Company · CIK 0000872589 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

REGENERON PHARMACEUTICALS, INC. · REGN

Insider activity reported against this company. All insider holders · On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market buys & salesbuys $464.7M · 11sales $509.9M · 98net −$45.2M

Reported at this company — common stock

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Jun 12, 2017 MForm 4 →	Jun 14, 4:36 pm EDT	Michael S BrownDirector	2,000	$177.82	$355,640	2,000	—	plan?
Jun 9, 2017 SForm 4 →	Jun 13, 5:06 pm EDT	Joseph L GoldsteinDirector	1,000	$482.55	$482,550	13,000	−7.14%	plan?
Jun 9, 2017 MForm 4 →	Jun 13, 5:06 pm EDT	Joseph L GoldsteinDirector	1,000	$273.67	$273,670	14,000	—	plan?
Jun 2, 2017 PForm 4 →	Jun 6, 5:00 pm EDT	Sanofi10% Owner	136,050	$478.17	$65,055,558	23,641,744	+0.58%	plan?
Jun 2, 2017 SForm 4 →	Jun 5, 4:52 pm EDT	Neil StahlEVP Research and Development	2,812	$479.49	$1,348,314	23,950	−10.5%	plan?
Jun 1, 2017 FMForm 4 →	Jun 5, 4:52 pm EDT	Neil StahlEVP Research and Development	18,276	$311.17	$5,686,949	26,762	—	plan?
May 25, 2017 SForm 4 →	May 26, 4:04 pm EDT	P Roy VagelosChairman of the Board, Director	9,295	$458.14	$4,258,373	83,652	−10.0%	plan?
May 12, 2017 SForm 4 →	May 15, 4:07 pm EDT	Michael S BrownDirector	3,000	$450.00	$1,350,000	0	−100%	plan?
May 12, 2017 MForm 4 →	May 15, 4:07 pm EDT	Michael S BrownDirector	3,000	$177.82	$533,460	3,000	—	plan?
May 5, 2017 GForm 5 →	Feb 5, 2018, 4:02 pm EST	Arthur F RyanDirector	3,500	—	—	32,000	—	plan?
Mar 29, 2017 SForm 4 →	Mar 30, 4:42 pm EDT	Michael S BrownDirector	1,000	$400.00	$400,000	0	−100%	plan?
Mar 29, 2017 MForm 4 →	Mar 30, 4:42 pm EDT	Michael S BrownDirector	1,000	$177.82	$177,820	1,000	—	plan?
Jan 11, 2017 PForm 4 →	Jan 13, 4:15 pm EST	Sanofi10% Owner	87,298	$369.71	$32,274,872	23,505,694	+0.37%	plan?
Jan 3, 2017 GForm 4 →	May 26, 4:04 pm EDT	P Roy VagelosChairman of the Board, Director	1,118	—	—	150,707	—	plan? late
Jan 3, 2017 MForm 4 →	Jan 4, 4:12 pm EST	George L SingDirector	7,000	$19.69	$137,830	119,772	—	plan?
Dec 20, 2016 GForm 5 →	Feb 10, 2017, 8:31 pm EST	George YancopoulosPresident & CSO, Director	3,918	—	—	64,058	—	plan?
Dec 15, 2016 FMForm 4 →	Dec 19, 4:07 pm EST	Leonard S SchleiferPresident & CEO, Director	385,397	$146.71	$56,543,046	157,409	—	plan?
Dec 12, 2016 SForm 4 →	Dec 14, 5:41 pm EST	Charles A BakerDirector	3,000	$392.02	$1,176,048	9,000	−25.0%	plan?
Dec 12, 2016 MForm 4 →	Dec 14, 5:41 pm EST	Charles A BakerDirector	3,000	$18.61	$55,830	12,000	—	plan?
Nov 22, 2016 GForm 4 →	Dec 20, 4:29 pm EST	P Roy VagelosChairman of the Board, Director	59,788	—	—	414,156	—	plan? late
Nov 15, 2016 GForm 4 →	Nov 16, 4:21 pm EST	Arthur F RyanDirector	1,000	—	—	35,500	—	plan?
