Company · CIK 0001178670 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

ALNYLAM PHARMACEUTICALS, INC. · ALNY

Insider activity reported against this company. All insider holders · Files at: RGLS. On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market activity at this companybuys $66.4M · 11sales $150.3M · 48net −$83.9M

Open-market trades as an insider elsewherebuys $0 · 0sales $7.2M · 1net −$7.2M

Reported at this company — common stock

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Sep 19, 2026 AForm 4 →	Sep 22, 4:07 pm EDT	Yvonne GreenstreetChief Executive Officer, Director	107	—	—	95,802	—
Jun 1, 2026 SForm 4 →	Jun 3, 4:25 pm EDT	David E I PyottDirector	3,830	$299.18	$1,145,853	1,582	−70.8%	10b5-1
Jun 1, 2026 MForm 4 →	Jun 3, 4:25 pm EDT	David E I PyottDirector	3,830	—	—	5,412	—	10b5-1
Oct 18, 2018 FJMForm 4 →	Nov 26, 4:11 pm EST	John MaraganoreChief Executive Officer, Director	158,593	$40.75	$6,462,318	3,038	—	plan? late
Aug 30, 2018 SForm 4 →	Sep 4, 4:15 pm EDT	Yvonne GreenstreetEVP, Chief Operating Officer	2,500	$120.00	$300,000	1,916	−56.6%	plan?
Jul 25, 2018 SForm 4 →	Jul 27, 4:07 pm EDT	John MaraganoreChief Executive Officer, Director	50,000	$105.39	$5,269,457	151,297	−24.8%	plan?
Jul 10, 2018 AFJForm 4 →	Aug 14, 6:05 pm EDT	Laurie KeatingSVP, GC & Secretary	2,000	$90.95	$55,025	320	—	plan? late
Jun 20, 2018 SForm 4 →	Jun 22, 4:20 pm EDT	Laurie KeatingSVP, GC & Secretary	1,563	$105.04	$164,178	14,500	−9.73%	plan?
May 31, 2018 SForm 4 →	Jun 4, 4:25 pm EDT	John K ClarkeDirector	15,000	$100.31	$1,504,678	8,891	−62.8%	plan?
May 31, 2018 MForm 4 →	Jun 4, 4:25 pm EDT	John K ClarkeDirector	15,000	$27.28	$409,200	23,891	—	plan?
Apr 16, 2018 AFJForm 4 →	Aug 14, 6:55 pm EDT	Akshay VaishnawPresident, R&D	2,547	$90.95	$69,668	395	—	plan? late
Apr 16, 2018 AFJForm 4 →	Aug 14, 6:21 pm EDT	Yvonne GreenstreetEVP, Chief Operating Officer	10,659	$90.95	$280,490	308	—	plan? late
Apr 16, 2018 JMForm 4 →	Jul 27, 4:07 pm EDT	John MaraganoreChief Executive Officer, Director	50,061	$21.35	$1,067,500	3,021	—	plan? late
Apr 16, 2018 JMForm 4 →	Jun 22, 4:20 pm EDT	Laurie KeatingSVP, GC & Secretary	1,594	$42.22	$65,990	288	—	plan? late
Mar 26, 2018 SForm 4 →	Mar 28, 4:39 pm EDT	Yvonne GreenstreetEVP, Chief Operating Officer	7,221	$136.54	$985,958	0	−100%	plan?
Mar 26, 2018 JMForm 4 →	Mar 28, 4:39 pm EDT	Yvonne GreenstreetEVP, Chief Operating Officer	7,454	$42.22	$304,871	233	—	plan?
Mar 20, 2018 SForm 4 →	Mar 22, 6:18 pm EDT	Laurie KeatingSVP, GC & Secretary	1,562	$149.83	$234,033	14,500	−9.72%	plan?
Mar 20, 2018 MForm 4 →	Mar 22, 6:18 pm EDT	Laurie KeatingSVP, GC & Secretary	1,562	$42.22	$65,948	16,062	—	plan?
Mar 14, 2018 SForm 4 →	Mar 16, 5:05 pm EDT	Akshay VaishnawPresident, R&D	88,554	$143.10	$12,672,126	11,215	−88.8%	plan?
Mar 14, 2018 MForm 4 →	Mar 16, 5:05 pm EDT	Akshay VaishnawPresident, R&D	88,554	$17.03	$1,507,842	99,769	—	plan?
Mar 14, 2018 SForm 4 →	Mar 16, 5:05 pm EDT	Barry E GreenePresident	38,460	$143.10	$5,503,736	61,968	−38.3%	plan?
