Company · CIK 0001724344 · SIC 2834 — Pharmaceutical Preparations

Entasis Therapeutics Holdings Inc. · ETTX

Insider activity reported against this company. All insider holders · On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market buys & salesbuys $64.1M · 10sales $0 · 0net $64.1M

Reported at this company — common stock

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Dec 21, 2018 MForm 4 →	Dec 26, 4:45 pm EST	Ruben TommasiChief Scientific Officer	22,024	$3.45	$75,921	22,024	—	plan?
Sep 28, 2018 PForm 4 →	Oct 2, 9:42 pm EDT	James N TopperDirector, 10% Owner	375,887	$15.00	$5,638,305	1,349,953	+38.6%	plan?
Sep 28, 2018 CForm 4 →	Oct 2, 9:42 pm EDT	James N TopperDirector, 10% Owner	910,092	—	—	974,066	—	plan?
Sep 28, 2018 PForm 4 →	Oct 2, 9:41 pm EDT	Sofinnova Venture Partners IX, L.P. +410% Owner	337,724	$15.00	$5,065,860	1,180,178	+40.1%	plan?
Sep 28, 2018 CForm 4 →	Oct 2, 9:41 pm EDT	Sofinnova Venture Partners IX, L.P. +410% Owner	817,692	—	—	842,454	—	plan?
Sep 28, 2018 PForm 4 →	Oct 2, 9:40 pm EDT	Heather PrestonDirector, 10% Owner	337,724	$15.00	$5,065,860	1,180,178	+40.1%	plan?
Sep 28, 2018 CForm 4 →	Oct 2, 9:40 pm EDT	Heather PrestonDirector, 10% Owner	817,692	—	—	842,454	—	plan?
Sep 28, 2018 PForm 4 →	Oct 2, 9:39 pm EDT	Pivotal bioVenture Partners Fund I, L.P. +210% Owner	337,724	$15.00	$5,065,860	1,180,178	+40.1%	plan?
Sep 28, 2018 CForm 4 →	Oct 2, 9:39 pm EDT	Pivotal bioVenture Partners Fund I, L.P. +210% Owner	817,692	—	—	842,454	—	plan?
Sep 28, 2018 PForm 4 →	Oct 2, 9:38 pm EDT	Nicholas GalakatosDirector, 10% Owner	453,395	$15.00	$6,800,925	1,623,405	+38.8%	plan?
Sep 28, 2018 CForm 4 →	Oct 2, 9:38 pm EDT	Nicholas GalakatosDirector, 10% Owner	1,097,753	—	—	1,170,010	—	plan?
Sep 28, 2018 PForm 4 →	Oct 2, 9:38 pm EDT	Frazier Life Sciences VIII, L.P. +310% Owner	375,887	$15.00	$5,638,305	1,349,953	+38.6%	plan?
Sep 28, 2018 CForm 4 →	Oct 2, 9:38 pm EDT	Frazier Life Sciences VIII, L.P. +310% Owner	910,092	—	—	974,066	—	plan?
Sep 28, 2018 PForm 4 →	Oct 2, 9:36 pm EDT	Clarus Lifesciences III, L.P. +710% Owner	453,395	$15.00	$6,800,925	1,623,405	+38.8%	plan?
Sep 28, 2018 CForm 4 →	Oct 2, 9:36 pm EDT	Clarus Lifesciences III, L.P. +710% Owner	1,097,753	—	—	1,170,010	—	plan?
Sep 28, 2018 PForm 4 →	Oct 2, 9:35 pm EDT	ASTRAZENECA PLC +110% Owner	246,666	$15.00	$3,699,990	2,164,855	+12.9%	plan?
Sep 28, 2018 CForm 4 →	Oct 2, 9:35 pm EDT	ASTRAZENECA PLC +110% Owner	1,918,185	—	—	1,918,189	—	plan?
Sep 28, 2018 PForm 4 →	Oct 2, 4:46 pm EDT	TPG Group Holdings (SBS) Advisors, Inc. +2Other	262,539	$15.00	$3,938,085	1,020,748	+34.6%	plan?
Sep 28, 2018 CJForm 4 →	Oct 2, 4:46 pm EDT	TPG Group Holdings (SBS) Advisors, Inc. +2Other	758,209	—	—	758,209	—	plan?
Sep 28, 2018 PForm 4 →	Oct 1, 4:36 pm EDT	Novo Holdings A/S10% Owner	1,089,835	$15.00	$16,347,525	2,181,843	+99.8%	plan?
Sep 28, 2018 CForm 4 →	Oct 1, 4:36 pm EDT	Novo Holdings A/S10% Owner	1,092,008	—	—	1,092,008	—	plan?