Nov 15, 2016 SForm 4 →	Nov 16, 4:21 pm EST	Arthur F RyanDirector	2,000	$429.34	$858,680	36,500	−5.19%	plan?
Nov 14, 2016 SForm 4 →	Nov 15, 4:08 pm EST	Joseph L GoldsteinDirector	2,125	$450.00	$956,250	13,000	−14.0%	plan?
Nov 14, 2016 MForm 4 →	Nov 15, 4:08 pm EST	Joseph L GoldsteinDirector	2,125	$273.67	$581,549	15,125	—	plan?
Sep 1, 2016 FForm 4 →	Sep 2, 4:02 pm EDT	Joseph J LarosaSVP General Counsel and Secret	4,943	$392.63	$1,940,770	11,813	—	plan?
Jul 29, 2016 SForm 4 →	Aug 1, 4:04 pm EDT	Joseph L GoldsteinDirector	2,125	$425.00	$903,125	13,000	−14.0%	plan?
Jul 29, 2016 MForm 4 →	Aug 1, 4:04 pm EDT	Joseph L GoldsteinDirector	2,125	$273.67	$581,549	15,125	—	plan?
Jul 21, 2016 FGMForm 4 →	Dec 19, 4:09 pm EST	George YancopoulosPresident Regeneron Laboratori, Director	1,300,731	$146.71	$44,121,274	67,976	—	plan? late
Jul 1, 2016 FGMForm 4 →	Nov 9, 4:10 pm EST	P Roy VagelosChairman of the Board, Director	119,816	$138.33	$16,416,843	151,825	—	plan? late
Jun 14, 2016 PForm 4 →	Jun 16, 5:47 pm EDT	Sanofi10% Owner	64,731	$363.86	$23,552,859	23,418,396	+0.28%	plan?
May 24, 2016 SForm 4 →	May 25, 4:02 pm EDT	Arthur F RyanDirector	1,000	$396.64	$396,640	39,500	−2.47%	plan?
May 18, 2016 SForm 4 →	May 19, 4:26 pm EDT	Daniel P Van PlewEVP & General Mgr Industrial O	4,413	$385.77	$1,702,403	1,921	−69.7%	plan?
May 17, 2016 FMForm 4 →	May 19, 4:26 pm EDT	Daniel P Van PlewEVP & General Mgr Industrial O	14,507	$155.01	$2,248,702	6,334	—	plan?
May 16, 2016 GForm 4 →	Dec 19, 4:15 pm EST	Peter PowchikSVP Clinical Development & Reg	9,836	—	—	2,459	—	plan? late
Apr 6, 2016 MForm 4 →	Apr 7, 4:19 pm EDT	Joseph L GoldsteinDirector	1,000	$177.82	$177,820	14,000	—	plan?
Apr 6, 2016 SForm 4 →	Apr 7, 4:19 pm EDT	Joseph L GoldsteinDirector	2,000	$425.00	$850,000	13,000	−13.3%	plan?
Apr 1, 2016 SForm 4 →	Apr 4, 4:16 pm EDT	Joseph L GoldsteinDirector	2,000	$400.00	$800,000	14,000	−12.5%	plan?
Apr 1, 2016 MForm 4 →	Apr 4, 4:16 pm EDT	Joseph L GoldsteinDirector	2,000	$177.82	$355,640	16,000	—	plan?
Mar 21, 2016 SForm 4 →	Mar 21, 4:27 pm EDT	Joseph L GoldsteinDirector	2,000	$375.00	$750,000	14,000	−12.5%	plan?
Mar 21, 2016 MForm 4 →	Mar 21, 4:27 pm EDT	Joseph L GoldsteinDirector	2,000	$177.82	$355,640	16,000	—	plan?
Feb 26, 2016 GForm 4 →	May 25, 4:02 pm EDT	Arthur F RyanDirector	2,000	—	—	38,500	—	plan? late
Feb 19, 2016 GForm 4 →	Dec 20, 4:28 pm EST	Neil StahlEVP Research and Development	9,376	—	—	23,950	—	plan? late
Feb 16, 2016 PForm 4 →	Feb 18, 5:45 pm EST	Sanofi10% Owner	161,157	$392.46	$63,247,910	23,353,665	+0.69%	plan?
