Insider · CIK 0001055951

ORBIMED ADVISORS LLC

Files at: ADRX, ETRA, BLSM, BRVE, SCTX, YARW, SION, ELVN and 42 more. On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market buys & salesbuys $283.0M · 50sales $721.7M · 54net −$438.7M

Reported trades — common stock

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Nov 29, 2016 JForm 4 →	Dec 1, 8:48 pm EST	RESPONSE BIOMEDICAL CORPRBM	5,788,459	—	—	0	—	plan?
Aug 22, 2016 PForm 4 →	Aug 24, 4:31 pm EDT	ViewRay, Inc.VRAY	1,138,074	$2.95	$3,357,318	86,107	—	plan?
Aug 10, 2016 SForm 4 →	Aug 12, 8:35 pm EDT	GLAUKOS CorpGKOS	292,938	$33.69	$9,869,285	20,570	−93.4%	plan?
Aug 10, 2016 SForm 4 →	Aug 12, 4:36 pm EDT	Loxo Oncology, Inc.LOXO	447,857	$26.96	$12,074,225	1,728,000	−20.6%	plan?
Aug 3, 2016 SForm 4 →	Aug 5, 4:05 pm EDT	GLAUKOS CorpGKOS	425,000	$30.59	$13,000,750	23,334	−94.8%	plan?
Jul 25, 2016 PForm 4 →	Jul 25, 5:07 pm EDT	Audentes Therapeutics, Inc.BOLD	33,334	$15.00	$500,010	4,801,638	+0.70%	plan?
Jul 25, 2016 CForm 4 →	Jul 25, 5:07 pm EDT	Audentes Therapeutics, Inc.BOLD	4,544,066	—	—	4,768,304	—	plan?
Jul 22, 2016 SForm 4 →	Jul 26, 6:04 pm EDT	Relypsa IncRLYP	4,043,600	$32.00	$129,388,328	3,356,400	−54.6%	plan?
Jun 27, 2016 PForm 4 →	Jun 29, 8:55 pm EDT	SELECTA BIOSCIENCES INCSELB	550,000	$14.00	$7,700,000	1,825,415	+43.1%	plan?
Jun 27, 2016 CForm 4 →	Jun 29, 8:55 pm EDT	SELECTA BIOSCIENCES INCSELB	1,177,995	—	—	1,280,604	—	plan?
Jun 27, 2016 PForm 4 →	Jun 29, 4:49 pm EDT	SELECTA BIOSCIENCES INCSELB	550,000	$14.00	$7,700,000	1,825,415	+43.1%	plan?
Jun 27, 2016 CForm 4 →	Jun 29, 4:49 pm EDT	SELECTA BIOSCIENCES INCSELB	1,177,995	—	—	1,280,604	—	plan?
Jun 23, 2016 PForm 4 →	Jun 27, 6:47 pm EDT	Corvus Pharmaceuticals, Inc.CRVS	1,000	$12.98	$12,983	5,379,349	+0.02%	plan?
Jun 17, 2016 PForm 4 →	Jun 21, 6:55 pm EDT	Corvus Pharmaceuticals, Inc.CRVS	38,383	$12.75	$489,192	5,378,349	+0.72%	plan?
Jun 16, 2016 PForm 4 →	Jun 20, 5:40 pm EDT	RESPONSE BIOMEDICAL CORPRBM	892,858	$0.56	$500,000	2,149,902	+71.0%	plan?
Jun 14, 2016 PForm 4 →	Jun 16, 5:59 pm EDT	Corvus Pharmaceuticals, Inc.CRVS	20,000	$12.35	$247,000	5,339,966	+0.38%	plan?
Jun 9, 2016 PForm 4 →	Jun 13, 5:18 pm EDT	Corvus Pharmaceuticals, Inc.CRVS	50,000	$12.96	$648,100	5,319,966	+0.95%	plan?
May 20, 2016 PForm 4 →	May 25, 6:41 pm EDT	Adaptimmune Therapeutics PLCADAP	1,712,400	$10.42	$17,849,568	29,753,404	+6.11%	plan? late
May 20, 2016 PForm 4 →	May 24, 4:37 pm EDT	Corvus Pharmaceuticals, Inc.CRVS	4,716	$13.09	$61,732	5,269,966	+0.09%	plan?
