Company · CIK 0001423824 · SIC 2834 — Pharmaceutical Preparations

ALDER BIOPHARMACEUTICALS INC · ALDR

Insider activity reported against this company. All insider holders · On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market buys & salesbuys $300k · 2sales $103.8M · 94net −$103.5M

Reported at this company — common stock

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Mar 4, 2019 AForm 4 →	Mar 6, 4:24 pm EST	Redmile Group, LLC +1Director	1,739,130	$11.50	$19,999,995	8,244,896	—	plan?
Dec 3, 2018 SForm 4 →	Dec 4, 6:39 pm EST	Jeffrey T L SmithManaging Director	5,044	$13.84	$69,826	831	−85.9%	plan?
Dec 3, 2018 MForm 4 →	Dec 4, 6:39 pm EST	Jeffrey T L SmithManaging Director	5,044	$0.99	$4,994	5,875	—	plan?
Nov 30, 2018 AForm 4 →	Feb 8, 2019, 4:47 pm EST	John A LathamChief Scientific Officer	487	$9.35	$4,553	244,180	—	plan? late
Nov 30, 2018 AForm 4 →	Feb 8, 2019, 4:43 pm EST	James B BucherEVP & General Counsel	273	$9.35	$2,553	3,896	—	plan? late
Nov 1, 2018 SForm 4 →	Nov 5, 5:47 pm EST	Jeffrey T L SmithManaging Director	5,040	$13.42	$67,637	831	−85.8%	plan?
Nov 1, 2018 MForm 4 →	Nov 5, 5:47 pm EST	Jeffrey T L SmithManaging Director	5,040	$0.99	$4,990	5,871	—	plan?
Nov 1, 2018 SForm 4 →	Nov 5, 5:43 pm EST	John A LathamChief Scientific Officer	25,002	$13.42	$335,589	243,693	−9.30%	plan?
Nov 1, 2018 MForm 4 →	Nov 5, 5:43 pm EST	John A LathamChief Scientific Officer	25,002	$9.12	$227,954	268,695	—	plan?
Oct 1, 2018 SForm 4 →	Oct 3, 6:33 pm EDT	Jeffrey T L SmithManaging Director	5,040	$15.54	$78,329	831	−85.8%	plan?
Oct 1, 2018 MForm 4 →	Oct 3, 6:33 pm EDT	Jeffrey T L SmithManaging Director	5,040	$0.99	$4,990	5,871	—	plan?
Oct 1, 2018 SForm 4 →	Oct 3, 6:31 pm EDT	John A LathamChief Scientific Officer	24,999	$15.44	$386,006	243,693	−9.30%	plan?
Oct 1, 2018 MForm 4 →	Oct 3, 6:31 pm EDT	John A LathamChief Scientific Officer	24,999	$4.36	$109,108	268,692	—	plan?
Sep 4, 2018 SForm 4 →	Sep 6, 5:08 pm EDT	Jeffrey T L SmithManaging Director	5,040	$18.00	$90,699	831	−85.8%	plan?
Sep 4, 2018 MForm 4 →	Sep 6, 5:08 pm EDT	Jeffrey T L SmithManaging Director	5,040	$0.99	$4,990	5,871	—	plan?
Sep 4, 2018 SForm 4 →	Sep 6, 5:05 pm EDT	John A LathamChief Scientific Officer	24,999	$17.99	$449,680	243,693	−9.30%	plan?
Sep 4, 2018 MForm 4 →	Sep 6, 5:05 pm EDT	John A LathamChief Scientific Officer	24,999	$3.47	$86,622	268,692	—	plan?
Aug 1, 2018 SForm 4 →	Aug 2, 5:48 pm EDT	Jeffrey T L SmithManaging Director	5,040	$19.54	$98,489	831	−85.8%	plan?
Aug 1, 2018 MForm 4 →	Aug 2, 5:48 pm EDT	Jeffrey T L SmithManaging Director	5,040	$0.99	$4,990	5,871	—	plan?
Aug 1, 2018 SForm 4 →	Aug 2, 5:40 pm EDT	John A LathamChief Scientific Officer	24,999	$19.55	$488,768	243,693	−9.30%	plan?
Aug 1, 2018 MForm 4 →	Aug 2, 5:40 pm EDT	John A LathamChief Scientific Officer	24,999	$3.47	$86,622	268,692	—	plan?