Mar 13, 2018 SForm 4 →	Mar 14, 7:40 pm EDT	Dennis A AusielloDirector	17,117	$150.00	$2,567,550	0	−100%	plan?
Mar 13, 2018 MForm 4 →	Mar 14, 7:40 pm EDT	Dennis A AusielloDirector	17,117	$59.82	$1,023,942	17,117	—	plan?
Mar 13, 2018 SForm 4 →	Mar 14, 7:39 pm EDT	Philip A SharpDirector	15,000	$149.00	$2,235,000	140,795	−9.63%	plan?
Mar 13, 2018 MForm 4 →	Mar 14, 7:39 pm EDT	Philip A SharpDirector	15,000	$21.35	$320,250	155,795	—	plan?
Mar 13, 2018 SForm 4 →	Mar 14, 7:39 pm EDT	Paul SchimmelDirector	27,823	$150.00	$4,173,450	0	−100%	plan?
Mar 13, 2018 MForm 4 →	Mar 14, 7:39 pm EDT	Paul SchimmelDirector	27,823	$49.24	$1,369,927	27,823	—	plan?
Mar 12, 2018 SForm 4 →	Mar 14, 7:40 pm EDT	Laurie KeatingSVP, GC & Secretary	20,000	$145.00	$2,900,000	14,500	−58.0%	plan?
Mar 12, 2018 MForm 4 →	Mar 14, 7:40 pm EDT	Laurie KeatingSVP, GC & Secretary	20,000	$77.40	$1,548,000	24,500	—	plan?
Mar 9, 2018 SForm 4 →	Mar 13, 5:22 pm EDT	Philip A SharpDirector	15,000	$129.00	$1,935,000	140,795	−9.63%	plan?
Mar 9, 2018 MForm 4 →	Mar 13, 5:22 pm EDT	Philip A SharpDirector	15,000	$27.28	$409,200	155,795	—	plan?
Jan 17, 2018 GJForm 4 →	Aug 14, 7:14 pm EDT	Barry E GreenePresident	18,134	—	—	9,030	—	plan? late
Jan 17, 2018 AFJForm 4 →	Aug 14, 6:00 pm EDT	Michael MasonVP, Finance and Treasurer	1,511	$90.95	$40,837	276	—	plan? late
Jan 4, 2018 SForm 4 →	Jan 8, 5:02 pm EST	Michael MasonVP, Finance and Treasurer	36,745	$131.59	$4,835,171	0	−100%	plan?
Jan 4, 2018 MForm 4 →	Jan 8, 5:02 pm EST	Michael MasonVP, Finance and Treasurer	31,781	$88.26	$2,804,911	36,745	—	plan?
Dec 30, 2017 FMForm 4 →	Jan 3, 2018, 5:26 pm EST	Michael MasonVP, Finance and Treasurer	12,040	$127.05	$449,503	4,964	—	plan?
Dec 29, 2017 MForm 4 →	Jan 3, 2018, 5:13 pm EST	Laurie KeatingSVP, GC & Secretary	3,000	$77.40	$232,200	14,500	—	plan?
Dec 20, 2017 SForm 4 →	Dec 21, 5:00 pm EST	Laurie KeatingSVP, GC & Secretary	6,249	$121.20	$757,398	11,500	−35.2%	plan?
Dec 20, 2017 MForm 4 →	Dec 21, 5:00 pm EST	Laurie KeatingSVP, GC & Secretary	6,249	$42.22	$263,833	17,749	—	plan?
Dec 19, 2017 GForm 4 →	Dec 21, 4:45 pm EST	Akshay VaishnawEVP, R&D	320	—	—	11,215	—	plan?
Dec 19, 2017 MForm 4 →	Dec 21, 4:36 pm EST	John MaraganoreChief Executive Officer, Director	1,587	$63.00	$99,981	151,297	—	plan?
Dec 1, 2017 SForm 4 →	Dec 5, 5:47 pm EST	Laurie KeatingSVP, GC and Secretary	30,000	$135.89	$4,076,823	11,500	−72.3%	plan?
Dec 1, 2017 MForm 4 →	Dec 5, 5:47 pm EST	Laurie KeatingSVP, GC and Secretary	30,000	$77.40	$2,322,000	41,500	—	plan?
Nov 22, 2017 SForm 4 →	Nov 24, 6:55 pm EST	John MaraganoreChief Executive Officer, Director	73,415	$130.90	$9,609,736	149,710	−32.9%	plan?
