Security	Date	Code	Shares	Price	A/D	Owned after	D/I
Common Stock^F2,F3,F4	Jul 26, 2016	C	820,935	$0.00	A	820,935	D
Common Stock^F6,F3,F4	Jul 26, 2016	C	527,088	$0.00	A	1,348,023	D
Common Stock^F8,F3,F4	Jul 26, 2016	X	40,025	$7.46	A	1,388,048	D
Common Stock^F9,F3,F4	Jul 26, 2016	F	21,313	$14.00	D	1,366,735	D

Table II — derivative securities

Security	Conv. / exercise price	Date	Code	Shares	A/D	Exercisable	Expires	Underlying	Underlying shares	D/I
Series 1 Preferred Stock^F10,F1	—	Jul 26, 2016	C	820,935	D	—	—	Common Stock	820,935	D
Series 2 Preferred Stock^F10,F5	—	Jul 26, 2016	C	421,683	D	—	—	Common Stock	421,683	D
Series 2 Preferred Warrant (Right to Buy)^F10,F5	$9.32	Jul 26, 2016	X	32,022	D	—	Jun 30, 2017	Common Stock	32,022	D

Explanation of responses

F1Each share of Series 1 Preferred Stock automatically converted into one share of Common Stock immediately prior to the completion of the Issuer's initial public offering of Common Stock and had no expiration date.
F10Not applicable.
F2815,666 of these shares are held of record by ARCH Venture Fund V, L.P.; and 5,269 of these shares are held of record by ARCH V Entrepreneurs Fund, L.P.
F3ARCH Venture Partners V, L.P., as the sole general partner of ARCH Venture Fund V, L.P. and ARCH V Entrepreneurs Fund, L.P., may be deemed to beneficially own certain of the shares held of record by ARCH Venture Fund V, L.P. and ARCH V Entrepreneurs Fund, L.P., but disclaims beneficial ownership of such shares, in which it does not have an actual pecuniary interest. ARCH Venture Partners V, LLC, as the sole general partner of ARCH Venture Partners V, L.P., may be deemed to beneficially own certain of the shares held of record by ARCH Venture Fund V, L.P. and ARCH V Entrepreneurs Fund, L.P. but disclaims beneficial ownership of such shares, in which it does not have an actual pecuniary interest.
F4Robert Nelsen, Keith Crandell and Steven Lazarus are managing directors of ARCH Venture Partners V, LLC, and may be deemed to beneficially own certain of the shares held of record by ARCH Venture Fund V, L.P. and ARCH V Entrepreneurs Fund, L.P. Mr. Nelsen, Mr. Crandell and Mr. Lazarus disclaim beneficial ownership of all shares held of record by ARCH Venture Fund V, L.P. and ARCH V Entrepreneurs Fund, L.P., in which they do not have an actual pecuniary interest. By virtue of their relationship as affiliated entities who have overlapping general partners and managing directors, ARCH Venture Fund V, L.P., ARCH V Entrepreneurs Fund, L.P., ARCH Venture Partners V, L.P., ARCH Venture Partners V, LLC and Mr. Crandell, Mr. Nelsen and Mr. Lazarus may be deemed to share the voting and investment control of the record shares.
F5Each share of Series 2 Preferred Stock automatically converted into 1.24996780424983 shares of Common Stock immediately prior to the completion of the Issuer's initial public offering of Common Stock and had no expiration date.
F61,339,228 of these shares are held of record by ARCH Venture Fund V, L.P.; and 8,795 of these shares are held of record by ARCH V Entrepreneurs Fund, L.P.
F7The warrant was automatically net exercised immediately prior to the completion of the Issuer's initial public offering of Common Stock.
F81,378,986 of these shares are held of record by ARCH Venture Fund V, L.P.; and 9,062 of these shares are held of record by ARCH V Entrepreneurs Fund, L.P.
F91,357,816 of these shares are held of record by ARCH Venture Fund V, L.P.; and 8,919 of these shares are held of record by ARCH V Entrepreneurs Fund, L.P.