Company · CIK 0000884731 · SIC 2836 — Biological Products, (No Diagnostic Substances)

ARIAD PHARMACEUTICALS INC · ARIA

Insider activity reported against this company. All insider holders · On EDGAR ↗

Period1M 3M 6M 1Y 2Y All datashares as filed — not split-adjusted

Open-market buys & salesbuys $842k · 5sales $12.1M · 76net −$11.2M

Reported at this company — common stock

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Feb 16, 2017 DForm 4 →	Feb 16, 2:18 pm EST	Timothy P ClacksonPresident, R&D, CSO	220,444	—	—	0	—	plan?
Feb 16, 2017 DForm 4 →	Feb 16, 2:17 pm EST	Jules HaimovitzDirector	18,008	—	—	0	—	plan?
Feb 16, 2017 DForm 4 →	Feb 16, 2:17 pm EST	George BickerstaffDirector	18,008	—	—	0	—	plan?
Feb 16, 2017 DForm 4 →	Feb 16, 2:17 pm EST	Jennifer Lyn HerronExec V.P. Chief Comm'l Officer	450	—	—	0	—	plan?
Feb 16, 2017 DForm 4 →	Feb 16, 2:16 pm EST	Hugh M ColeSVP, Chief Business Officer	42,834	—	—	0	—	plan?
Feb 16, 2017 DForm 4 →	Feb 16, 2:16 pm EST	Norbert G RiedelDirector	139,867	—	—	0	—	plan?
Feb 16, 2017 DForm 4 →	Feb 16, 2:15 pm EST	Daniel M BollagSr. VP, Reg. Affairs & Quality	126,352	—	—	0	—	plan?
Feb 16, 2017 DForm 4 →	Feb 16, 2:15 pm EST	Paris PanayiotopoulosPresident and CEO, Director	159,378	—	—	0	—	plan?
Feb 16, 2017 DForm 4 →	Feb 16, 2:15 pm EST	Anna ProtopapasDirector	41,910	—	—	0	—	plan?
Feb 16, 2017 DForm 4 →	Feb 16, 2:14 pm EST	Manmeet Singh SoniEVP, CFO & Treasurer	3,273	—	—	0	—	plan?
Feb 16, 2017 DForm 4 →	Feb 16, 2:14 pm EST	Alexander J DennerDirector	12,903,173	—	—	0	—	plan?
Feb 13, 2017 DGForm 4 →	Feb 16, 2:18 pm EST	Sarah J. SchlesingerDirector	71,108	—	—	0	—	plan? late
Jan 31, 2017 FMForm 4 →	Feb 2, 4:42 pm EST	Daniel M BollagSr. VP, Reg. Affairs & Quality	44,000	$23.81	$349,293	126,352	—	plan?
Jan 31, 2017 FMForm 4 →	Feb 2, 4:41 pm EST	Timothy P ClacksonPresident, R&D, CSO	38,943	$23.82	$228,886	219,867	—	plan?
Jan 31, 2017 AForm 4 →	Feb 2, 9:39 am EST	Alexander J DennerDirector	18,008	—	—	53,173	—	plan?
Jan 31, 2017 AForm 4 →	Feb 1, 4:56 pm EST	George BickerstaffDirector	18,008	—	—	18,008	—	plan?
Jan 31, 2017 AForm 4 →	Feb 1, 4:56 pm EST	Sarah J. SchlesingerDirector	18,008	—	—	55,508	—	plan?
Jan 31, 2017 AForm 4 →	Feb 1, 4:55 pm EST	Jules HaimovitzDirector	18,008	—	—	18,008	—	plan?
Jan 31, 2017 AForm 4 →	Feb 1, 4:55 pm EST	Norbert G RiedelDirector	18,008	—	—	139,867	—	plan?
Jan 31, 2017 AForm 4 →	Feb 1, 4:54 pm EST	Anna ProtopapasDirector	18,008	—	—	41,910	—	plan?
Jan 13, 2017 FMForm 4 →	Jan 17, 5:06 pm EST	Paris PanayiotopoulosPresident and CEO, Director	99,900	$23.69	$788,934	159,378	—	plan?
Jan 9, 2017 SForm 4 →	Jan 10, 6:17 pm EST	Daniel M BollagSr. VP, Reg. Affairs & Quality	32,000	$23.78	$760,960	129,404	−19.8%	plan?
