Company · CIK 0000875320 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

VERTEX PHARMACEUTICALS INC / MA · VRTX

Insider activity reported against this company. All insider holders · Files at: CRSP. On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market activity at this companybuys $2,878 · 1sales $662.8M · 396net −$662.8M

Reported at this company — common stock

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Sep 8, 2026 AForm 4 →	Sep 10, 4:31 pm EDT	Jasper van GrunsvenEVP, CP and NPPO	8,682	—	—	8,682	—
Aug 28, 2026 AForm 4 →	Sep 1, 4:39 pm EDT	Kristen AmbroseSVP & Chief Accounting Officer	5,000	—	—	11,624	—
Aug 27, 2026 GForm 4 →	Aug 31, 4:20 pm EDT	Bruce I SachsDirector	6,000	—	—	39,000	—
Jul 21, 2026 AForm 4 →	Jul 23, 4:15 pm EDT	Ourania TatsisEVP, Chief Reg. & Quality Off.	8,251	—	—	53,572	—
Jul 21, 2026 AForm 4 →	Jul 23, 4:13 pm EDT	Amit SachdevEVP Chief Patient & Ext Af Off	8,251	—	—	66,512	—
Jul 2, 2026 SForm 4 →	Jul 7, 4:15 pm EDT	Ourania TatsisEVP, Chief Reg. & Quality Off.	1,500	$524.99	$787,485	45,321	−3.20%	10b5-1
Jul 2, 2026 SForm 4 →	Jul 7, 4:08 pm EDT	Duncan McKechnieEVP, Chief Commercial Officer	1,541	$519.00	$799,779	11,001	−12.3%	10b5-1
Jul 1, 2026 SForm 4 →	Jul 6, 4:13 pm EDT	Joy LiuEVP and Chief Legal Officer	828	$502.71	$416,244	19,131	−4.15%	10b5-1
Jun 26, 2026 SForm 4 →	Jun 30, 4:09 pm EDT	Carmen BozicEVP and CMO	596	$482.50	$287,570	15,337	−3.74%	10b5-1
Jun 18, 2026 SForm 4 →	Jun 23, 4:08 pm EDT	Carmen BozicEVP and CMO	1,020	$462.17	$471,413	15,933	−6.02%	10b5-1
Jun 15, 2026 SForm 4 →	Jun 17, 4:12 pm EDT	Carmen BozicEVP and CMO	4,062	$450.00	$1,827,900	16,953	−19.3%	10b5-1
Jun 5, 2026 SForm 4 →	Jun 9, 4:24 pm EDT	Carmen BozicEVP and CMO	1,745	$450.00	$785,250	21,015	−7.67%	10b5-1
Jun 1, 2026 SForm 4 →	Jun 3, 4:06 pm EDT	Joy LiuEVP and Chief Legal Officer	828	$439.91	$364,245	19,959	−3.98%	10b5-1
Feb 21, 2019 AForm 4 →	Feb 22, 4:12 pm EST	Lloyd CarneyDirector	2,161	—	—	2,161	—	plan?
Feb 19, 2019 SForm 4 →	Feb 21, 4:27 pm EST	Paul M SilvaSVP & Interim CFO	2,812	$186.97	$525,747	17,759	−13.7%	plan?
Feb 19, 2019 SForm 4 →	Feb 21, 4:26 pm EST	Michael PariniEVP, CL&AO	5,624	$186.98	$1,051,585	35,003	−13.8%	plan?
Feb 19, 2019 SForm 4 →	Feb 21, 4:24 pm EST	Jeffrey M LeidenCEO & President, Director	20,997	$186.98	$3,926,113	106,195	−16.5%	plan?
Feb 19, 2019 SForm 4 →	Feb 21, 4:22 pm EST	Reshma KewalramaniEVP and CMO	1,488	$186.94	$278,163	13,736	−9.77%	plan?
Feb 19, 2019 SForm 4 →	Feb 21, 4:21 pm EST	David AltshulerEVP, Global Research and CSO	5,624	$187.00	$1,051,716	31,553	−15.1%	plan?
Feb 11, 2019 SForm 4 →	Feb 13, 4:40 pm EST	Amit SachdevEVP, CRO	35,095	$180.06	$6,319,216	40,165	−46.6%	plan?
Feb 11, 2019 SForm 4 →	Feb 13, 4:39 pm EST	Jeffrey M LeidenCEO & President, Director	111,431	$180.24	$20,083,804	127,192	−46.7%	plan?
