SEC Form 4 · accession 0000874015-15-000007

IONIS PHARMACEUTICALS INC · IONS

Statement of changes in beneficial ownership, as filed. Original on EDGAR ↗

Reporting owner

Patrick R. O'Neil

Officer — SVP, Legal & General Counsel

Period of report

Jan 1, 2015

Accepted (ET)

Jan 5, 2015 · 8:03 pm EST

Rule 10b5-1 plan

unknown — predates the checkbox

Issuer CIK

0000874015

Table I — non-derivative securities

Security	Date	Code	Shares	Price	A/D	Owned after	D/I
Common Stock	Jan 1, 2015	J	329	$30.0475	A	4,082	D
Common Stock^F2	Jan 2, 2015	M	1,217	$10.82	A	5,299	D
Common Stock^F2	Jan 2, 2015	S	1,217	$62.115	D	4,082	D
Common Stock^F2	Jan 2, 2015	M	283	$7.25	A	4,365	D
Common Stock^F2	Jan 2, 2015	S	283	$62.115	D	4,082	D

Table II — derivative securities

Security	Conv. / exercise price	Date	Code	Shares	A/D	Exercisable	Expires	Underlying	Underlying shares	Owned after	D/I
Employee Stock Option (right to buy)^F3	$61.57	Jan 2, 2015	A	31,457	A	Jan 2, 2016	Jan 1, 2022	Common Stock	31,457	31,457	D
Employee Stock Option (right to buy)^F4	$10.82	Jan 2, 2015	M	1,217	D	Jan 2, 2014	Jan 1, 2020	Common Stock	1,217	13,353	D
Employee Stock Option (right to buy)^F5	$7.25	Jan 2, 2015	M	283	D	Jan 3, 2013	Jan 2, 2019	Common Stock	283	9,750	D

Explanation of responses

F1Reporting 329 shares acquired under the Isis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2015. These 329 shares may not be sold until July 2, 2015.
F2Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 1/2/2014.
F3Grant of 1/2/2015 to reporting person of stock options under the Isis Pharmacueticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 1/2/2016. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 7,865 shares per year. The option was exercisable as to 0 on 1/2/2015.
F4Grant of 1/2/2013 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/2/2014. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 3,925 shares per year. Following this transaction, the option was exercisable as to 5,503 on 1/2/2015.
F5Grant of 1/3/2012 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/3/2013. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 4,875 shares per year. Following this transaction, the option was exercisable as to 4,468 on 1/2/2015.