Form4insider filings, from the source

Company · CIK 0001636282 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

Spyre Therapeutics, Inc. · SYRE

Insider activity reported against this company. All insider holders · On EDGAR ↗

1M3M6M1Y2YAll datashares as filed — not split-adjusted
Open-market buys & salesbuys $9.0M · 9sales $419.9M · 19net −$410.9M
$100k$100k$10M$10M$1B$1BbuyssalesApr 2016Jan 2018Sep 2019Jun 2021Mar 2023Dec 2024Sep 2026

Reported at this company — common stock

TradeReported (ET)InsiderSharesAvg priceTotalOwned afterΔ stakeFlags
Sep 1, 2026 SForm 4 →Sep 3, 9:34 pm EDTHeidy King-JonesSee Remarks28,399$87.35$2,480,5292,845−90.9%10b5-1
Sep 1, 2026 MForm 4 →Sep 3, 9:34 pm EDTHeidy King-JonesSee Remarks28,399$14.50$411,7863,245—10b5-1
Sep 1, 2026 SForm 4 →Sep 3, 9:33 pm EDTScott L BurrowsChief Financial Officer25,732$88.75$2,283,82179,762−24.4%10b5-1
Sep 1, 2026 MForm 4 →Sep 3, 9:33 pm EDTScott L BurrowsChief Financial Officer7,500$14.50$108,750105,494—10b5-1
Sep 1, 2026 SForm 4 →Sep 3, 9:33 pm EDTCameron TurtleChief Executive Officer, Director15,000$87.29$1,309,410552,540−2.64%10b5-1
Aug 7, 2026 SForm 4 →Aug 10, 9:31 pm EDTJeffrey W. AlbersDirector23,000$104.53$2,404,1909,360−71.1%10b5-1
Aug 7, 2026 MForm 4 →Aug 10, 9:31 pm EDTJeffrey W. AlbersDirector5,000$10.39$51,9505,000—10b5-1
Aug 3, 2026 SForm 4 →Aug 5, 9:32 pm EDTScott L BurrowsChief Financial Officer7,500$95.57$716,77197,994−7.11%10b5-1
Aug 3, 2026 MForm 4 →Aug 5, 9:32 pm EDTScott L BurrowsChief Financial Officer7,500$14.50$108,750105,494—10b5-1
Aug 3, 2026 SForm 4 →Aug 5, 9:31 pm EDTCameron TurtleChief Executive Officer, Director15,000$95.51$1,432,705567,540−2.57%10b5-1
Jul 1, 2026 SForm 4 →Jul 2, 9:33 pm EDTScott L BurrowsChief Financial Officer7,500$87.74$658,04097,994−7.11%10b5-1
Jul 1, 2026 MForm 4 →Jul 2, 9:33 pm EDTScott L BurrowsChief Financial Officer7,500$14.50$108,750105,494—10b5-1
Jul 1, 2026 SForm 4 →Jul 2, 9:33 pm EDTSheldon SloanChief Medical Officer8,334$87.70$730,8960−100%10b5-1
Jul 1, 2026 MForm 4 →Jul 2, 9:33 pm EDTSheldon SloanChief Medical Officer8,334$27.46$228,8528,334—10b5-1
Jul 1, 2026 SForm 4 →Jul 2, 9:32 pm EDTCameron TurtleChief Executive Officer, Director15,000$87.69$1,315,346582,540−2.51%10b5-1
Jun 25, 2026 SForm 4 →Jun 26, 9:31 pm EDTScott L BurrowsChief Financial Officer15,000$87.13$1,307,00097,994−13.3%
Jun 25, 2026 MForm 4 →Jun 26, 9:31 pm EDTScott L BurrowsChief Financial Officer15,000$14.50$217,500112,994—