Feb 11, 2019 SForm 4 →	Feb 13, 4:37 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	33,073	$180.21	$5,959,969	38,864	−46.0%	plan?
Feb 11, 2019 SForm 4 →	Feb 13, 4:36 pm EST	David AltshulerEVP, Global Research and CSO	32,956	$180.22	$5,939,188	37,177	−47.0%	plan?
Feb 11, 2019 SForm 4 →	Feb 13, 4:33 pm EST	Michael PariniEVP, CL&AO	12,136	$180.22	$2,187,190	40,627	−23.0%	plan?
Feb 11, 2019 SForm 4 →	Feb 13, 4:27 pm EST	Paul M SilvaSVP & Interim CFO	4,215	$180.16	$759,367	20,571	−17.0%	plan?
Feb 6, 2019 AForm 4 →	Feb 8, 4:51 pm EST	Amit SachdevEVP, CRO	37,223	—	—	75,260	—	plan?
Feb 6, 2019 AForm 4 →	Feb 8, 4:50 pm EST	Paul M SilvaSVP & Interim CFO	12,137	—	—	24,786	—	plan?
Feb 6, 2019 AForm 4 →	Feb 8, 4:48 pm EST	Jeffrey M LeidenCEO & President, Director	113,758	—	—	238,623	—	plan?
Feb 6, 2019 AForm 4 →	Feb 8, 4:43 pm EST	Michael PariniEVP, CL&AO	16,604	—	—	52,763	—	plan?
Feb 6, 2019 AForm 4 →	Feb 8, 4:39 pm EST	Reshma KewalramaniEVP and CMO	13,315	—	—	15,224	—	plan?
Feb 6, 2019 AForm 4 →	Feb 8, 4:37 pm EST	David AltshulerEVP, Global Research and CSO	31,020	—	—	70,133	—	plan?
Feb 6, 2019 AForm 4 →	Feb 8, 4:33 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	35,535	—	—	71,937	—	plan?
Feb 6, 2019 SForm 4 →	Feb 7, 4:04 pm EST	Paul M SilvaSVP & Interim CFO	1,289	$193.00	$248,777	12,649	−9.25%	plan?
Feb 6, 2019 MForm 4 →	Feb 7, 4:04 pm EST	Paul M SilvaSVP & Interim CFO	1,289	$91.05	$117,363	13,938	—	plan?
Feb 4, 2019 SForm 4 →	Feb 6, 4:51 pm EST	Amit SachdevEVP, CRO	12,722	$186.86	$2,377,296	38,037	−25.1%	plan?
Feb 4, 2019 MForm 4 →	Feb 6, 4:51 pm EST	Amit SachdevEVP, CRO	4,097	$88.90	$364,235	48,817	—	plan?
Feb 4, 2019 SForm 4 →	Feb 6, 4:50 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	18,309	$186.20	$3,409,082	36,402	−33.5%	plan?
Feb 4, 2019 MForm 4 →	Feb 6, 4:50 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	7,959	$99.97	$795,657	54,711	—	plan?
Feb 4, 2019 SForm 4 →	Feb 6, 4:49 pm EST	Paul M SilvaSVP & Interim CFO	4,247	$187.02	$794,273	12,649	−25.1%	plan?
Feb 4, 2019 MForm 4 →	Feb 6, 4:49 pm EST	Paul M SilvaSVP & Interim CFO	809	$86.52	$69,995	16,896	—	plan?
Feb 4, 2019 SForm 4 →	Feb 6, 4:47 pm EST	Jeffrey M LeidenCEO & President, Director	32,250	$186.35	$6,009,682	124,865	−20.5%	plan?
Feb 4, 2019 SForm 4 →	Feb 6, 4:46 pm EST	David AltshulerEVP, Global Research and CSO	4,126	$189.19	$780,598	39,113	−9.54%	plan?
Feb 4, 2019 MForm 4 →	Feb 6, 4:46 pm EST	David AltshulerEVP, Global Research and CSO	4,126	$88.49	$365,117	41,443	—	plan?
Feb 4, 2019 SForm 4 →	Feb 6, 4:45 pm EST	Michael PariniEVP, CL&AO	2,330	$189.19	$440,813	36,159	−6.05%	plan?
Feb 4, 2019 MForm 4 →	Feb 6, 4:45 pm EST	Michael PariniEVP, CL&AO	2,330	$86.52	$201,592	38,489	—	plan?
