Company · CIK 0000897448 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

AMARIN CORP PLC\UK · AMRN

Insider activity reported against this company. All insider holders · On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market buys & salesbuys $81k · 2sales $114.0M · 43net −$113.9M

Reported at this company — common stock

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Aug 1, 2026 FMForm 4 →	Aug 3, 4:30 pm EDT	Peter L. FishmanSVP, CFO	468	$14.26	$2,210	7,619	—
Jul 1, 2026 FMForm 4 →	Jul 15, 5:00 pm EDT	Peter L. FishmanSVP, CFO	3,653	$15.94	$19,224	7,461	—	late
Jul 1, 2026 FMForm 4 →	Jul 15, 5:00 pm EDT	David Paul KeenanEVP, Chief Operating Officer	5,614	$15.94	$30,700	13,470	—	late
Jul 1, 2026 FMForm 4 →	Jul 15, 5:00 pm EDT	Steven B KetchumEVP, Chief Scientific Officer	5,575	$15.94	$30,079	42,680	—	late
Jul 1, 2026 FMForm 4 →	Jul 15, 5:00 pm EDT	Jonathan ProvoostEVP, Chief Legal Officer	4,952	$15.94	$20,148	4,624	—	late
Jun 26, 2026 FMForm 4 →	Jun 30, 5:20 pm EDT	Aaron BergPresident and CEO	9,447	$16.35	$52,271	85,648	—
Mar 4, 2019 SForm 4 →	Mar 6, 8:16 pm EST	John F TheroPresident and CEO, Director	250,000	$21.31	$5,327,234	2,087,428	−10.7%	plan?
Mar 4, 2019 SForm 4 →	Mar 6, 8:16 pm EST	Lars EkmanDirector	135,377	$21.31	$2,884,905	0	−100%	plan?
Mar 4, 2019 MForm 4 →	Mar 6, 8:16 pm EST	Lars EkmanDirector	135,377	$2.04	$276,743	135,377	—	plan?
Mar 1, 2019 SForm 4 →	Mar 1, 8:18 pm EST	Michael Wayne KalbSVP and CFO	100,000	$22.09	$2,209,098	20,551	−83.0%	plan?
Mar 1, 2019 MForm 4 →	Mar 1, 8:18 pm EST	Michael Wayne KalbSVP and CFO	100,000	$2.83	$283,350	120,551	—	plan?
Feb 28, 2019 SForm 4 →	Mar 1, 8:19 pm EST	Steven B KetchumChief Scientific Officer	55,543	$21.85	$1,213,524	354,492	−13.5%	plan?
Feb 28, 2019 MForm 4 →	Mar 1, 8:19 pm EST	Steven B KetchumChief Scientific Officer	55,543	$2.47	$137,239	400,492	—	plan?
Feb 28, 2019 SForm 4 →	Mar 1, 8:17 pm EST	Joseph T KennedyGeneral Counsel	27,231	$20.72	$564,172	31,260	−46.6%	plan?
Feb 28, 2019 MForm 4 →	Mar 1, 8:17 pm EST	Joseph T KennedyGeneral Counsel	27,231	$2.57	$69,929	58,491	—	plan?
Feb 22, 2019 SForm 4 →	Feb 22, 9:34 pm EST	Joseph S ZakrzewskiDirector	180,625	$19.90	$3,594,437	84,547	−68.1%	plan?
Feb 22, 2019 MForm 4 →	Feb 22, 9:34 pm EST	Joseph S ZakrzewskiDirector	180,625	$8.70	$1,572,313	265,172	—	plan?
Feb 22, 2019 SForm 4 →	Feb 22, 9:33 pm EST	G Jan Van HeekDirector	203,382	$20.02	$4,071,423	14,168	−93.5%	plan?
Feb 22, 2019 MForm 4 →	Feb 22, 9:33 pm EST	G Jan Van HeekDirector	192,347	$4.46	$857,170	217,550	—	plan?
Feb 22, 2019 SForm 4 →	Feb 22, 9:32 pm EST	Kristine PetersonDirector	163,500	$20.02	$3,274,038	0	−100%	plan?
Feb 22, 2019 MForm 4 →	Feb 22, 9:32 pm EST	Kristine PetersonDirector	163,500	$5.80	$947,730	163,500	—	plan?
Feb 22, 2019 SForm 4 →	Feb 22, 9:31 pm EST	Michael Wayne KalbSVP and CFO	50,000	$18.97	$948,500	20,551	−70.9%	plan?