Jul 2, 2018 SForm 4 →	Jul 3, 5:28 pm EDT	Jeffrey T L SmithManaging Director	12,161	$15.49	$188,364	831	−93.6%	plan?
Jul 2, 2018 MForm 4 →	Jul 3, 5:28 pm EDT	Jeffrey T L SmithManaging Director	12,161	$1.38	$16,739	12,992	—	plan?
Jul 2, 2018 SForm 4 →	Jul 3, 5:22 pm EDT	John A LathamChief Scientific Officer	24,999	$15.48	$387,002	243,693	−9.30%	plan?
Jul 2, 2018 MForm 4 →	Jul 3, 5:22 pm EDT	John A LathamChief Scientific Officer	24,999	$3.47	$86,622	268,692	—	plan?
Jun 1, 2018 SForm 4 →	Jun 5, 5:43 pm EDT	John A LathamChief Scientific Officer	24,999	$17.85	$446,356	243,693	−9.30%	plan?
Jun 1, 2018 MForm 4 →	Jun 5, 5:43 pm EDT	John A LathamChief Scientific Officer	24,999	$4.37	$109,121	268,692	—	plan?
Jun 1, 2018 SForm 4 →	Jun 5, 5:41 pm EDT	Jeffrey T L SmithManaging Director	12,161	$17.85	$217,127	831	−93.6%	plan?
Jun 1, 2018 MForm 4 →	Jun 5, 5:41 pm EDT	Jeffrey T L SmithManaging Director	12,161	$1.38	$16,739	12,992	—	plan?
Jun 1, 2018 SForm 4 →	Jun 5, 5:40 pm EDT	Mark James LittonChief Business Officer	22,727	$17.84	$405,412	102,189	−18.2%	plan?
Jun 1, 2018 MForm 4 →	Jun 5, 5:40 pm EDT	Mark James LittonChief Business Officer	22,727	$0.99	$22,500	124,916	—	plan?
May 31, 2018 AForm 4 →	Feb 8, 2019, 4:41 pm EST	Larry BenedictEVP and PAO	2,273	$9.35	$21,253	34,407	—	plan? late
May 31, 2018 AForm 4 →	Nov 27, 5:35 pm EST	James B BucherSr. VP & General Counsel	2,000	$9.35	$18,700	3,623	—	plan? late
May 16, 2018 SForm 4 →	May 18, 5:57 pm EDT	Jeffrey T L SmithManaging Director	12,161	$15.03	$182,758	831	−93.6%	plan?
May 16, 2018 MForm 4 →	May 18, 5:57 pm EDT	Jeffrey T L SmithManaging Director	12,161	$1.38	$16,739	12,992	—	plan?
Nov 30, 2017 AForm 4 →	Dec 18, 6:25 pm EST	James B BucherSr. VP & General Counsel	1,623	$9.35	$15,175	1,623	—	plan? late
Nov 13, 2017 SForm 4 →	Nov 15, 5:54 pm EST	Mark James LittonChief Business Officer	16,519	$10.80	$178,486	99,932	−14.2%	plan?
Nov 13, 2017 MForm 4 →	Nov 15, 5:54 pm EST	Mark James LittonChief Business Officer	16,519	$1.65	$27,256	116,451	—	plan?
Nov 1, 2017 MForm 4 →	Nov 3, 5:48 pm EDT	Clay B SiegallDirector	27,270	$1.30	$35,496	31,714	—	plan?
Oct 16, 2017 SForm 4 →	Oct 18, 6:20 pm EDT	Mark James LittonChief Business Officer	16,520	$12.33	$203,703	99,932	−14.2%	plan?
Oct 16, 2017 MForm 4 →	Oct 18, 6:20 pm EDT	Mark James LittonChief Business Officer	16,520	$1.65	$27,258	116,452	—	plan?
Jul 18, 2017 PForm 4 →	Jul 18, 7:52 pm EDT	Wendy L YarnoDirector	5,000	$10.00	$50,000	5,000	—	plan?
Jul 18, 2017 PForm 4 →	Jul 18, 7:50 pm EDT	Stephen M DowDirector	25,000	$10.00	$250,000	307,190	+8.86%	plan?
Jun 20, 2017 SForm 4 →	Jun 22, 6:12 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	585	$20.00	$11,700	831	−41.3%	plan?
Jun 20, 2017 MForm 4 →	Jun 22, 6:12 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	585	$0.99	$579	1,416	—	plan?