Jun 23, 2026 SForm 4 →Jun 23, 9:56 pm EDTFairmount Funds Management LLC +3Director4,684,781$85.31$399,658,6670−100%
Jun 23, 2026 CForm 4 →Jun 23, 9:56 pm EDTFairmount Funds Management LLC +3Director666,680——4,684,781—
Jun 22, 2026 SForm 4 →Jun 23, 9:32 pm EDTMichael Thomas HendersonDirector20,000$100.00$2,000,00068,606−22.6%10b5-1
Jun 3, 2026 SForm 4 →Jun 3, 9:32 pm EDTSheldon SloanChief Medical Officer8,333$75.00$624,9750−100%10b5-1
Jun 3, 2026 MForm 4 →Jun 3, 9:32 pm EDTSheldon SloanChief Medical Officer8,333$27.46$228,8248,333—10b5-1
Jun 1, 2026 SForm 4 →Jun 3, 9:31 pm EDTCameron TurtleChief Executive Officer, Director15,000$70.43$1,056,486597,540−2.45%10b5-1
Jun 1, 2026 SForm 4 →Jun 3, 9:30 pm EDTScott L BurrowsChief Financial Officer7,500$71.06$532,93797,994−7.11%10b5-1
Jun 1, 2026 MForm 4 →Jun 3, 9:30 pm EDTScott L BurrowsChief Financial Officer7,500$14.50$108,750105,494—10b5-1
Feb 6, 2019 MForm 4 →Feb 8, 4:15 pm ESTAnthony G. QuinnPresident & CEO, Director8,756$6.18$54,126276,433— plan?
Dec 7, 2018 MForm 4 →Dec 10, 5:40 pm ESTAnthony G. QuinnPresident & CEO, Director171,890$4.37$751,816267,677— plan?
Sep 27, 2018 SForm 4 →Sep 28, 5:11 pm EDTAaron SchuchartChief Business Officer6,000$9.50$57,0052,500−70.6% plan?
Aug 17, 2018 MForm 4 →Aug 21, 4:24 pm EDTAaron SchuchartChief Business Officer8,500$3.50$29,7508,500— plan?
Aug 13, 2018 MForm 4 →Aug 15, 4:40 pm EDTGeorge GeorgiouDirector37,333$5.91$220,784175,861— plan?
Jul 12, 2018 MForm 4 →Jul 16, 9:04 am EDTAnthony G. QuinnInterim CEO, Director38,866$6.76$262,76492,793— plan?
Jul 11, 2018 MForm 4 →Jul 13, 9:05 am EDTAnthony G. QuinnInterim CEO, Director3,307$5.46$18,05653,927— plan?
May 11, 2018 SForm 4 →May 14, 4:01 pm EDTNovartis Bioventures Ltd +110% Owner19,550$10.06$196,6732,175,314−0.89% plan?
May 9, 2018 SForm 4 →May 11, 4:28 pm EDTNovartis Bioventures Ltd +110% Owner73,955$10.12$748,1402,194,864−3.26% plan?
May 7, 2018 SForm 4 →May 9, 4:01 pm EDTNovartis Bioventures Ltd +110% Owner42,105$10.06$423,5572,268,819−1.82% plan?
Feb 15, 2018 PForm 4 →Dec 10, 5:40 pm ESTAnthony G. QuinnPresident & CEO, Director2,994$7.05$21,11595,787+3.23% plan? late
Feb 15, 2018 MForm 4 →Feb 20, 4:36 pm ESTAnthony G. QuinnInterim CEO, Director15,211$5.46$83,05250,620— plan?
Dec 6, 2017 PForm 4 →Dec 8, 7:06 pm ESTAnthony G. QuinnInterim CEO, Director8,288$4.96$41,07835,409+30.6% plan?
Dec 1, 2017 PForm 4 →Dec 5, 9:04 pm ESTAnthony G. QuinnDirector17,121$4.86$83,17727,121+171% plan?
Feb 16, 2017 PForm 4 →Feb 21, 5:58 pm ESTORBIMED ADVISORS LLC +210% Owner109,300$5.16$563,8821,469,524+8.04% plan?