Feb 22, 2019 MForm 4 →	Feb 22, 9:31 pm EST	Michael Wayne KalbSVP and CFO	50,000	$2.95	$147,500	70,551	—	plan?
Feb 15, 2019 SForm 4 →	Feb 15, 8:16 pm EST	Michael Wayne KalbSVP and CFO	25,000	$17.58	$439,525	20,551	−54.9%	plan?
Jan 31, 2019 FMForm 4 →	Feb 1, 8:35 pm EST	John F TheroPresident and CEO, Director	506,511	$16.94	$2,425,418	2,337,428	—	plan?
Jan 31, 2019 SForm 4 →	Feb 1, 8:35 pm EST	Steven B KetchumChief Scientific Officer	37,530	$17.17	$644,373	354,492	−9.57%	plan?
Jan 31, 2019 FMForm 4 →	Feb 1, 8:35 pm EST	Steven B KetchumChief Scientific Officer	131,689	$14.15	$708,000	382,481	—	plan?
Jan 31, 2019 SForm 4 →	Feb 1, 8:34 pm EST	Joseph T KennedyGeneral Counsel	42,624	$17.49	$745,468	31,260	−57.7%	plan?
Jan 31, 2019 FMForm 4 →	Feb 1, 8:34 pm EST	Joseph T KennedyGeneral Counsel	161,808	$11.16	$816,626	73,884	—	plan?
Jan 31, 2019 FMForm 4 →	Feb 1, 8:33 pm EST	Michael Wayne KalbSVP and CFO	81,935	$16.94	$456,279	45,551	—	plan?
Jan 22, 2019 SForm 4 →	Jan 24, 8:20 pm EST	Joseph T KennedyGeneral Counsel	1,040,194	$17.77	$18,487,911	0	−100%	plan?
Jan 22, 2019 MForm 4 →	Jan 24, 8:20 pm EST	Joseph T KennedyGeneral Counsel	822,260	$6.10	$5,015,403	609,115	—	plan?
Jan 11, 2019 SForm 4 →	Jan 11, 8:17 pm EST	Joseph T KennedyGeneral Counsel	3,173	$18.92	$60,033	217,934	−1.44%	plan?
Jan 11, 2019 MForm 4 →	Jan 11, 8:17 pm EST	Joseph T KennedyGeneral Counsel	3,173	$2.95	$9,360	221,107	—	plan?
Jan 10, 2019 SForm 4 →	Jan 11, 8:18 pm EST	Joseph S ZakrzewskiDirector	200,000	$16.98	$3,396,390	84,547	−70.3%	plan?
Jan 10, 2019 MForm 4 →	Jan 11, 8:18 pm EST	Joseph S ZakrzewskiDirector	200,000	$3.40	$680,000	284,547	—	plan?
Jan 10, 2019 SForm 4 →	Jan 11, 8:18 pm EST	David M StackDirector	125,504	$18.00	$2,259,072	0	−100%	plan?
Jan 10, 2019 MForm 4 →	Jan 11, 8:18 pm EST	David M StackDirector	125,504	$5.24	$657,027	98,572	—	plan?
Jan 10, 2019 SForm 4 →	Jan 11, 8:16 pm EST	Lars EkmanDirector	140,416	$17.28	$2,426,489	0	−100%	plan?
Jan 10, 2019 MForm 4 →	Jan 11, 8:16 pm EST	Lars EkmanDirector	100,416	$1.03	$103,428	140,416	—	plan?
Jan 9, 2019 SForm 4 →	Jan 11, 8:16 pm EST	Michael Wayne KalbSVP and CFO	200,000	$15.26	$3,051,080	17,486	−92.0%	plan?
Jan 9, 2019 MForm 4 →	Jan 11, 8:16 pm EST	Michael Wayne KalbSVP and CFO	200,000	$2.19	$438,000	217,486	—	plan?
Jan 2, 2019 MForm 4 →	Jan 2, 7:54 pm EST	Joseph S ZakrzewskiDirector	385,000	$3.21	$1,237,250	469,547	—	plan?
Dec 31, 2018 SForm 4 →	Jan 2, 2019, 7:53 pm EST	Joseph T KennedyGeneral Counsel	26,943	$13.49	$363,547	217,934	−11.0%	plan?
Dec 31, 2018 FMForm 4 →	Jan 2, 2019, 7:53 pm EST	Joseph T KennedyGeneral Counsel	79,933	$13.24	$350,794	244,877	—	plan?
Dec 31, 2018 SForm 4 →	Jan 2, 2019, 7:51 pm EST	Steven B KetchumChief Scientific Officer	17,041	$13.51	$230,212	341,297	−4.76%	plan?