May 31, 2017 AForm 4 →	Dec 18, 6:28 pm EST	John A LathamChief Scientific Officer	805	$10.90	$8,772	243,208	—	plan? late
Feb 9, 2017 SForm 4 →	Feb 13, 6:10 pm EST	Randall C SchatzmanPresident and CEO, Director	30,000	$25.03	$750,756	115,172	−20.7%	plan?
Feb 9, 2017 MForm 4 →	Feb 13, 6:10 pm EST	Randall C SchatzmanPresident and CEO, Director	30,000	$1.65	$49,500	145,172	—	plan?
Jan 18, 2017 SForm 4 →	Jan 20, 6:38 pm EST	Mark James LittonChief Business Officer	1,498	$23.10	$34,599	99,932	−1.48%	plan?
Jan 18, 2017 MForm 4 →	Jan 20, 6:38 pm EST	Mark James LittonChief Business Officer	1,498	$1.65	$2,472	101,430	—	plan?
Jan 5, 2017 SForm 4 →	Jan 9, 5:49 pm EST	Mark James LittonChief Business Officer	9,516	$23.01	$218,992	99,932	−8.69%	plan?
Jan 5, 2017 MForm 4 →	Jan 9, 5:49 pm EST	Mark James LittonChief Business Officer	9,516	$1.34	$12,741	100,432	—	plan?
Dec 1, 2016 SForm 4 →	Dec 5, 6:47 pm EST	Jeffrey T L SmithSr. VP Translational Medicine	3,000	$22.78	$68,328	831	−78.3%	plan?
Dec 1, 2016 MForm 4 →	Dec 5, 6:47 pm EST	Jeffrey T L SmithSr. VP Translational Medicine	3,000	$1.65	$4,950	3,831	—	plan?
Dec 1, 2016 SForm 4 →	Dec 5, 6:46 pm EST	John A LathamChief Scientific Officer	3,636	$22.78	$82,812	242,403	−1.48%	plan?
Dec 1, 2016 MForm 4 →	Dec 5, 6:46 pm EST	John A LathamChief Scientific Officer	3,636	$1.65	$5,999	246,039	—	plan?
Nov 30, 2016 AForm 4 →	Jan 31, 2017, 5:32 pm EST	Larry BenedictEVP and PAO	742	$20.20	$14,988	30,989	—	plan? late
Nov 30, 2016 AForm 4 →	Jan 31, 2017, 5:23 pm EST	Randall C SchatzmanPresident and CEO, Director	404	$20.20	$8,161	115,172	—	plan? late
Nov 9, 2016 SForm 4 →	Nov 14, 6:32 pm EST	John A LathamChief Scientific Officer	10,000	$30.18	$301,839	242,200	−3.97%	plan? late
Nov 9, 2016 MForm 4 →	Nov 14, 6:32 pm EST	John A LathamChief Scientific Officer	10,000	$1.65	$16,500	252,200	—	plan? late
Nov 7, 2016 SForm 4 →	Nov 9, 6:17 pm EST	Randall C SchatzmanPresident and CEO, Director	10,000	$25.16	$251,605	114,768	−8.01%	plan?
Nov 7, 2016 MForm 4 →	Nov 9, 6:17 pm EST	Randall C SchatzmanPresident and CEO, Director	10,000	$1.65	$16,500	124,768	—	plan?
Nov 1, 2016 SForm 4 →	Nov 3, 6:39 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	3,000	$24.34	$73,032	0	−100%	plan?
Nov 1, 2016 MForm 4 →	Nov 3, 6:39 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	3,000	$1.65	$4,950	3,000	—	plan?
Oct 17, 2016 SForm 4 →	Oct 19, 5:51 pm EDT	Mark James LittonChief Business Officer	6,000	$27.50	$164,998	26,000	−18.8%	plan?
Oct 3, 2016 SForm 4 →	Oct 5, 7:02 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	3,000	$31.14	$93,415	0	−100%	plan?
Oct 3, 2016 MForm 4 →	Oct 5, 7:02 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	3,000	$1.65	$4,950	3,000	—	plan?
Oct 3, 2016 SForm 4 →	Oct 5, 6:54 pm EDT	Randall C SchatzmanPresident and CEO, Director	8,181	$31.15	$254,811	114,768	−6.65%	plan?
Oct 3, 2016 MForm 4 →	Oct 5, 6:54 pm EDT	Randall C SchatzmanPresident and CEO, Director	8,181	$1.27	$10,349	122,949	—	plan?
