Company · CIK 0000874015 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

IONIS PHARMACEUTICALS INC · IONS

Insider activity reported against this company. All insider holders · Files at: AKCA, RGLS. On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market activity at this companybuys $1.1M · 1sales $99.1M · 181net −$98.0M

Open-market trades as an insider elsewherebuys $225.0M · 2sales $3.8M · 2net $221.2M

Reported at this company — common stock

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Jun 1, 2017 SForm 4 →	Jun 2, 6:15 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	70	$48.00	$3,360	10,299	−0.68%	plan?
Jun 1, 2017 MForm 4 →	Jun 2, 6:15 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	70	$10.82	$757	10,369	—	plan?
May 31, 2017 SForm 4 →	Jun 2, 6:16 pm EDT	Frederick T MutoDirector	12,500	$45.22	$565,250	4,658	−72.9%	plan?
May 31, 2017 MForm 4 →	Jun 2, 6:16 pm EDT	Frederick T MutoDirector	12,500	$9.77	$122,125	17,158	—	plan?
May 1, 2017 MForm 4 →	May 3, 6:01 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	500	$10.82	$5,410	10,799	—	plan?
May 1, 2017 SForm 4 →	May 3, 6:01 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	650	$48.75	$31,688	10,299	−5.94%	plan?
Apr 25, 2017 SForm 4 →	Apr 27, 6:03 pm EDT	Stanley T CrookeChairman and CEO, Director	16,500	$47.81	$788,865	3,062	−84.3%	plan?
Apr 25, 2017 MForm 4 →	Apr 27, 6:03 pm EDT	Stanley T CrookeChairman and CEO, Director	16,500	$7.25	$119,625	4,562	—	plan?
Apr 24, 2017 SForm 4 →	Apr 26, 5:58 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	500	$45.00	$22,500	10,449	−4.57%	plan?
Apr 24, 2017 MForm 4 →	Apr 26, 5:58 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	500	$10.82	$5,410	10,875	—	plan?
Apr 19, 2017 SForm 4 →	Apr 21, 5:42 pm EDT	Stanley T CrookeChairman and CEO, Director	5,500	$43.25	$237,875	3,062	−64.2%	plan?
Apr 19, 2017 MForm 4 →	Apr 21, 5:42 pm EDT	Stanley T CrookeChairman and CEO, Director	5,500	$7.25	$39,875	3,562	—	plan?
Apr 12, 2017 SForm 4 →	Apr 13, 7:25 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	$40.07	$40,070	10,449	−8.73%	plan?
Apr 12, 2017 SForm 4 →	Apr 13, 7:24 pm EDT	Stanley T CrookeChairman and CEO, Director	22,000	$40.69	$895,070	3,062	−87.8%	plan?
Apr 12, 2017 MForm 4 →	Apr 13, 7:24 pm EDT	Stanley T CrookeChairman and CEO, Director	22,000	$7.46	$164,060	3,562	—	plan?
Mar 3, 2017 SForm 4 →	Mar 6, 7:25 pm EST	C Frank BennettSVP, Antisense Research	5,000	$55.00	$275,000	14,788	−25.3%	plan?
Mar 3, 2017 MForm 4 →	Mar 6, 7:25 pm EST	C Frank BennettSVP, Antisense Research	5,000	$10.29	$51,450	19,788	—	plan?
Mar 2, 2017 SForm 4 →	Mar 6, 7:23 pm EST	Stanley T CrookeChairman and CEO, Director	12,100	$51.05	$617,705	3,062	−79.8%	plan?
Mar 2, 2017 MForm 4 →	Mar 6, 7:23 pm EST	Stanley T CrookeChairman and CEO, Director	12,100	$7.53	$91,069	4,162	—	plan?
Mar 1, 2017 SForm 4 →	Mar 2, 7:12 pm EST	B Lynne ParshallCOO, Director	4,625	$49.26	$227,828	25,651	−15.3%	plan?
Mar 1, 2017 MForm 4 →	Mar 2, 7:12 pm EST	B Lynne ParshallCOO, Director	4,625	$14.69	$67,941	30,276	—	plan?
Mar 1, 2017 SForm 4 →	Mar 2, 7:11 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	1,500	$49.29	$73,935	11,449	−11.6%	plan?