Feb 1, 2019 SForm 4 →	Feb 4, 4:05 pm EST	Michael PariniEVP, CL&AO	3,450	$190.92	$658,674	36,159	−8.71%	plan?
Jan 22, 2019 SForm 4 →	Jan 24, 4:47 pm EST	Michael PariniEVP, CL&AO	3,668	$195.00	$715,260	39,609	−8.48%	plan?
Jan 22, 2019 MForm 4 →	Jan 24, 4:47 pm EST	Michael PariniEVP, CL&AO	3,668	$155.57	$570,631	43,277	—	plan?
Jan 22, 2019 SForm 4 →	Jan 24, 4:46 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	2,125	$193.48	$411,145	46,752	−4.35%	plan?
Jan 22, 2019 MForm 4 →	Jan 24, 4:46 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	2,125	$131.89	$280,266	48,877	—	plan?
Jan 22, 2019 SForm 4 →	Jan 24, 4:45 pm EST	David AltshulerEVP, Global Research and CSO	2,125	$193.48	$411,145	39,113	−5.15%	plan?
Jan 22, 2019 MForm 4 →	Jan 24, 4:45 pm EST	David AltshulerEVP, Global Research and CSO	2,125	$131.89	$280,266	41,238	—	plan?
Jan 18, 2019 SForm 4 →	Jan 22, 4:07 pm EST	David AltshulerEVP, Global Research and CSO	1,223	$194.62	$238,020	39,113	−3.03%	plan?
Jan 18, 2019 MForm 4 →	Jan 22, 4:07 pm EST	David AltshulerEVP, Global Research and CSO	1,223	$155.70	$190,421	40,336	—	plan?
Jan 17, 2019 SForm 4 →	Jan 18, 4:18 pm EST	Paul M SilvaSVP & Corp Controller	3,007	$190.62	$573,182	16,087	−15.7%	plan?
Jan 17, 2019 MForm 4 →	Jan 18, 4:18 pm EST	Paul M SilvaSVP & Corp Controller	3,007	$90.62	$272,482	16,946	—	plan?
Jan 14, 2019 SForm 4 →	Jan 15, 4:03 pm EST	Michael PariniEVP, CL&AO	2,125	$186.71	$396,759	39,609	−5.09%	plan?
Jan 14, 2019 MForm 4 →	Jan 15, 4:03 pm EST	Michael PariniEVP, CL&AO	2,125	$90.29	$191,866	41,734	—	plan?
Jan 4, 2019 SForm 4 →	Jan 7, 4:02 pm EST	Michael PariniEVP, CL&AO	4,250	$165.90	$705,075	39,609	−9.69%	plan?
Jan 4, 2019 MForm 4 →	Jan 7, 4:02 pm EST	Michael PariniEVP, CL&AO	4,250	$122.45	$520,413	43,859	—	plan?
Dec 28, 2018 GForm 4 →	Jan 2, 2019, 4:58 pm EST	Bruce I SachsDirector	10,000	—	—	13,011	—	plan?
Dec 6, 2018 MForm 4 →	Dec 7, 4:06 pm EST	Bruce I SachsDirector	10,000	$34.24	$342,400	23,011	—	plan?
Dec 3, 2018 SForm 4 →	Dec 4, 4:04 pm EST	Paul M SilvaSVP & Corp Controller	809	$186.52	$150,895	16,087	−4.79%	plan?
Dec 3, 2018 MForm 4 →	Dec 4, 4:04 pm EST	Paul M SilvaSVP & Corp Controller	809	$86.52	$69,995	16,896	—	plan?
Nov 15, 2018 SForm 4 →	Nov 19, 5:52 pm EST	Paul M SilvaSVP & Corp Controller	12	$163.75	$1,965	16,087	−0.07%	plan?
Nov 15, 2018 SForm 4 →	Nov 19, 5:47 pm EST	Michael PariniEVP, CL&AO	90	$163.75	$14,738	39,609	−0.23%	plan?
Nov 15, 2018 SForm 4 →	Nov 19, 5:34 pm EST	Amit SachdevEVP, CRO	61	$163.75	$9,989	46,662	−0.13%	plan?
Nov 15, 2018 SForm 4 →	Nov 19, 5:28 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	29	$163.75	$4,749	46,752	−0.06%	plan?
Nov 15, 2018 SForm 4 →	Nov 19, 5:23 pm EST	David AltshulerEVP, Global Research and CSO	100	$163.75	$16,375	39,113	−0.26%	plan?
