Company · CIK 0000875320 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

VERTEX PHARMACEUTICALS INC / MA · VRTX

Insider activity reported against this company. All insider holders · Files at: CRSP. On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market activity at this companybuys $2,878 · 1sales $662.8M · 396net −$662.8M

Reported at this company — common stock

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Feb 2, 2018 MForm 4 →	Feb 5, 5:47 pm EST	David AltshulerEVP, Global Research and CSO	1,796	$91.05	$163,526	51,557	—	plan?
Feb 2, 2018 MForm 4 →	Feb 5, 5:43 pm EST	Jeffrey ChodakewitzEVP GMDA, CMO	1,796	$91.05	$163,526	54,320	—	plan?
Feb 2, 2018 SForm 4 →	Feb 5, 5:11 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	2,156	$169.42	$365,270	41,952	−4.89%	plan?
Feb 2, 2018 MForm 4 →	Feb 5, 5:11 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	2,156	$91.05	$196,304	44,108	—	plan?
Feb 1, 2018 SForm 4 →	Feb 5, 5:43 pm EST	Jeffrey ChodakewitzEVP GMDA, CMO	3,696	$166.79	$616,465	52,524	−6.57%	plan?
Feb 1, 2018 SForm 4 →	Feb 5, 5:39 pm EST	Paul M SilvaSVP & Corp Controller	9,883	$173.50	$1,714,684	16,634	−37.3%	plan?
Feb 1, 2018 MForm 4 →	Feb 5, 5:39 pm EST	Paul M SilvaSVP & Corp Controller	9,883	$96.11	$949,864	17,923	—	plan?
Feb 1, 2018 SForm 4 →	Feb 5, 5:35 pm EST	Michael PariniEVP, CL&AO	3,450	$174.11	$600,680	25,493	−11.9%	plan?
Jan 29, 2018 SForm 4 →	Jan 30, 5:10 pm EST	Amit SachdevEVP, CRO	15,085	$170.00	$2,564,450	39,163	−27.8%	plan?
Jan 29, 2018 MForm 4 →	Jan 30, 5:10 pm EST	Amit SachdevEVP, CRO	15,085	$91.05	$1,373,489	54,248	—	plan?
Jan 24, 2018 SForm 4 →	Jan 26, 4:46 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	8,969	$169.00	$1,515,761	41,952	−17.6%	plan?
Jan 24, 2018 MForm 4 →	Jan 26, 4:46 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	8,969	$88.70	$795,522	50,921	—	plan?
Jan 23, 2018 SForm 4 →	Jan 25, 6:33 pm EST	Amit SachdevEVP, CRO	5,824	$165.00	$960,960	39,163	−12.9%	plan?
Jan 23, 2018 MForm 4 →	Jan 25, 6:33 pm EST	Amit SachdevEVP, CRO	5,824	$86.52	$503,892	44,987	—	plan?
Jan 22, 2018 SForm 4 →	Jan 24, 5:35 pm EST	Margaret G McGlynnDirector	20,000	$162.50	$3,250,000	6,217	−76.3%	plan?
Jan 22, 2018 MForm 4 →	Jan 24, 5:35 pm EST	Margaret G McGlynnDirector	20,000	$59.55	$1,191,000	16,217	—	plan?
Jan 22, 2018 SForm 4 →	Jan 24, 5:33 pm EST	Paul M SilvaSVP & Corp Controller	5,435	$164.03	$891,487	16,634	−24.6%	plan?
Jan 22, 2018 MForm 4 →	Jan 24, 5:33 pm EST	Paul M SilvaSVP & Corp Controller	5,435	$88.79	$482,556	19,642	—	plan?
Jan 22, 2018 SForm 4 →	Jan 24, 5:29 pm EST	David AltshulerEVP, Global Research and CSO	1,796	$160.00	$287,360	49,761	−3.48%	plan?
Jan 22, 2018 MForm 4 →	Jan 24, 5:29 pm EST	David AltshulerEVP, Global Research and CSO	1,796	$91.05	$163,526	51,557	—	plan?
Jan 19, 2018 SForm 4 →	Jan 23, 4:56 pm EST	Amit SachdevEVP, CRO	46,172	$158.65	$7,325,400	39,163	−54.1%	plan?
Jan 19, 2018 MForm 4 →	Jan 23, 4:56 pm EST	Amit SachdevEVP, CRO	46,172	$80.91	$3,735,932	52,913	—	plan?