Nov 22, 2017 MForm 4 →	Nov 24, 6:55 pm EST	John MaraganoreChief Executive Officer, Director	73,415	$31.39	$2,304,497	223,125	—	plan?
Nov 15, 2017 SForm 4 →	Nov 17, 5:35 pm EST	John MaraganoreChief Executive Officer, Director	74,000	$126.86	$9,387,951	149,710	−33.1%	plan?
Nov 15, 2017 MForm 4 →	Nov 17, 5:35 pm EST	John MaraganoreChief Executive Officer, Director	74,000	$31.39	$2,322,860	223,710	—	plan?
Nov 2, 2017 SForm 4 →	Nov 3, 8:14 pm EDT	Dennis A AusielloDirector	20,000	$130.00	$2,600,000	0	−100%	plan?
Nov 2, 2017 MForm 4 →	Nov 3, 8:14 pm EDT	Dennis A AusielloDirector	20,000	$30.09	$601,800	20,000	—	plan?
Oct 30, 2017 SForm 4 →	Nov 1, 5:33 pm EDT	Akshay VaishnawEVP, R&D	33,666	$121.46	$4,088,967	11,535	−74.5%	plan?
Oct 30, 2017 MForm 4 →	Nov 1, 5:33 pm EDT	Akshay VaishnawEVP, R&D	33,666	$21.35	$718,769	45,201	—	plan?
Oct 2, 2017 SForm 4 →	Oct 4, 7:45 pm EDT	Barry E GreenePresident	85,316	$125.00	$10,664,500	100,428	−45.9%	plan?
Oct 2, 2017 MForm 4 →	Oct 4, 7:45 pm EDT	Barry E GreenePresident	85,316	$21.35	$1,821,497	185,744	—	plan?
Sep 22, 2017 IForm 5 →	Feb 9, 2018, 5:04 pm EST	Michael MasonVP, Finance and Treasurer	1,950	$115.47	$225,167	226	—	plan?
Sep 20, 2017 SForm 4 →	Sep 22, 5:05 pm EDT	Barry E GreenePresident	76,815	$100.00	$7,681,500	88,584	−46.4%	plan?
Sep 20, 2017 MForm 4 →	Sep 22, 5:05 pm EDT	Barry E GreenePresident	88,659	$28.84	$2,557,265	100,428	—	plan?
Jul 25, 2017 JForm 4 →	Aug 14, 2018, 5:54 pm EDT	Manmeet Singh SoniChief Financial Officer	83	—	—	83	—	plan? late
Jun 13, 2017 FMForm 4 →	Jun 15, 5:45 pm EDT	Akshay VaishnawEVP, R&D	2,098	$30.49	$63,961	11,535	—	plan?
May 31, 2017 PForm 4 →	Jun 1, 7:41 pm EDT	Sanofi10% Owner	297,501	$71.87	$21,381,397	10,554,134	+2.90%	plan?
May 30, 2017 PForm 4 →	May 31, 5:22 pm EDT	Laurie KeatingSVP, GC and Secretary	11,500	$65.35	$751,502	11,500	—	plan?
May 23, 2017 SForm 4 →	May 25, 6:39 pm EDT	Akshay VaishnawEVP, R&D	11,000	$75.00	$825,000	10,297	−51.7%	plan?
May 23, 2017 MForm 4 →	May 25, 6:39 pm EDT	Akshay VaishnawEVP, R&D	11,000	$21.35	$234,850	21,297	—	plan?
May 16, 2017 SForm 4 →	May 17, 6:45 pm EDT	Michael MasonVP, Finance and Treasurer	9,375	$70.00	$656,250	0	−100%	plan?
May 16, 2017 MForm 4 →	May 17, 6:45 pm EDT	Michael MasonVP, Finance and Treasurer	9,375	$14.04	$131,588	9,375	—	plan?
May 15, 2017 SForm 4 →	May 17, 6:31 pm EDT	Akshay VaishnawSVP, R&D	43,750	$65.00	$2,843,750	10,297	−80.9%	plan?
May 15, 2017 MForm 4 →	May 17, 6:31 pm EDT	Akshay VaishnawSVP, R&D	43,750	$28.87	$1,262,873	21,297	—	plan?
Feb 1, 2017 SForm 4 →	Feb 3, 4:32 pm EST	Philip A SharpDirector	25,000	$39.80	$995,125	140,795	−15.1%	plan?
Feb 1, 2017 MForm 4 →	Feb 3, 4:32 pm EST	Philip A SharpDirector	25,000	$31.29	$782,250	165,795	—	plan?