Jan 12, 2016 PForm 4 →	Jan 14, 5:46 pm EST	Sanofi10% Owner	83,938	$465.04	$39,034,660	23,192,508	+0.36%	plan?
Jan 4, 2016 FGMForm 4 →	May 13, 4:40 pm EDT	P Roy VagelosChairman of the Board, Director	356,388	$142.58	$50,676,556	152,964	—	plan? late
Dec 29, 2015 SForm 4 →	Dec 29, 7:44 pm EST	Douglas S McCorkleVP Controller and Asst Treasur	3,954	$552.08	$2,182,924	6,866	−36.5%	plan?
Dec 29, 2015 MForm 4 →	Dec 29, 7:44 pm EST	Douglas S McCorkleVP Controller and Asst Treasur	3,954	$52.03	$205,727	10,820	—	plan?
Dec 17, 2015 MForm 4 →	Dec 18, 4:28 pm EST	Michael S AbermanSVP Strategy Investor Relation	4,000	$24.00	$96,000	16,498	—	plan?
Dec 16, 2015 MForm 4 →	Dec 18, 4:28 pm EST	Douglas S McCorkleVP Controller and Asst Treasur	1,921	$52.03	$99,950	6,866	—	plan?
Dec 16, 2015 MForm 4 →	Dec 18, 4:27 pm EST	Peter PowchikSVP Clinical Development & Reg	1,921	$52.03	$99,950	17,742	—	plan?
Dec 16, 2015 MForm 4 →	Dec 18, 4:27 pm EST	Neil StahlEVP Research and Development	1,921	$52.03	$99,950	27,594	—	plan?
Dec 16, 2015 MForm 4 →	Dec 18, 4:27 pm EST	Daniel P Van PlewSVP & General Mgr Industrial O	1,921	$52.03	$99,950	1,921	—	plan?
Dec 16, 2015 MForm 4 →	Dec 18, 4:26 pm EST	George YancopoulosPresident Regeneron Laboratori, Director	1,921	$52.03	$99,950	501,921	—	plan?
Dec 10, 2015 SForm 4 →	Dec 11, 4:14 pm EST	Michael S BrownDirector	3,000	$546.45	$1,639,365	0	−100%	plan?
Dec 10, 2015 MForm 4 →	Dec 11, 4:14 pm EST	Michael S BrownDirector	3,000	$177.82	$533,460	3,000	—	plan?
Dec 2, 2015 SForm 4 →	Dec 4, 4:13 pm EST	George YancopoulosPresident Regeneron Laboratori, Director	43,348	$549.03	$23,799,539	500,000	−7.98%	plan?
Nov 18, 2015 SForm 4 →	Nov 20, 4:04 pm EST	George L SingDirector	3,500	$580.00	$2,030,000	4,500	−43.8%	plan?
Nov 18, 2015 MForm 4 →	Nov 20, 4:04 pm EST	George L SingDirector	3,000	$19.69	$59,070	115,772	—	plan?
Nov 18, 2015 SForm 4 →	Nov 19, 4:20 pm EST	P Roy VagelosChairman of the Board, Director	17,240	$587.90	$10,135,312	334,611	−4.90%	plan?
Nov 16, 2015 GForm 4 →	Dec 4, 4:13 pm EST	George YancopoulosPresident Regeneron Laboratori, Director	1,612	—	—	567,976	—	plan? late
Nov 10, 2015 SForm 4 →	Nov 10, 4:06 pm EST	Daniel P Van PlewSVP & General Mgr Industrial O	5,123	$554.85	$2,842,520	0	−100%	plan?
Nov 6, 2015 FMForm 4 →	Nov 10, 4:06 pm EST	Daniel P Van PlewSVP & General Mgr Industrial O	17,249	$216.52	$3,734,815	5,123	—	plan?