Jan 16, 2018 SForm 4 →	Jan 17, 4:46 pm EST	David AltshulerEVP, Global Research and CSO	56,250	$156.99	$8,830,755	49,761	−53.1%	plan?
Jan 16, 2018 SForm 4 →	Jan 17, 4:45 pm EST	Jeffrey M LeidenCEO & President, Director	99,563	$156.99	$15,630,614	132,497	−42.9%	plan?
Jan 16, 2018 MForm 4 →	Jan 17, 4:45 pm EST	Jeffrey M LeidenCEO & President, Director	99,563	$46.72	$4,651,914	232,060	—	plan?
Jan 16, 2018 SForm 4 →	Jan 17, 4:40 pm EST	Ian F SmithEVP, COO	2,125	$157.29	$334,232	40,888	−4.94%	plan?
Jan 16, 2018 MForm 4 →	Jan 17, 4:40 pm EST	Ian F SmithEVP, COO	2,125	$96.87	$205,849	43,013	—	plan?
Jan 16, 2018 SForm 4 →	Jan 17, 4:38 pm EST	Jeffrey ChodakewitzEVP GMDA, CMO	1,719	$157.28	$270,358	54,424	−3.06%	plan?
Jan 16, 2018 MForm 4 →	Jan 17, 4:38 pm EST	Jeffrey ChodakewitzEVP GMDA, CMO	1,719	$96.87	$166,520	56,143	—	plan?
Jan 16, 2018 SForm 4 →	Jan 17, 4:34 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	2,125	$158.28	$336,345	41,952	−4.82%	plan?
Jan 16, 2018 MForm 4 →	Jan 17, 4:34 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	2,125	$96.87	$205,849	44,077	—	plan?
Jan 12, 2018 SForm 4 →	Jan 16, 5:01 pm EST	Michael PariniEVP, CL&AO	2,125	$157.16	$333,965	28,943	−6.84%	plan?
Jan 12, 2018 MForm 4 →	Jan 16, 5:01 pm EST	Michael PariniEVP, CL&AO	2,125	$90.29	$191,866	31,068	—	plan?
Jan 11, 2018 SForm 4 →	Jan 12, 4:16 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	4,250	$159.00	$675,750	41,952	−9.20%	plan?
Jan 11, 2018 MForm 4 →	Jan 12, 4:16 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	4,250	$109.14	$463,845	46,202	—	plan?
Jan 5, 2018 SForm 4 →	Jan 9, 5:33 pm EST	Sangeeta N. BhatiaDirector	10,753	$156.00	$1,677,468	3,953	−73.1%	plan?
Jan 5, 2018 MForm 4 →	Jan 9, 5:33 pm EST	Sangeeta N. BhatiaDirector	10,753	$126.68	$1,362,190	14,706	—	plan?
Jan 2, 2018 SForm 4 →	Jan 3, 4:56 pm EST	Jeffrey ChodakewitzEVP GMDA, CMO	3,438	$151.80	$521,895	54,424	−5.94%	plan?
Jan 2, 2018 MForm 4 →	Jan 3, 4:56 pm EST	Jeffrey ChodakewitzEVP GMDA, CMO	3,438	$73.51	$252,727	57,862	—	plan?
Jan 2, 2018 SForm 4 →	Jan 3, 4:49 pm EST	Thomas GraneyChief Financial Officer	777	$149.95	$116,511	8,789	−8.12%	plan?
Dec 27, 2017 SForm 4 →	Dec 28, 4:31 pm EST	Paul M SilvaSVP & Corp Controller	1,289	$152.31	$196,328	16,634	−7.19%	plan?
Dec 27, 2017 MForm 4 →	Dec 28, 4:31 pm EST	Paul M SilvaSVP & Corp Controller	1,289	$77.31	$99,653	17,923	—	plan?
Dec 20, 2017 GForm 5 →	Jan 17, 2018, 4:42 pm EST	Bruce I SachsDirector	10,000	—	—	13,398	—	plan?
Dec 11, 2017 SForm 4 →	Dec 11, 6:30 pm EST	Jeffrey M LeidenCEO & President, Director	125,000	$141.35	$17,668,896	132,497	−48.5%	plan?
Nov 15, 2017 SForm 4/A →	Dec 6, 5:40 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	48	$147.29	$7,070	41,952	−0.11%	plan?