Jan 9, 2017 MForm 4 →	Jan 10, 6:17 pm EST	Daniel M BollagSr. VP, Reg. Affairs & Quality	32,000	$7.82	$250,240	161,404	—	plan?
Oct 24, 2016 SForm 4 →	Oct 25, 4:07 pm EDT	Timothy P ClacksonPresident, R&D, CSO	19,638	$9.56	$187,739	197,884	−9.03%	plan?
Oct 3, 2016 SForm 4 →	Oct 5, 4:17 pm EDT	Daniel M BollagSr. VP, Reg. Affairs & Quality	47,384	$13.46	$637,812	129,404	−26.8%	plan?
Sep 28, 2016 SForm 4 →	Sep 28, 4:19 pm EDT	Timothy P ClacksonPresident, R&D, CSO	8,750	$13.98	$122,311	217,522	−3.87%	plan?
Sep 26, 2016 MForm 4 →	Sep 28, 4:20 pm EDT	Daniel M BollagSr. VP, Reg. Affairs & Quality	10,000	—	—	176,788	—	plan?
Sep 26, 2016 MForm 4 →	Sep 28, 4:19 pm EDT	Timothy P ClacksonPresident, R&D, CSO	17,500	—	—	226,272	—	plan?
Sep 22, 2016 SForm 4 →	Sep 23, 5:46 pm EDT	Timothy P ClacksonPresident, R&D, CSO	20,000	$13.43	$268,536	208,772	−8.74%	plan?
Sep 15, 2016 SForm 4 →	Sep 16, 5:08 pm EDT	Timothy P ClacksonPresident, R&D, CSO	59,369	$11.73	$696,398	228,772	−20.6%	plan?
Sep 15, 2016 MForm 4 →	Sep 16, 5:08 pm EDT	Timothy P ClacksonPresident, R&D, CSO	59,369	$7.82	$464,266	288,141	—	plan?
Aug 22, 2016 SForm 4 →	Aug 23, 4:12 pm EDT	Timothy P ClacksonPresident, R&D, CSO	19,436	$10.47	$203,538	228,772	−7.83%	plan?
Aug 12, 2016 SForm 4 →	Aug 15, 4:16 pm EDT	Timothy P ClacksonPresident, R&D, CSO	25,000	$10.50	$262,500	248,208	−9.15%	plan?
Aug 12, 2016 MForm 4 →	Aug 15, 4:16 pm EDT	Timothy P ClacksonPresident, R&D, CSO	25,000	$7.69	$192,250	273,208	—	plan?
Jul 22, 2016 SForm 4 →	Jul 25, 4:39 pm EDT	Timothy P ClacksonPresident, R&D, CSO	18,286	$8.11	$148,230	248,208	−6.86%	plan?
Jul 13, 2016 FMForm 4 →	Jul 14, 4:23 pm EDT	Paris PanayiotopoulosPresident and CEO, Director	95,211	$7.14	$204,283	126,078	—	plan?
Jul 1, 2016 SForm 4 →	Jul 5, 4:07 pm EDT	Timothy P ClacksonPresident, R&D, CSO	61,422	$7.48	$459,634	266,494	−18.7%	plan?
Jul 1, 2016 MForm 4 →	Jul 5, 4:07 pm EDT	Timothy P ClacksonPresident, R&D, CSO	61,422	$3.88	$238,585	296,494	—	plan?
Jun 28, 2016 SForm 4 →	Jun 29, 4:25 pm EDT	Hugh M ColeSVP, Chief Business Officer	6,012	$7.05	$42,385	29,916	−16.7%	plan?
Jun 27, 2016 MForm 4 →	Jun 29, 4:25 pm EDT	Hugh M ColeSVP, Chief Business Officer	19,166	—	—	35,928	—	plan?
Jun 22, 2016 SForm 4 →	Jun 23, 4:11 pm EDT	Timothy P ClacksonPresident, R&D, CSO	23,999	$7.28	$174,638	264,742	−8.31%	plan?
Jun 13, 2016 SForm 4 →	Jun 15, 4:19 pm EDT	Athanese LavidasDirector	76,250	$8.21	$626,039	131,631	−36.7%	plan?
Jun 13, 2016 MForm 4 →	Jun 15, 4:19 pm EDT	Athanese LavidasDirector	76,250	$6.38	$486,488	177,881	—	plan?