Nov 7, 2018 SForm 4 →	Nov 8, 4:26 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	2,125	$179.00	$380,375	46,752	−4.35%	plan?
Nov 7, 2018 MForm 4 →	Nov 8, 4:26 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	2,125	$131.89	$280,266	48,877	—	plan?
Nov 7, 2018 SForm 4 →	Nov 8, 4:18 pm EST	David AltshulerEVP, Global Research and CSO	2,125	$181.89	$386,516	39,113	−5.15%	plan?
Nov 7, 2018 MForm 4 →	Nov 8, 4:18 pm EST	David AltshulerEVP, Global Research and CSO	2,125	$131.89	$280,266	41,238	—	plan?
Nov 5, 2018 SForm 4 →	Nov 6, 4:32 pm EST	Michael PariniEVP, CL&AO	2,330	$172.08	$400,946	39,609	−5.56%	plan?
Nov 5, 2018 MForm 4 →	Nov 6, 4:32 pm EST	Michael PariniEVP, CL&AO	2,330	$86.52	$201,592	41,939	—	plan?
Nov 5, 2018 SForm 4 →	Nov 6, 4:24 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	5,803	$172.08	$998,580	46,752	−11.0%	plan?
Nov 5, 2018 MForm 4 →	Nov 6, 4:24 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	5,803	$103.09	$598,211	48,305	—	plan?
Nov 2, 2018 SForm 4 →	Nov 6, 4:45 pm EST	Amit SachdevEVP, CRO	4,096	$173.27	$709,709	46,662	−8.07%	plan?
Nov 2, 2018 MForm 4 →	Nov 6, 4:45 pm EST	Amit SachdevEVP, CRO	4,096	$88.90	$364,148	48,603	—	plan?
Nov 2, 2018 SForm 4 →	Nov 6, 4:11 pm EST	David AltshulerEVP, Global Research and CSO	4,126	$173.51	$715,893	39,113	−9.54%	plan?
Nov 2, 2018 MForm 4 →	Nov 6, 4:11 pm EST	David AltshulerEVP, Global Research and CSO	4,126	$88.49	$365,117	41,443	—	plan?
Nov 2, 2018 SForm 4 →	Nov 5, 4:52 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	2,155	$175.36	$377,901	46,752	−4.41%	plan?
Nov 2, 2018 MForm 4 →	Nov 5, 4:52 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	2,155	$91.05	$196,213	48,907	—	plan?
Oct 12, 2018 SForm 4 →	Oct 16, 4:29 pm EDT	Michael PariniEVP, CL&AO	2,125	$177.20	$376,550	39,609	−5.09%	plan?
Oct 12, 2018 MForm 4 →	Oct 16, 4:29 pm EDT	Michael PariniEVP, CL&AO	2,125	$90.29	$191,866	41,734	—	plan?
Oct 8, 2018 SForm 4 →	Oct 9, 4:50 pm EDT	Reshma KewalramaniEVP and CMO	2,305	$186.95	$430,920	1,909	−54.7%	plan?
Oct 4, 2018 SForm 4 →	Oct 5, 5:35 pm EDT	Michael PariniEVP, CL&AO	4,250	$191.58	$814,215	39,609	−9.69%	plan?
Oct 4, 2018 MForm 4 →	Oct 5, 5:35 pm EDT	Michael PariniEVP, CL&AO	4,250	$122.45	$520,413	43,859	—	plan?
Oct 3, 2018 SForm 4 →	Oct 5, 5:28 pm EDT	Sangeeta N. BhatiaDirector	6,818	$192.13	$1,309,942	4,879	−58.3%	plan?
Oct 3, 2018 MForm 4 →	Oct 5, 5:28 pm EDT	Sangeeta N. BhatiaDirector	6,818	$126.38	$861,650	9,579	—	plan?
Oct 1, 2018 SForm 4 →	Oct 2, 4:30 pm EDT	David AltshulerEVP, Global Research and CSO	2,445	$194.62	$475,846	39,113	−5.88%	plan?
Oct 1, 2018 MForm 4 →	Oct 2, 4:30 pm EDT	David AltshulerEVP, Global Research and CSO	2,445	$155.57	$380,369	41,558	—	plan?
Oct 1, 2018 SForm 4 →	Oct 2, 4:24 pm EDT	Thomas GraneyChief Financial Officer	1,076	$193.24	$207,926	12,430	−7.97%	plan?