Dec 31, 2018 MForm 4 →	Jan 2, 2019, 7:51 pm EST	Steven B KetchumChief Scientific Officer	17,041	$2.41	$40,985	358,338	—	plan?
Dec 31, 2018 FMForm 4 →	Jan 2, 2019, 7:45 pm EST	John F TheroPresident and CEO, Director	52,257	$13.24	$195,383	2,117,271	—	plan?
Dec 28, 2018 SForm 4 →	Jan 2, 2019, 7:54 pm EST	Joseph S ZakrzewskiDirector	526,500	$13.07	$6,882,371	84,547	−86.2%	plan?
Nov 30, 2018 SForm 4 →	Nov 30, 6:34 pm EST	Steven B KetchumChief Scientific Officer	17,042	$17.79	$303,174	341,297	−4.76%	plan?
Nov 30, 2018 MForm 4 →	Nov 30, 6:34 pm EST	Steven B KetchumChief Scientific Officer	17,042	$2.41	$40,988	358,339	—	plan?
Nov 30, 2018 SForm 4 →	Nov 30, 6:33 pm EST	Joseph T KennedyGeneral Counsel	23,306	$17.81	$414,998	217,934	−9.66%	plan?
Nov 30, 2018 MForm 4 →	Nov 30, 6:33 pm EST	Joseph T KennedyGeneral Counsel	23,306	$2.25	$52,510	241,240	—	plan?
Nov 12, 2018 SForm 4 →	Nov 14, 6:02 pm EST	John F TheroPresident and CEO, Director	607,611	$19.07	$11,587,896	2,094,528	−22.5%	plan?
Nov 12, 2018 MForm 4 →	Nov 14, 6:02 pm EST	John F TheroPresident and CEO, Director	407,611	$1.35	$550,275	2,702,139	—	plan?
Oct 31, 2018 SForm 4 →	Nov 2, 6:11 pm EDT	Steven B KetchumChief Scientific Officer	17,042	$20.74	$353,454	341,297	−4.76%	plan?
Oct 31, 2018 MForm 4 →	Nov 2, 6:11 pm EDT	Steven B KetchumChief Scientific Officer	17,042	$2.41	$40,988	358,339	—	plan?
Oct 31, 2018 SForm 4 →	Nov 2, 6:10 pm EDT	Joseph T KennedyGeneral Counsel	23,307	$20.74	$483,362	217,934	−9.66%	plan?
Oct 31, 2018 MForm 4 →	Nov 2, 6:10 pm EDT	Joseph T KennedyGeneral Counsel	23,307	$2.25	$52,513	241,241	—	plan?
Oct 1, 2018 SForm 4 →	Oct 2, 7:02 pm EDT	Joseph T KennedyGeneral Counsel	50,249	$16.81	$844,528	217,934	−18.7%	plan?
Sep 30, 2018 FMForm 4 →	Oct 2, 7:11 pm EDT	John F TheroPresident and CEO, Director	52,257	$16.27	$240,096	2,294,528	—	plan?
Sep 30, 2018 FMForm 4 →	Oct 2, 7:02 pm EDT	Joseph T KennedyGeneral Counsel	103,239	$9.71	$483,584	268,183	—	plan?
Sep 28, 2018 SForm 4 →	Oct 2, 7:05 pm EDT	Steven B KetchumChief Scientific Officer	316,604	$16.13	$5,105,589	341,297	−48.1%	plan?
Sep 28, 2018 MForm 4 →	Oct 2, 7:05 pm EDT	Steven B KetchumChief Scientific Officer	316,604	$8.44	$2,670,893	457,901	—	plan?
Sep 24, 2018 SForm 4 →	Sep 26, 8:54 pm EDT	Joseph S ZakrzewskiDirector	500,000	$10.60	$5,299,334	226,047	−68.9%	plan?
Sep 24, 2018 MForm 4 →	Sep 26, 8:54 pm EDT	Joseph S ZakrzewskiDirector	500,000	$3.40	$1,700,000	726,047	—	plan?
Sep 24, 2018 SForm 4 →	Sep 26, 8:52 pm EDT	Steven B KetchumChief Scientific Officer	879,241	$11.10	$9,760,024	341,297	−72.0%	plan?
Sep 24, 2018 MForm 4 →	Sep 26, 8:52 pm EDT	Steven B KetchumChief Scientific Officer	820,065	$5.02	$4,120,711	541,297	—	plan?