Nov 15, 2017 SForm 4 →	Nov 17, 4:48 pm EST	David AltshulerEVP, Global Research and CSO	306	$149.12	$45,630	106,011	−0.29%	plan?
Nov 15, 2017 SForm 4 →	Nov 17, 4:46 pm EST	Paul M SilvaSVP & Corp Controller	23	$147.29	$3,388	16,634	−0.14%	plan?
Nov 15, 2017 SForm 4 →	Nov 17, 4:44 pm EST	Ian F SmithEVP, COO	7	$147.29	$1,031	40,888	−0.02%	plan?
Nov 15, 2017 SForm 4 →	Nov 17, 4:41 pm EST	Amit SachdevEVP, CRO	83	$147.29	$12,225	50,710	−0.16%	plan?
Nov 15, 2017 SForm 4 →	Nov 17, 4:37 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	221	$147.29	$32,551	41,952	−0.52%	plan? amended
Nov 6, 2017 SForm 4 →	Nov 7, 5:15 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	4,250	$148.17	$629,723	41,952	−9.20%	plan?
Nov 6, 2017 MForm 4 →	Nov 7, 5:15 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	4,250	$77.31	$328,568	46,202	—	plan?
Nov 3, 2017 SForm 4 →	Nov 7, 5:26 pm EST	Ian F SmithEVP, COO	6,405	$150.00	$960,750	40,888	−13.5%	plan?
Nov 3, 2017 MForm 4 →	Nov 7, 5:26 pm EST	Ian F SmithEVP, COO	6,405	$81.93	$524,780	45,138	—	plan?
Nov 3, 2017 SForm 4 →	Nov 7, 5:23 pm EST	Michael PariniEVP, CL&AO	2,330	$149.50	$348,335	28,809	−7.48%	plan?
Nov 3, 2017 MForm 4 →	Nov 7, 5:23 pm EST	Michael PariniEVP, CL&AO	2,330	$86.52	$201,592	31,139	—	plan?
Nov 3, 2017 SForm 4 →	Nov 7, 5:12 pm EST	Sangeeta N. BhatiaDirector	7,073	$143.05	$1,011,793	3,953	−64.1%	plan?
Nov 3, 2017 MForm 4 →	Nov 7, 5:12 pm EST	Sangeeta N. BhatiaDirector	7,073	$93.51	$661,396	11,026	—	plan?
Nov 2, 2017 SForm 4 →	Nov 6, 5:50 pm EST	Jeffrey ChodakewitzEVP GMDA, CMO	5,390	$144.71	$779,998	54,424	−9.01%	plan?
Nov 2, 2017 MForm 4 →	Nov 6, 5:50 pm EST	Jeffrey ChodakewitzEVP GMDA, CMO	5,390	$103.11	$555,775	58,018	—	plan?
Oct 31, 2017 SForm 4 →	Oct 31, 6:18 pm EDT	Ian F SmithEVP, COO	75,000	$145.06	$10,879,858	40,888	−64.7%	plan?
Oct 31, 2017 SForm 4 →	Oct 31, 6:15 pm EDT	Jeffrey ChodakewitzEVP GMDA, CMO	60,000	$145.05	$8,703,161	54,424	−52.4%	plan?
Oct 31, 2017 SForm 4 →	Oct 31, 6:12 pm EDT	Amit SachdevEVP, CRO	40,000	$145.05	$5,802,084	50,710	−44.1%	plan?
Oct 27, 2017 MForm 4 →	Oct 31, 6:16 pm EDT	Stuart A ArbuckleEVP\Chief Commercial Officer	2,125	$96.87	$205,849	119,077	—	plan?
Oct 27, 2017 SForm 4 →	Oct 31, 6:16 pm EDT	Stuart A ArbuckleEVP\Chief Commercial Officer	81,290	$144.74	$11,766,243	41,952	−66.0%	plan?
Oct 16, 2017 SForm 4 →	Oct 18, 5:41 pm EDT	Ian F SmithEVP, COO	2,125	$155.61	$330,671	115,888	−1.80%	plan?
Oct 16, 2017 MForm 4 →	Oct 18, 5:41 pm EDT	Ian F SmithEVP, COO	2,125	$96.87	$205,849	118,013	—	plan?
Oct 16, 2017 SForm 4 →	Oct 18, 5:35 pm EDT	Jeffrey ChodakewitzEVP GMDA, CMO	1,718	$155.19	$266,610	114,424	−1.48%	plan?