Mar 1, 2017 MForm 4 →	Mar 2, 7:11 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	500	$10.82	$5,410	12,949	—	plan?
Feb 24, 2017 MForm 4 →	Feb 27, 7:15 pm EST	Spencer R BerthelsenDirector	12,500	$9.77	$122,125	88,958	—	plan?
Feb 6, 2017 MForm 4 →	Feb 8, 6:32 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	500	$10.68	$5,342	12,930	—	plan?
Feb 6, 2017 SForm 4 →	Feb 8, 6:32 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	1,500	$46.17	$69,254	12,449	−10.8%	plan?
Feb 3, 2017 MForm 4 →	Feb 3, 6:31 pm EST	Joseph LoscalzoDirector	937	—	—	4,814	—	plan?
Jan 17, 2017 SForm 4 →	Jan 18, 6:48 pm EST	Sarah BoyceChief Business Officer	1,361	$46.29	$63,001	5,252	−20.6%	plan?
Jan 17, 2017 SForm 4 →	Jan 18, 6:38 pm EST	Brett P MoniaSVP, Antisense Drug Discovery	2,502	$46.29	$115,819	11,772	−17.5%	plan?
Jan 17, 2017 SForm 4 →	Jan 18, 6:37 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	2,246	$46.29	$103,968	13,449	−14.3%	plan?
Jan 17, 2017 SForm 4 →	Jan 18, 6:37 pm EST	C Frank BennettSVP, Antisense Research	2,421	$46.29	$112,069	14,788	−14.1%	plan?
Jan 17, 2017 SForm 4 →	Jan 18, 6:36 pm EST	Stanley T CrookeChairman and CEO, Director	15,957	$46.29	$738,643	3,062	−83.9%	plan?
Jan 17, 2017 SForm 4 →	Jan 18, 6:36 pm EST	B Lynne ParshallCOO, Director	7,246	$46.29	$335,414	25,651	−22.0%	plan?
Jan 17, 2017 SForm 4 →	Jan 18, 6:35 pm EST	Elizabeth L HougenSVP, Finance & CFO	2,273	$46.29	$105,218	10,288	−18.1%	plan?
Jan 17, 2017 SForm 4 →	Jan 18, 6:35 pm EST	Richard S GearySVP, Development	2,441	$46.29	$112,996	12,962	−15.8%	plan?
Jan 15, 2017 MForm 4 →	Jan 18, 6:48 pm EST	Sarah BoyceChief Business Officer	3,483	—	—	5,758	—	plan?
Jan 15, 2017 MForm 4 →	Jan 18, 6:38 pm EST	Brett P MoniaSVP, Antisense Drug Discovery	6,402	—	—	12,395	—	plan?
Jan 15, 2017 MForm 4 →	Jan 18, 6:37 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	5,745	—	—	14,072	—	plan?
Jan 15, 2017 MForm 4 →	Jan 18, 6:37 pm EST	C Frank BennettSVP, Antisense Research	6,195	—	—	15,411	—	plan?
Jan 15, 2017 MForm 4 →	Jan 18, 6:36 pm EST	Stanley T CrookeChairman and CEO, Director	29,834	—	—	3,193	—	plan?
Jan 15, 2017 MForm 4 →	Jan 18, 6:36 pm EST	B Lynne ParshallCOO, Director	16,033	—	—	27,727	—	plan?
Jan 15, 2017 MForm 4 →	Jan 18, 6:35 pm EST	Elizabeth L HougenSVP, Finance & CFO	5,814	—	—	10,911	—	plan?
Jan 15, 2017 MForm 4 →	Jan 18, 6:35 pm EST	Richard S GearySVP, Development	6,246	—	—	13,585	—	plan?
Jan 10, 2017 SForm 4 →	Jan 12, 6:18 pm EST	Stanley T CrookeChairman and CEO, Director	13,200	$49.25	$650,100	2,170	−85.9%	plan?
Jan 10, 2017 MForm 4 →	Jan 12, 6:18 pm EST	Stanley T CrookeChairman and CEO, Director	13,200	$7.53	$99,348	3,370	—	plan?
Jan 3, 2017 SForm 4 →	Jan 4, 6:35 pm EST	Stanley T CrookeChairman and CEO, Director	18,700	$48.89	$914,320	2,170	−89.6%	plan?