Jun 10, 2016 SForm 4 →	Jun 14, 6:13 pm EDT	Massimo RadaelliDirector	108,569	$8.25	$896,135	105,500	−50.7%	plan?
Jun 10, 2016 MForm 4 →	Jun 14, 6:13 pm EDT	Massimo RadaelliDirector	108,569	$5.39	$584,733	111,750	—	plan?
May 23, 2016 SForm 4 →	May 25, 4:04 pm EDT	Timothy P ClacksonPresident, R&D, CSO	17,762	$8.08	$143,430	288,741	−5.80%	plan?
May 12, 2016 PForm 4 →	May 13, 5:59 pm EDT	Paris PanayiotopoulosPresident and CEO, Director	26,990	$7.41	$199,996	88,089	+44.2%	plan?
May 2, 2016 SForm 4 →	May 2, 5:28 pm EDT	Timothy P ClacksonPresident, R&D, CSO	11,700	$7.13	$83,478	306,503	−3.68%	plan?
Apr 29, 2016 FMForm 4 →	May 2, 5:33 pm EDT	Frank HaluskaSVP, Clinical R&D, CMO	22,968	$7.18	$40,452	158,711	—	plan?
Apr 29, 2016 FMForm 4 →	May 2, 5:32 pm EDT	Maria E CantorSVP, Corporate Affairs	17,668	$7.18	$31,118	144,667	—	plan?
Apr 29, 2016 FMForm 4 →	May 2, 5:30 pm EDT	Daniel M BollagSr. VP, Reg. Affairs & Quality	22,968	$7.18	$40,452	166,788	—	plan?
Apr 29, 2016 FMForm 4 →	May 2, 5:29 pm EDT	Hugh M ColeSVP, Chief Business Officer	22,968	$7.18	$40,452	16,762	—	plan?
Apr 29, 2016 MForm 4 →	May 2, 5:28 pm EDT	Timothy P ClacksonPresident, R&D, CSO	23,400	—	—	318,203	—	plan?
Apr 29, 2016 FMForm 4 →	May 2, 5:26 pm EDT	Martin J DuvallEVP, CCO	23,850	$7.18	$42,003	105,189	—	plan?
Apr 22, 2016 SForm 4 →	Apr 25, 4:04 pm EDT	Timothy P ClacksonPresident, R&D, CSO	21,409	$7.37	$157,864	294,803	−6.77%	plan?
Mar 22, 2016 SForm 4 →	Mar 23, 4:41 pm EDT	Timothy P ClacksonPresident, R&D, CSO	23,834	$6.58	$156,871	316,212	−7.01%	plan?
Mar 21, 2016 SForm 4 →	Mar 22, 4:02 pm EDT	David L BersteinSVP, Chief IP Counsel	2,375	$6.47	$15,356	262,115	−0.90%	plan?
Mar 21, 2016 SForm 4 →	Mar 22, 4:02 pm EDT	Daniel M BollagSr. VP, Reg. Affairs & Quality	4,000	$6.47	$25,871	155,088	−2.51%	plan?
Mar 21, 2016 SForm 4 →	Mar 22, 4:01 pm EDT	Edward M FitzgeraldExecutive VP	5,417	$6.47	$35,037	320,367	−1.66%	plan?
Mar 21, 2016 SForm 4 →	Mar 22, 4:01 pm EDT	Frank HaluskaSVP, Clinical R&D, CMO	3,575	$6.47	$23,116	147,011	−2.37%	plan?
Mar 19, 2016 SForm 4 →	Mar 22, 4:03 pm EDT	Martin J DuvallEVP, CCO	4,000	$6.47	$25,867	93,039	−4.12%	plan?
Mar 19, 2016 MForm 4 →	Mar 22, 4:03 pm EDT	Martin J DuvallEVP, CCO	8,000	—	—	97,039	—	plan?
Mar 19, 2016 MForm 4 →	Mar 22, 4:02 pm EDT	David L BersteinSVP, Chief IP Counsel	4,750	—	—	264,490	—	plan?
Mar 19, 2016 MForm 4 →	Mar 22, 4:02 pm EDT	Daniel M BollagSr. VP, Reg. Affairs & Quality	8,000	—	—	159,088	—	plan?
Mar 19, 2016 SForm 4 →	Mar 22, 4:02 pm EDT	Maria E CantorSVP, Corporate Affairs	3,575	$6.46	$23,102	135,667	−2.57%	plan?