May 18, 2016 PForm 4 →	May 20, 5:21 pm EDT	Corvus Pharmaceuticals, Inc.CRVS	6,800	$11.77	$80,035	5,265,250	+0.13%	plan?
May 11, 2016 PForm 4 →	May 13, 4:58 pm EDT	Intellia Therapeutics, Inc.NTLA	250,000	$18.00	$4,500,000	2,662,180	+10.4%	plan?
May 11, 2016 CForm 4 →	May 13, 4:58 pm EDT	Intellia Therapeutics, Inc.NTLA	2,412,180	—	—	2,412,180	—	plan?
Mar 29, 2016 PForm 4 →	Mar 29, 12:21 pm EDT	Corvus Pharmaceuticals, Inc.CRVS	550,000	$15.00	$8,250,000	5,258,450	+11.7%	plan?
Mar 29, 2016 CForm 4 →	Mar 29, 12:21 pm EDT	Corvus Pharmaceuticals, Inc.CRVS	4,708,450	—	—	4,708,450	—	plan?
Dec 21, 2015 SForm 4 →	Dec 23, 5:06 pm EST	Relypsa IncRLYP	500,000	$27.18	$13,588,013	7,400,000	−6.33%	plan?
Nov 25, 2015 SForm 4 →	Nov 30, 6:55 pm EST	Otonomy, Inc.OTIC	67,106	$28.93	$1,941,224	1,850,094	−3.50%	plan?
Nov 20, 2015 SForm 4 →	Nov 24, 8:31 pm EST	Otonomy, Inc.OTIC	200,800	$28.56	$5,735,336	1,917,200	−9.48%	plan?
Nov 17, 2015 SForm 4 →	Nov 19, 8:39 pm EST	Otonomy, Inc.OTIC	138,398	$28.62	$3,960,460	2,118,000	−6.13%	plan?
Oct 27, 2015 PForm 4 →	Oct 29, 6:15 pm EDT	Dimension Therapeutics, Inc.DMTX	200,000	$13.00	$2,600,000	5,397,698	+3.85%	plan?
Oct 27, 2015 CForm 4 →	Oct 29, 6:15 pm EDT	Dimension Therapeutics, Inc.DMTX	5,197,698	—	—	5,197,698	—	plan?
Oct 22, 2015 PForm 4 →	Oct 22, 6:00 pm EDT	Relypsa IncRLYP	500,000	$12.56	$6,280,165	7,900,000	+6.76%	plan?
Oct 12, 2015 SForm 4 →	Oct 13, 4:01 pm EDT	Sientra, Inc.SIEN	287,891	$5.98	$1,721,588	17,100	−94.4%	plan?
Oct 7, 2015 SForm 4 →	Oct 9, 7:49 pm EDT	Sientra, Inc.SIEN	666,609	$7.18	$4,788,048	19,885	−97.1%	plan?
Oct 2, 2015 SForm 4 →	Oct 6, 7:34 pm EDT	Sientra, Inc.SIEN	193,000	$8.71	$1,680,925	26,217	−88.0%	plan?
Sep 29, 2015 SForm 4 →	Oct 1, 5:55 pm EDT	Sientra, Inc.SIEN	101,898	$10.24	$1,043,427	27,842	−78.5%	plan?
Sep 24, 2015 SForm 4 →	Sep 28, 9:14 pm EDT	Sientra, Inc.SIEN	150,908	$10.58	$1,596,599	28,700	−84.0%	plan?
Jul 21, 2015 PForm 4 →	Jul 21, 7:00 pm EDT	ProNAi Therapeutics IncDNAI	175,000	$17.00	$2,975,000	1,989,949	+9.64%	plan?
Jul 21, 2015 CJForm 4 →	Jul 21, 7:00 pm EDT	ProNAi Therapeutics IncDNAI	1,814,949	$5.22	$464,964	1,814,949	—	plan?
Jul 17, 2015 AForm 4 →	Jul 21, 9:25 pm EDT	INTERCEPT PHARMACEUTICALS INCICPT	285	—	—	1,120,609	—	plan?
Jul 6, 2015 PForm 4 →	Jul 8, 5:46 pm EDT	PIERIS PHARMACEUTICALS, INC.PIRS	500,000	$2.75	$1,375,000	65,398	—	plan?