Oct 3, 2016 SForm 4 →	Oct 5, 6:53 pm EDT	John A LathamChief Scientific Officer	10,000	$31.32	$313,152	242,200	−3.97%	plan?
Oct 3, 2016 MForm 4 →	Oct 5, 6:53 pm EDT	John A LathamChief Scientific Officer	10,000	$1.65	$16,500	252,200	—	plan?
Sep 1, 2016 SForm 4 →	Sep 6, 6:39 pm EDT	John A LathamChief Scientific Officer	10,000	$32.49	$324,949	242,200	−3.97%	plan?
Sep 1, 2016 MForm 4 →	Sep 6, 6:39 pm EDT	John A LathamChief Scientific Officer	10,000	$1.65	$16,500	252,200	—	plan?
Sep 1, 2016 SForm 4 →	Sep 6, 6:36 pm EDT	Randall C SchatzmanPresident and CEO, Director	10,000	$32.48	$324,820	114,768	−8.01%	plan?
Sep 1, 2016 MForm 4 →	Sep 6, 6:36 pm EDT	Randall C SchatzmanPresident and CEO, Director	10,000	$1.27	$12,650	124,768	—	plan?
Sep 1, 2016 SForm 4 →	Sep 6, 6:34 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	3,000	$32.49	$97,483	0	−100%	plan?
Sep 1, 2016 MForm 4 →	Sep 6, 6:34 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	3,000	$1.65	$4,950	3,000	—	plan?
Aug 15, 2016 SForm 4 →	Aug 17, 6:55 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	3,000	$31.17	$93,512	0	−100%	plan?
Aug 15, 2016 MForm 4 →	Aug 17, 6:55 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	3,000	$1.65	$4,950	3,000	—	plan?
Aug 1, 2016 SForm 4 →	Aug 3, 6:42 pm EDT	Randall C SchatzmanPresident and CEO, Director	10,000	$31.15	$311,513	114,768	−8.01%	plan?
Aug 1, 2016 MForm 4 →	Aug 3, 6:42 pm EDT	Randall C SchatzmanPresident and CEO, Director	10,000	$1.27	$12,650	124,768	—	plan?
Aug 1, 2016 SForm 4 →	Aug 3, 6:33 pm EDT	John A LathamChief Scientific Officer	6,426	$30.88	$198,464	242,200	−2.58%	plan?
Aug 1, 2016 MSForm 4 →	Aug 3, 6:33 pm EDT	John A LathamChief Scientific Officer	13,574	$9.58	$129,984	242,232	—	plan?
Jul 26, 2016 SForm 4 →	Jul 28, 6:37 pm EDT	John A LathamChief Scientific Officer	10,000	$30.14	$301,415	242,200	−3.97%	plan?
Jul 26, 2016 MForm 4 →	Jul 28, 6:37 pm EDT	John A LathamChief Scientific Officer	10,000	$1.65	$16,500	251,387	—	plan?
Jul 25, 2016 SForm 4 →	Jul 27, 6:19 pm EDT	Randall C SchatzmanPresident and CEO, Director	10,000	$28.08	$280,805	114,768	−8.01%	plan?
Jul 25, 2016 MForm 4 →	Jul 27, 6:19 pm EDT	Randall C SchatzmanPresident and CEO, Director	10,000	$1.27	$12,650	124,768	—	plan?
Jul 12, 2016 MForm 4 →	Jul 14, 7:14 pm EDT	Mark James LittonChief Business Officer	25,000	$0.385	$9,625	99,567	—	plan?
Jun 13, 2016 SForm 4 →	Jun 15, 7:02 pm EDT	Mark James LittonChief Business Officer	6,000	$28.94	$173,664	28,000	−17.6%	plan?
Jun 3, 2016 SForm 4 →	Jun 7, 7:32 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	16,090	$30.20	$485,933	0	−100%	plan?
Jun 3, 2016 MForm 4 →	Jun 7, 7:32 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	16,090	$1.27	$20,354	16,090	—	plan?
Jun 1, 2016 SForm 4 →	Jun 3, 7:16 pm EDT	Randall C SchatzmanPresident and CEO, Director	10,000	$29.65	$296,544	114,768	−8.01%	plan?
Jun 1, 2016 MForm 4 →	Jun 3, 7:16 pm EDT	Randall C SchatzmanPresident and CEO, Director	10,000	$1.27	$12,650	124,768	—	plan?
