SEC Form 4 · accession 0000874015-15-000041

IONIS PHARMACEUTICALS INC · IONS

Statement of changes in beneficial ownership, as filed. Original on EDGAR ↗

Reporting owner

Patrick R. O'Neil

Officer — SVP, Legal & General Counsel

Period of report

Mar 19, 2015

Accepted (ET)

Mar 20, 2015 · 6:55 pm EDT

Rule 10b5-1 plan

unknown — predates the checkbox

Issuer CIK

0000874015

Table I — non-derivative securities

Security	Date	Code	Shares	Price	A/D	Owned after	D/I
Common Stock^F1	Mar 19, 2015	M	1,617	$10.29	A	7,791	D
Common Stock^F1	Mar 19, 2015	S	1,617	$74.767	D	6,174	D
Common Stock^F1	Mar 19, 2015	M	5,683	$7.25	A	11,857	D
Common Stock^F1	Mar 19, 2015	S	5,683	$74.767	D	6,174	D
Common Stock^F1	Mar 19, 2015	M	6,100	$10.82	A	12,274	D
Common Stock^F1	Mar 19, 2015	S	6,100	$74.767	D	6,174	D
Common Stock^F1	Mar 19, 2015	M	4,000	$10.82	A	10,174	D
Common Stock^F1	Mar 19, 2015	S	4,000	$74.767	D	6,174	D
Common Stock^F1	Mar 19, 2015	M	2,600	$39.87	A	8,774	D
Common Stock^F1	Mar 19, 2015	S	2,600	$74.767	D	6,174	D
Common Stock^F1	Mar 19, 2015	M	10,525	$39.87	A	16,699	D
Common Stock^F1	Mar 19, 2015	S	10,525	$75.004	D	6,174	D

Table II — derivative securities

Security	Conv. / exercise price	Date	Code	Shares	A/D	Exercisable	Expires	Underlying	Underlying shares	Owned after	D/I
Employee Stock Option (right to buy)	$10.29	Mar 19, 2015	M	1,617	D	Jan 3, 2015	Jan 2, 2018	Common Stock	1,617	0	D
Employee Stock Option (right to buy)^F2	$7.25	Mar 19, 2015	M	5,683	D	Jan 3, 2013	Jan 2, 2019	Common Stock	5,683	4,067	D
Employee Stock Option (right to buy)^F3	$10.82	Mar 19, 2015	M	6,100	D	Jan 2, 2014	Jan 1, 2020	Common Stock	6,100	7,253	D
Employee Stock Option (right to buy)^F4	$10.82	Mar 19, 2015	M	4,000	D	Jan 2, 2014	Jan 1, 2020	Common Stock	4,000	3,500	D
Employee Stock Option (right to buy)^F5	$39.87	Mar 19, 2015	M	13,125	D	Jan 2, 2015	Jan 1, 2021	Common Stock	13,125	31,875	D

Explanation of responses

F1Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 2/3/2015.
F2Grant of 1/3/2012 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/3/2013. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 4,875 shares per year. Following this transaction, the option was exercisable as to 4 on 3/19/2015.
F3Grant of 1/2/2013 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/2/2014. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 3,925 shares per year. Following this transaction, the option was exercisable as to 57 on 3/19/2015.
F4Grant of 1/2/2013 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/2/2014. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 1,875 shares per year. Following this transaction, the option was exercisable as to 62 on 3/19/2015.
F5Grant of 1/2/2014 to reporting person of stock options under the Isis Pharmacueticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 1/2/2015. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 11,250 shares per year. Following this transaction, the option was exercisable as to 0 on 3/19/2015.