Jan 25, 2017 SForm 4 →	Jan 27, 4:10 pm EST	Philip A SharpDirector	15,000	$37.95	$569,250	140,795	−9.63%	plan?
Jan 25, 2017 MForm 4 →	Jan 27, 4:10 pm EST	Philip A SharpDirector	15,000	$31.39	$470,850	155,795	—	plan?
Jan 18, 2017 SForm 4 →	Jan 20, 4:12 pm EST	Philip A SharpDirector	15,000	$37.83	$567,456	140,795	−9.63%	plan?
Jan 18, 2017 MForm 4 →	Jan 20, 4:12 pm EST	Philip A SharpDirector	15,000	$15.91	$238,650	155,795	—	plan?
Jan 5, 2017 MForm 4 →	Jan 6, 4:22 pm EST	John MaraganoreChief Executive Officer, Director	1,340	$18.66	$25,004	149,710	—	plan?
Dec 30, 2016 FMForm 4 →	Jan 4, 2017, 5:30 pm EST	Akshay VaishnawEVP, R&D	14,547	$25.74	$374,451	10,297	—	plan?
Dec 12, 2016 FMForm 4 →	Dec 14, 4:18 pm EST	John MaraganoreChief Executive Officer, Director	52,861	$31.28	$1,653,608	148,370	—	plan?
Dec 1, 2016 SForm 4 →	Dec 5, 4:55 pm EST	Barry E GreenePresident	31,825	$42.99	$1,368,128	88,584	−26.4%	plan?
Dec 1, 2016 MForm 4 →	Dec 5, 4:55 pm EST	Barry E GreenePresident	55,605	$22.75	$1,265,014	120,409	—	plan?
Nov 30, 2016 SForm 4 →	Dec 2, 4:59 pm EST	Akshay VaishnawEVP, R&D, CMO	29,165	$44.99	$1,311,998	5,750	−83.5%	plan?
Nov 30, 2016 MForm 4 →	Dec 2, 4:59 pm EST	Akshay VaishnawEVP, R&D, CMO	29,165	$22.75	$663,504	34,915	—	plan?
Oct 13, 2016 PForm 4 →	Oct 14, 4:22 pm EDT	David E I PyottDirector	27,900	$37.00	$1,032,328	27,900	—	plan?
Oct 12, 2016 MForm 4 →	Oct 14, 4:17 pm EDT	John MaraganoreChief Executive Officer, Director	7,540	$13.26	$99,994	140,929	—	plan?
Jul 19, 2016 SForm 4 →	Jul 21, 5:44 pm EDT	John MaraganoreCEO, Director	30,151	$64.69	$1,950,590	133,389	−18.4%	plan?
Jul 19, 2016 MForm 4 →	Jul 21, 5:44 pm EDT	John MaraganoreCEO, Director	30,151	$22.75	$685,935	148,464	—	plan?
Apr 19, 2016 SForm 4 →	Apr 21, 5:01 pm EDT	John MaraganoreChief Executive Officer, Director	30,151	$67.46	$2,033,972	133,389	−18.4%	plan?
Apr 19, 2016 MForm 4 →	Apr 21, 5:01 pm EDT	John MaraganoreChief Executive Officer, Director	30,151	$22.75	$685,935	148,464	—	plan?
Mar 24, 2016 MForm 4 →	Mar 28, 5:27 pm EDT	Barry E GreenePresident and COO	16,540	$8.20	$135,672	64,804	—	plan?
Mar 9, 2016 PForm 4 →	Mar 10, 6:35 pm EST	Michael W BonneyDirector	2,000	$58.36	$116,720	4,000	+100%	plan?
Feb 22, 2016 PForm 4 →	Feb 24, 6:21 pm EST	David-Alexandre C GrosSVP, Chief Business Officer	1,000	$62.75	$62,749	1,000	—	plan?
Feb 1, 2016 PForm 4 →	Feb 3, 7:00 am EST	Sanofi10% Owner	205,030	$69.75	$14,300,843	10,256,633	+2.04%	plan?
Jan 19, 2016 SForm 4 →	Jan 21, 6:59 pm EST	John MaraganoreChief Executive Officer, Director	30,152	$71.78	$2,164,219	133,389	−18.4%	plan?
Jan 19, 2016 MForm 4 →	Jan 21, 6:59 pm EST	John MaraganoreChief Executive Officer, Director	30,152	$22.75	$685,958	148,465	—	plan?
Dec 4, 2015 SForm 4 →	Dec 4, 6:11 pm EST	Philip A SharpDirector	30,000	$109.00	$3,270,000	140,795	−17.6%	plan?