Aug 28, 2018 SForm 4 →	Aug 30, 4:07 pm EDT	David AltshulerEVP, Global Research and CSO	2,125	$181.89	$386,516	39,113	−5.15%	plan?
Aug 28, 2018 MForm 4 →	Aug 30, 4:07 pm EDT	David AltshulerEVP, Global Research and CSO	2,125	$131.89	$280,266	41,238	—	plan?
Aug 3, 2018 SForm 4 →	Aug 7, 4:46 pm EDT	Michael PariniEVP, CL&AO	2,330	$174.20	$405,886	39,609	−5.56%	plan?
Aug 3, 2018 MForm 4 →	Aug 7, 4:46 pm EDT	Michael PariniEVP, CL&AO	2,330	$86.52	$201,592	41,939	—	plan?
Aug 2, 2018 SForm 4 →	Aug 6, 6:19 pm EDT	Amit SachdevEVP, CRO	4,097	$175.96	$720,902	46,662	−8.07%	plan?
Aug 2, 2018 MForm 4 →	Aug 6, 6:19 pm EDT	Amit SachdevEVP, CRO	4,097	$88.90	$364,235	48,604	—	plan?
Aug 2, 2018 SForm 4 →	Aug 6, 5:42 pm EDT	David AltshulerEVP, Global Research and CSO	4,126	$174.37	$719,450	39,113	−9.54%	plan?

Reported at this company — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake
Jul 15, 2026 AForm 4 →	Jul 17, 4:06 pm EDT	Bruce I SachsDirector	100	$475.28	$47,500	15,772	—
Jul 15, 2026 AForm 4 →	Jul 17, 4:05 pm EDT	Alan M GarberDirector	32	$475.28	$15,000	65	—
Feb 6, 2019 AForm 4 →	Feb 8, 4:51 pm EST	Amit SachdevEVP, CRO	25,026	—	—	25,026	—
Feb 6, 2019 AForm 4 →	Feb 8, 4:50 pm EST	Paul M SilvaSVP & Interim CFO	7,449	—	—	7,449	—
Feb 6, 2019 AForm 4 →	Feb 8, 4:48 pm EST	Jeffrey M LeidenCEO & President, Director	72,647	—	—	72,647	—
Feb 6, 2019 AForm 4 →	Feb 8, 4:43 pm EST	Michael PariniEVP, CL&AO	20,855	—	—	20,855	—
Feb 6, 2019 AForm 4 →	Feb 8, 4:39 pm EST	Reshma KewalramaniEVP and CMO	25,026	—	—	25,026	—
Feb 6, 2019 AForm 4 →	Feb 8, 4:37 pm EST	David AltshulerEVP, Global Research and CSO	20,855	—	—	20,855	—
Feb 6, 2019 AForm 4 →	Feb 8, 4:33 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	25,026	—	—	25,026	—
Feb 6, 2019 MForm 4 →	Feb 7, 4:04 pm EST	Paul M SilvaSVP & Interim CFO	1,289	—	—	5,157	—
Feb 4, 2019 MForm 4 →	Feb 6, 4:51 pm EST	Amit SachdevEVP, CRO	4,097	$88.90	$364,235	8,622	—
Feb 4, 2019 MForm 4 →	Feb 6, 4:50 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	7,959	—	—	12,426	—
Feb 4, 2019 MForm 4 →	Feb 6, 4:49 pm EST	Paul M SilvaSVP & Interim CFO	809	—	—	6,472	—
Feb 4, 2019 MForm 4 →	Feb 6, 4:46 pm EST	David AltshulerEVP, Global Research and CSO	4,126	—	—	18,639	—
Feb 4, 2019 MForm 4 →	Feb 6, 4:45 pm EST	Michael PariniEVP, CL&AO	2,330	—	—	18,639	—
Jan 22, 2019 MForm 4 →	Jan 24, 4:47 pm EST	Michael PariniEVP, CL&AO	3,668	—	—	15,898	—
Jan 22, 2019 MForm 4 →	Jan 24, 4:46 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	2,125	—	—	4,250	—
Jan 22, 2019 MForm 4 →	Jan 24, 4:45 pm EST	David AltshulerEVP, Global Research and CSO	2,125	—	—	4,250	—