Jan 3, 2017 MForm 4 →	Jan 4, 6:35 pm EST	Stanley T CrookeChairman and CEO, Director	18,700	$7.53	$140,743	2,870	—	plan?
Jan 3, 2017 SForm 4 →	Jan 4, 6:34 pm EST	Brett P MoniaSVP, Antisense Drug Discovery	309	$48.60	$15,017	7,872	−3.78%	plan?
Jan 1, 2017 JForm 4 →	Jan 4, 6:35 pm EST	Sarah BoyceChief Business Officer	992	$20.76	$20,591	3,130	—	plan?
Jan 1, 2017 JForm 4 →	Jan 4, 6:34 pm EST	Brett P MoniaSVP, Antisense Drug Discovery	309	$20.76	$6,414	8,181	—	plan?
Jan 1, 2017 JForm 4 →	Jan 4, 6:34 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	424	$20.76	$8,801	9,950	—	plan?
Jan 1, 2017 JForm 4 →	Jan 4, 6:33 pm EST	Elizabeth L HougenSVP, Finance & CFO	199	$20.76	$4,131	6,747	—	plan?
Jan 1, 2017 JForm 4 →	Jan 4, 6:32 pm EST	C Frank BennettSVP, Antisense Research	211	$20.76	$4,380	11,014	—	plan?
Jan 1, 2017 JForm 4 →	Jan 4, 6:31 pm EST	B Lynne ParshallCOO, Director	171	$20.76	$3,549	16,864	—	plan?
Jan 1, 2017 JForm 4 →	Jan 4, 6:30 pm EST	Richard S GearySVP, Development	640	$20.76	$13,284	9,157	—	plan?
Dec 20, 2016 SForm 4 →	Dec 20, 6:48 pm EST	Brett P MoniaSVP, Antisense Drug Discovery	130	$52.48	$6,822	7,872	−1.62%	plan?
Dec 15, 2016 SForm 4 →	Dec 16, 7:21 pm EST	B Lynne ParshallCOO, Director	4,000	$50.00	$200,000	0	−100%	plan?
Dec 15, 2016 MForm 4 →	Dec 16, 7:21 pm EST	B Lynne ParshallCOO, Director	4,000	$7.25	$29,000	1,000	—	plan?
Dec 5, 2016 SForm 4 →	Dec 7, 7:51 pm EST	Elizabeth L HougenSVP, Finance & CFO	2,500	$46.05	$115,125	6,548	−27.6%	plan?
Dec 5, 2016 MForm 4 →	Dec 7, 7:51 pm EST	Elizabeth L HougenSVP, Finance & CFO	2,500	$11.27	$28,175	9,048	—	plan?
Dec 5, 2016 SForm 4 →	Dec 7, 7:27 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	350	$45.00	$15,750	9,526	−3.54%	plan?
Dec 5, 2016 MForm 4 →	Dec 7, 7:27 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	350	$10.82	$3,787	9,876	—	plan?
Dec 1, 2016 SForm 4 →	Dec 2, 6:58 pm EST	B Lynne ParshallCOO, Director	12,500	$42.23	$527,865	16,693	−42.8%	plan?
Dec 1, 2016 MForm 4 →	Dec 2, 6:58 pm EST	B Lynne ParshallCOO, Director	12,500	$14.69	$183,625	22,193	—	plan?
Nov 14, 2016 SForm 4 →	Nov 16, 11:56 am EST	Elizabeth L HougenSVP, Finance & CFO	2,500	$47.50	$118,750	6,548	−27.6%	plan?
Nov 14, 2016 MForm 4 →	Nov 16, 11:56 am EST	Elizabeth L HougenSVP, Finance & CFO	2,500	$11.27	$28,175	9,048	—	plan?
Nov 14, 2016 SForm 4 →	Nov 14, 6:53 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	$45.00	$45,000	9,526	−9.50%	plan?
Nov 14, 2016 MForm 4 →	Nov 14, 6:53 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	$10.82	$10,820	10,332	—	plan?