Aug 15, 2016 PForm 4 →Dec 5, 2017, 9:07 pm ESTCharles N York IIChief Financial Officer and VP25,959$4.48$116,22334,787+294% plan? late
Apr 12, 2016 CForm 4/A →Apr 14, 7:35 pm EDTLILLY ELI & CO +210% Owner2,010,924——2,068,543— plan?
Apr 12, 2016 PForm 4 →Apr 14, 6:41 pm EDTLILLY ELI & CO10% Owner500,000$10.00$5,000,0002,568,543+24.2% plan?
Apr 12, 2016 CForm 4 →Apr 14, 6:41 pm EDTLILLY ELI & CO10% Owner2,010,924——2,068,543— plan?
Apr 12, 2016 CForm 4 →Apr 12, 5:15 pm EDTCharles N York IIChief Financial Officer and VP12,884——11,560— plan?
Apr 12, 2016 CForm 4 →Apr 12, 5:13 pm EDTJoseph E TylerVP, Manufacturing31,260——42,428— plan?
Apr 12, 2016 CForm 4 →Apr 12, 5:12 pm EDTScott W RowlinsonVP, Research11,204——11,204— plan?
Apr 12, 2016 PForm 4 →Apr 12, 5:10 pm EDTAnthony QuinnDirector10,000$10.00$100,00010,000— plan?
Apr 12, 2016 PForm 4 →Apr 12, 5:09 pm EDTNovartis Bioventures Ltd +110% Owner300,000$10.00$3,000,0002,310,924+14.9% plan?
Apr 12, 2016 CForm 4 →Apr 12, 5:09 pm EDTNovartis Bioventures Ltd +110% Owner2,010,924——2,010,924— plan?
Apr 12, 2016 CForm 4 →Apr 12, 5:07 pm EDTDavid George LoweCEO and President, Director5,658——5,658— plan?
Apr 12, 2016 PForm 4 →Apr 12, 5:06 pm EDTRussell J. CoxDirector7,000$10.00$70,0007,000— plan?

Reported at this company — derivatives (options, RSUs, warrants)

TradeReported (ET)InsiderSharesAvg priceTotalOwned afterΔ stakeFlags
Sep 1, 2026 MForm 4 →Sep 3, 9:34 pm EDTHeidy King-JonesSee Remarks28,399——511,411—10b5-1
Sep 1, 2026 MForm 4 →Sep 3, 9:33 pm EDTScott L BurrowsChief Financial Officer7,500——337,357—10b5-1
Aug 7, 2026 MForm 4 →Aug 10, 9:31 pm EDTJeffrey W. AlbersDirector5,000——45,000—10b5-1
Aug 3, 2026 MForm 4 →Aug 5, 9:32 pm EDTScott L BurrowsChief Financial Officer7,500——344,857—10b5-1
Jul 1, 2026 MForm 4 →Jul 2, 9:33 pm EDTScott L BurrowsChief Financial Officer7,500——352,357—10b5-1
Jul 1, 2026 MForm 4 →Jul 2, 9:33 pm EDTSheldon SloanChief Medical Officer8,334——305,000—10b5-1
Jun 25, 2026 MForm 4 →Jun 26, 9:31 pm EDTScott L BurrowsChief Financial Officer15,000——359,857—
Jun 23, 2026 CForm 4 →Jun 23, 9:56 pm EDTFairmount Funds Management LLC +3Director16,667——0—
Jun 3, 2026 MForm 4 →Jun 3, 9:32 pm EDTSheldon SloanChief Medical Officer8,333——313,334—10b5-1
Jun 1, 2026 MForm 4 →Jun 3, 9:30 pm EDTScott L BurrowsChief Financial Officer7,500——374,857—10b5-1
Mar 6, 2019 AForm 4 →Mar 8, 4:41 pm ESTLeslie SloanChief Operating Officer36,000——36,000—
Feb 28, 2019 AForm 4 →Mar 1, 5:10 pm ESTCharles N York IIChief Financial Officer and VP87,600——87,600—
