Company · CIK 0001649904 · SIC 2834 — Pharmaceutical Preparations · Nasdaq
RHYTHM PHARMACEUTICALS, INC. · RYTM
Insider activity reported against this company. All insider holders · On EDGAR ↗
Reported at this company — common stock
| Trade | Reported (ET) | Insider | Shares | Avg price | Total | Owned after | Δ stake | Flags |
|---|---|---|---|---|---|---|---|---|
| Sep 14, 2026 SForm 4 → | Sep 14, 7:37 pm EDT | David P MeekerPresident and CEO, Director | 50,000 | $102.67 | $5,133,442 | 239,258 | −17.3% | 10b5-1 |
| Sep 14, 2026 MForm 4 → | Sep 14, 7:37 pm EDT | David P MeekerPresident and CEO, Director | 50,000 | $6.05 | $302,500 | 289,258 | — | 10b5-1 |
| Aug 31, 2026 SForm 4 → | Sep 1, 4:22 pm EDT | Hunter C SmithChief Financial Officer | 62,774 | $105.46 | $6,619,913 | 114,024 | −35.5% | 10b5-1 |
| Aug 31, 2026 MForm 4 → | Sep 1, 4:22 pm EDT | Hunter C SmithChief Financial Officer | 57,187 | $25.79 | $1,474,853 | 176,798 | — | 10b5-1 |
| Aug 13, 2026 SForm 4 → | Aug 17, 6:00 pm EDT | Joseph ShulmanChief Technical Officer | 5,079 | $119.75 | $608,210 | 15,915 | −24.2% | 10b5-1 |
| Aug 13, 2026 MForm 4 → | Aug 17, 6:00 pm EDT | Joseph ShulmanChief Technical Officer | 2,024 | $6.80 | $13,763 | 20,994 | — | 10b5-1 |
| Aug 13, 2026 SForm 4 → | Aug 17, 5:57 pm EDT | Alastair GarfieldChief Scientific Officer | 7,763 | $117.57 | $912,703 | 2,295 | −77.2% | 10b5-1 |
| Aug 13, 2026 SForm 4 → | Aug 14, 7:04 pm EDT | Jennifer Kayden LeeEVP, Head of North America | 75,834 | $117.38 | $8,901,531 | 0 | −100% | 10b5-1 |
| Aug 13, 2026 MForm 4 → | Aug 14, 7:04 pm EDT | Jennifer Kayden LeeEVP, Head of North America | 56,601 | $17.62 | $997,037 | 75,834 | — | 10b5-1 |
| Aug 12, 2026 SForm 4 → | Aug 14, 7:01 pm EDT | Yann MazabraudEVP, Head of International | 57,000 | $116.15 | $6,620,575 | 55,655 | −50.6% | 10b5-1 |
| Aug 12, 2026 MForm 4 → | Aug 14, 7:01 pm EDT | Yann MazabraudEVP, Head of International | 46,625 | $6.80 | $317,050 | 112,655 | — | 10b5-1 |
| Jul 1, 2026 FMForm 4 → | Jul 2, 4:52 pm EDT | Alastair GarfieldChief Scientific Officer | 6,595 | $110.41 | $237,382 | 10,058 | — | |
| Jun 23, 2026 MForm 4 → | Jun 25, 6:09 pm EDT | Christophe JeanDirector | 4,712 | — | — | 11,712 | — | |
| Jun 23, 2026 MForm 4 → | Jun 25, 6:08 pm EDT | David W J McGirrDirector | 4,712 | — | — | 11,712 | — | |
| Jun 23, 2026 MForm 4 → | Jun 25, 6:06 pm EDT | Lynn A. TetraultDirector | 4,712 | — | — | 11,712 | — | |
| Jun 23, 2026 MForm 4 → | Jun 25, 6:03 pm EDT | Stuart A ArbuckleDirector | 4,712 | — | — | 11,712 | — | |
| Jun 23, 2026 MForm 4 → | Jun 25, 6:01 pm EDT | Jennifer L GoodDirector | 4,712 | — | — | 11,712 | — | |
| Jun 22, 2026 SForm 4 → | Jun 24, 4:15 pm EDT | Lynn A. TetraultDirector | 37,000 | $100.32 | $3,711,896 | 7,000 | −84.1% | 10b5-1 |
| Jun 22, 2026 MForm 4 → | Jun 24, 4:15 pm EDT | Lynn A. TetraultDirector | 37,000 | $28.27 | $1,045,990 | 44,000 | — | 10b5-1 |