Mar 19, 2016 MForm 4 →	Mar 22, 4:02 pm EDT	Maria E CantorSVP, Corporate Affairs	6,500	—	—	139,242	—	plan?
Mar 19, 2016 SForm 4 →	Mar 22, 4:01 pm EDT	Timothy P ClacksonPresident, R&D, CSO	5,417	$6.47	$35,039	340,046	−1.57%	plan?
Mar 19, 2016 MForm 4 →	Mar 22, 4:01 pm EDT	Timothy P ClacksonPresident, R&D, CSO	10,833	—	—	345,463	—	plan?
Mar 19, 2016 MForm 4 →	Mar 22, 4:01 pm EDT	Edward M FitzgeraldExecutive VP	10,833	—	—	325,784	—	plan?
Mar 19, 2016 MForm 4 →	Mar 22, 4:01 pm EDT	Frank HaluskaSVP, Clinical R&D, CMO	6,500	—	—	150,586	—	plan?
Mar 16, 2016 FMForm 4 →	Mar 18, 4:04 pm EDT	Hugh M ColeSVP, Chief Business Officer	9,938	$6.21	$61,715	5,062	—	plan?
Mar 15, 2016 DMForm 4 →	Mar 17, 4:45 pm EDT	Daniel M BollagSr. VP, Reg. Affairs & Quality	26,564	$5.49	$145,884	132,024	—	plan?
Mar 3, 2016 SForm 4 →	Mar 3, 8:12 pm EST	Edward M FitzgeraldExecutive VP, CFO	9,625	$6.12	$58,866	314,951	−2.97%	plan?
Mar 3, 2016 SForm 4 →	Mar 3, 8:08 pm EST	David L BersteinSVP, Chief IP Counsel	9,625	$6.12	$58,887	259,740	−3.57%	plan?
Mar 3, 2016 SForm 4 →	Mar 3, 8:07 pm EST	Martin J DuvallEVP, CCO	9,625	$6.12	$58,863	89,039	−9.76%	plan?
Mar 3, 2016 SForm 4 →	Mar 3, 8:00 pm EST	Maria E CantorSVP, Corporate Affairs	9,625	$6.12	$58,869	132,742	−6.76%	plan?
Mar 3, 2016 SForm 4 →	Mar 3, 7:59 pm EST	Daniel M BollagSr. VP, Reg. Affairs & Quality	9,625	$6.11	$58,852	151,088	−5.99%	plan?
Mar 3, 2016 SForm 4 →	Mar 3, 7:58 pm EST	Frank HaluskaSVP, Clinical R&D, CMO	10,588	$6.11	$64,733	144,086	−6.85%	plan?
Mar 2, 2016 SForm 4 →	Mar 3, 8:00 pm EST	Timothy P ClacksonPresident, R&D, CSO	34,672	$6.03	$209,149	334,630	−9.39%	plan?
Mar 1, 2016 MForm 4 →	Mar 3, 8:12 pm EST	Edward M FitzgeraldExecutive VP, CFO	19,250	—	—	324,576	—	plan?
Mar 1, 2016 MForm 4 →	Mar 3, 8:08 pm EST	David L BersteinSVP, Chief IP Counsel	19,250	—	—	269,365	—	plan?
Mar 1, 2016 MForm 4 →	Mar 3, 8:07 pm EST	Martin J DuvallEVP, CCO	19,250	—	—	98,664	—	plan?
Mar 1, 2016 MForm 4 →	Mar 3, 8:00 pm EST	Maria E CantorSVP, Corporate Affairs	19,250	—	—	142,367	—	plan?
Mar 1, 2016 MForm 4 →	Mar 3, 8:00 pm EST	Timothy P ClacksonPresident, R&D, CSO	19,250	—	—	369,302	—	plan?
Mar 1, 2016 MForm 4 →	Mar 3, 7:59 pm EST	Daniel M BollagSr. VP, Reg. Affairs & Quality	19,250	—	—	160,713	—	plan?
Mar 1, 2016 MForm 4 →	Mar 3, 7:58 pm EST	Frank HaluskaSVP, Clinical R&D, CMO	19,250	—	—	154,674	—	plan?