Jan 18, 2019 MForm 4 →	Jan 22, 4:07 pm EST	David AltshulerEVP, Global Research and CSO	1,223	—	—	15,898	—
Jan 17, 2019 MForm 4 →	Jan 18, 4:18 pm EST	Paul M SilvaSVP & Corp Controller	3,007	—	—	5,157	—
Jan 15, 2019 AForm 4 →	Jan 16, 4:52 pm EST	Bruce I SachsDirector	243	$184.90	$45,000	9,330	—
Jan 14, 2019 MForm 4 →	Jan 15, 4:03 pm EST	Michael PariniEVP, CL&AO	2,125	—	—	12,750	—
Jan 4, 2019 MForm 4 →	Jan 7, 4:02 pm EST	Michael PariniEVP, CL&AO	4,250	—	—	17,000	—
Dec 6, 2018 MForm 4 →	Dec 7, 4:06 pm EST	Bruce I SachsDirector	10,000	—	—	0	—
Dec 3, 2018 MForm 4 →	Dec 4, 4:04 pm EST	Paul M SilvaSVP & Corp Controller	809	—	—	7,281	—
Nov 7, 2018 MForm 4 →	Nov 8, 4:26 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	2,125	—	—	6,375	—
Nov 7, 2018 MForm 4 →	Nov 8, 4:18 pm EST	David AltshulerEVP, Global Research and CSO	2,125	—	—	6,375	—
Nov 5, 2018 MForm 4 →	Nov 6, 4:32 pm EST	Michael PariniEVP, CL&AO	2,330	—	—	20,969	—
Nov 5, 2018 MForm 4 →	Nov 6, 4:24 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	5,803	—	—	13,980	—
Nov 2, 2018 MForm 4 →	Nov 6, 4:45 pm EST	Amit SachdevEVP, CRO	4,096	—	—	17,475	—
Nov 2, 2018 MForm 4 →	Nov 6, 4:11 pm EST	David AltshulerEVP, Global Research and CSO	4,126	—	—	20,969	—
Nov 2, 2018 MForm 4 →	Nov 5, 4:52 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	2,155	—	—	10,776	—
Oct 15, 2018 AForm 4 →	Oct 17, 9:44 am EDT	Bruce I SachsDirector	251	$179.29	$45,000	9,087	—
Oct 12, 2018 MForm 4 →	Oct 16, 4:29 pm EDT	Michael PariniEVP, CL&AO	2,125	—	—	14,875	—
Oct 4, 2018 MForm 4 →	Oct 5, 5:35 pm EDT	Michael PariniEVP, CL&AO	4,250	—	—	21,250	—
Oct 3, 2018 MForm 4 →	Oct 5, 5:28 pm EDT	Sangeeta N. BhatiaDirector	6,818	—	—	14,547	—
Oct 1, 2018 MForm 4 →	Oct 2, 4:30 pm EDT	David AltshulerEVP, Global Research and CSO	2,445	—	—	17,121	—
Aug 28, 2018 MForm 4 →	Aug 30, 4:07 pm EDT	David AltshulerEVP, Global Research and CSO	2,125	—	—	8,500	—
Aug 3, 2018 MForm 4 →	Aug 7, 4:46 pm EDT	Michael PariniEVP, CL&AO	2,330	—	—	23,299	—
Aug 2, 2018 MForm 4 →	Aug 6, 6:19 pm EDT	Amit SachdevEVP, CRO	4,097	—	—	19,416	—
Aug 2, 2018 MForm 4 →	Aug 6, 5:42 pm EDT	David AltshulerEVP, Global Research and CSO	4,126	—	—	23,299	—
Aug 2, 2018 MForm 4 →	Aug 6, 5:38 pm EDT	Paul M SilvaSVP & Corp Controller	2,098	—	—	8,090	—
Aug 2, 2018 MForm 4 →	Aug 6, 5:21 pm EDT	Stuart A ArbuckleEVP\Chief Commercial Officer	10,083	—	—	15,533	—
Jul 16, 2018 MForm 4 →	Jul 18, 5:44 pm EDT	Paul M SilvaSVP & Corp Controller	860	—	—	0	—
Jul 16, 2018 MForm 4 →	Jul 18, 5:32 pm EDT	David AltshulerEVP, Global Research and CSO	23,375	—	—	10,625	—
Jul 16, 2018 AForm 4 →	Jul 18, 5:23 pm EDT	Bruce I SachsDirector	249	$180.97	$45,000	8,836	—
