SEC Form 4 · accession 0000874015-15-000079

IONIS PHARMACEUTICALS INC · IONS

Statement of changes in beneficial ownership, as filed. Original on EDGAR ↗

Reporting owner

Officer — Chairman and CEO · Director

Period of report

Oct 21, 2015

Accepted (ET)

Oct 23, 2015 · 7:35 pm EDT

Rule 10b5-1 plan

unknown — predates the checkbox

Issuer CIK

0000874015

Table I — non-derivative securities

Security	Date	Code	Shares	Price	A/D	Owned after	D/I	Nature of ownership
Common Stock^F1	Oct 21, 2015	M	15,000	$11.27	A	29,642	D
Common Stock^F1,F2	Oct 21, 2015	S	15,000	$43.00	D	14,642	D
Common Stock^F3	Oct 21, 2015	M	1,000	$11.27	A	2,297	I	By wife
Common Stock^F3	Oct 21, 2015	S	1,000	$43.00	D	1,297	I	By wife
Common Stock^F3	Oct 21, 2015	M	500	$9.22	A	1,797	I	By wife
Common Stock^F3	Oct 21, 2015	S	500	$43.00	D	1,297	I	By wife
Common Stock^F1	Oct 23, 2015	M	4,163	$11.27	A	18,805	D
Common Stock^F1	Oct 23, 2015	S	4,163	$43.90	D	14,642	D
Common Stock^F1	Oct 23, 2015	M	15,837	$10.29	A	30,479	D
Common Stock^F1,F4	Oct 23, 2015	S	15,837	$44.175	D	14,642	D
Common Stock^F1	Oct 23, 2015	M	5,000	$10.29	A	19,642	D
Common Stock^F1	Oct 23, 2015	S	5,000	$45.30	D	14,642	D
Common Stock^F3	Oct 23, 2015	M	2,000	$9.22	A	3,297	I	By wife
Common Stock^F3,F4	Oct 23, 2015	S	2,000	$44.175	D	1,297	I	By wife
Common Stock^F3	Oct 23, 2015	M	500	$9.22	A	1,797	I	By wife
Common Stock^F3	Oct 23, 2015	S	500	$45.30	D	1,297	I	By wife
Common Stock	holding	—	—		—	725,391	I	By Trust

Security	Conv. / exercise price	Date	Code	Shares	A/D	Exercisable	Expires	Underlying	Underlying shares	Owned after	D/I
Employee Stock Option (right to buy)	$11.27	Oct 21, 2015	M	15,000	D	Jan 4, 2014	Jan 3, 2017	Common Stock	15,000	4,163	D
Employee Stock Option (right to buy)	$11.27	Oct 21, 2015	M	1,000	D	Jan 4, 2014	Jan 3, 2017	Common Stock	1,000	0	I
Employee Stock Option (right to buy)	$9.22	Oct 21, 2015	M	500	D	Jul 19, 2014	Jul 18, 2017	Common Stock	500	4,500	I
Employee Stock Option (right to buy)	$11.27	Oct 23, 2015	M	4,163	D	Jan 4, 2014	Jan 3, 2017	Common Stock	4,163	0	D
Employee Stock Option (right to buy)	$10.29	Oct 23, 2015	M	20,837	D	Jan 3, 2015	Jan 2, 2018	Common Stock	20,837	101,259	D
Employee Stock Option (right to buy)	$9.22	Oct 23, 2015	M	2,500	D	Jul 19, 2014	Jul 18, 2017	Common Stock	2,500	2,000	I

F1Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 9/21/2015.
F2The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $42.60 to $43.40, inclusive. The reporting person undertakes to provide to Isis Pharmaceuticals, Inc., any security holder of Isis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.
F3Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 9/21/2015.
F4The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $43.90 to $44.70, inclusive. The reporting person undertakes to provide to Isis Pharmaceuticals, Inc., any security holder of Isis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (4) on this Form 4.