SEC Form 4 · accession 0000874015-15-000039

IONIS PHARMACEUTICALS INC · IONS

Statement of changes in beneficial ownership, as filed. Original on EDGAR ↗

Reporting owner

Officer — SVP, Finance & CFO

Period of report

Mar 5, 2015

Accepted (ET)

Mar 9, 2015 · 7:27 pm EDT

Rule 10b5-1 plan

unknown — predates the checkbox

Issuer CIK

0000874015

Table I — non-derivative securities

Security	Date	Code	Shares	Price	A/D	Owned after	D/I
Common Stock^F1	Mar 5, 2015	M	12,657	$14.47	A	16,044	D
Common Stock^F1	Mar 5, 2015	S	12,657	$71.668	D	3,387	D
Common Stock^F1	Mar 5, 2015	M	8,000	$7.25	A	11,387	D
Common Stock^F1	Mar 5, 2015	S	8,000	$71.668	D	3,387	D
Common Stock^F1	Mar 5, 2015	M	7,437	$7.25	A	10,824	D
Common Stock^F1	Mar 5, 2015	S	7,437	$71.316	D	3,387	D

Security	Conv. / exercise price	Date	Code	Shares	A/D	Exercisable	Expires	Underlying	Underlying shares	Owned after	D/I
Employee Stock Option (right to buy)	$14.47	Mar 5, 2015	M	12,657	D	Jan 2, 2013	Jan 2, 2016	Common Stock	12,657	0	D
Employee Stock Option (right to buy)^F2	$7.25	Mar 5, 2015	M	15,437	D	Jan 3, 2013	Jan 2, 2019	Common Stock	15,437	4,063	D

F1Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 2/3/2015.
F2Grant of 1/3/2012 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/3/2013. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 4,875 shares per year. Following this transaction, the option was exercisable as to 0 on 3/5/2015.