Sep 24, 2018 SForm 4 →	Sep 26, 8:50 pm EDT	Joseph T KennedyGeneral Counsel	1,079,706	$10.56	$11,400,975	217,934	−83.2%	plan?
Sep 24, 2018 MForm 4 →	Sep 26, 8:50 pm EDT	Joseph T KennedyGeneral Counsel	1,079,706	$2.22	$2,393,014	1,297,640	—	plan?
Sep 24, 2018 SForm 4 →	Sep 26, 8:47 pm EDT	Michael Wayne KalbSVP and CFO	150,000	$10.42	$1,562,751	14,996	−90.9%	plan?
Sep 24, 2018 MForm 4 →	Sep 26, 8:47 pm EDT	Michael Wayne KalbSVP and CFO	150,000	$2.19	$328,500	164,996	—	plan?
Sep 22, 2018 AForm 4 →	Sep 25, 6:36 pm EDT	Joseph T KennedyGeneral Counsel	199,500	—	—	217,934	—	plan?
Sep 22, 2018 AForm 4 →	Sep 25, 6:36 pm EDT	Steven B KetchumChief Scientific Officer	199,500	—	—	400,473	—	plan?
Sep 22, 2018 AFForm 4 →	Sep 25, 6:35 pm EDT	John F TheroPresident and CEO, Director	1,763,126	$2.99	$1,488,649	2,271,785	—	plan?
Jul 2, 2018 SForm 4 →	Jul 3, 4:09 pm EDT	Joseph T KennedyGeneral Counsel	26,942	$3.00	$80,955	18,434	−59.4%	plan?
Jun 30, 2018 FMForm 4 →	Jul 3, 4:11 pm EDT	John F TheroPresident and CEO, Director	52,257	$3.09	$45,599	1,504,411	—	plan?
Jun 30, 2018 FMForm 4 →	Jul 3, 4:09 pm EDT	Joseph T KennedyGeneral Counsel	79,932	$3.09	$81,870	45,376	—	plan?
Apr 2, 2018 SForm 4 →	Apr 3, 8:12 pm EDT	Joseph T KennedyGeneral Counsel	26,942	$2.90	$78,072	18,434	−59.4%	plan?
Mar 31, 2018 FMForm 4 →	Apr 3, 8:12 pm EDT	John F TheroPresident and CEO, Director	52,257	$3.01	$44,419	1,481,668	—	plan?
Mar 31, 2018 FMForm 4 →	Apr 3, 8:12 pm EDT	Joseph T KennedyGeneral Counsel	79,932	$3.01	$79,750	45,376	—	plan?
Jan 31, 2018 FMForm 4 →	Feb 2, 8:28 pm EST	John F TheroPresident and CEO, Director	697,180	$3.83	$756,475	1,458,925	—	plan?
Jan 31, 2018 FMForm 4 →	Feb 2, 8:26 pm EST	Steven B KetchumChief Scientific Officer	174,032	$3.83	$219,949	200,973	—	plan?
Jan 31, 2018 SForm 4 →	Feb 2, 8:25 pm EST	Joseph T KennedyGeneral Counsel	44,857	$3.73	$167,388	18,434	−70.9%	plan?
Jan 31, 2018 FMForm 4 →	Feb 2, 8:25 pm EST	Joseph T KennedyGeneral Counsel	183,917	$3.83	$230,999	63,291	—	plan?
Jan 31, 2018 FMForm 4 →	Feb 2, 8:24 pm EST	Michael Wayne KalbSVP and CFO	43,004	$3.83	$53,635	14,996	—	plan?
Jan 23, 2018 SForm 4 →	Jan 23, 6:00 pm EST	Steven B KetchumChief Scientific Officer	135,205	$4.41	$596,430	141,797	−48.8%	plan?
Jan 23, 2018 MForm 4 →	Jan 23, 6:00 pm EST	Steven B KetchumChief Scientific Officer	135,205	$2.04	$275,818	277,002	—	plan?
Jan 12, 2018 SForm 4 →	Jan 17, 5:58 pm EST	Joseph T KennedyGeneral Counsel	51,106	$4.10	$209,450	0	−100%	plan?
Jan 11, 2018 SForm 4 →	Jan 16, 6:00 pm EST	Steven B KetchumChief Scientific Officer	2,612	$4.40	$11,493	141,797	−1.81%	plan?
Jan 11, 2018 MForm 4 →	Jan 16, 6:00 pm EST	Steven B KetchumChief Scientific Officer	2,612	$2.04	$5,328	144,409	—	plan?
Jan 5, 2018 SForm 4 →	Jan 9, 6:00 pm EST	Steven B KetchumChief Scientific Officer	64,683	$4.40	$284,631	141,797	−31.3%	plan?