Oct 16, 2017 MForm 4 →	Oct 18, 5:35 pm EDT	Jeffrey ChodakewitzEVP GMDA, CMO	1,718	$96.87	$166,423	116,142	—	plan?
Oct 12, 2017 SForm 4 →	Oct 16, 4:59 pm EDT	Michael PariniEVP, CL&AO	2,125	$152.93	$324,976	28,809	−6.87%	plan?
Oct 12, 2017 MForm 4 →	Oct 16, 4:59 pm EDT	Michael PariniEVP, CL&AO	2,125	$90.29	$191,866	30,934	—	plan?
Oct 2, 2017 SForm 4 →	Oct 4, 5:01 pm EDT	Jeffrey ChodakewitzEVP GMDA, CMO	3,437	$151.64	$521,198	114,424	−2.92%	plan?
Oct 2, 2017 MForm 4 →	Oct 4, 5:01 pm EDT	Jeffrey ChodakewitzEVP GMDA, CMO	3,437	$73.51	$252,654	117,861	—	plan?
Sep 13, 2017 AForm 4 →	Sep 15, 8:28 am EDT	Thomas GraneyChief Financial Officer	9,566	—	—	9,566	—	plan?
Aug 31, 2017 SForm 4 →	Sep 5, 4:42 pm EDT	David AltshulerEVP, Global Research and CSO	1,796	$160.00	$287,360	106,011	−1.67%	plan?
Aug 31, 2017 MForm 4 →	Sep 5, 4:42 pm EDT	David AltshulerEVP, Global Research and CSO	1,796	$91.05	$163,526	107,807	—	plan?
Aug 7, 2017 SForm 4 →	Aug 9, 4:38 pm EDT	Paul M SilvaSVP & Corp Controller	1,289	$152.88	$197,062	16,634	−7.19%	plan?
Aug 7, 2017 MForm 4 →	Aug 9, 4:38 pm EDT	Paul M SilvaSVP & Corp Controller	1,289	$77.31	$99,653	17,923	—	plan?
Aug 7, 2017 SForm 4 →	Aug 9, 4:36 pm EDT	Stuart A ArbuckleEVP\Chief Commercial Officer	4,250	$152.88	$649,740	121,117	−3.39%	plan?
Aug 7, 2017 MForm 4 →	Aug 9, 4:36 pm EDT	Stuart A ArbuckleEVP\Chief Commercial Officer	4,250	$77.31	$328,568	125,367	—	plan?
Aug 7, 2017 SForm 4 →	Aug 9, 4:33 pm EDT	Ian F SmithEVP, CFO & COO	4,250	$155.39	$660,415	115,888	−3.54%	plan?
Aug 7, 2017 MForm 4 →	Aug 9, 4:33 pm EDT	Ian F SmithEVP, CFO & COO	4,250	$77.31	$328,568	120,138	—	plan?
Aug 3, 2017 SForm 4 →	Aug 4, 4:53 pm EDT	Stuart A ArbuckleEVP\Chief Commercial Officer	4,250	$155.72	$661,810	121,117	−3.39%	plan?
Aug 3, 2017 MForm 4 →	Aug 4, 4:53 pm EDT	Stuart A ArbuckleEVP\Chief Commercial Officer	4,250	$109.14	$463,845	125,367	—	plan?
Aug 3, 2017 SForm 4 →	Aug 4, 4:45 pm EDT	Michael PariniEVP, CL&AO	2,330	$155.72	$362,828	28,809	−7.48%	plan?
Aug 3, 2017 MForm 4 →	Aug 4, 4:45 pm EDT	Michael PariniEVP, CL&AO	2,330	$86.52	$201,592	31,139	—	plan?
Aug 2, 2017 SForm 4 →	Aug 4, 4:48 pm EDT	Ian F SmithEVP, CFO & COO	2,155	$154.17	$332,236	115,888	−1.83%	plan?
Aug 2, 2017 MForm 4 →	Aug 4, 4:48 pm EDT	Ian F SmithEVP, CFO & COO	2,155	$91.05	$196,213	118,043	—	plan?
Aug 2, 2017 SForm 4 →	Aug 4, 4:42 pm EDT	Jeffrey ChodakewitzEVP GMDA, CMO	5,390	$154.17	$830,960	114,424	−4.50%	plan?
Aug 2, 2017 MForm 4 →	Aug 4, 4:42 pm EDT	Jeffrey ChodakewitzEVP GMDA, CMO	5,390	$103.11	$555,775	118,018	—	plan?