Nov 6, 2015 SForm 4 →	Nov 9, 5:10 pm EST	Neil StahlEVP Research and Development	42,101	$561.45	$23,637,627	22,029	−65.6%	plan?
Nov 5, 2015 GForm 4 →	Jan 6, 2016, 4:02 pm EST	Michael S BrownDirector	1,000	—	—	17,349	—	plan? late
Nov 5, 2015 GForm 4 →	Jan 6, 2016, 4:02 pm EST	Arthur F RyanDirector	6,000	—	—	41,500	—	plan? late
Nov 2, 2015 GForm 4 →	Dec 14, 2018, 4:21 pm EST	George YancopoulosPresident and CSO, Director	3,268,478	—	—	400,000	—	plan? late
Nov 2, 2015 SForm 4 →	Nov 4, 4:05 pm EST	P Roy VagelosChairman of the Board, Director	17,242	$580.19	$10,003,663	351,851	−4.67%	plan?
Nov 2, 2015 SForm 4 →	Nov 3, 4:20 pm EST	George YancopoulosPresident Regeneron Laboratori, Director	43,348	$571.61	$24,778,125	543,348	−7.39%	plan?
Oct 30, 2015 FMForm 4 →	Nov 3, 4:20 pm EST	George YancopoulosPresident Regeneron Laboratori, Director	278,940	$200.29	$55,867,889	586,696	—	plan?
Oct 6, 2015 PForm 4 →	Oct 8, 5:50 pm EDT	Sanofi10% Owner	11,040	$472.33	$5,214,519	23,108,570	+0.05%	plan?
Oct 6, 2015 PForm 4 →	Oct 8, 5:45 pm EDT	Sanofi10% Owner	80,538	$459.71	$37,024,197	23,097,530	+0.35%	plan?
Oct 1, 2015 GForm 4 →	Nov 19, 4:20 pm EST	P Roy VagelosChairman of the Board, Director	2,186	—	—	153,935	—	plan? late
Sep 23, 2015 PForm 4 →	Sep 25, 5:45 pm EDT	Sanofi10% Owner	147,209	$534.67	$78,708,570	23,016,992	+0.64%	plan?
Sep 21, 2015 SForm 4 →	Sep 22, 2:39 pm EDT	Michael S BrownDirector	3,000	$551.55	$1,654,650	0	−100%	plan?
Sep 21, 2015 MForm 4 →	Sep 22, 2:39 pm EDT	Michael S BrownDirector	3,000	$57.11	$171,330	3,000	—	plan?
Sep 17, 2015 SForm 4 →	Sep 18, 4:06 pm EDT	Charles A BakerDirector	5,000	$550.00	$2,750,000	9,000	−35.7%	plan?
Sep 17, 2015 MForm 4 →	Sep 18, 4:06 pm EDT	Charles A BakerDirector	5,000	$18.61	$93,050	14,000	—	plan?
Sep 2, 2015 FMForm 4 →	Sep 3, 4:59 pm EDT	Leonard S SchleiferPresident & CEO, Director	13,733	$451.82	$6,204,788	42,806	—	plan?
Sep 1, 2015 MForm 4 →	Sep 2, 4:04 pm EDT	Joseph J LarosaSVP General Counsel and Secret	1,689	$59.20	$99,989	16,756	—	plan?
Aug 14, 2015 SForm 4 →	Aug 17, 4:01 pm EDT	Peter PowchikSVP Clinical Development & Reg	23,485	$573.38	$13,465,866	15,821	−59.7%	plan?
Aug 13, 2015 FMForm 4 →	Aug 17, 4:01 pm EDT	Peter PowchikSVP Clinical Development & Reg	97,237	$292.54	$28,446,181	39,306	—	plan?
Aug 12, 2015 SForm 4 →	Aug 12, 4:45 pm EDT	Christine A PoonDirector	112	$564.16	$63,186	790	−12.4%	plan?
Aug 11, 2015 FMForm 4 →	Aug 12, 4:45 pm EDT	Christine A PoonDirector	693	$370.50	$256,754	902	—	plan?
Aug 6, 2015 SForm 4 →	Aug 7, 6:15 pm EDT	Alfred G GilmanDirector	5,000	$587.12	$2,935,601	8,912	−35.9%	plan?