Jan 5, 2018 MForm 4 →	Jan 9, 6:00 pm EST	Steven B KetchumChief Scientific Officer	64,683	$2.04	$131,953	206,480	—	plan?
Jan 2, 2018 SForm 4 →	Jan 4, 7:40 pm EST	Steven B KetchumChief Scientific Officer	128,257	$4.25	$545,092	141,797	−47.5%	plan?
Jan 2, 2018 MForm 4 →	Jan 4, 7:40 pm EST	Steven B KetchumChief Scientific Officer	128,257	$1.20	$153,583	270,054	—	plan?
Dec 31, 2017 FMForm 4 →	Jan 2, 2018, 4:32 pm EST	John F TheroPresident and CEO, Director	53,232	$4.01	$63,085	1,156,771	—	plan?
Dec 31, 2017 FMForm 4 →	Jan 2, 2018, 4:32 pm EST	Joseph T KennedyGeneral Counsel	81,323	$4.01	$111,819	51,106	—	plan?
Nov 30, 2017 PForm 4 →	Dec 4, 9:02 am EST	John F TheroPresident and CEO, Director	10,000	$3.24	$32,446	1,135,003	+0.89%	plan? amended
Oct 5, 2017 SForm 4 →	Oct 6, 7:22 pm EDT	Steven B KetchumChief Scientific Officer	63,479	$3.48	$221,199	141,797	−30.9%	plan?
Sep 30, 2017 FMForm 4 →	Oct 3, 4:24 pm EDT	John F TheroPresident and CEO, Director	53,232	$3.50	$55,062	1,125,003	—	plan?

Reported at this company — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Aug 1, 2026 AForm 4 →	Aug 3, 4:30 pm EDT	Peter L. FishmanSVP, CFO	313	—	—	0	—
Jul 1, 2026 AForm 4 →	Jul 15, 5:00 pm EDT	Peter L. FishmanSVP, CFO	2,447	—	—	0	—	late
Jul 1, 2026 AForm 4 →	Jul 15, 5:00 pm EDT	David Paul KeenanEVP, Chief Operating Officer	3,688	—	—	0	—	late
Jul 1, 2026 AForm 4 →	Jul 15, 5:00 pm EDT	Steven B KetchumEVP, Chief Scientific Officer	3,688	—	—	0	—	late
Jul 1, 2026 AForm 4 →	Jul 15, 5:00 pm EDT	Jonathan ProvoostEVP, Chief Legal Officer	3,688	—	—	0	—	late
Jun 26, 2026 MForm 4 →	Jun 30, 5:20 pm EDT	Aaron BergPresident and CEO	6,250	—	—	6,250	—
Mar 4, 2019 MForm 4 →	Mar 6, 8:16 pm EST	Lars EkmanDirector	135,377	—	—	0	—
Mar 1, 2019 MForm 4 →	Mar 1, 8:18 pm EST	Michael Wayne KalbSVP and CFO	100,000	—	—	86,000	—
Feb 28, 2019 MForm 4 →	Mar 1, 8:19 pm EST	Steven B KetchumChief Scientific Officer	55,543	—	—	194,000	—
Feb 28, 2019 MForm 4 →	Mar 1, 8:17 pm EST	Joseph T KennedyGeneral Counsel	27,231	—	—	85,312	—
Feb 22, 2019 MForm 4 →	Feb 22, 9:34 pm EST	Joseph S ZakrzewskiDirector	180,625	—	—	0	—
Feb 22, 2019 MForm 4 →	Feb 22, 9:33 pm EST	G Jan Van HeekDirector	192,347	—	—	0	—
Feb 22, 2019 MForm 4 →	Feb 22, 9:32 pm EST	Kristine PetersonDirector	163,500	—	—	0	—
Feb 22, 2019 MForm 4 →	Feb 22, 9:31 pm EST	Michael Wayne KalbSVP and CFO	50,000	—	—	83,000	—
Jan 31, 2019 AMForm 4 →	Feb 1, 8:35 pm EST	John F TheroPresident and CEO, Director	881,934	—	—	302,500	—
Jan 31, 2019 AMForm 4 →	Feb 1, 8:35 pm EST	Steven B KetchumChief Scientific Officer	182,907	—	—	53,500	—
Jan 31, 2019 AMForm 4 →	Feb 1, 8:34 pm EST	Joseph T KennedyGeneral Counsel	209,546	—	—	53,500	—
Jan 31, 2019 AMForm 4 →	Feb 1, 8:33 pm EST	Michael Wayne KalbSVP and CFO	146,700	—	—	53,500	—