Feb 18, 2016 FMForm 4 →	Mar 30, 5:04 pm EDT	Thomas DesRosierEVP, General Counsel	73,370	$5.03	$92,401	36,630	—	plan? late
Feb 1, 2016 AForm 4/A →	Feb 9, 5:31 pm EST	Jay R LamarcheDirector	12,500	—	—	552,205	—	plan?
Feb 1, 2016 PForm 4 →	Feb 3, 5:43 pm EST	Paris PanayiotopoulosPresident and CEO, Director	61,099	$4.91	$299,996	61,099	—	plan?
Feb 1, 2016 AForm 4 →	Feb 3, 5:31 pm EST	Alexander J DennerDirector	12,500	—	—	35,165	—	plan?
Feb 1, 2016 AForm 4 →	Feb 3, 5:17 pm EST	Jay R LamarcheDirector	12,500	—	—	452,205	—	plan? amended
Feb 1, 2016 AForm 4 →	Feb 3, 5:15 pm EST	Wayne WilsonDirector	12,500	—	—	125,500	—	plan?
Feb 1, 2016 AForm 4 →	Feb 3, 5:08 pm EST	Athanese LavidasDirector	12,500	—	—	131,631	—	plan?
Feb 1, 2016 AForm 4 →	Feb 3, 4:56 pm EST	Anna ProtopapasDirector	23,902	—	—	23,902	—	plan?
Feb 1, 2016 AForm 4 →	Feb 3, 4:54 pm EST	Massimo RadaelliDirector	12,500	—	—	105,500	—	plan?
Feb 1, 2016 AForm 4 →	Feb 3, 4:50 pm EST	Sarah J. SchlesingerDirector	12,500	—	—	37,500	—	plan?
Feb 1, 2016 AForm 4 →	Feb 3, 4:47 pm EST	Norbert G RiedelDirector	12,500	—	—	121,859	—	plan?
Feb 1, 2016 SForm 4 →	Feb 3, 4:46 pm EST	Martin J DuvallEVP, CCO	14,667	$4.81	$70,578	79,414	−15.6%	plan?
Feb 1, 2016 MForm 4 →	Feb 3, 4:46 pm EST	Martin J DuvallEVP, CCO	29,333	—	—	94,081	—	plan?
Feb 1, 2016 SForm 4 →	Feb 3, 4:43 pm EST	Timothy P ClacksonPresident, R&D, CSO	14,667	$4.81	$70,517	350,052	−4.02%	plan?

Reported at this company — derivatives (options, RSUs, warrants)

Trade	Reported (ET)	Insider	Shares	Avg price	Total	Owned after	Δ stake	Flags
Feb 16, 2017 DForm 4 →	Feb 16, 2:18 pm EST	Sarah J. SchlesingerDirector	140,000	—	—	0	—
Feb 16, 2017 DForm 4 →	Feb 16, 2:18 pm EST	Timothy P ClacksonPresident, R&D, CSO	321,655	—	—	0	—
Feb 16, 2017 DForm 4 →	Feb 16, 2:17 pm EST	Jules HaimovitzDirector	100,000	—	—	0	—
Feb 16, 2017 DForm 4 →	Feb 16, 2:17 pm EST	George BickerstaffDirector	100,000	—	—	0	—
Feb 16, 2017 DForm 4 →	Feb 16, 2:17 pm EST	Jennifer Lyn HerronExec V.P. Chief Comm'l Officer	305,291	—	—	0	—
Feb 16, 2017 DForm 4 →	Feb 16, 2:16 pm EST	Hugh M ColeSVP, Chief Business Officer	252,521	—	—	0	—
Feb 16, 2017 DForm 4 →	Feb 16, 2:16 pm EST	Jayne M. GanslerSenior V.P. Human Resources	218,910	—	—	0	—
Feb 16, 2017 DForm 4 →	Feb 16, 2:16 pm EST	Norbert G RiedelDirector	125,000	—	—	0	—
Feb 16, 2017 DForm 4 →	Feb 16, 2:15 pm EST	Daniel M BollagSr. VP, Reg. Affairs & Quality	202,105	—	—	0	—
Feb 16, 2017 DForm 4 →	Feb 16, 2:15 pm EST	Paris PanayiotopoulosPresident and CEO, Director	1,566,800	—	—	0	—