| Feb 26, 2019 SForm 4 → | Feb 28, 4:01 pm EST | Keith Michael GottesdienerCEO and President, Director | 2,449 | $30.04 | $73,571 | 525,617 | −0.46% | plan? |
| Feb 15, 2019 SForm 4 → | Feb 20, 4:01 pm EST | Keith Michael GottesdienerCEO and President, Director | 12,920 | $30.02 | $387,886 | 528,066 | −2.39% | plan? |
| Feb 13, 2019 SForm 4 → | Feb 15, 4:09 pm EST | Keith Michael GottesdienerCEO and President, Director | 3,934 | $30.00 | $118,020 | 540,986 | −0.72% | plan? |
| Jan 31, 2019 MForm 4 → | Feb 4, 4:01 pm EST | Hunter C SmithChief Financial Officer | 3,000 | $6.88 | $20,640 | 6,000 | — | plan? |
| Jan 22, 2019 SForm 4 → | Jan 24, 4:03 pm EST | Keith Michael GottesdienerCEO and President, Director | 15,779 | $30.05 | $474,176 | 544,920 | −2.81% | plan? |
| Jan 18, 2019 SForm 4 → | Jan 22, 4:07 pm EST | Keith Michael GottesdienerCEO & President, Director | 10,115 | $30.01 | $303,551 | 560,699 | −1.77% | plan? |
| Jan 16, 2019 SForm 4 → | Jan 18, 4:02 pm EST | Leonardus H.T. Van der PloegChief Scientific Officer | 200 | $30.00 | $6,000 | 42,339 | −0.47% | plan? |
| Jan 16, 2019 SForm 4 → | Jan 17, 6:13 pm EST | Keith Michael GottesdienerCEO & President, Director | 662 | $30.00 | $19,860 | 570,814 | −0.12% | plan? |
| Dec 3, 2018 SForm 4 → | Dec 6, 4:03 pm EST | Keith Michael GottesdienerCEO and President, Director | 563 | $30.00 | $16,890 | 571,476 | −0.10% | plan? |
| Nov 2, 2018 SForm 4 → | Nov 6, 5:21 pm EST | Keith Michael GottesdienerCEO and President, Director | 16,500 | $30.08 | $496,320 | 572,039 | −2.80% | plan? |
| Nov 2, 2018 SForm 4 → | Nov 6, 5:20 pm EST | Leonardus H.T. Van der PloegChief Scientific Officer | 38,000 | $30.09 | $1,143,420 | 42,539 | −47.2% | plan? |
| Nov 2, 2018 MForm 4 → | Nov 6, 5:20 pm EST | Leonardus H.T. Van der PloegChief Scientific Officer | 28,200 | $6.18 | $174,238 | 80,539 | — | plan? |
| Sep 25, 2018 SForm 4 → | Sep 27, 4:02 pm EDT | Leonardus H.T. Van der PloegChief Scientific Officer | 31,800 | $29.80 | $947,540 | 52,339 | −37.8% | plan? |
| Sep 5, 2018 MForm 4 → | Sep 6, 4:02 pm EDT | Hunter C SmithChief Financial Officer | 3,000 | $6.88 | $20,640 | 3,000 | — | plan? |
| Aug 30, 2018 JForm 4 → | Sep 4, 4:06 pm EDT | THIRD ROCK VENTURES LP +510% Owner | 1,000,000 | — | — | 2,981,437 | — | plan? |
| Aug 10, 2018 MForm 4 → | Aug 14, 4:01 pm EDT | Nithya DesikanChief Commercial Officer | 14,534 | $6.88 | $99,994 | 14,534 | — | plan? |
| Jun 29, 2018 GMForm 4 → | Sep 27, 4:02 pm EDT | Leonardus H.T. Van der PloegChief Scientific Officer | 23,800 | $4.59 | $100,062 | 84,139 | — | plan? late |
| Jun 25, 2018 PForm 5 → | Feb 11, 2019, 1:23 pm EST | Todd FoleyDirector | 378,501 | $26.42 | $9,999,996 | 3,074,893 | +14.0% | plan? |
| May 22, 2018 SForm 4 → | May 24, 4:13 pm EDT | ORBIMED ADVISORS LLC +110% Owner | 19,580 | $30.43 | $595,768 | 2,750,079 | −0.71% | plan? |
| May 18, 2018 SForm 4 → | May 21, 6:15 pm EDT | ORBIMED ADVISORS LLC +110% Owner | 131,636 | $30.88 | $4,065,440 | 2,769,659 | −4.54% | plan? |