Jan 22, 2019 MForm 4 →	Jan 24, 8:20 pm EST	Joseph T KennedyGeneral Counsel	822,260	—	—	0	—
Jan 11, 2019 MForm 4 →	Jan 11, 8:17 pm EST	Joseph T KennedyGeneral Counsel	3,173	—	—	161,827	—
Jan 10, 2019 MForm 4 →	Jan 11, 8:18 pm EST	Joseph S ZakrzewskiDirector	200,000	—	—	500,000	—
Jan 10, 2019 MForm 4 →	Jan 11, 8:18 pm EST	David M StackDirector	125,504	—	—	0	—
Jan 10, 2019 MForm 4 →	Jan 11, 8:16 pm EST	Lars EkmanDirector	100,416	—	—	19,584	—
Jan 9, 2019 MForm 4 →	Jan 11, 8:16 pm EST	Michael Wayne KalbSVP and CFO	200,000	—	—	275,000	—
Jan 2, 2019 MForm 4 →	Jan 2, 7:54 pm EST	Joseph S ZakrzewskiDirector	385,000	—	—	0	—
Dec 31, 2018 MForm 4 →	Jan 2, 2019, 7:53 pm EST	Joseph T KennedyGeneral Counsel	53,438	—	—	12,500	—
Dec 31, 2018 MForm 4 →	Jan 2, 2019, 7:51 pm EST	Steven B KetchumChief Scientific Officer	17,041	—	—	69,770	—
Dec 31, 2018 MForm 4 →	Jan 2, 2019, 7:45 pm EST	John F TheroPresident and CEO, Director	37,500	—	—	75,000	—
Nov 30, 2018 MForm 4 →	Nov 30, 6:34 pm EST	Steven B KetchumChief Scientific Officer	17,042	—	—	72,540	—
Nov 30, 2018 MForm 4 →	Nov 30, 6:33 pm EST	Joseph T KennedyGeneral Counsel	23,306	—	—	131,261	—
Nov 12, 2018 MForm 4 →	Nov 14, 6:02 pm EST	John F TheroPresident and CEO, Director	407,611	—	—	0	—
Oct 31, 2018 MForm 4 →	Nov 2, 6:11 pm EDT	Steven B KetchumChief Scientific Officer	17,042	—	—	75,311	—
Oct 31, 2018 MForm 4 →	Nov 2, 6:10 pm EDT	Joseph T KennedyGeneral Counsel	23,307	—	—	150,010	—
Sep 30, 2018 MForm 4 →	Oct 2, 7:11 pm EDT	John F TheroPresident and CEO, Director	37,500	—	—	112,500	—
Sep 30, 2018 MForm 4 →	Oct 2, 7:02 pm EDT	Joseph T KennedyGeneral Counsel	76,744	—	—	41,666	—
Sep 28, 2018 MForm 4 →	Oct 2, 7:05 pm EDT	Steven B KetchumChief Scientific Officer	316,604	—	—	41,666	—
Sep 24, 2018 MForm 4 →	Sep 26, 8:54 pm EDT	Joseph S ZakrzewskiDirector	500,000	—	—	1,050,000	—
Sep 24, 2018 MForm 4 →	Sep 26, 8:52 pm EDT	Steven B KetchumChief Scientific Officer	820,065	—	—	300,000	—
Sep 24, 2018 MForm 4 →	Sep 26, 8:50 pm EDT	Joseph T KennedyGeneral Counsel	1,079,706	—	—	44,270	—
Sep 24, 2018 MForm 4 →	Sep 26, 8:47 pm EDT	Michael Wayne KalbSVP and CFO	150,000	—	—	475,000	—
Jun 30, 2018 MForm 4 →	Jul 3, 4:11 pm EDT	John F TheroPresident and CEO, Director	37,500	—	—	150,000	—
Jun 30, 2018 MForm 4 →	Jul 3, 4:09 pm EDT	Joseph T KennedyGeneral Counsel	53,437	—	—	25,000	—
May 14, 2018 AForm 4 →	Oct 2, 7:13 pm EDT	Joseph S ZakrzewskiDirector	78,126	—	—	31,153	—	late
May 14, 2018 AForm 4 →	Oct 2, 7:12 pm EDT	G Jan Van HeekDirector	78,126	—	—	31,153	—	late
May 14, 2018 AForm 4 →	Oct 2, 7:10 pm EDT	David M StackDirector	78,126	—	—	31,153	—	late
May 14, 2018 AForm 4 →	Oct 2, 7:08 pm EDT	Kristine PetersonDirector	78,126	—	—	31,153	—	late