Dec 4, 2015 MForm 4 →	Dec 4, 6:11 pm EST	Philip A SharpDirector	30,000	$14.28	$428,400	170,795	—	plan?
Dec 2, 2015 SForm 4 →	Dec 4, 5:10 pm EST	John MaraganoreChief Executive Officer, Director	58,689	$104.87	$6,154,715	133,389	−30.6%	plan?
Dec 2, 2015 MForm 4 →	Dec 4, 5:10 pm EST	John MaraganoreChief Executive Officer, Director	58,689	$13.12	$770,000	192,078	—	plan?
Nov 25, 2015 MForm 4 →	Nov 30, 5:45 pm EST	Akshay VaishnawEVP, R&D, CMO	5,750	$17.35	$99,750	5,750	—	plan?
Nov 20, 2015 SForm 4 →	Nov 20, 6:12 pm EST	John MaraganoreChief Executive Officer, Director	58,690	$102.88	$6,037,933	133,389	−30.6%	plan?
Nov 20, 2015 MForm 4 →	Nov 20, 6:12 pm EST	John MaraganoreChief Executive Officer, Director	69,254	$12.20	$845,017	192,079	—	plan?
Nov 19, 2015 GForm 4 →	Dec 22, 4:36 pm EST	Paul SchimmelDirector	4,000	—	—	306,996	—	plan? late
Nov 18, 2015 GForm 4 →	Dec 22, 4:50 pm EST	Barry E GreenePresident and COO	2,100	—	—	48,264	—	plan? late

Reported at this company — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Jun 1, 2026 MForm 4 →	Jun 3, 4:25 pm EDT	David E I PyottDirector	3,830	—	—	0	—	10b5-1
Jun 1, 2026 AForm 4 →	Jun 3, 4:23 pm EDT	Benjamin CravattDirector	4,393	—	—	4,393	—
Feb 28, 2019 AForm 4 →	Mar 1, 6:11 pm EST	Yvonne GreenstreetEVP, Chief Operating Officer	32,500	—	—	32,500	—
Feb 28, 2019 AForm 4 →	Mar 1, 6:10 pm EST	Barry E GreenePresident	32,500	—	—	32,500	—
Feb 28, 2019 AForm 4 →	Mar 1, 6:10 pm EST	Manmeet Singh SoniChief Financial Officer	20,000	—	—	20,000	—
Feb 28, 2019 AForm 4 →	Mar 1, 6:10 pm EST	Akshay VaishnawPresident, R&D	32,500	—	—	32,500	—
Feb 28, 2019 AForm 4 →	Mar 1, 6:09 pm EST	Laurie KeatingSVP, GC & Secretary	25,000	—	—	25,000	—
Feb 28, 2019 AForm 4 →	Mar 1, 6:09 pm EST	John MaraganoreChief Executive Officer, Director	85,000	—	—	85,000	—
Jan 10, 2019 AForm 4 →	Jan 11, 4:07 pm EST	Margaret A HamburgDirector	18,000	—	—	18,000	—
Nov 21, 2018 MForm 4 →	Nov 26, 4:11 pm EST	John MaraganoreChief Executive Officer, Director	98,636	—	—	0	—
Sep 27, 2018 AForm 4 →	Sep 28, 4:59 pm EDT	Laurie KeatingSVP, GC & Secretary	9,750	—	—	12,500	—
Sep 27, 2018 AForm 4 →	Sep 28, 4:58 pm EDT	Yvonne GreenstreetEVP, Chief Operating Officer	6,250	—	—	12,500	—
Sep 27, 2018 AForm 4 →	Sep 28, 4:57 pm EDT	Akshay VaishnawPresident, R&D	13,750	—	—	12,500	—
Sep 27, 2018 AForm 4 →	Sep 28, 4:56 pm EDT	John MaraganoreChief Executive Officer, Director	22,500	—	—	12,500	—
Sep 27, 2018 AForm 4 →	Sep 28, 4:55 pm EDT	Michael MasonVP, Finance and Treasurer	3,187	—	—	2,775	—
Sep 27, 2018 AForm 4 →	Sep 28, 4:54 pm EDT	Barry E GreenePresident	16,250	—	—	12,500	—
Aug 21, 2018 AForm 4 →	Aug 23, 4:15 pm EDT	John MaraganoreChief Executive Officer, Director	16,250	—	—	32,500	—