Feb 28, 2019 AForm 4 →Mar 1, 5:09 pm ESTJames WooldridgeChief Medical Officer50,200——50,200—
Feb 28, 2019 AForm 4 →Mar 1, 5:09 pm ESTAaron SchuchartChief Business Officer60,000——60,000—
Feb 28, 2019 AForm 4 →Mar 1, 5:08 pm ESTAnthony G. QuinnPresident & CEO, Director280,000——280,000—
Feb 6, 2019 MForm 4 →Feb 8, 4:15 pm ESTAnthony G. QuinnPresident & CEO, Director8,756——137,517—
Dec 7, 2018 MForm 4 →Dec 10, 5:40 pm ESTAnthony G. QuinnPresident & CEO, Director171,890——144,950—
Aug 17, 2018 MForm 4 →Aug 21, 4:24 pm EDTAaron SchuchartChief Business Officer8,500——91,500—
Aug 13, 2018 MForm 4 →Aug 15, 4:40 pm EDTGeorge GeorgiouDirector37,333——10,000—
Jul 18, 2018 AForm 4 →Jul 20, 5:26 pm EDTAnthony G. QuinnPresident & CEO, Director500,000——50,000—
Jul 13, 2018 AForm 4 →Jul 17, 4:27 pm EDTV Bryan LawlisDirector36,800——36,800—
Jul 12, 2018 MForm 4 →Jul 16, 9:04 am EDTAnthony G. QuinnInterim CEO, Director38,866——163,534—
Jul 11, 2018 MForm 4 →Jul 13, 9:05 am EDTAnthony G. QuinnInterim CEO, Director3,307——5,291—
Jun 7, 2018 AForm 4 →Jun 8, 6:47 pm EDTArmen ShanafeltDirector, 10% Owner18,400——18,400—
Jun 7, 2018 AForm 4 →Jun 8, 6:45 pm EDTSandesh MahatmeDirector18,400——18,400—
Jun 7, 2018 AForm 4 →Jun 8, 6:44 pm EDTGeorge GeorgiouDirector18,400——18,400—
Jun 7, 2018 AForm 4 →Jun 8, 6:43 pm EDTRussell J. CoxDirector18,400——18,400—
Jun 7, 2018 AForm 4 →Jun 8, 6:42 pm EDTSuzanne Louise BruhnDirector18,400——18,400—
Mar 22, 2018 AForm 4 →Mar 26, 8:05 am EDTIvana MagovcevicDirector36,800——36,800—
Feb 20, 2018 AForm 4 →Feb 22, 6:25 pm ESTJames WooldridgeChief Medical Officer45,000——45,000—
Feb 20, 2018 AForm 4 →Feb 22, 6:24 pm ESTCharles N York IIChief Financial Officer and VP92,100——92,100—
Feb 20, 2018 AForm 4 →Feb 22, 6:23 pm ESTAnthony G. QuinnInterim CEO, Director178,400——178,400—
Feb 20, 2018 AForm 4 →Feb 22, 6:22 pm ESTAaron SchuchartChief Business Officer20,000——20,000—
Feb 15, 2018 MForm 4 →Feb 20, 4:36 pm ESTAnthony G. QuinnInterim CEO, Director15,211——8,598—
Dec 1, 2017 AForm 4 →Dec 5, 9:06 pm ESTArmen ShanafeltDirector, 10% Owner30,000——30,000—
Dec 1, 2017 AForm 4 →Dec 5, 9:03 pm ESTSandesh MahatmeDirector30,000——30,000—
Dec 1, 2017 AForm 4 →Dec 5, 9:01 pm ESTGeorge GeorgiouDirector30,000——30,000—
Dec 1, 2017 AForm 4 →Dec 5, 9:00 pm ESTRussell J. CoxDirector30,000——30,000—
Aug 31, 2017 AForm 4 →Sep 1, 5:10 pm EDTAnthony G. QuinnInterim CEO, Director150,000——150,000—
Aug 22, 2017 AForm 4 →Aug 24, 6:04 pm EDTCharles N York IIChief Financial Officer and VP58,500——58,500—