Jun 1, 2016 SForm 4 →	Jun 3, 7:11 pm EDT	John A LathamChief Scientific Officer	10,000	$30.02	$300,216	242,200	−3.97%	plan?
Jun 1, 2016 MForm 4 →	Jun 3, 7:11 pm EDT	John A LathamChief Scientific Officer	10,000	$1.65	$16,500	252,200	—	plan?
May 31, 2016 AForm 4 →	Oct 11, 4:56 pm EDT	Larry BenedictEVP and PAO	2,000	$8.50	$17,000	30,247	—	plan? late
May 27, 2016 SForm 4 →	Jun 1, 7:53 pm EDT	John A LathamChief Scientific Officer	40,000	$30.04	$1,201,619	242,200	−14.2%	plan?
May 27, 2016 MForm 4 →	Jun 1, 7:53 pm EDT	John A LathamChief Scientific Officer	40,000	$1.35	$54,100	275,799	—	plan?
May 27, 2016 SForm 4 →	Jun 1, 7:49 pm EDT	Mark James LittonChief Business Officer	25,000	$30.05	$751,259	74,567	−25.1%	plan?
May 27, 2016 MForm 4 →	Jun 1, 7:49 pm EDT	Mark James LittonChief Business Officer	25,000	$0.385	$9,625	94,287	—	plan?

Reported at this company — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Feb 6, 2019 AForm 4 →	Feb 8, 4:52 pm EST	Jeffrey T L SmithManaging Director	100,000	—	—	100,000	—
Feb 6, 2019 AForm 4 →	Feb 8, 4:51 pm EST	Erin LavelleChief Operating Officer	150,000	—	—	150,000	—
Feb 6, 2019 AForm 4 →	Feb 8, 4:47 pm EST	John A LathamChief Scientific Officer	160,000	—	—	160,000	—
Feb 6, 2019 AForm 4 →	Feb 8, 4:45 pm EST	Randal HasslerEVP, Pharmaceutical Ops.	150,000	—	—	150,000	—
Feb 6, 2019 AForm 4 →	Feb 8, 4:43 pm EST	James B BucherEVP & General Counsel	135,000	—	—	135,000	—
Feb 6, 2019 AForm 4 →	Feb 8, 4:41 pm EST	Larry BenedictEVP and PAO	100,000	—	—	100,000	—
Feb 6, 2019 AForm 4 →	Feb 8, 4:40 pm EST	Robert AzelbyPresident and CEO, Director	520,000	—	—	15,000	—
Jan 21, 2019 AForm 4/A →	Feb 1, 5:32 pm EST	Paul StreckChief Medical Officer	250,000	—	—	250,000	—
Jan 21, 2019 AForm 4 →	Jan 23, 5:23 pm EST	Paul StreckChief Medical Officer	250,000	—	—	250,000	—	amended
Dec 31, 2018 JForm 4 →	Jan 3, 2019, 4:40 pm EST	Redmile Group, LLC +1Director	18,558	$2,558,346.17	$47,477,788,223	760,753	—
Dec 12, 2018 AForm 4 →	Dec 14, 5:20 pm EST	Carlos CampoyChief Financial Officer	270,000	—	—	270,000	—
Dec 3, 2018 MForm 4 →	Dec 4, 6:39 pm EST	Jeffrey T L SmithManaging Director	5,044	—	—	0	—
Nov 25, 2018 AForm 4 →	Nov 27, 5:35 pm EST	James B BucherSr. VP & General Counsel	70,000	—	—	70,000	—
Nov 1, 2018 MForm 4 →	Nov 5, 5:47 pm EST	Jeffrey T L SmithManaging Director	5,040	—	—	5,044	—
Nov 1, 2018 MForm 4 →	Nov 5, 5:43 pm EST	John A LathamChief Scientific Officer	25,002	—	—	0	—
Oct 1, 2018 MForm 4 →	Oct 3, 6:33 pm EDT	Jeffrey T L SmithManaging Director	5,040	—	—	10,084	—
Oct 1, 2018 MForm 4 →	Oct 3, 6:31 pm EDT	John A LathamChief Scientific Officer	24,999	—	—	6,821	—
Sep 4, 2018 MForm 4 →	Sep 6, 5:08 pm EDT	Jeffrey T L SmithManaging Director	5,040	—	—	15,124	—