Aug 21, 2018 AForm 4 →	Aug 23, 4:15 pm EDT	Barry E GreenePresident	10,000	—	—	20,000	—
Aug 21, 2018 AForm 4 →	Aug 23, 4:15 pm EDT	Akshay VaishnawPresident, R&D	7,500	—	—	15,000	—
Aug 21, 2018 AForm 4 →	Aug 23, 4:14 pm EDT	Laurie KeatingSVP, GC & Secretary	3,500	—	—	7,000	—
Aug 21, 2018 AForm 4 →	Aug 23, 4:13 pm EDT	Michael MasonVP, Finance and Treasurer	1,800	—	—	3,600	—
Aug 13, 2018 AForm 4 →	Aug 14, 6:21 pm EDT	Yvonne GreenstreetEVP, Chief Operating Officer	25,000	—	—	25,000	—
Aug 13, 2018 AForm 4 →	Aug 14, 5:54 pm EDT	Manmeet Singh SoniChief Financial Officer	25,000	—	—	25,000	—
Aug 10, 2018 AForm 4 →	Aug 14, 7:14 pm EDT	Barry E GreenePresident	30,875	—	—	47,625	—
Aug 10, 2018 AForm 4 →	Aug 14, 6:55 pm EDT	Akshay VaishnawPresident, R&D	22,539	—	—	35,125	—
Aug 10, 2018 AForm 4 →	Aug 14, 6:33 pm EDT	John MaraganoreChief Executive Officer, Director	50,000	—	—	75,000	—
Aug 10, 2018 AForm 4 →	Aug 14, 6:05 pm EDT	Laurie KeatingSVP, GC & Secretary	1,984	—	—	5,958	—
Aug 10, 2018 AForm 4 →	Aug 14, 6:00 pm EDT	Michael MasonVP, Finance and Treasurer	4,416	—	—	2,750	—
Jul 25, 2018 MForm 4 →	Jul 27, 4:07 pm EDT	John MaraganoreChief Executive Officer, Director	50,000	—	—	98,636	—
Jun 20, 2018 MForm 4 →	Jun 22, 4:20 pm EDT	Laurie KeatingSVP, GC & Secretary	1,563	—	—	15,626	—
Jun 20, 2018 AForm 4 →	Jun 22, 4:20 pm EDT	Philip A SharpDirector	9,000	—	—	9,000	—
Jun 20, 2018 AForm 4 →	Jun 22, 4:19 pm EDT	Amy W SchulmanDirector	9,000	—	—	9,000	—
Jun 20, 2018 AForm 4 →	Jun 22, 4:19 pm EDT	Paul SchimmelDirector	9,000	—	—	9,000	—
Jun 20, 2018 AForm 4 →	Jun 22, 4:19 pm EDT	David E I PyottDirector	9,000	—	—	9,000	—
Jun 20, 2018 AForm 4 →	Jun 22, 4:18 pm EDT	Steven M PaulDirector	9,000	—	—	9,000	—
Jun 20, 2018 AForm 4 →	Jun 22, 4:18 pm EDT	Marsha FanucciDirector	9,000	—	—	9,000	—
Jun 20, 2018 AForm 4 →	Jun 22, 4:18 pm EDT	John K ClarkeDirector	9,000	—	—	9,000	—
Jun 20, 2018 AForm 4 →	Jun 22, 4:17 pm EDT	Michael W BonneyDirector	9,000	—	—	9,000	—
Jun 20, 2018 AForm 4 →	Jun 22, 4:17 pm EDT	Dennis A AusielloDirector	9,000	—	—	9,000	—
Jun 1, 2018 AForm 4 →	Jun 4, 4:44 pm EDT	Colleen F ReitanDirector	18,000	—	—	18,000	—
May 31, 2018 MForm 4 →	Jun 4, 4:25 pm EDT	John K ClarkeDirector	15,000	—	—	0	—
Mar 26, 2018 MForm 4 →	Mar 28, 4:39 pm EDT	Yvonne GreenstreetEVP, Chief Operating Officer	7,221	—	—	17,779	—
Mar 20, 2018 MForm 4 →	Mar 22, 6:18 pm EDT	Laurie KeatingSVP, GC & Secretary	1,562	—	—	17,189	—
Mar 14, 2018 MForm 4 →	Mar 16, 5:05 pm EDT	Akshay VaishnawPresident, R&D	88,554	—	—	0	—
Mar 13, 2018 MForm 4 →	Mar 14, 7:40 pm EDT	Dennis A AusielloDirector	17,117	—	—	0	—
Mar 13, 2018 MForm 4 →	Mar 14, 7:39 pm EDT	Philip A SharpDirector	15,000	—	—	0	—