Reported at this company — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake
Jan 18, 2019 AForm 4 →	Jan 22, 5:04 pm EST	James N TopperDirector, 10% Owner	15,000	—	—	15,000	—
Jan 18, 2019 AForm 4 →	Jan 22, 5:03 pm EST	Ruben TommasiChief Scientific Officer	56,500	—	—	56,500	—
Jan 18, 2019 AForm 4 →	Jan 22, 5:02 pm EST	Manoussos PerrosPresident and CEO, Director	123,500	—	—	123,500	—
Jan 18, 2019 AForm 4 →	Jan 22, 5:02 pm EST	Gregory NordenDirector	15,000	—	—	15,000	—
Jan 18, 2019 AForm 4 →	Jan 22, 5:01 pm EST	John Patrick MuellerChief Development Officer	56,500	—	—	56,500	—
Jan 18, 2019 AForm 4 →	Jan 22, 5:00 pm EST	Robin IsaacsChief Medical Officer	56,500	—	—	56,500	—
Jan 18, 2019 AForm 4 →	Jan 22, 4:58 pm EST	David C HastingsDirector	15,000	—	—	15,000	—
Jan 18, 2019 AForm 4 →	Jan 22, 4:57 pm EST	Michael GutchCFO and Chief Business Officer	56,500	—	—	56,500	—
Jan 18, 2019 AForm 4 →	Jan 22, 4:57 pm EST	Nicholas GalakatosDirector, 10% Owner	15,000	—	—	15,000	—
Jan 18, 2019 AForm 4 →	Jan 22, 4:56 pm EST	Heather BehannaDirector	15,000	—	—	15,000	—
Dec 21, 2018 MForm 4 →	Dec 26, 4:45 pm EST	Ruben TommasiChief Scientific Officer	22,024	—	—	24,858	—
Sep 28, 2018 CForm 4 →	Oct 2, 9:42 pm EDT	James N TopperDirector, 10% Owner	18,864,407	—	—	0	—
Sep 28, 2018 CForm 4 →	Oct 2, 9:41 pm EDT	Sofinnova Venture Partners IX, L.P. +410% Owner	16,949,153	—	—	0	—
Sep 28, 2018 CForm 4 →	Oct 2, 9:40 pm EDT	Heather PrestonDirector, 10% Owner	16,949,153	—	—	0	—
Sep 28, 2018 CForm 4 →	Oct 2, 9:39 pm EDT	Pivotal bioVenture Partners Fund I, L.P. +210% Owner	16,949,153	—	—	0	—
Sep 28, 2018 CForm 4 →	Oct 2, 9:38 pm EDT	Nicholas GalakatosDirector, 10% Owner	22,754,237	—	—	0	—
Sep 28, 2018 CForm 4 →	Oct 2, 9:38 pm EDT	Frazier Life Sciences VIII, L.P. +310% Owner	18,864,407	—	—	0	—
Sep 28, 2018 CForm 4 →	Oct 2, 9:36 pm EDT	Clarus Lifesciences III, L.P. +710% Owner	22,754,237	—	—	0	—
Sep 28, 2018 CForm 4 →	Oct 2, 9:35 pm EDT	ASTRAZENECA PLC +110% Owner	33,499,900	—	—	0	—
Sep 28, 2018 CForm 4 →	Oct 2, 4:46 pm EDT	TPG Group Holdings (SBS) Advisors, Inc. +2Other	15,254,237	—	—	0	—
Sep 28, 2018 CForm 4 →	Oct 1, 4:36 pm EDT	Novo Holdings A/S10% Owner	21,237,288	—	—	0	—
Sep 25, 2018 AForm 4 →	Sep 27, 6:14 pm EDT	Manoussos PerrosPresident and CEO, Director	79,698	—	—	79,698	—
Sep 25, 2018 AForm 4 →	Sep 27, 6:07 pm EDT	Ruben TommasiChief Scientific Officer	50,411	—	—	50,411	—
Sep 25, 2018 AForm 4 →	Sep 27, 6:01 pm EDT	John Patrick MuellerChief Development Officer	7,265	—	—	7,265	—
Sep 25, 2018 AForm 4 →	Sep 27, 6:00 pm EDT	Robin IsaacsChief Medical Officer	32,116	—	—	32,116	—
Sep 25, 2018 AForm 4 →	Sep 27, 5:59 pm EDT	Michael GutchCFO and Chief Business Officer	15,956	—	—	15,956	—