Aug 6, 2015 MForm 4 →	Aug 7, 6:15 pm EDT	Alfred G GilmanDirector	5,000	$57.11	$285,550	13,912	—	plan?
Aug 6, 2015 SForm 4 →	Aug 7, 6:14 pm EDT	Robert J TerifaySVP Commercial	13,423	$588.97	$7,905,781	23,293	−36.6%	plan?
Aug 6, 2015 SForm 4 →	Aug 7, 6:13 pm EDT	Daniel P Van PlewSVP & General Mgr Industrial O	4,028	$584.36	$2,353,807	0	−100%	plan?
Aug 5, 2015 FMForm 4 →	Aug 7, 6:14 pm EDT	Robert J TerifaySVP Commercial	48,313	$213.27	$10,303,639	36,716	—	plan?
Aug 5, 2015 FMForm 4 →	Aug 7, 6:13 pm EDT	Daniel P Van PlewSVP & General Mgr Industrial O	13,372	$222.72	$2,978,196	4,028	—	plan?
Aug 5, 2015 SForm 4 →	Aug 6, 9:00 pm EDT	Robert E LandrySVP Finance & CFO	4,000	$592.84	$2,371,350	7,099	−36.0%	plan?
Aug 5, 2015 MForm 4 →	Aug 6, 9:00 pm EDT	Robert E LandrySVP Finance & CFO	4,000	$272.70	$1,090,800	11,099	—	plan?
Aug 5, 2015 SForm 4 →	Aug 5, 8:58 pm EDT	Douglas S McCorkleVP Controller and Asst Treasur	5,000	$585.53	$2,927,648	4,945	−50.3%	plan?
Aug 5, 2015 MForm 4 →	Aug 5, 8:58 pm EDT	Douglas S McCorkleVP Controller and Asst Treasur	5,000	$270.43	$1,352,150	9,745	—	plan?
Aug 5, 2015 SForm 4 →	Aug 5, 8:55 pm EDT	Marc Tessier-LavigneDirector	5,000	$590.26	$2,951,275	1,187	−80.8%	plan?
Aug 5, 2015 MForm 4 →	Aug 5, 8:55 pm EDT	Marc Tessier-LavigneDirector	5,000	$57.11	$285,550	6,187	—	plan?
Aug 4, 2015 SForm 4 →	Aug 5, 10:03 am EDT	Joseph L GoldsteinDirector	2,000	$586.00	$1,172,000	14,000	−12.5%	plan?
Jul 31, 2015 CForm 4 →	Aug 3, 7:23 pm EDT	Alfred G GilmanDirector	8,912	—	—	8,912	—	plan?
Jul 27, 2015 PForm 4 →	Jul 29, 5:46 pm EDT	Sanofi10% Owner	10,639	$537.48	$5,718,272	22,869,783	+0.05%	plan?
Jul 15, 2015 SForm 4 →	Jul 15, 4:09 pm EDT	Joseph L GoldsteinDirector	2,000	$550.00	$1,100,000	16,000	−11.1%	plan?
Jun 22, 2015 SForm 4 →	Jun 22, 5:02 pm EDT	Joseph L GoldsteinDirector	2,000	$526.85	$1,053,700	18,000	−10.0%	plan?

