Form4insider filings, from the source

Company · CIK 0001636282 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

Spyre Therapeutics, Inc. · SYRE

Insider activity reported against this company. All insider holders · On EDGAR ↗

1M3M6M1Y2YAll datashares as filed — not split-adjusted
Open-market buys & salesbuys $0 · 0sales $6.1M · 3net −$6.1M
$10k$10k$100k$100k$1M$1M$10M$10MbuyssalesAug 28Sep 2Sep 7Sep 12Sep 18Sep 23Sep 28

Reported at this company — common stock

TradeReported (ET)InsiderSharesAvg priceTotalOwned afterΔ stakeFlags
Sep 1, 2026 SForm 4 →Sep 3, 9:34 pm EDTHeidy King-JonesSee Remarks28,399$87.35$2,480,5292,845−90.9%10b5-1
Sep 1, 2026 MForm 4 →Sep 3, 9:34 pm EDTHeidy King-JonesSee Remarks28,399$14.50$411,7863,245—10b5-1
Sep 1, 2026 SForm 4 →Sep 3, 9:33 pm EDTScott L BurrowsChief Financial Officer25,732$88.75$2,283,82179,762−24.4%10b5-1
Sep 1, 2026 MForm 4 →Sep 3, 9:33 pm EDTScott L BurrowsChief Financial Officer7,500$14.50$108,750105,494—10b5-1
Sep 1, 2026 SForm 4 →Sep 3, 9:33 pm EDTCameron TurtleChief Executive Officer, Director15,000$87.29$1,309,410552,540−2.64%10b5-1

Reported at this company — derivatives (options, RSUs, warrants)

TradeReported (ET)InsiderSharesAvg priceTotalOwned afterΔ stakeFlags
Sep 1, 2026 MForm 4 →Sep 3, 9:34 pm EDTHeidy King-JonesSee Remarks28,399——511,411—10b5-1
Sep 1, 2026 MForm 4 →Sep 3, 9:33 pm EDTScott L BurrowsChief Financial Officer7,500——337,357—10b5-1