Aug 22, 2017 AForm 4 →Aug 24, 6:04 pm EDTJames WooldridgeChief Medical Officer175,000——10,000—
Aug 22, 2017 AForm 4 →Aug 24, 6:03 pm EDTJoseph E TylerVP, Manufacturing25,000——25,000—
Aug 22, 2017 AForm 4 →Aug 24, 6:02 pm EDTAaron SchuchartChief Business Officer10,000——10,000—
Aug 22, 2017 AForm 4 →Aug 24, 6:02 pm EDTScott W RowlinsonVP, Research25,000——25,000—
Jun 16, 2017 AForm 4 →Jun 20, 5:06 pm EDTAaron SchuchartChief Business Officer100,000——100,000—
Apr 21, 2017 AForm 4 →Apr 25, 5:10 pm EDTAnthony Quinninterim Chief Medical Officer, Director24,000——24,000—
Mar 20, 2017 AForm 4 →Mar 22, 5:00 pm EDTCharles N York IIChief Financial Officer and VP90,000——90,000—
Mar 20, 2017 AForm 4 →Mar 22, 5:00 pm EDTJoseph E TylerVP, Manufacturing39,000——39,000—
Mar 20, 2017 AForm 4 →Mar 22, 4:54 pm EDTScott W RowlinsonVP, Research60,000——60,000—
Mar 20, 2017 AForm 4 →Mar 22, 4:53 pm EDTDavid George LoweCEO and President, Director160,000——160,000—
Mar 20, 2017 AForm 4 →Mar 22, 4:52 pm EDTHenry HebelVP, Product Development38,200——38,200—
Feb 15, 2017 AForm 4 →Feb 16, 5:13 pm ESTSuzanne Louise BruhnDirector82,000——82,000—
May 17, 2016 AForm 4 →May 19, 4:39 pm EDTCharles N York IIChief Financial Officer and VP55,000——55,000—
May 17, 2016 AForm 4 →May 19, 4:39 pm EDTJoseph E TylerVP, Manufacturing33,000——33,000—
May 17, 2016 AForm 4 →May 19, 4:38 pm EDTArmen ShanafeltDirector, 10% Owner24,000——24,000—
May 17, 2016 AForm 4 →May 19, 4:37 pm EDTScott W RowlinsonVP, Research47,000——47,000—
May 17, 2016 AForm 4 →May 19, 4:37 pm EDTSandra Rojas-CaroChief Medical Officer200,000——200,000—
May 17, 2016 AForm 4 →May 19, 4:35 pm EDTSandesh MahatmeDirector10,000——10,000—
May 17, 2016 AForm 4 →May 19, 4:35 pm EDTDavid George LoweCEO and President, Director160,000——160,000—
May 17, 2016 AForm 4 →May 19, 4:34 pm EDTHenry HebelVP, Product Development43,000——43,000—
May 17, 2016 AForm 4 →May 19, 4:33 pm EDTGeorge GeorgiouDirector24,000——24,000—
May 17, 2016 AForm 4 →May 19, 4:33 pm EDTRussell J. CoxDirector10,000——10,000—
Apr 12, 2016 CForm 4 →Apr 14, 6:41 pm EDTLILLY ELI & CO10% Owner2,010,924——0—
Apr 12, 2016 CForm 4 →Apr 12, 5:15 pm EDTCharles N York IIChief Financial Officer and VP12,884——0—
Apr 12, 2016 CForm 4 →Apr 12, 5:13 pm EDTJoseph E TylerVP, Manufacturing31,260——0—
Apr 12, 2016 CForm 4 →Apr 12, 5:12 pm EDTScott W RowlinsonVP, Research11,204——0—
Apr 12, 2016 CForm 4 →Apr 12, 5:09 pm EDTNovartis Bioventures Ltd +110% Owner2,010,924——0—
Apr 12, 2016 CForm 4 →Apr 12, 5:07 pm EDTDavid George LoweCEO and President, Director5,658——0—