Nov 9, 2016 SForm 4 →	Nov 14, 6:52 pm EST	Elizabeth L HougenSVP, Finance & CFO	5,000	$39.75	$198,725	6,548	−43.3%	plan? late
Nov 9, 2016 MForm 4 →	Nov 14, 6:52 pm EST	Elizabeth L HougenSVP, Finance & CFO	5,000	$11.27	$56,350	9,048	—	plan? late
Nov 9, 2016 SForm 4 →	Nov 14, 6:51 pm EST	Stanley T CrookeChairman and CEO, Director	33,000	$37.72	$1,244,866	2,170	−93.8%	plan? late
Nov 9, 2016 MForm 4 →	Nov 14, 6:51 pm EST	Stanley T CrookeChairman and CEO, Director	33,000	$9.02	$297,797	3,170	—	plan? late
Nov 9, 2016 SForm 4 →	Nov 14, 6:51 pm EST	C Frank BennettSVP, Antisense Research	22,805	$37.56	$856,605	10,803	−67.9%	plan? late
Nov 9, 2016 MForm 4 →	Nov 14, 6:51 pm EST	C Frank BennettSVP, Antisense Research	22,805	$11.27	$257,012	28,608	—	plan? late
Nov 7, 2016 SForm 4 →	Nov 9, 6:22 pm EST	C Frank BennettSVP, Antisense Research	5,000	$34.00	$170,000	10,803	−31.6%	plan?
Nov 7, 2016 MForm 4 →	Nov 9, 6:22 pm EST	C Frank BennettSVP, Antisense Research	5,000	$11.27	$56,350	15,803	—	plan?
Oct 5, 2016 SForm 4 →	Oct 7, 5:49 pm EDT	Stanley T CrookeChairman and CEO, Director	11,000	$36.61	$402,710	2,170	−83.5%	plan?
Oct 5, 2016 MForm 4 →	Oct 7, 5:49 pm EDT	Stanley T CrookeChairman and CEO, Director	11,000	$10.29	$113,190	3,170	—	plan?
Sep 27, 2016 SForm 4 →	Sep 29, 5:05 pm EDT	Stanley T CrookeChairman and CEO, Director	22,000	$36.02	$792,500	2,170	−91.0%	plan?
Sep 27, 2016 MForm 4 →	Sep 29, 5:05 pm EDT	Stanley T CrookeChairman and CEO, Director	22,000	$10.29	$226,380	4,170	—	plan?
Sep 21, 2016 SForm 4 →	Sep 23, 6:31 pm EDT	Stanley T CrookeChairman and CEO, Director	22,000	$35.50	$781,000	2,170	−91.0%	plan?
Sep 21, 2016 MForm 4 →	Sep 23, 6:31 pm EDT	Stanley T CrookeChairman and CEO, Director	22,000	$10.29	$226,380	4,170	—	plan?
Sep 1, 2016 SForm 4 →	Sep 6, 6:52 pm EDT	B Lynne ParshallCOO, Director	12,500	$29.88	$373,545	16,693	−42.8%	plan?
Sep 1, 2016 MForm 4 →	Sep 6, 6:52 pm EDT	B Lynne ParshallCOO, Director	12,500	$9.41	$117,669	20,328	—	plan?
Jul 1, 2016 MForm 4 →	Jul 6, 6:41 pm EDT	Spencer R BerthelsenDirector	2,115	—	—	76,458	—	plan?
Jul 1, 2016 MForm 4 →	Jul 6, 6:41 pm EDT	Frederick T MutoDirector	2,115	—	—	4,658	—	plan?
Jul 1, 2016 MForm 4 →	Jul 6, 6:38 pm EDT	Joseph LoscalzoDirector	1,334	—	—	3,877	—	plan?
Jul 1, 2016 MForm 4 →	Jul 6, 6:37 pm EDT	Joseph Klein IIIDirector	2,115	—	—	7,658	—	plan?
Jul 1, 2016 MForm 4 →	Jul 6, 6:37 pm EDT	Breaux CastlemanDirector	2,740	—	—	6,221	—	plan?
Jul 1, 2016 MForm 4 →	Jul 6, 6:36 pm EDT	Joseph H WenderDirector	2,115	—	—	33,780	—	plan?
Jul 1, 2016 JForm 4 →	Jul 1, 8:22 pm EDT	B Lynne ParshallCOO, Director	403	$20.76	$8,365	16,693	—	plan?
Jul 1, 2016 JForm 4 →	Jul 1, 8:21 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	402	$20.76	$8,344	9,526	—	plan?