| May 9, 2018 MForm 4 → | May 10, 4:08 pm EDT | Keith Michael GottesdienerC.E.O. and President, Director | 3,000 | $4.59 | $13,770 | 588,539 | — | plan? |
| Oct 10, 2017 CForm 4 → | Oct 12, 5:16 pm EDT | Neil ExterDirector | — | — | — | 0 | — | plan? |
| Oct 10, 2017 CForm 4 → | Oct 11, 4:00 pm EDT | THIRD ROCK VENTURES LP +510% Owner | 3,963,810 | — | — | 3,981,437 | — | plan? |
| Oct 10, 2017 PForm 4 → | Oct 11, 2:25 pm EDT | MPM BIOVENTURES V, L.P. +510% Owner | 100,000 | $17.00 | $1,700,000 | 2,696,392 | +3.85% | plan? |
| Oct 10, 2017 CForm 4 → | Oct 11, 2:25 pm EDT | MPM BIOVENTURES V, L.P. +510% Owner | 2,567,014 | — | — | 2,596,392 | — | plan? |
| Oct 10, 2017 PForm 4 → | Oct 11, 2:24 pm EDT | Todd FoleyDirector, 10% Owner | 100,000 | $17.00 | $1,700,000 | 2,696,392 | +3.85% | plan? |
| Oct 10, 2017 CForm 4 → | Oct 11, 2:24 pm EDT | Todd FoleyDirector, 10% Owner | 2,567,014 | — | — | 2,596,392 | — | plan? |
| Oct 10, 2017 PForm 4 → | Oct 10, 4:36 pm EDT | Ravi Viswanathan10% Owner | 550,000 | $17.00 | $9,350,000 | 4,909,956 | +12.6% | plan? |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:36 pm EDT | Ravi Viswanathan10% Owner | 4,330,578 | — | — | 4,359,956 | — | plan? |
| Oct 10, 2017 PForm 4 → | Oct 10, 4:35 pm EDT | Scott D Sandell10% Owner | 550,000 | $17.00 | $9,350,000 | 4,909,956 | +12.6% | plan? |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:35 pm EDT | Scott D Sandell10% Owner | 4,330,578 | — | — | 4,359,956 | — | plan? |
| Oct 10, 2017 PForm 4 → | Oct 10, 4:35 pm EDT | David M Mott10% Owner | 550,000 | $17.00 | $9,350,000 | 4,909,956 | +12.6% | plan? |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:35 pm EDT | David M Mott10% Owner | 4,330,578 | — | — | 4,359,956 | — | plan? |
| Oct 10, 2017 PForm 4 → | Oct 10, 4:34 pm EDT | Patrick J Kerins10% Owner | 550,000 | $17.00 | $9,350,000 | 4,909,956 | +12.6% | plan? |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:34 pm EDT | Patrick J Kerins10% Owner | 4,330,578 | — | — | 4,359,956 | — | plan? |
| Oct 10, 2017 PForm 4 → | Oct 10, 4:34 pm EDT | Forest Baskett10% Owner | 550,000 | $17.00 | $9,350,000 | 4,909,956 | +12.6% | plan? |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:34 pm EDT | Forest Baskett10% Owner | 4,330,578 | — | — | 4,359,956 | — | plan? |
| Oct 10, 2017 PForm 4 → | Oct 10, 4:33 pm EDT | Peter J Barris10% Owner | 550,000 | $17.00 | $9,350,000 | 4,909,956 | +12.6% | plan? |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:33 pm EDT | Peter J Barris10% Owner | 4,330,578 | — | — | 4,359,956 | — | plan? |
| Oct 10, 2017 PForm 4 → | Oct 10, 4:33 pm EDT | M James Barrett10% Owner | 550,000 | $17.00 | $9,350,000 | 4,909,956 | +12.6% | plan? |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:33 pm EDT | M James Barrett10% Owner | 4,330,578 | — | — | 4,359,956 | — | plan? |
| Oct 10, 2017 PForm 4 → | Oct 10, 4:32 pm EDT | NEW ENTERPRISE ASSOCIATES 13 LP +210% Owner | 550,000 | $17.00 | $9,350,000 | 4,909,956 | +12.6% | plan? |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:32 pm EDT | NEW ENTERPRISE ASSOCIATES 13 LP +210% Owner | 4,330,578 | — | — | 4,359,956 | — | plan? |