Feb 16, 2017 DForm 4 →	Feb 16, 2:15 pm EST	Anna ProtopapasDirector	125,000	—	—	0	—
Feb 16, 2017 DForm 4 →	Feb 16, 2:14 pm EST	Manmeet Singh SoniEVP, CFO & Treasurer	557,937	—	—	0	—
Feb 16, 2017 DForm 4 →	Feb 16, 2:14 pm EST	Elona Kogan Esq.Sr. V. P. - General Counsel	306,085	—	—	0	—
Feb 16, 2017 DForm 4 →	Feb 16, 2:14 pm EST	Alexander J DennerDirector	8,950,000	—	—	0	—
Feb 6, 2017 AForm 4 →	Feb 7, 4:59 pm EST	Elona Kogan Esq.Sr. V. P. - General Counsel	6,085	—	—	6,085	—
Feb 6, 2017 AForm 4 →	Feb 7, 4:58 pm EST	Manmeet Singh SoniEVP, CFO & Treasurer	7,937	—	—	7,937	—
Feb 6, 2017 AForm 4 →	Feb 7, 4:58 pm EST	Daniel M BollagSr. VP, Reg. Affairs & Quality	3,439	—	—	3,439	—
Feb 6, 2017 AForm 4 →	Feb 7, 4:58 pm EST	Timothy P ClacksonPresident, R&D, CSO	14,550	—	—	14,550	—
Feb 6, 2017 AForm 4 →	Feb 7, 4:57 pm EST	Jayne M. GanslerSenior V.P. Human Resources	2,910	—	—	2,910	—
Feb 6, 2017 AForm 4 →	Feb 7, 4:57 pm EST	Jennifer Lyn HerronExec V.P. Chief Comm'l Officer	5,291	—	—	5,291	—
Jan 31, 2017 MForm 4 →	Feb 2, 4:42 pm EST	Daniel M BollagSr. VP, Reg. Affairs & Quality	29,333	—	—	0	—
Jan 31, 2017 MForm 4 →	Feb 2, 4:41 pm EST	Timothy P ClacksonPresident, R&D, CSO	29,333	—	—	0	—
Jan 31, 2017 AForm 4 →	Feb 2, 9:39 am EST	Alexander J DennerDirector	25,000	$23.82	$595,500	25,000	—
Jan 31, 2017 AForm 4 →	Feb 1, 4:56 pm EST	George BickerstaffDirector	25,000	$23.82	$595,500	25,000	—
Jan 31, 2017 AForm 4 →	Feb 1, 4:56 pm EST	Sarah J. SchlesingerDirector	25,000	$23.82	$595,500	25,000	—
Jan 31, 2017 AForm 4 →	Feb 1, 4:55 pm EST	Jules HaimovitzDirector	25,000	$23.82	$595,500	25,000	—
Jan 31, 2017 AForm 4 →	Feb 1, 4:55 pm EST	Norbert G RiedelDirector	25,000	$23.82	$595,500	25,000	—
Jan 31, 2017 AForm 4 →	Feb 1, 4:54 pm EST	Anna ProtopapasDirector	25,000	$23.82	$595,500	25,000	—
Jan 13, 2017 MForm 4 →	Jan 17, 5:06 pm EST	Paris PanayiotopoulosPresident and CEO, Director	66,600	—	—	66,800	—
Jan 9, 2017 MForm 4 →	Jan 10, 6:17 pm EST	Daniel M BollagSr. VP, Reg. Affairs & Quality	32,000	—	—	0	—
Sep 26, 2016 MForm 4 →	Sep 28, 4:20 pm EDT	Daniel M BollagSr. VP, Reg. Affairs & Quality	10,000	—	—	0	—
Sep 26, 2016 MForm 4 →	Sep 28, 4:19 pm EDT	Timothy P ClacksonPresident, R&D, CSO	17,500	—	—	0	—
Sep 15, 2016 MForm 4 →	Sep 16, 5:08 pm EDT	Timothy P ClacksonPresident, R&D, CSO	59,369	—	—	0	—
Aug 12, 2016 MForm 4 →	Aug 15, 4:16 pm EDT	Timothy P ClacksonPresident, R&D, CSO	25,000	—	—	0	—
Jul 15, 2016 AForm 4 →	Jul 19, 4:09 pm EDT	Elona Kogan Esq.Sr. V. P. - General Counsel	300,000	$7.13	$1,426,000	100,000	—