Reported at this company — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake
Dec 12, 2016 MForm 4 →	Dec 14, 5:41 pm EST	Charles A BakerDirector	3,000	—	—	2,000	—
Nov 14, 2016 MForm 4 →	Nov 15, 4:08 pm EST	Joseph L GoldsteinDirector	2,125	—	—	8,500	—
Nov 7, 2016 MForm 4 →	Nov 9, 4:10 pm EST	P Roy VagelosChairman of the Board, Director	76,895	—	—	0	—
Sep 9, 2016 AForm 4 →	Sep 12, 4:25 pm EDT	Huda Y ZoghbiDirector	15,353	—	—	15,353	—
Sep 9, 2016 AForm 4 →	Sep 12, 4:24 pm EDT	Bonnie L BasslerDirector	15,353	—	—	15,353	—
Jul 29, 2016 MForm 4 →	Aug 1, 4:04 pm EDT	Joseph L GoldsteinDirector	2,125	—	—	10,625	—
May 17, 2016 MForm 4 →	May 19, 4:26 pm EDT	Daniel P Van PlewEVP & General Mgr Industrial O	9,460	—	—	32,735	—
May 12, 2016 MForm 4 →	May 13, 4:40 pm EDT	P Roy VagelosChairman of the Board, Director	230,684	—	—	76,895	—
Apr 6, 2016 MForm 4 →	Apr 7, 4:19 pm EDT	Joseph L GoldsteinDirector	1,000	—	—	0	—
Apr 1, 2016 MForm 4 →	Apr 4, 4:16 pm EDT	Joseph L GoldsteinDirector	2,000	—	—	1,000	—
Mar 21, 2016 MForm 4 →	Mar 21, 4:27 pm EDT	Joseph L GoldsteinDirector	2,000	—	—	3,000	—
Jan 4, 2016 AForm 4 →	Jan 6, 4:02 pm EST	Michael S BrownDirector	9,212	—	—	9,212	—
Jan 4, 2016 AForm 4 →	Jan 6, 4:02 pm EST	Joseph L GoldsteinDirector	9,212	—	—	9,212	—
Jan 4, 2016 AForm 4 →	Jan 6, 4:02 pm EST	Arthur F RyanDirector	9,212	—	—	9,212	—
Jan 4, 2016 AForm 4 →	Jan 6, 4:02 pm EST	George L SingDirector	9,212	—	—	9,212	—
Jan 4, 2016 AForm 4 →	Jan 6, 4:01 pm EST	Marc Tessier-LavigneDirector	9,212	—	—	9,212	—
Jan 4, 2016 AForm 4 →	Jan 6, 4:01 pm EST	Charles A BakerDirector	9,212	—	—	9,212	—
Jan 4, 2016 AForm 4 →	Jan 6, 4:01 pm EST	Christine A PoonDirector	9,212	—	—	9,212	—
Dec 29, 2015 MForm 4 →	Dec 29, 7:44 pm EST	Douglas S McCorkleVP Controller and Asst Treasur	3,954	—	—	0	—
Dec 16, 2015 AMForm 4 →	Dec 18, 4:28 pm EST	Michael S AbermanSVP Strategy Investor Relation	29,500	—	—	25,500	—
Dec 16, 2015 AForm 4 →	Dec 18, 4:28 pm EST	Robert E LandrySVP Finance & CFO	28,900	—	—	28,900	—
Dec 16, 2015 AForm 4 →	Dec 18, 4:28 pm EST	Joseph J LarosaSVP General Counsel and Secret	28,900	—	—	28,900	—
Dec 16, 2015 AMForm 4 →	Dec 18, 4:28 pm EST	Douglas S McCorkleVP Controller and Asst Treasur	5,721	—	—	3,800	—
Dec 16, 2015 AMForm 4 →	Dec 18, 4:27 pm EST	Peter PowchikSVP Clinical Development & Reg	26,921	—	—	25,000	—
Dec 16, 2015 AForm 4 →	Dec 18, 4:27 pm EST	Leonard S SchleiferPresident & CEO, Director	172,723	—	—	172,723	—
Dec 16, 2015 AMForm 4 →	Dec 18, 4:27 pm EST	Neil StahlEVP Research and Development	70,559	—	—	68,638	—