| Oct 10, 2017 PForm 4 → | Oct 10, 4:24 pm EDT | David P MeekerDirector | 25,000 | $17.00 | $425,000 | 101,335 | +32.8% | plan? |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:24 pm EDT | David P MeekerDirector | 54,525 | — | — | 76,335 | — | plan? |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:23 pm EDT | Keith Michael GottesdienerCEO and President, Director | 27,262 | — | — | 585,539 | — | plan? |
| Oct 10, 2017 PForm 4 → | Oct 10, 4:22 pm EDT | PFIZER INC10% Owner | 40,000 | $17.00 | $680,000 | 1,427,639 | +2.88% | plan? |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:22 pm EDT | PFIZER INC10% Owner | 1,387,639 | — | — | 1,387,639 | — | plan? |
| Oct 10, 2017 PForm 4 → | Oct 10, 4:22 pm EDT | Ipsen, S.A.10% Owner | 20,000 | $17.00 | $340,000 | 833,099 | +2.46% | plan? |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:22 pm EDT | Ipsen, S.A.10% Owner | 213,769 | — | — | 813,099 | — | plan? |
| Oct 10, 2017 PForm 4 → | Oct 10, 4:21 pm EDT | ORBIMED ADVISORS LLC +210% Owner | 355,000 | $17.00 | $6,035,000 | 2,901,295 | +13.9% | plan? |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:21 pm EDT | ORBIMED ADVISORS LLC +210% Owner | 2,546,295 | — | — | 2,546,295 | — | plan? |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:06 pm EDT | Hadley Harbor Master Investors (Cayman) L.P.10% Owner | 545,256 | — | — | 545,256 | — | plan? |
| Oct 10, 2017 PForm 4 → | Oct 10, 9:40 am EDT | James E Flynn +510% Owner | 355,000 | $17.00 | $6,035,000 | 468,505 | +313% | plan? |
| Oct 10, 2017 CForm 4 → | Oct 10, 9:40 am EDT | James E Flynn +510% Owner | 582,010 | — | — | 291,005 | — | plan? |
| Oct 5, 2017 PForm 4 → | Oct 6, 3:58 pm EDT | BAKER BROS. ADVISORS LP +3Other | 885,000 | $17.00 | $15,045,000 | 1,878,242 | +89.1% | plan? |
| Oct 5, 2017 CForm 4 → | Oct 6, 3:58 pm EDT | BAKER BROS. ADVISORS LP +3Other | 1,164,020 | — | — | 1,081,051 | — | plan? |
Reported at this company — derivatives (options, RSUs, warrants)
| Trade | Reported (ET) | Insider | Shares | Avg price | Total | Owned after | Δ stake | Flags |
|---|---|---|---|---|---|---|---|---|
| Sep 14, 2026 MForm 4 → | Sep 14, 7:37 pm EDT | David P MeekerPresident and CEO, Director | 50,000 | — | — | 15,431 | — | 10b5-1 |
| Aug 31, 2026 MForm 4 → | Sep 1, 4:22 pm EDT | Hunter C SmithChief Financial Officer | 57,187 | — | — | 3,813 | — | 10b5-1 |
| Aug 17, 2026 AForm 4 → | Aug 18, 5:35 pm EDT | Manher JoshiChief Medical Officer | 75,000 | — | — | 25,000 | — | |
| Aug 13, 2026 MForm 4 → | Aug 17, 6:00 pm EDT | Joseph ShulmanChief Technical Officer | 2,024 | — | — | 5,945 | — | 10b5-1 |
| Aug 13, 2026 MForm 4 → | Aug 14, 7:04 pm EDT | Jennifer Kayden LeeEVP, Head of North America | 56,601 | — | — | 0 | — | 10b5-1 |
| Aug 12, 2026 MForm 4 → | Aug 14, 7:01 pm EDT | Yann MazabraudEVP, Head of International | 46,625 | — | — | 35,875 | — | 10b5-1 |