Jul 13, 2018 MForm 4 →	Jul 17, 6:30 pm EDT	Amit SachdevEVP, CRO	13,750	—	—	0	—
Jul 13, 2018 MForm 4 →	Jul 17, 6:23 pm EDT	Stuart A ArbuckleEVP\Chief Commercial Officer	8,500	—	—	0	—
Jul 12, 2018 MForm 4 →	Jul 16, 4:37 pm EDT	Michael PariniEVP, CL&AO	2,125	—	—	17,000	—
Jul 12, 2018 MForm 4 →	Jul 16, 4:19 pm EDT	Paul M SilvaSVP & Corp Controller	860	—	—	6,875	—
Jul 5, 2018 MForm 4 →	Jul 9, 6:14 pm EDT	Michael PariniEVP, CL&AO	4,250	—	—	25,500	—
Jun 29, 2018 MForm 4 →	Jul 3, 4:29 pm EDT	David AltshulerEVP, Global Research and CSO	13,445	—	—	25,629	—
Jun 29, 2018 MForm 4 →	Jul 3, 4:25 pm EDT	Ian F SmithEVP, COO	23,375	—	—	10,625	—
Jun 29, 2018 MForm 4 →	Jul 3, 4:20 pm EDT	Stuart A ArbuckleEVP\Chief Commercial Officer	3,708	—	—	17,086	—
Jun 29, 2018 MForm 4 →	Jul 3, 4:16 pm EDT	Paul M SilvaSVP & Corp Controller	2,957	—	—	8,899	—
Jun 29, 2018 MForm 4 →	Jul 3, 4:12 pm EDT	Amit SachdevEVP, CRO	4,096	—	—	15,086	—
Jun 22, 2018 MForm 4 →	Jun 26, 5:20 pm EDT	Stuart A ArbuckleEVP\Chief Commercial Officer	4,250	—	—	12,750	—
Jun 22, 2018 MForm 4 →	Jun 26, 5:18 pm EDT	Ian F SmithEVP, COO	4,250	—	—	12,750	—
Jun 22, 2018 MForm 4 →	Jun 26, 5:18 pm EDT	Jeffrey M LeidenCEO & President, Director	106,500	—	—	0	—
Jun 1, 2018 AForm 4 →	Jun 5, 5:45 pm EDT	Margaret G McGlynnDirector	5,417	—	—	2,188	—
Jun 1, 2018 AForm 4 →	Jun 5, 5:39 pm EDT	Sangeeta N. BhatiaDirector	3,229	—	—	3,229	—
Jun 1, 2018 AForm 4 →	Jun 5, 5:32 pm EDT	Bruce I SachsDirector	5,417	—	—	8,587	—
Jun 1, 2018 AForm 4 →	Jun 5, 5:13 pm EDT	Alan M GarberDirector	3,229	—	—	3,229	—
Jun 1, 2018 AForm 4 →	Jun 5, 4:58 pm EDT	Terrence C KearneyDirector	3,229	—	—	3,229	—
Jun 1, 2018 AForm 4 →	Jun 5, 4:48 pm EDT	Yuchun LeeDirector	3,229	—	—	3,229	—
Jun 1, 2018 AForm 4 →	Jun 5, 4:38 pm EDT	Elaine UllianDirector	3,229	—	—	3,229	—
Jun 1, 2018 AForm 4 →	Jun 5, 4:30 pm EDT	William D YoungDirector	3,229	—	—	3,229	—
May 11, 2018 MForm 4 →	May 15, 4:21 pm EDT	Ian F SmithEVP, COO	4,096	—	—	21,358	—
May 3, 2018 MForm 4 →	May 4, 4:23 pm EDT	Michael PariniEVP, CL&AO	2,330	—	—	25,629	—
Apr 25, 2018 MForm 4 →	Apr 27, 4:37 pm EDT	Ian F SmithEVP, COO	67,297	—	—	17,000	—
Apr 18, 2018 MForm 4 →	Apr 19, 5:37 pm EDT	Paul M SilvaSVP & Corp Controller	859	—	—	7,735	—
Apr 16, 2018 AForm 4 →	Apr 18, 2:51 pm EDT	Bruce I SachsDirector	280	$160.89	$45,000	6,399	—
Apr 16, 2018 MForm 4 →	Apr 18, 2:50 pm EDT	Stuart A ArbuckleEVP\Chief Commercial Officer	2,125	—	—	2,125	—
Mar 9, 2018 MForm 4 →	Mar 12, 5:36 pm EDT	Amit SachdevEVP, CRO	13,750	—	—	13,750	—
Mar 2, 2018 MForm 4 →	Mar 5, 6:13 pm EST	Margaret G McGlynnDirector	10,000	—	—	10,000	—