May 14, 2018 AForm 4 →	Oct 2, 7:07 pm EDT	Patrick J O'SullivanDirector	78,126	—	—	31,153	—	late
May 14, 2018 AForm 4 →	Oct 2, 7:00 pm EDT	Lars EkmanDirector	85,940	—	—	34,269	—	late
Mar 31, 2018 MForm 4 →	Apr 3, 8:12 pm EDT	John F TheroPresident and CEO, Director	37,500	—	—	187,500	—
Mar 31, 2018 MForm 4 →	Apr 3, 8:12 pm EDT	Joseph T KennedyGeneral Counsel	53,437	—	—	31,250	—
Feb 1, 2018 AForm 4 →	Feb 2, 8:27 pm EST	Mark SalyerChief Commercial Officer	195,000	$3.80	$444,600	117,000	—
Jan 31, 2018 AMForm 4 →	Feb 2, 8:28 pm EST	John F TheroPresident and CEO, Director	1,428,667	$3.80	$2,120,400	558,000	—
Jan 31, 2018 AMForm 4 →	Feb 2, 8:26 pm EST	Steven B KetchumChief Scientific Officer	311,604	$3.80	$444,600	117,000	—
Jan 31, 2018 AMForm 4 →	Feb 2, 8:25 pm EST	Joseph T KennedyGeneral Counsel	318,604	$3.80	$444,600	117,000	—
Jan 31, 2018 AMForm 4 →	Feb 2, 8:24 pm EST	Michael Wayne KalbSVP and CFO	224,000	$3.80	$444,600	117,000	—
Jan 23, 2018 MForm 4 →	Jan 23, 6:00 pm EST	Steven B KetchumChief Scientific Officer	135,205	—	—	0	—
Jan 11, 2018 MForm 4 →	Jan 16, 6:00 pm EST	Steven B KetchumChief Scientific Officer	2,612	—	—	135,205	—
Jan 5, 2018 MForm 4 →	Jan 9, 6:00 pm EST	Steven B KetchumChief Scientific Officer	64,683	—	—	137,817	—
Jan 2, 2018 MForm 4 →	Jan 4, 7:40 pm EST	Steven B KetchumChief Scientific Officer	128,257	—	—	65,104	—
Dec 31, 2017 MForm 4 →	Jan 2, 2018, 4:32 pm EST	John F TheroPresident and CEO, Director	37,500	—	—	225,000	—
Dec 31, 2017 MForm 4 →	Jan 2, 2018, 4:32 pm EST	Joseph T KennedyGeneral Counsel	53,438	—	—	37,500	—
Sep 30, 2017 MForm 4 →	Oct 3, 4:24 pm EDT	John F TheroPresident and CEO, Director	37,500	—	—	262,500	—
Sep 30, 2017 MForm 4 →	Oct 3, 4:24 pm EDT	Joseph T KennedyGeneral Counsel	53,438	—	—	43,750	—
May 15, 2017 AMForm 4 →	Jul 3, 7:21 pm EDT	John F TheroPresident and CEO, Director	396,500	—	—	300,000	—	late
May 15, 2017 AForm 4 →	Jul 3, 7:21 pm EDT	Steven B KetchumChief Scientific Officer	87,000	—	—	87,000	—	late
May 15, 2017 AMForm 4 →	Jul 3, 7:20 pm EDT	Joseph T KennedyGeneral Counsel	161,437	—	—	50,000	—	late
May 15, 2017 AForm 4 →	Jul 3, 7:19 pm EDT	Michael Wayne KalbSVP and CFO	87,000	—	—	87,000	—	late
May 15, 2017 AForm 4 →	May 17, 5:25 pm EDT	David M StackDirector	35,852	—	—	14,706	—
May 15, 2017 AForm 4 →	May 17, 5:24 pm EDT	G Jan Van HeekDirector	35,852	—	—	14,706	—
May 15, 2017 AForm 4 →	May 17, 5:23 pm EDT	Kristine PetersonDirector	35,852	—	—	14,706	—
May 15, 2017 AForm 4 →	May 17, 5:23 pm EDT	Joseph S ZakrzewskiDirector	35,852	—	—	14,706	—
May 15, 2017 AForm 4 →	May 17, 5:21 pm EDT	Lars EkmanDirector	43,819	—	—	17,974	—
May 15, 2017 AForm 4 →	May 17, 5:13 pm EDT	Patrick J O'SullivanDirector	35,852	—	—	14,706	—