Sep 4, 2018 MForm 4 →	Sep 6, 5:05 pm EDT	John A LathamChief Scientific Officer	24,999	—	—	18,185	—
Aug 1, 2018 MForm 4 →	Aug 2, 5:48 pm EDT	Jeffrey T L SmithManaging Director	5,040	—	—	20,164	—
Aug 1, 2018 MForm 4 →	Aug 2, 5:40 pm EDT	John A LathamChief Scientific Officer	24,999	—	—	43,184	—
Jul 2, 2018 MForm 4 →	Jul 3, 5:28 pm EDT	Jeffrey T L SmithManaging Director	12,161	—	—	25,204	—
Jul 2, 2018 MForm 4 →	Jul 3, 5:22 pm EDT	John A LathamChief Scientific Officer	24,999	—	—	68,183	—
Jun 30, 2018 JForm 4 →	Jul 18, 4:27 pm EDT	Redmile Group, LLC +1Director	16,927	$2,333,332.21	$39,496,314,319	742,195	—	late
Jun 13, 2018 AForm 4 →	Jun 15, 4:02 pm EDT	Robert AzelbyPresident and CEO, Director	1,000,000	—	—	1,000,000	—
Jun 1, 2018 MForm 4 →	Jun 5, 5:43 pm EDT	John A LathamChief Scientific Officer	24,999	—	—	93,182	—
Jun 1, 2018 MForm 4 →	Jun 5, 5:41 pm EDT	Jeffrey T L SmithManaging Director	12,161	—	—	30,244	—
Jun 1, 2018 MForm 4 →	Jun 5, 5:40 pm EDT	Mark James LittonChief Business Officer	22,727	—	—	0	—
May 23, 2018 AForm 4 →	May 25, 5:23 pm EDT	Paul Rutherford CarterDirector	15,000	—	—	15,000	—
May 23, 2018 AForm 4 →	May 25, 5:21 pm EDT	Wendy L YarnoDirector	15,000	—	—	15,000	—
May 23, 2018 AForm 4 →	May 25, 5:19 pm EDT	Clay B SiegallDirector	15,000	—	—	15,000	—
May 23, 2018 AForm 4 →	May 25, 5:16 pm EDT	Deepika PakianathanDirector	15,000	—	—	15,000	—
May 23, 2018 AForm 4 →	May 25, 5:14 pm EDT	Alan Bruce MontgomeryDirector	15,000	—	—	15,000	—
May 23, 2018 AForm 4 →	May 25, 1:32 pm EDT	Redmile Group, LLC +1Director	15,000	—	—	15,000	—
May 16, 2018 MForm 4 →	May 18, 5:57 pm EDT	Jeffrey T L SmithManaging Director	12,161	—	—	14,242	—
Apr 25, 2018 AForm 4 →	Apr 26, 5:06 pm EDT	Redmile Group, LLC +1Director	30,000	—	—	30,000	—
Apr 23, 2018 AForm 4 →	Apr 25, 5:27 pm EDT	Eric G CarterInterim Chief Medical Officer	75,000	—	—	75,000	—
Apr 16, 2018 AForm 4 →	Apr 18, 5:10 pm EDT	Erin LavelleChief Commercial Officer	300,000	—	—	300,000	—
Mar 26, 2018 AForm 4 →	Mar 27, 6:35 pm EDT	Paul B ClevelandInterim President and CEO, Director	100,000	—	—	100,000	—
Feb 16, 2018 AForm 4 →	Feb 21, 5:46 pm EST	James B BucherSr. VP & General Counsel	70,000	—	—	70,000	—
Feb 16, 2018 AForm 4 →	Feb 21, 5:44 pm EST	Larry BenedictEVP and PAO	60,000	—	—	60,000	—
Feb 16, 2018 AForm 4 →	Feb 21, 5:42 pm EST	Elisabeth SandovalCCO & EVP, Corporate Strategy	60,000	—	—	60,000	—
Feb 16, 2018 AForm 4 →	Feb 21, 5:41 pm EST	John A LathamChief Scientific Officer	60,000	—	—	60,000	—
Feb 16, 2018 AForm 4 →	Feb 21, 5:39 pm EST	Randall C SchatzmanPresident and CEO, Director	200,000	—	—	200,000	—
Feb 16, 2018 AForm 4 →	Feb 21, 5:36 pm EST	Jeffrey T L SmithManaging Director	60,000	—	—	60,000	—
Feb 16, 2018 AForm 4 →	Feb 21, 5:34 pm EST	Randal HasslerEVP, Pharmaceutical Ops.	80,000	—	—	80,000	—
