SEC Form 4 · accession 0000874015-16-000114

IONIS PHARMACEUTICALS INC · IONS

Statement of changes in beneficial ownership, as filed. Original on EDGAR ↗

Reporting owner

Officer — Chairman and CEO · Director

Period of report

Mar 31, 2016

Accepted (ET)

Apr 1, 2016 · 6:18 pm EDT

Rule 10b5-1 plan

unknown — predates the checkbox

Issuer CIK

0000874015

Table I — non-derivative securities

Security	Date	Code	Shares	Price	A/D	Owned after	D/I	Nature of ownership
Common Stock^F1	Mar 31, 2016	M	5,000	$10.29	A	30,029	D
Common Stock^F1	Mar 31, 2016	S	5,000	$40.75	D	25,029	D
Common Stock^F1	Mar 31, 2016	M	5,000	$10.29	A	30,029	D
Common Stock^F1	Mar 31, 2016	S	5,000	$40.72	D	25,029	D
Common Stock^F2	Mar 31, 2016	M	500	$9.22	A	2,670	I	By wife
Common Stock^F2	Mar 31, 2016	S	500	$40.72	D	2,170	I	By wife
Common Stock^F2	Mar 31, 2016	M	500	$10.29	A	2,670	I	By wife
Common Stock^F2	Mar 31, 2016	S	500	$40.75	D	2,170	I	By wife
Common Stock	holding	—	—		—	725,391	I	By trust

Security	Conv. / exercise price	Date	Code	Shares	A/D	Exercisable	Expires	Underlying	Underlying shares	Owned after	D/I
Employee Stock Option (right to buy)	$10.29	Mar 31, 2016	M	10,000	D	Jan 3, 2015	Jan 2, 2018	Common Stock	10,000	76,259	D
Employee Stock Option (right to buy)	$9.22	Mar 31, 2016	M	500	D	Jul 19, 2014	Jul 18, 2017	Common Stock	500	0	I
Employee Stock Option (right to buy)	$10.29	Mar 31, 2016	M	500	D	Jan 3, 2015	Jan 2, 2018	Common Stock	500	14,500	I

F1Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 9/21/2015.
F2Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 9/21/2015.