Jun 30, 2015 CFMForm 4 →	Jun 30, 5:51 pm EDT	GLAUKOS CorpGKOS	2,921,405	$18.00	$211,212	27,344	—	plan?
May 18, 2015 SForm 4 →	May 20, 8:30 pm EDT	Relypsa IncRLYP	1,457,551	$34.13	$49,746,216	7,400,000	−16.5%	plan?
Mar 26, 2015 SForm 4 →	Mar 30, 3:58 pm EDT	INTERCEPT PHARMACEUTICALS INCICPT	157,200	$286.75	$45,076,442	1,120,324	−12.3%	plan?
Mar 23, 2015 SForm 4 →	Mar 25, 7:28 pm EDT	INTERCEPT PHARMACEUTICALS INCICPT	207,800	$274.41	$57,022,706	1,277,524	−14.0%	plan?
Feb 3, 2015 PForm 4 →	Feb 5, 5:26 pm EST	Mirati Therapeutics, Inc.MRTX	100,000	$20.00	$2,000,000	1,267,000	+8.57%	plan?

Reported trades — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Company	Shares	Avg price	Total	Owned after	Δ stake	Flags
Sep 21, 2026 CForm 4 →	Sep 23, 5:29 pm EDT	Electra Therapeutics, Inc.ETRA	5,551,837	—	—	0	—
Aug 10, 2026 CForm 4 →	Aug 12, 4:43 pm EDT	BlossomHill Therapeutics, Inc.BLSM	2,089,279	—	—	0	—
Aug 7, 2026 CForm 4 →	Aug 11, 5:27 pm EDT	Braveheart Bio, Inc.BRVE	40,000,000	—	—	0	—
Jul 27, 2026 CForm 4 →	Jul 29, 6:47 pm EDT	Scribe Therapeutics, Inc.SCTX	2,065,672	—	—	0	—
Jun 11, 2026 PForm 4 →	Jun 15, 6:12 pm EDT	Shattuck Labs, Inc.STTK	1,250,000	—	—	5,303,908	—
Jun 8, 2026 CForm 4 →	Jun 9, 8:58 pm EDT	Shattuck Labs, Inc.STTK	36,879,576	—	—	0	—
Feb 19, 2019 CForm 4 →	Feb 19, 7:14 pm EST	AVEDRO INCAVDR	4,087,710	—	—	0	—
Feb 11, 2019 CForm 4 →	Feb 11, 7:11 pm EST	Alector, Inc.ALEC	12,682,329	—	—	0	—
Jan 18, 2019 PForm 4 →	Jan 23, 5:58 pm EST	ALPINE IMMUNE SCIENCES, INC.ALPN	145,251	—	—	145,251	—
Dec 11, 2018 CForm 4 →	Dec 13, 6:33 pm EST	Synthorx, Inc.THOR	6,333,206	—	—	0	—
Oct 23, 2018 CForm 4 →	Oct 25, 6:28 pm EDT	LogicBio Therapeutics, Inc.LOGC	10,078,289	—	—	0	—
Oct 19, 2018 CForm 4 →	Oct 19, 4:52 pm EDT	SI-BONE, Inc.SIBN	751,730	—	—	0	—
Oct 9, 2018 CForm 4 →	Oct 11, 4:01 pm EDT	Guardant Health, Inc.GH	1,534,464	—	—	0	—
Sep 18, 2018 CForm 4 →	Sep 20, 6:59 pm EDT	Principia Biopharma Inc.PRNB	2,355,713	—	—	0	—
Sep 17, 2018 AForm 4 →	Sep 19, 11:07 am EDT	Xtant Medical Holdings, Inc.XTNT	1,200,000	—	—	434,008	—
Aug 30, 2018 PSForm 4 →	Sep 7, 5:05 pm EDT	SteadyMed Ltd.STDY	2,343,098	$3.85	$423,500	0	—	late
Aug 7, 2018 MForm 4 →	Aug 10, 7:36 pm EDT	ViewRay, Inc.VRAY	91,578	—	—	0	—	late
Jul 23, 2018 CForm 4 →	Jul 24, 4:46 pm EDT	CONSTELLATION PHARMACEUTICALS INCCNST	7,000,000	—	—	0	—