| Jul 1, 2026 MForm 4 → | Jul 2, 4:52 pm EDT | Alastair GarfieldChief Scientific Officer | 4,445 | — | — | 8,888 | — | |
| Jun 23, 2026 AMForm 4 → | Jun 25, 6:09 pm EDT | Christophe JeanDirector | 10,727 | — | — | 2,324 | — | |
| Jun 23, 2026 AMForm 4 → | Jun 25, 6:08 pm EDT | David W J McGirrDirector | 10,727 | — | — | 2,324 | — | |
| Jun 23, 2026 AMForm 4 → | Jun 25, 6:06 pm EDT | Lynn A. TetraultDirector | 10,727 | — | — | 2,324 | — | |
| Jun 23, 2026 AMForm 4 → | Jun 25, 6:03 pm EDT | Stuart A ArbuckleDirector | 10,727 | — | — | 2,324 | — | |
| Jun 23, 2026 AMForm 4 → | Jun 25, 6:01 pm EDT | Jennifer L GoodDirector | 10,727 | — | — | 2,324 | — | |
| Jun 22, 2026 MForm 4 → | Jun 24, 4:15 pm EDT | Lynn A. TetraultDirector | 37,000 | — | — | 0 | — | 10b5-1 |
| Feb 13, 2019 AForm 4 → | Feb 15, 4:10 pm EST | Hunter C SmithChief Financial Officer | 70,000 | — | — | 70,000 | — | |
| Feb 13, 2019 AForm 4 → | Feb 15, 4:09 pm EST | Keith Michael GottesdienerCEO and President, Director | 225,000 | — | — | 225,000 | — | |
| Feb 13, 2019 AForm 4 → | Feb 15, 4:09 pm EST | Nithya DesikanChief Commercial Officer | 70,000 | — | — | 70,000 | — | |
| Feb 13, 2019 AForm 4 → | Feb 15, 4:08 pm EST | Murray StewartChief Medical Officer | 60,000 | — | — | 60,000 | — | |
| Feb 13, 2019 AForm 4 → | Feb 15, 4:08 pm EST | Leonardus H.T. Van der PloegChief Scientific Officer | 70,000 | — | — | 70,000 | — | |
| Feb 13, 2019 AForm 4 → | Feb 15, 4:07 pm EST | Simon KelnerChief Human Resources Officer | 55,000 | — | — | 55,000 | — | |
| Jan 31, 2019 MForm 4 → | Feb 4, 4:01 pm EST | Hunter C SmithChief Financial Officer | 3,000 | — | — | 195,744 | — | |
| Nov 2, 2018 MForm 4 → | Nov 6, 5:20 pm EST | Leonardus H.T. Van der PloegChief Scientific Officer | 28,200 | — | — | 30,894 | — | |
| Oct 15, 2018 AForm 4 → | Oct 17, 5:30 pm EDT | Murray StewartChief Medical Officer | 100,000 | — | — | 100,000 | — | |
| Sep 25, 2018 MForm 4 → | Sep 27, 4:02 pm EDT | Leonardus H.T. Van der PloegChief Scientific Officer | 21,800 | — | — | 41,671 | — | |
| Sep 5, 2018 MForm 4 → | Sep 6, 4:02 pm EDT | Hunter C SmithChief Financial Officer | 3,000 | — | — | 198,744 | — | |
| Aug 10, 2018 MForm 4 → | Aug 14, 4:01 pm EDT | Nithya DesikanChief Commercial Officer | 14,534 | — | — | 187,210 | — | |
| Jun 6, 2018 AForm 4 → | Jun 8, 5:04 pm EDT | Edward T MathersDirector | 10,000 | — | — | 10,000 | — | |
| Jun 6, 2018 AForm 4 → | Jun 8, 4:09 pm EDT | Simon KelnerChief Human Resources Officer | 60,000 | — | — | 60,000 | — | |
| Jun 6, 2018 AForm 4 → | Jun 8, 4:08 pm EDT | Christophe JeanDirector | 10,000 | — | — | 10,000 | — | |
| Jun 6, 2018 AForm 4 → | Jun 8, 4:06 pm EDT | Neil ExterDirector | 10,000 | — | — | 10,000 | — | |
| Jun 6, 2018 AForm 4 → | Jun 8, 4:06 pm EDT | David P MeekerDirector | 10,000 | — | — | 10,000 | — | |
| Jun 6, 2018 AForm 4 → | Jun 8, 4:04 pm EDT | David W J McGirrDirector | 10,000 | — | — | 10,000 | — | |
| Jun 6, 2018 AForm 4 → | Jun 8, 4:03 pm EDT | Todd FoleyDirector | 10,000 | — | — | 10,000 | — | |