Aug 2, 2017 SForm 4 →	Aug 4, 4:36 pm EDT	Paul M SilvaSVP & Corp Controller	1,289	$151.80	$195,670	16,634	−7.19%	plan?
Aug 2, 2017 MForm 4 →	Aug 4, 4:36 pm EDT	Paul M SilvaSVP & Corp Controller	1,289	$91.05	$117,363	17,923	—	plan?
Jul 31, 2017 SForm 4 →	Aug 2, 4:56 pm EDT	Jeffrey M LeidenCEO & President, Director	11,063	$152.81	$1,690,552	257,392	−4.12%	plan?
Jul 31, 2017 MForm 4 →	Aug 2, 4:56 pm EDT	Jeffrey M LeidenCEO & President, Director	11,063	$45.11	$499,052	268,455	—	plan?
Jul 31, 2017 SForm 4 →	Aug 2, 4:51 pm EDT	Ian F SmithEVP, CFO & COO	2,125	$152.88	$324,865	115,888	−1.80%	plan?
Jul 31, 2017 MForm 4 →	Aug 2, 4:51 pm EDT	Ian F SmithEVP, CFO & COO	2,125	$83.36	$177,140	118,013	—	plan?
Jul 31, 2017 SForm 4 →	Aug 2, 4:47 pm EDT	Paul M SilvaSVP & Corp Controller	860	$152.99	$131,571	16,634	−4.92%	plan?
Jul 31, 2017 MForm 4 →	Aug 2, 4:47 pm EDT	Paul M SilvaSVP & Corp Controller	860	$83.36	$71,690	17,494	—	plan?
Jul 31, 2017 SForm 4 →	Aug 2, 4:44 pm EDT	Stuart A ArbuckleEVP\Chief Commercial Officer	2,125	$152.99	$325,104	121,117	−1.72%	plan?
Jul 31, 2017 MForm 4 →	Aug 2, 4:44 pm EDT	Stuart A ArbuckleEVP\Chief Commercial Officer	2,125	$83.36	$177,140	123,242	—	plan?

Reported at this company — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Oct 12, 2016 MForm 4 →	Oct 14, 11:53 am EDT	Joshua S BogerDirector	6,500	—	—	86,000	—
Oct 5, 2016 MForm 4 →	Oct 7, 11:56 am EDT	Joshua S BogerDirector	6,500	—	—	92,500	—
Sep 28, 2016 MForm 4 →	Sep 30, 4:44 pm EDT	Joshua S BogerDirector	6,500	—	—	99,000	—
Sep 21, 2016 MForm 4 →	Sep 23, 4:50 pm EDT	Joshua S BogerDirector	6,500	—	—	105,500	—
Sep 14, 2016 MForm 4 →	Sep 16, 3:21 pm EDT	Joshua S BogerDirector	6,500	—	—	112,000	—
Sep 7, 2016 MForm 4 →	Sep 9, 12:45 pm EDT	Joshua S BogerDirector	6,500	—	—	118,500	—
Aug 31, 2016 MForm 4 →	Sep 2, 12:17 pm EDT	Joshua S BogerDirector	6,500	—	—	125,000	—
Aug 24, 2016 MForm 4 →	Aug 26, 1:51 pm EDT	Joshua S BogerDirector	6,500	—	—	131,500	—
Aug 17, 2016 MForm 4 →	Aug 18, 4:26 pm EDT	Joshua S BogerDirector	6,500	—	—	138,000	—
Aug 10, 2016 MForm 4 →	Aug 11, 4:11 pm EDT	Joshua S BogerDirector	6,500	—	—	144,500	—
Aug 3, 2016 MForm 4 →	Aug 5, 1:01 pm EDT	Joshua S BogerDirector	6,500	—	—	151,000	—
Jul 27, 2016 MForm 4 →	Jul 29, 3:26 pm EDT	Joshua S BogerDirector	6,500	—	—	157,500	—
Jul 20, 2016 MForm 4 →	Jul 22, 2:11 pm EDT	Joshua S BogerDirector	6,500	—	—	164,000	—
Jul 15, 2016 AForm 4 →	Jul 19, 4:46 pm EDT	Bruce I SachsDirector	461	$89.45	$41,250	950	—
Jul 13, 2016 MForm 4 →	Jul 15, 3:30 pm EDT	Joshua S BogerDirector	6,500	—	—	170,500	—