Feb 26, 2018 MForm 4 →	Feb 28, 9:30 am EST	Amit SachdevEVP, CRO	2,155	—	—	17,242	—
Feb 26, 2018 MForm 4 →	Feb 28, 9:22 am EST	Stuart A ArbuckleEVP\Chief Commercial Officer	1,554	—	—	18,639	—
Feb 6, 2018 AForm 4 →	Feb 8, 6:33 pm EST	Paul M SilvaSVP & Corp Controller	9,783	—	—	9,783	—
Feb 6, 2018 AForm 4 →	Feb 8, 6:28 pm EST	Ian F SmithEVP, COO	19,566	—	—	19,566	—
Feb 6, 2018 AForm 4 →	Feb 8, 6:23 pm EST	Thomas GraneyChief Financial Officer	10,436	—	—	10,436	—
Feb 6, 2018 AForm 4 →	Feb 8, 6:17 pm EST	Michael PariniEVP, CL&AO	19,566	—	—	19,566	—
Feb 6, 2018 AForm 4 →	Feb 8, 6:10 pm EST	Amit SachdevEVP, CRO	23,479	—	—	23,479	—
Feb 6, 2018 AForm 4 →	Feb 8, 6:07 pm EST	Jeffrey M LeidenCEO & President, Director	73,046	—	—	73,046	—
Feb 6, 2018 AForm 4 →	Feb 8, 5:58 pm EST	David AltshulerEVP, Global Research and CSO	19,566	—	—	19,566	—
Feb 6, 2018 AForm 4 →	Feb 8, 5:53 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	19,566	—	—	19,566	—
Feb 6, 2018 AForm 4 →	Feb 8, 5:49 pm EST	Jeffrey ChodakewitzEVP GMDA, CMO	23,479	—	—	23,479	—
Feb 5, 2018 MForm 4 →	Feb 7, 6:26 pm EST	Amit SachdevEVP, CRO	4,520	—	—	0	—
Feb 5, 2018 MForm 4 →	Feb 7, 6:16 pm EST	Jeffrey ChodakewitzEVP GMDA, CMO	3,594	—	—	14,375	—
Feb 5, 2018 MForm 4 →	Feb 7, 5:56 pm EST	Michael PariniEVP, CL&AO	2,330	—	—	27,959	—
Feb 5, 2018 MForm 4 →	Feb 7, 5:46 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	8,500	—	—	17,000	—
Feb 5, 2018 MForm 4 →	Feb 7, 5:37 pm EST	Paul M SilvaSVP & Corp Controller	2,098	—	—	9,708	—
Feb 2, 2018 MForm 4 →	Feb 5, 5:47 pm EST	David AltshulerEVP, Global Research and CSO	1,796	—	—	14,368	—
Feb 2, 2018 MForm 4 →	Feb 5, 5:43 pm EST	Jeffrey ChodakewitzEVP GMDA, CMO	1,796	—	—	14,368	—
Feb 2, 2018 MForm 4 →	Feb 5, 5:11 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	2,156	—	—	17,241	—
Feb 1, 2018 MForm 4 →	Feb 5, 5:39 pm EST	Paul M SilvaSVP & Corp Controller	9,883	—	—	10,313	—
Jan 29, 2018 MForm 4 →	Jan 30, 5:10 pm EST	Amit SachdevEVP, CRO	15,085	—	—	19,397	—
Jan 24, 2018 MForm 4 →	Jan 26, 4:46 pm EST	Stuart A ArbuckleEVP\Chief Commercial Officer	8,969	—	—	20,193	—
Jan 23, 2018 MForm 4 →	Jan 25, 6:33 pm EST	Amit SachdevEVP, CRO	5,824	—	—	25,241	—
Jan 22, 2018 MForm 4 →	Jan 24, 5:35 pm EST	Margaret G McGlynnDirector	20,000	—	—	0	—
Jan 22, 2018 MForm 4 →	Jan 24, 5:33 pm EST	Paul M SilvaSVP & Corp Controller	5,435	—	—	8,594	—

Filed by this entity as an insider elsewhere — common stock

No reported common-stock activity in this period.

Filed by this entity as an insider elsewhere — derivatives (options, RSUs, warrants)

No reported derivative activity in this period.