| May 9, 2018 MForm 4 → | May 10, 4:08 pm EDT | Keith Michael GottesdienerC.E.O. and President, Director | 3,000 | — | — | 124,780 | — | |
| Feb 14, 2018 AForm 4 → | Feb 16, 4:03 pm EST | Hunter C SmithCFO and Treasurer | 61,000 | — | — | 61,000 | — | |
| Feb 14, 2018 AForm 4 → | Feb 16, 4:03 pm EST | Keith Michael GottesdienerCEO & President, Director | 175,000 | — | — | 175,000 | — | |
| Feb 14, 2018 AForm 4 → | Feb 16, 4:03 pm EST | Fred T. FiedorekChief Medical Officer | 50,000 | — | — | 25,000 | — | |
| Feb 14, 2018 AForm 4 → | Feb 16, 4:02 pm EST | Nithya DesikanChief Commercial Officer | 61,000 | — | — | 61,000 | — | |
| Feb 14, 2018 AForm 4 → | Feb 16, 4:02 pm EST | Leonardus H.T. Van der PloegChief Scientific Officer | 55,000 | — | — | 55,000 | — | |
| Oct 10, 2017 CForm 4 → | Oct 12, 5:16 pm EDT | Neil ExterDirector | — | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 11, 4:00 pm EDT | THIRD ROCK VENTURES LP +510% Owner | 36,348,144 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 11, 2:25 pm EDT | MPM BIOVENTURES V, L.P. +510% Owner | 23,539,534 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:36 pm EDT | Ravi Viswanathan10% Owner | 4,330,578 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:35 pm EDT | Scott D Sandell10% Owner | 4,330,578 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:35 pm EDT | David M Mott10% Owner | 4,330,578 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:34 pm EDT | Patrick J Kerins10% Owner | 4,330,578 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:34 pm EDT | Forest Baskett10% Owner | 4,330,578 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:33 pm EDT | Peter J Barris10% Owner | 4,330,578 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:33 pm EDT | M James Barrett10% Owner | 4,330,578 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:32 pm EDT | NEW ENTERPRISE ASSOCIATES 13 LP +210% Owner | 4,330,578 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:24 pm EDT | David P MeekerDirector | 54,525 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:23 pm EDT | Keith Michael GottesdienerCEO and President, Director | 27,262 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:22 pm EDT | PFIZER INC10% Owner | 1,387,639 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:22 pm EDT | Ipsen, S.A.10% Owner | 213,769 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:21 pm EDT | ORBIMED ADVISORS LLC +210% Owner | 2,546,295 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 10, 4:06 pm EDT | Hadley Harbor Master Investors (Cayman) L.P.10% Owner | 5,000,000 | — | — | 0 | — | |
| Oct 10, 2017 CForm 4 → | Oct 10, 9:40 am EDT | James E Flynn +510% Owner | 5,337,036 | — | — | 0 | — | |
| Oct 5, 2017 CForm 4 → | Oct 6, 3:58 pm EDT | BAKER BROS. ADVISORS LP +3Other | 10,674,071 | — | — | 0 | — | |
| Aug 18, 2017 ACForm 4 → | Oct 11, 2:24 pm EDT | Todd FoleyDirector, 10% Owner | 26,555,449 | $1.00 | $3,015,915 | 0 | — | late |