Form4insider filings, from the source

Company · CIK 0002022626 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

Upstream Bio, Inc. · UPB

Insider activity reported against this company. All insider holders · On EDGAR ↗

1M3M6M1Y2YAll datashares as filed — not split-adjusted
Open-market buys & salesbuys $0 · 0sales $28k · 5net −$28k
$10k$10k$100k$100k$1M$1MbuyssalesJun 28Jul 13Jul 28Aug 13Aug 28Sep 13Sep 28

Reported at this company — common stock

TradeReported (ET)InsiderSharesAvg priceTotalOwned afterΔ stakeFlags
Sep 16, 2026 SForm 4 →Sep 17, 4:05 pm EDTMichael GrayCFO and COO853$5.49$4,68327,942−2.96%
Sep 16, 2026 SForm 4 →Sep 17, 4:05 pm EDTAllison AmbroseGeneral Counsel485$5.49$2,66315,563−3.02%
Sep 16, 2026 SForm 4 →Sep 17, 4:05 pm EDTAaron DeykinChief Medical Officer895$5.49$4,91432,302−2.70%
Sep 16, 2026 SForm 4 →Sep 17, 4:05 pm EDTEverett Rand SutherlandChief Executive Officer, Director2,095$5.49$11,50268,717−2.96%
Sep 16, 2026 SForm 4 →Sep 17, 4:05 pm EDTAdam HoughtonChief Business Officer700$5.49$3,84322,901−2.97%

Reported at this company — derivatives (options, RSUs, warrants)

No reported derivative activity in this period.