Jul 2, 2018 CForm 4 →	Jul 2, 9:11 pm EDT	Tricida, Inc.TCDA	41,873,036	—	—	0	—
May 7, 2018 CForm 4 →	May 9, 9:21 pm EDT	Inspire Medical Systems, Inc.INSP	12,809,940	—	—	0	—
Feb 14, 2018 DForm 4 →	Feb 23, 6:55 pm EST	Xtant Medical Holdings, Inc.XTNT	54,238,167	$46.07	$2,499,008,212	0	—	late
Feb 13, 2018 MForm 4 →	Feb 15, 4:57 pm EST	PIERIS PHARMACEUTICALS, INC.PIRS	7,897	—	—	0	—
Jan 30, 2018 CForm 4 →	Jan 30, 6:41 pm EST	resTORbio, Inc.TORC	4,297,051	—	—	0	—
Jan 30, 2018 CForm 4 →	Jan 30, 5:14 pm EST	ARMO BioSciences, Inc.ARMO	4,118,903	—	—	0	—
Dec 18, 2017 MForm 4 →	Dec 20, 5:12 pm EST	PIERIS PHARMACEUTICALS, INC.PIRS	147,635	—	—	0	—
Nov 21, 2017 CForm 4 →	Nov 21, 7:13 pm EST	scPharmaceuticals Inc.SCPH	18,500,000	—	—	0	—
Nov 20, 2017 CForm 4 →	Nov 20, 5:32 pm EST	Arsanis, Inc.ASNS	3,969,587	—	—	0	—
Oct 10, 2017 CForm 4 →	Oct 10, 4:21 pm EDT	RHYTHM PHARMACEUTICALS, INC.RYTM	2,546,295	—	—	0	—
Sep 7, 2017 XForm 4 →	Sep 11, 2:16 pm EDT	Audentes Therapeutics, Inc.BOLD	5,000	—	—	0	—
Jul 25, 2017 CForm 4 →	Jul 27, 7:17 pm EDT	Kala Pharmaceuticals, Inc.KALA	10,707,985	—	—	0	—
Jun 13, 2017 CForm 4 →	Jun 15, 5:40 pm EDT	CTI BIOPHARMA CORPCTIC	7,500	—	—	0	—
Apr 25, 2017 PForm 4 →	Apr 27, 4:58 pm EDT	SteadyMed Ltd.STDY	587,000	$0.125	$73,375	293,500	—
Jan 18, 2017 PForm 4 →	Jan 20, 4:24 pm EST	ViewRay, Inc.VRAY	66,114	$0.125	$8,264	3,843	—
Sep 21, 2016 PForm 4 →	Sep 23, 4:15 pm EDT	Roka BioScience, Inc.ROKA	5,718,286	—	—	53,909	—
Aug 22, 2016 PForm 4 →	Aug 24, 4:31 pm EDT	ViewRay, Inc.VRAY	341,421	$0.125	$42,678	3,220	—
Jul 25, 2016 CForm 4 →	Jul 25, 5:07 pm EDT	Audentes Therapeutics, Inc.BOLD	4,544,066	—	—	0	—
Jun 27, 2016 CForm 4 →	Jun 29, 8:55 pm EDT	SELECTA BIOSCIENCES INCSELB	924,271	—	—	0	—
Jun 27, 2016 CForm 4 →	Jun 29, 4:49 pm EDT	SELECTA BIOSCIENCES INCSELB	924,271	—	—	0	—
May 11, 2016 CForm 4 →	May 13, 4:58 pm EDT	Intellia Therapeutics, Inc.NTLA	3,730,618	—	—	0	—
Mar 29, 2016 CForm 4 →	Mar 29, 12:21 pm EDT	Corvus Pharmaceuticals, Inc.CRVS	4,708,450	—	—	0	—
Oct 27, 2015 CForm 4 →	Oct 29, 6:15 pm EDT	Dimension Therapeutics, Inc.DMTX	15,192,874	—	—	0	—
Jul 21, 2015 CForm 4 →	Jul 21, 7:00 pm EDT	ProNAi Therapeutics IncDNAI	1,725,790	—	—	0	—
Jun 30, 2015 CMForm 4 →	Jun 30, 5:51 pm EDT	GLAUKOS CorpGKOS	2,909,671	—	—	0	—