Jul 12, 2016 AForm 4 →	Jul 14, 4:28 pm EDT	Paul M SilvaSVP & Corp Controller	13,750	—	—	13,750	—
Jul 12, 2016 AForm 4 →	Jul 14, 4:26 pm EDT	Michael PariniEVP & CLO	34,000	—	—	34,000	—
Jul 6, 2016 MForm 4 →	Jul 8, 8:57 am EDT	Joshua S BogerDirector	5,140	—	—	0	—
Jun 29, 2016 MForm 4 →	Jun 30, 3:33 pm EDT	Joshua S BogerDirector	5,130	—	—	5,140	—
Jun 22, 2016 MForm 4 →	Jun 24, 4:24 pm EDT	Joshua S BogerDirector	5,130	—	—	10,270	—
Jun 15, 2016 MForm 4 →	Jun 17, 3:16 pm EDT	Joshua S BogerDirector	5,130	—	—	15,400	—
Jun 8, 2016 MForm 4 →	Jun 10, 3:09 pm EDT	Joshua S BogerDirector	5,130	—	—	25,660	—
Jun 1, 2016 AMForm 4 →	Jun 3, 5:11 pm EDT	Joshua S BogerDirector	12,203	—	—	30,790	—
Jun 1, 2016 AForm 4 →	Jun 3, 5:10 pm EDT	William D YoungDirector	7,073	—	—	7,073	—
Jun 1, 2016 AForm 4 →	Jun 3, 5:10 pm EDT	Elaine UllianDirector	7,073	—	—	7,073	—
Jun 1, 2016 AForm 4 →	Jun 3, 5:09 pm EDT	Bruce I SachsDirector	7,073	—	—	7,073	—
Jun 1, 2016 AForm 4 →	Jun 3, 5:08 pm EDT	Margaret G McGlynnDirector	7,073	—	—	7,073	—
Jun 1, 2016 AForm 4 →	Jun 3, 5:08 pm EDT	Yuchun LeeDirector	7,073	—	—	7,073	—
Jun 1, 2016 AForm 4 →	Jun 3, 5:07 pm EDT	Terrence C KearneyDirector	7,073	—	—	7,073	—
Jun 1, 2016 AForm 4 →	Jun 3, 5:06 pm EDT	Sangeeta N. BhatiaDirector	7,073	—	—	7,073	—
May 25, 2016 MForm 4 →	May 27, 10:15 am EDT	Joshua S BogerDirector	5,130	—	—	30,790	—
May 18, 2016 MForm 4 →	May 20, 3:30 pm EDT	Joshua S BogerDirector	5,130	—	—	35,920	—
May 11, 2016 MForm 4 →	May 13, 3:20 pm EDT	Joshua S BogerDirector	5,130	—	—	41,050	—
May 4, 2016 MForm 4 →	May 6, 3:42 pm EDT	Joshua S BogerDirector	5,130	—	—	46,180	—
Apr 27, 2016 MForm 4 →	Apr 29, 3:17 pm EDT	Joshua S BogerDirector	5,130	—	—	51,310	—
Apr 26, 2016 MForm 4 →	Apr 27, 2018, 4:38 pm EDT	Michael PariniEVP, CL&AO	40,375	—	—	29,750	—	late
Apr 20, 2016 MForm 4 →	Apr 22, 3:11 pm EDT	Joshua S BogerDirector	5,130	—	—	56,440	—
Apr 15, 2016 AForm 4 →	Apr 19, 6:17 pm EDT	Bruce I SachsDirector	489	$87.60	$42,860	489	—
Apr 13, 2016 MForm 4 →	Apr 15, 3:18 pm EDT	Joshua S BogerDirector	5,130	—	—	61,570	—
Apr 6, 2016 MForm 4 →	Apr 8, 3:15 pm EDT	Joshua S BogerDirector	5,130	—	—	66,700	—
Mar 30, 2016 MForm 4 →	Apr 1, 4:03 pm EDT	Joshua S BogerDirector	5,130	—	—	71,830	—
Mar 23, 2016 MForm 4 →	Mar 25, 3:20 pm EDT	Joshua S BogerDirector	5,130	—	—	76,960	—
Mar 16, 2016 MForm 4 →	Mar 18, 3:19 pm EDT	Joshua S BogerDirector	5,130	—	—	82,090	—
Mar 9, 2016 MForm 4 →	Mar 11, 2:50 pm EST	Joshua S BogerDirector	5,130	—	—	87,220	—
Mar 2, 2016 MForm 4 →	Mar 4, 3:21 pm EST	Joshua S BogerDirector	5,130	—	—	92,350	—