Feb 16, 2018 AForm 4 →	Feb 21, 5:31 pm EST	Mark James LittonChief Business Officer	75,000	—	—	75,000	—
Dec 20, 2017 AForm 4 →	Dec 21, 5:14 pm EST	Elisabeth SandovalChief Commercial Officer	150,000	—	—	150,000	—
Dec 14, 2017 AForm 4 →	Dec 18, 6:30 pm EST	Jeffrey T L SmithSr. VP Translational Medicine	50,000	—	—	50,000	—
Dec 14, 2017 AForm 4 →	Dec 18, 6:28 pm EST	John A LathamChief Scientific Officer	75,000	—	—	75,000	—
Dec 14, 2017 AForm 4 →	Dec 18, 6:25 pm EST	James B BucherSr. VP & General Counsel	35,000	—	—	35,000	—
Dec 14, 2017 AForm 4 →	Dec 18, 6:23 pm EST	Randal HasslerSVP, Pharmaceutical Ops	60,000	—	—	60,000	—
Nov 13, 2017 MForm 4 →	Nov 15, 5:54 pm EST	Mark James LittonChief Business Officer	16,519	—	—	0	—
Nov 1, 2017 MForm 4 →	Nov 3, 5:48 pm EDT	Clay B SiegallDirector	27,270	—	—	0	—
Oct 16, 2017 MForm 4 →	Oct 18, 6:20 pm EDT	Mark James LittonChief Business Officer	16,520	—	—	16,519	—
Jun 20, 2017 MForm 4 →	Jun 22, 6:12 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	585	—	—	40,324	—
May 24, 2017 AForm 4 →	May 26, 7:02 pm EDT	Deepika PakianathanDirector, 10% Owner	15,000	—	—	15,000	—
May 24, 2017 AForm 4 →	May 26, 6:27 pm EDT	Heather PrestonDirector	15,000	—	—	15,000	—
May 24, 2017 AForm 4 →	May 26, 6:20 pm EDT	Stephen M DowDirector	15,000	—	—	15,000	—
May 24, 2017 AForm 4 →	May 26, 6:15 pm EDT	Alan Bruce MontgomeryDirector	15,000	—	—	15,000	—
May 24, 2017 AForm 4 →	May 26, 6:12 pm EDT	Wendy L YarnoDirector	15,000	—	—	15,000	—
May 24, 2017 AForm 4 →	May 26, 6:03 pm EDT	Paul B ClevelandDirector	15,000	—	—	15,000	—
May 24, 2017 AForm 4 →	May 26, 5:55 pm EDT	Clay B SiegallDirector	15,000	—	—	15,000	—
May 24, 2017 AForm 4 →	May 26, 5:47 pm EDT	Paul Rutherford CarterDirector	15,000	—	—	15,000	—
Apr 11, 2017 AForm 4 →	Apr 13, 6:10 pm EDT	Wendy L YarnoDirector	30,000	—	—	30,000	—
Feb 9, 2017 MForm 4 →	Feb 13, 6:10 pm EST	Randall C SchatzmanPresident and CEO, Director	30,000	—	—	78,181	—
Jan 27, 2017 AForm 4 →	Jan 31, 5:33 pm EST	James B BucherSr. VP & General Counsel	50,000	—	—	50,000	—
Jan 27, 2017 AForm 4 →	Jan 31, 5:32 pm EST	Larry BenedictEVP and PAO	50,000	—	—	50,000	—
Jan 27, 2017 AForm 4 →	Jan 31, 5:31 pm EST	Randal HasslerSVP, Pharmaceutical Ops	60,000	—	—	60,000	—
Jan 27, 2017 AForm 4 →	Jan 31, 5:29 pm EST	Timothy M WhitakerChief Medical Officer	75,000	—	—	75,000	—
Jan 27, 2017 AForm 4 →	Jan 31, 5:28 pm EST	John A LathamChief Scientific Officer	95,000	—	—	95,000	—
Jan 27, 2017 AForm 4 →	Jan 31, 5:26 pm EST	Elisabeth SandovalChief Commercial Officer	75,000	—	—	75,000	—
Jan 27, 2017 AForm 4 →	Jan 31, 5:25 pm EST	Jeffrey T L SmithSr. VP Translational Medicine	85,000	—	—	85,000	—
Jan 27, 2017 AForm 4 →	Jan 31, 5:23 pm EST	Randall C SchatzmanPresident and CEO, Director	275,000	—	—	275,000	—