Mar 31, 2017 MForm 4 →	Apr 3, 5:01 pm EDT	Joseph T KennedyGeneral Counsel	53,437	—	—	56,250	—
Mar 31, 2017 MForm 4 →	Apr 3, 5:00 pm EDT	John F TheroPresident and CEO, Director	37,500	—	—	337,500	—
Feb 1, 2017 AForm 4 →	Feb 2, 5:03 pm EST	Michael Wayne KalbSVP and CFO	133,000	$2.95	$392,350	133,000	—
Jan 31, 2017 AMForm 4 →	Feb 2, 5:07 pm EST	John F TheroPresident and CEO, Director	1,099,500	$2.95	$1,622,500	550,000	—
Jan 31, 2017 AMForm 4 →	Feb 2, 5:06 pm EST	Steven B KetchumChief Scientific Officer	277,105	$2.95	$392,350	133,000	—
Jan 31, 2017 AMForm 4 →	Feb 2, 5:04 pm EST	Joseph T KennedyGeneral Counsel	309,105	$2.95	$486,750	165,000	—
Dec 31, 2016 MForm 4 →	Jan 3, 2017, 4:31 pm EST	Joseph T KennedyGeneral Counsel	53,438	—	—	62,500	—
Dec 31, 2016 MForm 4 →	Jan 3, 2017, 4:30 pm EST	John F TheroPresident and CEO, Director	37,500	—	—	375,000	—
Sep 30, 2016 MForm 4 →	Sep 30, 9:26 pm EDT	Joseph T KennedyGeneral Counsel	53,438	—	—	68,750	—
Sep 30, 2016 MForm 4 →	Sep 30, 9:25 pm EDT	John F TheroPresident and CEO, Director	37,500	—	—	412,500	—
Jul 11, 2016 AForm 4 →	Jul 13, 4:29 pm EDT	James HealyDirector	49,395	—	—	20,548	—
Jul 11, 2016 AForm 4 →	Jul 13, 4:28 pm EDT	Patrick J O'SullivanDirector	49,395	—	—	20,548	—
Jul 11, 2016 AForm 4 →	Jul 13, 4:26 pm EDT	Kristine PetersonDirector	49,395	—	—	20,548	—
Jul 11, 2016 AForm 4 →	Jul 13, 4:26 pm EDT	David M StackDirector	49,395	—	—	20,548	—
Jul 11, 2016 AForm 4 →	Jul 13, 4:25 pm EDT	G Jan Van HeekDirector	49,395	—	—	20,548	—
Jul 11, 2016 AForm 4 →	Jul 13, 4:24 pm EDT	Joseph S ZakrzewskiDirector	49,395	—	—	20,548	—
Jul 11, 2016 AForm 4 →	Jul 13, 4:23 pm EDT	Lars EkmanDirector	60,373	—	—	25,115	—
Jul 1, 2016 AForm 4 →	Jul 5, 7:10 pm EDT	Michael Wayne KalbSVP and CFO	625,000	—	—	625,000	—
Jun 30, 2016 MForm 4 →	Jul 5, 7:09 pm EDT	John F TheroPresident and CEO, Director	37,500	—	—	450,000	—
Jun 30, 2016 MForm 4 →	Jul 5, 7:08 pm EDT	Joseph T KennedyGeneral Counsel	53,437	—	—	75,000	—
Mar 31, 2016 MForm 4 →	Apr 1, 6:00 pm EDT	Joseph T KennedyGeneral Counsel	53,437	—	—	81,250	—
Mar 31, 2016 MForm 4 →	Apr 1, 5:58 pm EDT	John F TheroPresident and CEO, Director	37,500	—	—	487,500	—
Jan 31, 2016 AMForm 4 →	Feb 2, 4:18 pm EST	John F TheroPresident and CEO, Director	1,339,500	$1.40	$770,000	550,000	—
Jan 31, 2016 AMForm 4 →	Feb 2, 4:17 pm EST	Steven B KetchumChief Scientific Officer	322,438	$1.40	$175,000	125,000	—
Jan 31, 2016 AMForm 4 →	Feb 2, 4:15 pm EST	Joseph T KennedyGeneral Counsel	322,438	$1.40	$175,000	125,000	—
Jan 31, 2016 AMForm 4 →	Feb 2, 4:14 pm EST	Michael James FarrellVP, Finance	119,250	$1.40	$77,000	55,000	—
Dec 31, 2015 MForm 4 →	Jan 4, 2016, 5:15 pm EST	John F TheroPresident and CEO, Director	37,500	—	—	525,000	—