Feb 24, 2016 MForm 4 →	Feb 26, 3:39 pm EST	Joshua S BogerDirector	5,130	—	—	97,480	—
Feb 17, 2016 MForm 4 →	Feb 19, 12:08 pm EST	Joshua S BogerDirector	5,130	—	—	102,610	—
Feb 10, 2016 MForm 4 →	Feb 12, 3:00 pm EST	Joshua S BogerDirector	5,130	—	—	107,740	—
Feb 3, 2016 MForm 4 →	Feb 5, 3:12 pm EST	Joshua S BogerDirector	5,130	—	—	112,870	—
Feb 2, 2016 AForm 4 →	Feb 4, 6:54 pm EST	Ian F SmithEVP & CFO	34,482	—	—	34,482	—
Feb 2, 2016 AForm 4 →	Feb 4, 6:53 pm EST	Paul M SilvaSVP & Corp Controller	20,625	—	—	20,625	—
Feb 2, 2016 AForm 4 →	Feb 4, 6:52 pm EST	Amit SachdevEVP, Policy, Access & Value	34,482	—	—	34,482	—
Feb 2, 2016 AForm 4 →	Feb 4, 6:52 pm EST	Jeffrey M LeidenCEO & President, Director	107,276	—	—	107,276	—
Feb 2, 2016 AForm 4 →	Feb 4, 6:51 pm EST	Jeffrey ChodakewitzEVP GMDA, CMO	28,735	—	—	28,735	—
Feb 2, 2016 AForm 4 →	Feb 4, 6:51 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	34,482	—	—	34,482	—
Feb 2, 2016 AForm 4 →	Feb 4, 6:50 pm EST	David AltshulerEVP, Global Research and CSO	28,735	—	—	28,735	—
Jan 27, 2016 MForm 4 →	Jan 29, 4:08 pm EST	Joshua S BogerDirector	11,200	—	—	0	—
Jan 20, 2016 MForm 4 →	Jan 22, 4:20 pm EST	Joshua S BogerDirector	10,400	—	—	11,200	—
Jan 13, 2016 MForm 4 →	Jan 15, 4:30 pm EST	Joshua S BogerDirector	10,400	—	—	21,600	—
Jan 11, 2016 GForm 4 →	Jan 14, 9:22 pm EST	Jeffrey M LeidenCEO & President, Director	398,250	—	—	110,625	—	late
Jan 6, 2016 MForm 4 →	Jan 8, 4:03 pm EST	Joshua S BogerDirector	10,400	—	—	32,000	—
Jan 4, 2016 AForm 4 →	Jan 6, 5:07 pm EST	Michael PariniEVP & CLO	68,000	—	—	68,000	—
Jan 4, 2016 MForm 4 →	Jan 6, 5:03 pm EST	Yuchun LeeDirector	1,333	—	—	23,334	—
Dec 30, 2015 MForm 4 →	Jan 4, 2016, 4:03 pm EST	Joshua S BogerDirector	10,400	—	—	42,400	—
Dec 21, 2015 MForm 4 →	Dec 22, 10:11 am EST	Joshua S BogerDirector	10,400	—	—	52,800	—
Dec 16, 2015 MForm 4 →	Dec 18, 5:22 pm EST	Joshua S BogerDirector	10,400	—	—	63,200	—
Dec 9, 2015 MForm 4 →	Dec 11, 8:43 am EST	Joshua S BogerDirector	10,400	—	—	73,600	—
Dec 4, 2015 MForm 4 →	Dec 8, 4:17 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	4,531	—	—	13,594	—
Dec 2, 2015 MForm 4 →	Dec 4, 4:18 pm EST	Joshua S BogerDirector	10,400	—	—	84,000	—
Dec 1, 2015 MForm 4 →	Dec 3, 9:05 pm EST	Elaine UllianDirector	22,500	—	—	0	—
Dec 1, 2015 MForm 4 →	Dec 3, 9:04 pm EST	Yuchun LeeDirector	1,333	—	—	24,667	—
Dec 1, 2015 MForm 4 →	Dec 3, 9:02 pm EST	David AltshulerEVP, Global Research and CSO	5,000	—	—	7,500	—
Nov 23, 2015 MForm 4 →	Nov 25, 10:26 am EST	Joshua S BogerDirector	10,400	—	—	94,400	—
Nov 18, 2015 MForm 4 →	Nov 20, 4:13 pm EST	Jeffrey ChodakewitzEVP GMDA, CMO	10,315	—	—	30,938	—