Dec 16, 2015 AForm 4 →	Dec 18, 4:27 pm EST	Robert J TerifaySVP Commercial	40,000	—	—	40,000	—
Dec 16, 2015 AMForm 4 →	Dec 18, 4:27 pm EST	Daniel P Van PlewSVP & General Mgr Industrial O	41,921	—	—	40,000	—
Dec 16, 2015 AMForm 4 →	Dec 18, 4:26 pm EST	George YancopoulosPresident Regeneron Laboratori, Director	148,736	—	—	146,815	—
Dec 16, 2015 AForm 4 →	Dec 18, 4:26 pm EST	P Roy VagelosChairman of the Board, Director	92,123	—	—	92,123	—
Dec 10, 2015 MForm 4 →	Dec 11, 4:14 pm EST	Michael S BrownDirector	3,000	—	—	12,000	—
Nov 18, 2015 MForm 4 →	Nov 20, 4:04 pm EST	George L SingDirector	3,000	—	—	7,000	—
Nov 6, 2015 MForm 4 →	Nov 10, 4:06 pm EST	Daniel P Van PlewSVP & General Mgr Industrial O	11,186	—	—	42,195	—
Nov 5, 2015 MForm 4 →	Nov 9, 5:10 pm EST	Neil StahlEVP Research and Development	100,000	—	—	46,736	—
Oct 30, 2015 MForm 4 →	Nov 3, 4:20 pm EST	George YancopoulosPresident Regeneron Laboratori, Director	182,818	—	—	0	—
Sep 21, 2015 MForm 4 →	Sep 22, 2:39 pm EDT	Michael S BrownDirector	3,000	—	—	0	—
Sep 17, 2015 MForm 4 →	Sep 18, 4:06 pm EDT	Charles A BakerDirector	5,000	—	—	5,000	—
Sep 2, 2015 MForm 4 →	Sep 3, 4:59 pm EDT	Leonard S SchleiferPresident & CEO, Director	7,226	—	—	0	—
Sep 1, 2015 MForm 4 →	Sep 2, 4:04 pm EDT	Joseph J LarosaSVP General Counsel and Secret	1,689	—	—	0	—
Aug 13, 2015 MForm 4 →	Aug 17, 4:01 pm EDT	Peter PowchikSVP Clinical Development & Reg	60,361	—	—	30,000	—
Aug 11, 2015 MForm 4 →	Aug 12, 4:45 pm EDT	Christine A PoonDirector	470	—	—	12,280	—
Aug 6, 2015 MForm 4 →	Aug 7, 6:15 pm EDT	Alfred G GilmanDirector	5,000	—	—	0	—
Aug 5, 2015 MForm 4 →	Aug 7, 6:14 pm EDT	Robert J TerifaySVP Commercial	32,500	—	—	0	—
Aug 5, 2015 MForm 4 →	Aug 7, 6:13 pm EDT	Daniel P Van PlewSVP & General Mgr Industrial O	8,700	—	—	53,381	—
Aug 5, 2015 MForm 4 →	Aug 6, 9:00 pm EDT	Robert E LandrySVP Finance & CFO	4,000	—	—	66,000	—
Aug 5, 2015 MForm 4 →	Aug 5, 8:58 pm EDT	Douglas S McCorkleVP Controller and Asst Treasur	5,000	—	—	15,000	—
Aug 5, 2015 MForm 4 →	Aug 5, 8:55 pm EDT	Marc Tessier-LavigneDirector	5,000	—	—	5,000	—
Jul 31, 2015 CForm 4 →	Aug 3, 7:23 pm EDT	Alfred G GilmanDirector	8,912	—	—	0	—
May 27, 2015 MForm 4 →	May 29, 4:19 pm EDT	George L SingDirector	5,000	—	—	10,000	—
May 22, 2015 MForm 4 →	May 27, 4:02 pm EDT	Robert Alexander IngramDirector	6,667	—	—	13,333	—
May 22, 2015 MForm 4 →	May 26, 4:32 pm EDT	Daniel P Van PlewSVP & General Mgr Industrial O	40,050	—	—	57,986	—
May 22, 2015 MForm 4 →	May 26, 4:31 pm EDT	Douglas S McCorkleVP Controller and Asst Treasur	13,464	—	—	13,000	—
May 19, 2015 CForm 4 →	May 20, 4:13 pm EDT	Joseph L GoldsteinDirector	20,000	—	—	0	—