Jan 27, 2017 AForm 4 →	Jan 31, 5:22 pm EST	Mark James LittonChief Business Officer	60,000	—	—	60,000	—
Jan 18, 2017 MForm 4 →	Jan 20, 6:38 pm EST	Mark James LittonChief Business Officer	1,498	—	—	33,039	—
Jan 5, 2017 MForm 4 →	Jan 9, 5:49 pm EST	Mark James LittonChief Business Officer	9,516	—	—	34,537	—
Dec 1, 2016 MForm 4 →	Dec 5, 6:47 pm EST	Jeffrey T L SmithSr. VP Translational Medicine	3,000	—	—	21,363	—
Dec 1, 2016 MForm 4 →	Dec 5, 6:46 pm EST	John A LathamChief Scientific Officer	3,636	—	—	0	—
Nov 9, 2016 MForm 4 →	Nov 14, 6:32 pm EST	John A LathamChief Scientific Officer	10,000	—	—	3,636	—	late
Nov 7, 2016 MForm 4 →	Nov 9, 6:17 pm EST	Randall C SchatzmanPresident and CEO, Director	10,000	—	—	108,181	—
Nov 1, 2016 MForm 4 →	Nov 3, 6:39 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	3,000	—	—	24,363	—
Oct 6, 2016 AForm 4 →	Oct 11, 4:56 pm EDT	Larry BenedictEVP and PAO	30,000	—	—	30,000	—	late
Oct 5, 2016 AForm 4 →	Oct 7, 6:09 pm EDT	Elisabeth SandovalChief Commercial Officer	225,000	—	—	225,000	—
Oct 3, 2016 MForm 4 →	Oct 5, 7:02 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	3,000	—	—	27,363	—
Oct 3, 2016 MForm 4 →	Oct 5, 6:54 pm EDT	Randall C SchatzmanPresident and CEO, Director	8,181	—	—	0	—
Oct 3, 2016 MForm 4 →	Oct 5, 6:53 pm EDT	John A LathamChief Scientific Officer	10,000	—	—	13,636	—
Sep 1, 2016 MForm 4 →	Sep 6, 6:39 pm EDT	John A LathamChief Scientific Officer	10,000	—	—	23,636	—
Sep 1, 2016 MForm 4 →	Sep 6, 6:36 pm EDT	Randall C SchatzmanPresident and CEO, Director	10,000	—	—	8,181	—
Sep 1, 2016 MForm 4 →	Sep 6, 6:34 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	3,000	—	—	30,363	—
Aug 15, 2016 MForm 4 →	Aug 17, 6:55 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	3,000	—	—	33,363	—
Aug 1, 2016 MForm 4 →	Aug 3, 6:42 pm EDT	Randall C SchatzmanPresident and CEO, Director	10,000	—	—	18,181	—
Aug 1, 2016 MForm 4 →	Aug 3, 6:33 pm EDT	John A LathamChief Scientific Officer	10,000	—	—	33,636	—
Jul 26, 2016 MForm 4 →	Jul 28, 6:37 pm EDT	John A LathamChief Scientific Officer	10,000	—	—	43,636	—
Jul 25, 2016 MForm 4 →	Jul 27, 6:19 pm EDT	Randall C SchatzmanPresident and CEO, Director	10,000	—	—	28,181	—
Jul 14, 2016 AForm 4 →	Jul 18, 6:46 pm EDT	Timothy M WhitakerChief Medical Officer	225,000	—	—	225,000	—
Jul 12, 2016 MForm 4 →	Jul 14, 7:14 pm EDT	Mark James LittonChief Business Officer	25,000	—	—	0	—
Jun 3, 2016 MForm 4 →	Jun 7, 7:32 pm EDT	Jeffrey T L SmithSr. VP Translational Medicine	16,090	—	—	0	—
Jun 1, 2016 MForm 4 →	Jun 3, 7:16 pm EDT	Randall C SchatzmanPresident and CEO, Director	10,000	—	—	38,181	—
Jun 1, 2016 MForm 4 →	Jun 3, 7:11 pm EDT	John A LathamChief Scientific Officer	10,000	—	—	53,636	—