Mar 13, 2018 MForm 4 →	Mar 14, 7:39 pm EDT	Paul SchimmelDirector	27,823	—	—	0	—
Mar 12, 2018 MForm 4 →	Mar 14, 7:40 pm EDT	Laurie KeatingSVP, GC & Secretary	20,000	—	—	72,000	—
Mar 9, 2018 MForm 4 →	Mar 13, 5:22 pm EDT	Philip A SharpDirector	15,000	—	—	0	—
Mar 1, 2018 AForm 4 →	Mar 5, 5:49 pm EST	Akshay VaishnawEVP, R&D	25,000	—	—	25,000	—
Mar 1, 2018 AForm 4 →	Mar 5, 5:49 pm EST	Manmeet Singh SoniChief Financial Officer	8,938	—	—	8,938	—
Mar 1, 2018 AForm 4 →	Mar 5, 5:49 pm EST	Michael MasonVP, Finance and Treasurer	4,000	—	—	4,000	—
Mar 1, 2018 AForm 4 →	Mar 5, 5:49 pm EST	John MaraganoreChief Executive Officer, Director	52,500	—	—	52,500	—
Mar 1, 2018 AForm 4 →	Mar 5, 5:48 pm EST	Laurie KeatingSVP, GC & Secretary	13,750	—	—	13,750	—
Mar 1, 2018 AForm 4 →	Mar 5, 5:48 pm EST	Yvonne GreenstreetEVP, Chief Operating Officer	25,000	—	—	25,000	—
Mar 1, 2018 AForm 4 →	Mar 5, 5:48 pm EST	Barry E GreenePresident	30,000	—	—	30,000	—
Jan 4, 2018 MForm 4 →	Jan 8, 5:02 pm EST	Michael MasonVP, Finance and Treasurer	31,781	—	—	0	—
Dec 30, 2017 MForm 4 →	Jan 3, 2018, 5:26 pm EST	Michael MasonVP, Finance and Treasurer	8,502	—	—	0	—
Dec 29, 2017 MForm 4 →	Jan 3, 2018, 5:13 pm EST	Laurie KeatingSVP, GC & Secretary	3,000	—	—	92,000	—
Dec 20, 2017 AForm 4 →	Dec 21, 5:00 pm EST	Michael MasonVP, Finance and Treasurer	1,388	—	—	1,388	—
Dec 20, 2017 AForm 4 →	Dec 21, 5:00 pm EST	Yvonne GreenstreetEVP, Chief Operating Officer	6,250	—	—	6,250	—
Dec 20, 2017 AMForm 4 →	Dec 21, 5:00 pm EST	Laurie KeatingSVP, GC & Secretary	12,499	—	—	18,751	—
Dec 20, 2017 AForm 4 →	Dec 21, 4:45 pm EST	Akshay VaishnawEVP, R&D	6,250	—	—	6,250	—
Dec 20, 2017 AForm 4 →	Dec 21, 4:37 pm EST	Barry E GreenePresident	6,250	—	—	6,250	—
Dec 19, 2017 AMForm 4 →	Dec 21, 4:36 pm EST	John MaraganoreChief Executive Officer, Director	7,837	—	—	148,413	—
Dec 1, 2017 MForm 4 →	Dec 5, 5:47 pm EST	Laurie KeatingSVP, GC and Secretary	30,000	—	—	95,000	—
Nov 22, 2017 MForm 4 →	Nov 24, 6:55 pm EST	John MaraganoreChief Executive Officer, Director	73,415	—	—	0	—
Nov 15, 2017 MForm 4 →	Nov 17, 5:35 pm EST	John MaraganoreChief Executive Officer, Director	74,000	—	—	73,415	—
Nov 6, 2017 AForm 4 →	Nov 8, 5:26 pm EST	Akshay VaishnawEVP, R&D	7,500	—	—	7,500	—
Nov 6, 2017 AForm 4 →	Nov 8, 5:25 pm EST	Michael MasonVP, Finance and Treasurer	1,800	—	—	1,800	—
Nov 6, 2017 AForm 4 →	Nov 8, 5:25 pm EST	John MaraganoreChief Executive Officer, Director	16,250	—	—	16,250	—
Nov 6, 2017 AForm 4 →	Nov 8, 5:25 pm EST	Laurie KeatingSVP, GC & Secretary	3,500	—	—	3,500	—
Nov 6, 2017 AForm 4 →	Nov 8, 5:25 pm EST	Barry E GreenePresident	10,000	—	—	10,000	—
Nov 2, 2017 MForm 4 →	Nov 3, 8:14 pm EDT	Dennis A AusielloDirector	20,000	—	—	0	—