Jul 1, 2016 JForm 4 →	Jul 1, 8:20 pm EDT	Brett P MoniaSVP, Antisense Drug Discovery	309	$20.76	$6,414	8,002	—	plan?
Jul 1, 2016 JForm 4 →	Jul 1, 8:20 pm EDT	Elizabeth L HougenSVP, Finance & CFO	217	$20.76	$4,504	6,548	—	plan?
Jul 1, 2016 JForm 4 →	Jul 1, 8:19 pm EDT	Richard S GearySVP, Development	163	$20.76	$3,383	8,517	—	plan?
Jul 1, 2016 JForm 4 →	Jul 1, 8:18 pm EDT	Sarah BoyceChief Business Officer	403	$20.76	$8,365	2,138	—	plan?
Jul 1, 2016 JForm 4 →	Jul 1, 8:18 pm EDT	C Frank BennettSVP, Antisense Research	213	$20.76	$4,421	10,803	—	plan?
May 31, 2016 SForm 4 →	Jun 2, 6:25 pm EDT	Frederick T MutoDirector	12,500	$22.31	$278,900	2,543	−83.1%	plan?
May 31, 2016 MForm 4 →	Jun 2, 6:25 pm EDT	Frederick T MutoDirector	12,500	$5.93	$74,125	15,043	—	plan?
Apr 6, 2016 SForm 4 →	Apr 7, 6:18 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	$45.00	$45,000	9,124	−9.88%	plan?

Reported at this company — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake
Dec 15, 2015 MForm 4 →	Dec 17, 7:23 pm EST	C Frank BennettSVP, Antisense Research	7,909	—	—	0	—
Dec 1, 2015 MForm 4 →	Dec 2, 6:49 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	—	—	2,067	—
Nov 11, 2015 MForm 4 →	Nov 12, 7:02 pm EST	Joseph Klein IIIDirector	6,875	—	—	2,812	—
Nov 10, 2015 MForm 4 →	Nov 12, 7:03 pm EST	C Frank BennettSVP, Antisense Research	5,000	—	—	7,909	—
Nov 9, 2015 GForm 4 →	Nov 9, 7:45 pm EST	B Lynne ParshallCOO & Secretary, Director	8,000	—	—	1,000	—
Nov 6, 2015 MForm 4 →	Nov 9, 7:28 pm EST	C Frank BennettSVP, Antisense Research	5,000	—	—	12,909	—
Nov 3, 2015 MForm 4 →	Nov 4, 7:00 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	1,000	—	—	3,067	—
Oct 21, 2015 MForm 4 →	Oct 23, 7:35 pm EDT	Stanley T CrookeChairman and CEO, Director	44,000	—	—	2,000	—
Oct 1, 2015 MForm 4 →	Oct 5, 7:14 pm EDT	B Lynne ParshallCOO & Secretary, Director	12,436	—	—	29,354	—
Jul 6, 2015 MForm 4 →	Jul 8, 5:55 pm EDT	B Lynne ParshallCOO & Secretary, Director	6,218	—	—	17,027	—
Jul 6, 2015 MForm 4 →	Jul 8, 5:54 pm EDT	Stanley T CrookeChairman and CEO, Director	6,175	—	—	5,000	—
Jul 1, 2015 MForm 4 →	Jul 2, 6:06 pm EDT	B Lynne ParshallCOO & Secretary, Director	6,218	—	—	1,375	—
Jul 1, 2015 MForm 4 →	Jul 2, 6:02 pm EDT	Stanley T CrookeChairman and CEO, Director	6,175	—	—	6,175	—
Jul 1, 2015 AMForm 4 →	Jul 2, 6:00 pm EDT	Joseph H WenderDirector	20,115	—	—	16,000	—
Jul 1, 2015 AMForm 4 →	Jul 2, 6:00 pm EDT	Frederick T MutoDirector	20,115	—	—	16,000	—
Jul 1, 2015 AMForm 4 →	Jul 2, 5:59 pm EDT	Joseph LoscalzoDirector	19,334	—	—	16,000	—
Jul 1, 2015 AMForm 4 →	Jul 2, 5:58 pm EDT	Joseph Klein IIIDirector	20,115	—	—	16,000	—
