere — common stock

No reported common-stock activity in this period.

Filed by this entity as an insider elsewhere — derivatives (options, RSUs, warrants)

No reported derivative activity in this period.