May 15, 2015 MForm 4 →	May 18, 4:50 pm EDT	Michael S BrownDirector	5,000	—	—	3,000	—
Apr 8, 2015 MForm 4 →	Apr 9, 4:03 pm EDT	Robert E LandrySVP Finance & CFO	10,000	—	—	70,000	—
Mar 25, 2015 MForm 4 →	Mar 26, 4:21 pm EDT	Joseph J LarosaSVP General Counsel and Secret	3,097	—	—	1,689	—
Mar 25, 2015 MForm 4 →	Mar 26, 4:20 pm EDT	Charles A BakerDirector	5,000	—	—	10,000	—
Mar 17, 2015 MForm 4 →	Mar 19, 4:05 pm EDT	Michael S AbermanSVP Strategy Investor Relation	11,398	—	—	14,168	—
Mar 16, 2015 MForm 4 →	Mar 18, 6:03 pm EDT	Robert J TerifaySVP Commercial	24,375	—	—	29,236	—
Mar 16, 2015 MForm 4 →	Mar 17, 4:57 pm EDT	Joseph J LarosaSVP General Counsel and Secret	20,281	—	—	54,933	—
Feb 26, 2015 MForm 4 →	Feb 27, 4:32 pm EST	Marc Tessier-LavigneDirector	3,000	—	—	9,279	—
Feb 23, 2015 MForm 4 →	Feb 25, 4:02 pm EST	Michael S AbermanSVP Strategy Investor Relation	7,500	—	—	7,500	—
Feb 23, 2015 MForm 4 →	Feb 25, 4:01 pm EST	Robert J TerifaySVP Commercial	24,375	—	—	53,611	—
Feb 20, 2015 MForm 4 →	Feb 24, 5:08 pm EST	George L SingDirector	15,000	—	—	0	—
Feb 20, 2015 MForm 4 →	Feb 24, 5:08 pm EST	Daniel P Van PlewSVP & General Mgr Industrial O	20,000	—	—	17,895	—
Feb 20, 2015 MForm 4 →	Feb 23, 4:07 pm EST	Michael S BrownDirector	1,000	—	—	8,000	—
Feb 20, 2015 MForm 4 →	Feb 23, 4:06 pm EST	Arthur F RyanDirector	29,250	—	—	8,500	—
Feb 20, 2015 MForm 4 →	Feb 20, 4:44 pm EST	Joseph L GoldsteinDirector	5,000	—	—	5,000	—
Feb 13, 2015 MForm 4 →	Feb 18, 4:40 pm EST	Michael S AbermanSVP Strategy Investor Relation	7,500	—	—	21,668	—
Jan 2, 2015 AForm 4 →	Jan 5, 5:26 pm EST	Arthur F RyanDirector	10,838	—	—	10,838	—
Jan 2, 2015 CForm 4 →	Jan 5, 4:56 pm EST	Leonard S SchleiferPresident & CEO, Director	1,500	—	—	15,775	—
Jan 2, 2015 AForm 4 →	Jan 5, 4:31 pm EST	Marc Tessier-LavigneDirector	10,838	—	—	10,838	—
Jan 2, 2015 AForm 4 →	Jan 5, 4:25 pm EST	Charles A BakerDirector	10,838	—	—	10,838	—
Jan 2, 2015 AForm 4 →	Jan 5, 4:23 pm EST	Christine A PoonDirector	10,838	—	—	10,838	—
Jan 2, 2015 AForm 4 →	Jan 5, 4:16 pm EST	George L SingDirector	10,838	—	—	10,838	—
Jan 2, 2015 AForm 4 →	Jan 5, 4:15 pm EST	Alfred G GilmanDirector	10,838	—	—	10,838	—
Jan 2, 2015 AForm 4 →	Jan 5, 4:14 pm EST	Joseph L GoldsteinDirector	10,838	—	—	10,838	—
Jan 2, 2015 AForm 4 →	Jan 5, 4:13 pm EST	Michael S BrownDirector	10,838	—	—	10,838	—
Jan 2, 2015 AForm 4 →	Jan 5, 4:12 pm EST	Robert Alexander IngramDirector	10,838	—	—	10,838	—
Dec 31, 2014 MForm 4 →	Jan 5, 2015, 4:28 pm EST	Peter PowchikSVP Clinical Development & Reg	25,000	—	—	37,079	—