Jul 1, 2015 AMForm 4 →	Jul 2, 5:57 pm EDT	Breaux CastlemanDirector	20,741	—	—	16,000	—
Jul 1, 2015 AMForm 4 →	Jul 2, 5:57 pm EDT	Spencer R BerthelsenDirector	20,115	—	—	16,000	—
Jun 8, 2015 MForm 4 →	Jun 10, 6:36 pm EDT	Brett P MoniaSVP, Antisense Drug Discovery	7,600	—	—	0	—
Jun 1, 2015 MForm 4 →	Jun 3, 5:29 pm EDT	Frederick T MutoDirector	10,000	—	—	0	—
Apr 17, 2015 MForm 4 →	Apr 17, 6:13 pm EDT	Spencer R BerthelsenDirector	10,000	—	—	0	—
Apr 7, 2015 MForm 4 →	Apr 8, 5:12 pm EDT	B Lynne ParshallCOO & Secretary, Director	5,565	—	—	37,628	—
Apr 7, 2015 MForm 4 →	Apr 8, 5:11 pm EDT	Stanley T CrookeChairman and CEO, Director	22,377	—	—	7,350	—
Apr 1, 2015 MForm 4 →	Apr 6, 11:51 am EDT	B Lynne ParshallCOO & Secretary, Director	5,377	—	—	43,193	—
Apr 1, 2015 MForm 4 →	Apr 6, 11:50 am EDT	Stanley T CrookeChairman and CEO, Director	21,623	—	—	9,384	—
Mar 23, 2015 MForm 4 →	Mar 25, 4:23 pm EDT	C Frank BennettSVP, Antisense Research	15,000	—	—	17,909	—
Mar 19, 2015 MForm 4 →	Mar 20, 6:58 pm EDT	Elizabeth L HougenSVP, Finance & CFO	10,000	—	—	10,000	—
Mar 19, 2015 MForm 4 →	Mar 20, 6:56 pm EDT	Richard S GearySVP, Development	8,000	—	—	17,240	—
Mar 19, 2015 MForm 4 →	Mar 20, 6:55 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	30,525	—	—	31,875	—
Mar 18, 2015 MForm 4 →	Mar 20, 6:57 pm EDT	Joseph H WenderDirector	12,500	—	—	0	—
Mar 5, 2015 MForm 4 →	Mar 9, 7:45 pm EDT	Richard S GearySVP, Development	15,080	—	—	7,035	—
Mar 5, 2015 MForm 4 →	Mar 9, 7:27 pm EDT	Elizabeth L HougenSVP, Finance & CFO	28,094	—	—	4,063	—
Mar 5, 2015 MForm 4 →	Mar 9, 7:27 pm EDT	Patrick R. O'NeilSVP, Legal & General Counsel	5,800	—	—	1,617	—
Mar 5, 2015 MForm 4 →	Mar 9, 7:26 pm EDT	Joseph H WenderDirector	12,500	—	—	0	—
Mar 5, 2015 MForm 4 →	Mar 9, 7:25 pm EDT	Joseph Klein IIIDirector	10,000	—	—	5,937	—
Feb 12, 2015 MForm 4 →	Feb 17, 5:39 pm EST	Joseph H WenderDirector	10,000	—	—	0	—
Feb 3, 2015 MForm 4 →	Feb 5, 6:08 pm EST	Joseph LoscalzoDirector	938	—	—	2,812	—
Jan 27, 2015 MForm 4 →	Jan 29, 7:03 pm EST	Stanley T CrookeChairman and CEO, Director	11,000	—	—	11,350	—
Jan 15, 2015 AMForm 4 →	Jan 20, 8:00 pm EST	Stanley T CrookeChairman and CEO, Director	46,375	—	—	1,062	—
Jan 15, 2015 AForm 4 →	Jan 20, 7:59 pm EST	Sarah BoyceChief Business Officer	8,750	—	—	8,750	—
Jan 15, 2015 AMForm 4 →	Jan 20, 7:58 pm EST	B Lynne ParshallCOO & Secretary, Director	29,824	—	—	10,312	—
Jan 15, 2015 AMForm 4 →	Jan 20, 7:57 pm EST	Brett P MoniaSVP, Antisense Drug Discovery	10,095	—	—	5,625	—
Jan 15, 2015 AMForm 4 →	Jan 20, 7:57 pm EST	Elizabeth L HougenSVP, Finance & CFO	8,901	—	—	5,625	—