Nov 18, 2015 MForm 4 →	Nov 20, 4:09 pm EST	Margaret G McGlynnDirector	12,500	—	—	0	—
Nov 18, 2015 MForm 4 →	Nov 20, 4:08 pm EST	Joshua S BogerDirector	10,400	—	—	104,800	—
Nov 18, 2015 MForm 4 →	Nov 20, 4:06 pm EST	David AltshulerEVP, Global Research and CSO	15,000	—	—	7,500	—
Nov 16, 2015 MForm 4 →	Nov 18, 4:32 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	3,650	—	—	38,250	—
Nov 11, 2015 MForm 4 →	Nov 13, 3:04 pm EST	Joshua S BogerDirector	10,400	—	—	115,200	—
Nov 5, 2015 MForm 4 →	Nov 9, 5:38 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	6,264	—	—	41,900	—
Nov 4, 2015 MForm 4 →	Nov 6, 1:55 pm EST	Joshua S BogerDirector	10,400	—	—	125,600	—
Nov 2, 2015 MForm 4 →	Nov 4, 4:15 pm EST	Elaine UllianDirector	20,000	—	—	0	—
Nov 2, 2015 MForm 4 →	Nov 4, 4:15 pm EST	Yuchun LeeDirector	1,334	—	—	26,000	—
Oct 28, 2015 MForm 4 →	Oct 30, 10:31 am EDT	Joshua S BogerDirector	10,400	—	—	136,000	—
Oct 21, 2015 MForm 4 →	Oct 23, 5:01 pm EDT	Joshua S BogerDirector	10,400	—	—	146,400	—
Oct 14, 2015 MForm 4 →	Oct 16, 3:31 pm EDT	Joshua S BogerDirector	10,400	—	—	156,800	—
Oct 7, 2015 MForm 4 →	Oct 9, 5:16 pm EDT	Joshua S BogerDirector	10,400	—	—	167,200	—
Oct 2, 2015 MForm 4 →	Oct 6, 4:40 pm EDT	Elaine UllianDirector	20,000	—	—	0	—
Oct 1, 2015 MForm 4 →	Oct 5, 8:16 pm EDT	Yuchun LeeDirector	1,333	—	—	27,334	—
Sep 30, 2015 MForm 4 →	Oct 1, 5:39 pm EDT	Joshua S BogerDirector	10,400	—	—	177,600	—
Sep 23, 2015 MForm 4 →	Sep 24, 3:45 pm EDT	Joshua S BogerDirector	10,400	—	—	188,000	—
Sep 16, 2015 MForm 4 →	Sep 18, 8:05 am EDT	Joshua S BogerDirector	10,400	—	—	198,400	—
Sep 9, 2015 MForm 4 →	Sep 11, 9:10 am EDT	Joshua S BogerDirector	10,400	—	—	208,800	—
Sep 4, 2015 MForm 4 →	Sep 9, 4:28 pm EDT	Stuart A ArbuckleEVP\Chief Commercial Officer	9,063	—	—	18,125	—
Sep 2, 2015 MForm 4 →	Sep 3, 5:25 pm EDT	Joshua S BogerDirector	10,400	—	—	219,200	—
Sep 1, 2015 AForm 4 →	Sep 3, 5:24 pm EDT	Yuchun LeeDirector	1,333	—	—	28,667	—
Aug 26, 2015 MForm 4 →	Aug 27, 3:46 pm EDT	Joshua S BogerDirector	10,400	—	—	229,600	—
Aug 19, 2015 MForm 4 →	Aug 20, 6:02 pm EDT	Joshua S BogerDirector	10,400	—	—	240,000	—
Aug 12, 2015 MForm 4 →	Aug 14, 2:33 pm EDT	Joshua S BogerDirector	10,400	—	—	250,400	—
Aug 5, 2015 MForm 4 →	Aug 7, 4:23 pm EDT	Joshua S BogerDirector	10,400	—	—	260,800	—

Filed by this entity as an insider elsewhere — common stock

No reported common-stock activity in this period.

Filed by this entity as an insider elsewhere — derivatives (options, RSUs, warrants)

No reported derivative activity in this period.