Form4insider filings, from the source

Company · CIK 0002022626 · SIC 2834 — Pharmaceutical Preparations · Nasdaq

Upstream Bio, Inc. · UPB

Insider activity reported against this company. All insider holders · On EDGAR ↗

1M3M6M1Y2YAll datashares as filed — not split-adjusted
Open-market buys & salesbuys $0 · 0sales $58k · 10net −$58k
$10k$10k$100k$100k$1M$1MbuyssalesJun 15Jun 30Jul 16Aug 1Aug 16Sep 1Sep 17

Reported at this company — common stock

TradeReported (ET)InsiderSharesAvg priceTotalOwned afterΔ stakeFlags
Sep 16, 2026 SForm 4 →Sep 17, 4:05 pm EDTMichael GrayCFO and COO853$5.49$4,68327,942−2.96%
Sep 16, 2026 SForm 4 →Sep 17, 4:05 pm EDTAllison AmbroseGeneral Counsel485$5.49$2,66315,563−3.02%
Sep 16, 2026 SForm 4 →Sep 17, 4:05 pm EDTAaron DeykinChief Medical Officer895$5.49$4,91432,302−2.70%
Sep 16, 2026 SForm 4 →Sep 17, 4:05 pm EDTEverett Rand SutherlandChief Executive Officer, Director2,095$5.49$11,50268,717−2.96%
Sep 16, 2026 SForm 4 →Sep 17, 4:05 pm EDTAdam HoughtonChief Business Officer700$5.49$3,84322,901−2.97%
Jun 16, 2026 SForm 4 →Jun 17, 4:05 pm EDTMichael GrayCFO and COO853$6.10$5,20328,795−2.88%
Jun 16, 2026 SForm 4 →Jun 17, 4:05 pm EDTEverett Rand SutherlandChief Executive Officer, Director2,095$6.10$12,78070,812−2.87%
Jun 16, 2026 SForm 4 →Jun 17, 4:05 pm EDTAdam HoughtonChief Business Officer700$6.10$4,27023,601−2.88%
Jun 16, 2026 SForm 4 →Jun 17, 4:05 pm EDTAaron DeykinChief Medical Officer895$6.10$5,46033,197−2.63%
Jun 16, 2026 SForm 4 →Jun 17, 4:05 pm EDTAllison AmbroseGeneral Counsel477$6.10$2,91016,048−2.89%

Reported at this company — derivatives (options, RSUs, warrants)

TradeReported (ET)InsiderSharesAvg priceTotalOwned afterΔ stakeFlags
Jun 9, 2026 AForm 4 →Jun 11, 8:00 pm EDTMarcella K. RuddyDirector17,096——17,096—
Jun 9, 2026 AForm 4 →Jun 11, 8:00 pm EDTRonald C Renaud Jr.Director17,096——17,096—
Jun 9, 2026 AForm 4 →Jun 11, 8:00 pm EDTHarold Edward FlemingDirector17,096——17,096—
Jun 9, 2026 AForm 4 →Jun 11, 8:00 pm EDTDaniella BeckmanDirector17,096——17,096—
Jun 9, 2026 AForm 4 →Jun 11, 8:00 pm EDTLiam RatcliffeDirector17,096——17,096—
Jun 9, 2026 AForm 4 →Jun 11, 8:00 pm EDTErez ChimovitsDirector17,096——17,096—