Jan 15, 2015 AMForm 4 →	Jan 20, 7:56 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	8,625	—	—	5,625	—
Jan 15, 2015 AMForm 4 →	Jan 20, 7:55 pm EST	C Frank BennettSVP, Antisense Research	9,226	—	—	5,625	—
Jan 15, 2015 AMForm 4 →	Jan 20, 7:53 pm EST	Richard S GearySVP, Development	9,567	—	—	5,625	—
Jan 9, 2015 MForm 4 →	Jan 13, 6:51 pm EST	Stanley T CrookeChairman and CEO, Director	11,000	—	—	12,350	—
Jan 6, 2015 MForm 4 →	Jan 8, 7:15 pm EST	Stanley T CrookeChairman and CEO, Director	22,000	—	—	13,350	—
Jan 2, 2015 AMForm 4 →	Jan 5, 8:04 pm EST	B Lynne ParshallCOO & Secretary, Director	143,658	—	—	48,570	—
Jan 2, 2015 AMForm 4 →	Jan 5, 8:03 pm EST	Patrick R. O'NeilSVP, Legal & General Counsel	32,957	—	—	9,750	—
Jan 2, 2015 AMForm 4 →	Jan 5, 8:02 pm EST	Stanley T CrookeChairman and CEO, Director	173,700	—	—	8,700	—
Jan 2, 2015 AForm 4 →	Jan 5, 8:01 pm EST	Elizabeth L HougenSVP, Finance & CFO	33,112	—	—	33,112	—
Jan 2, 2015 AForm 4 →	Jan 5, 7:59 pm EST	C Frank BennettSVP, Antisense Research	31,457	—	—	31,457	—
Jan 2, 2015 AForm 4 →	Jan 5, 7:57 pm EST	Richard S GearySVP, Development	33,112	—	—	33,112	—
Jan 2, 2015 AForm 4 →	Jan 5, 7:56 pm EST	Brett P MoniaSVP, Antisense Drug Discovery	36,423	—	—	36,423	—
Jan 1, 2015 AForm 4 →	Jan 5, 8:31 pm EST	Sarah BoyceChief Business Officer	52,500	—	—	52,500	—

Filed by this entity as an insider elsewhere — common stock

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Oct 17, 2018 JForm 4 →	Oct 18, 8:05 pm EDT	AKCEA THERAPEUTICS, INC.AKCA	1,671,849	—	—	67,383,965	—	plan?
Aug 3, 2018 JForm 4 →	Aug 6, 5:17 pm EDT	AKCEA THERAPEUTICS, INC.AKCA	1,597,571	—	—	65,712,116	—	plan?
Apr 17, 2018 PForm 4 →	Apr 19, 6:48 pm EDT	AKCEA THERAPEUTICS, INC.AKCA	10,666,666	$18.75	$199,999,988	64,114,545	+20.0%	plan?
Apr 17, 2018 JForm 4 →	Apr 19, 6:48 pm EDT	AKCEA THERAPEUTICS, INC.AKCA	8,000,000	—	—	53,447,879	—	plan?
Jul 19, 2017 PForm 4 →	Jul 21, 4:04 pm EDT	AKCEA THERAPEUTICS, INC.AKCA	3,125,000	$8.00	$25,000,000	45,447,879	+7.38%	plan?
Jul 19, 2017 CJForm 4 →	Jul 21, 4:04 pm EDT	AKCEA THERAPEUTICS, INC.AKCA	42,322,879	—	—	42,322,879	—	plan?
Jul 15, 2015 SForm 4 →	Jul 17, 6:08 pm EDT	Regulus Therapeutics Inc.RGLS	343,133	$10.60	$3,636,078	5,173,172	−6.22%	plan?
Jun 30, 2015 SForm 4 →	Jul 2, 4:28 pm EDT	Regulus Therapeutics Inc.RGLS	13,248	$10.79	$143,010	5,516,305	−0.24%	plan?
Jun 23, 2015 GForm 4 →	Jul 2, 4:28 pm EDT	Regulus Therapeutics Inc.RGLS	13,248	—	—	5,529,553	—	plan? late

Filed by this entity as an insider elsewhere — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Jul 19, 2017 CForm 4 →	Jul 21, 4:04 pm EDT	AKCEA THERAPEUTICS, INC.AKCA	28,884,540	—	—	0	—