Oct 30, 2017 MForm 4 →	Nov 1, 5:33 pm EDT	Akshay VaishnawEVP, R&D	33,666	—	—	0	—
Oct 2, 2017 MForm 4 →	Oct 4, 7:45 pm EDT	Barry E GreenePresident	85,316	—	—	0	—
Sep 20, 2017 AForm 4 →	Sep 22, 5:11 pm EDT	Akshay VaishnawEVP, R&D	10,834	—	—	10,834	—
Sep 20, 2017 AForm 4 →	Sep 22, 5:09 pm EDT	Michael MasonVP, Finance and Treasurer	1,667	—	—	1,667	—
Sep 20, 2017 AForm 4 →	Sep 22, 5:08 pm EDT	John MaraganoreChief Executive Officer, Director	25,000	—	—	25,000	—
Sep 20, 2017 AMForm 4 →	Sep 22, 5:05 pm EDT	Barry E GreenePresident	103,659	—	—	0	—
Jul 7, 2017 AForm 4 →	Jul 11, 4:35 pm EDT	Akshay VaishnawEVP, R&D	11,709	—	—	23,418	—
Jul 7, 2017 AForm 4 →	Jul 11, 4:35 pm EDT	Michael MasonVP, Finance and Treasurer	2,750	—	—	5,500	—
Jul 7, 2017 AForm 4 →	Jul 11, 4:34 pm EDT	John MaraganoreChief Executive Officer, Director	25,000	—	—	50,000	—
Jul 7, 2017 AForm 4 →	Jul 11, 4:34 pm EDT	Laurie KeatingSVP, GC & Secretary	1,987	—	—	3,974	—
Jul 7, 2017 AForm 4 →	Jul 11, 4:34 pm EDT	Barry E GreenePresident	15,875	—	—	31,750	—
Jun 13, 2017 MForm 4 →	Jun 15, 5:45 pm EDT	Akshay VaishnawEVP, R&D	1,668	—	—	33,666	—
Jun 2, 2017 AForm 4 →	Jun 6, 5:04 pm EDT	Kevin P StarrDirector	11,250	—	—	11,250	—
Jun 2, 2017 AForm 4 →	Jun 6, 5:02 pm EDT	Philip A SharpDirector	11,250	—	—	11,250	—
Jun 2, 2017 AForm 4 →	Jun 6, 5:01 pm EDT	Amy W SchulmanDirector	11,250	—	—	11,250	—
Jun 2, 2017 AForm 4 →	Jun 6, 4:59 pm EDT	Paul SchimmelDirector	11,250	—	—	11,250	—
Jun 2, 2017 AForm 4 →	Jun 6, 4:59 pm EDT	David E I PyottDirector	11,250	—	—	11,250	—
Jun 2, 2017 AForm 4 →	Jun 6, 4:58 pm EDT	Steven M PaulDirector	11,250	—	—	11,250	—
Jun 2, 2017 AForm 4 →	Jun 6, 4:56 pm EDT	Marsha FanucciDirector	11,250	—	—	11,250	—
Jun 2, 2017 AForm 4 →	Jun 6, 4:55 pm EDT	John K ClarkeDirector	11,250	—	—	11,250	—
Jun 2, 2017 AForm 4 →	Jun 6, 4:54 pm EDT	Michael W BonneyDirector	11,250	—	—	11,250	—
Jun 2, 2017 AForm 4 →	Jun 6, 4:53 pm EDT	Dennis A AusielloDirector	11,250	—	—	11,250	—
May 23, 2017 MForm 4 →	May 25, 6:39 pm EDT	Akshay VaishnawEVP, R&D	11,000	—	—	33,994	—
May 16, 2017 MForm 4 →	May 17, 6:45 pm EDT	Michael MasonVP, Finance and Treasurer	9,375	—	—	0	—
May 15, 2017 MForm 4 →	May 17, 6:31 pm EDT	Akshay VaishnawSVP, R&D	43,750	—	—	0	—
Feb 1, 2017 MForm 4 →	Feb 3, 4:32 pm EST	Philip A SharpDirector	25,000	—	—	0	—

Filed by this entity as an insider elsewhere — common stock

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Feb 23, 2016 SForm 4 →	Feb 24, 6:20 pm EST	Regulus Therapeutics Inc.RGLS	1,000,000	$7.18	$7,180,000	4,896,716	−17.0%	plan?

Filed by this entity as an insider elsewhere — derivatives (options, RSUs, warrants)

No reported derivative activity in this period.