Jul 13, 2016 MForm 4 →	Jul 14, 4:23 pm EDT	Paris PanayiotopoulosPresident and CEO, Director	66,600	—	—	133,400	—
Jul 1, 2016 MForm 4 →	Jul 5, 4:07 pm EDT	Timothy P ClacksonPresident, R&D, CSO	61,422	$3.88	$238,585	0	—
Jun 27, 2016 MForm 4 →	Jun 29, 4:25 pm EDT	Hugh M ColeSVP, Chief Business Officer	19,166	—	—	6,667	—
Jun 13, 2016 MForm 4 →	Jun 15, 4:19 pm EDT	Athanese LavidasDirector	76,250	$6.38	$486,488	18,750	—
Jun 10, 2016 MForm 4 →	Jun 14, 6:13 pm EDT	Massimo RadaelliDirector	108,569	$5.38	$584,596	18,750	—
Jun 6, 2016 AForm 4 →	Jun 8, 4:09 pm EDT	Jayne M. GanslerSenior V.P. Human Resources	216,000	$8.86	$1,275,840	72,000	—
May 31, 2016 AForm 4 →	Jun 1, 4:54 pm EDT	Jennifer Lyn HerronExec V.P. Chief Comm'l Officer	300,000	$8.85	$2,655,000	300,000	—
May 4, 2016 AForm 4 →	May 6, 4:20 pm EDT	Jules HaimovitzDirector	75,000	$6.65	$498,750	75,000	—
May 4, 2016 AForm 4 →	May 6, 4:19 pm EDT	George BickerstaffDirector	75,000	$6.65	$498,750	75,000	—
Apr 29, 2016 MForm 4 →	May 2, 5:33 pm EDT	Frank HaluskaSVP, Clinical R&D, CMO	17,334	—	—	0	—
Apr 29, 2016 MForm 4 →	May 2, 5:32 pm EDT	Maria E CantorSVP, Corporate Affairs	13,334	—	—	0	—
Apr 29, 2016 MForm 4 →	May 2, 5:30 pm EDT	Daniel M BollagSr. VP, Reg. Affairs & Quality	17,334	—	—	0	—
Apr 29, 2016 MForm 4 →	May 2, 5:29 pm EDT	Hugh M ColeSVP, Chief Business Officer	17,334	—	—	0	—
Apr 29, 2016 MForm 4 →	May 2, 5:28 pm EDT	Timothy P ClacksonPresident, R&D, CSO	23,400	—	—	0	—
Apr 29, 2016 MForm 4 →	May 2, 5:26 pm EDT	Martin J DuvallEVP, CCO	18,000	—	—	0	—
Mar 21, 2016 AForm 4 →	Mar 22, 4:00 pm EDT	Manmeet Singh SoniEVP, CFO & Treasurer	550,000	—	—	550,000	—
Mar 19, 2016 MForm 4 →	Mar 22, 4:03 pm EDT	Martin J DuvallEVP, CCO	8,000	—	—	0	—
Mar 19, 2016 MForm 4 →	Mar 22, 4:02 pm EDT	David L BersteinSVP, Chief IP Counsel	4,750	—	—	0	—
Mar 19, 2016 MForm 4 →	Mar 22, 4:02 pm EDT	Daniel M BollagSr. VP, Reg. Affairs & Quality	8,000	—	—	0	—
Mar 19, 2016 MForm 4 →	Mar 22, 4:02 pm EDT	Maria E CantorSVP, Corporate Affairs	6,500	—	—	0	—
Mar 19, 2016 MForm 4 →	Mar 22, 4:01 pm EDT	Timothy P ClacksonPresident, R&D, CSO	10,833	—	—	0	—
Mar 19, 2016 MForm 4 →	Mar 22, 4:01 pm EDT	Edward M FitzgeraldExecutive VP	10,833	—	—	0	—
Mar 19, 2016 MForm 4 →	Mar 22, 4:01 pm EDT	Frank HaluskaSVP, Clinical R&D, CMO	6,500	—	—	0	—
Mar 16, 2016 AMForm 4 →	Mar 18, 4:04 pm EDT	Hugh M ColeSVP, Chief Business Officer	22,500	$6.21	$46,575	7,500	—
Mar 15, 2016 MForm 4 →	Mar 17, 4:45 pm EDT	Daniel M BollagSr. VP, Reg. Affairs & Quality	3,750	$1.30	$4,875	0	—
Mar 7, 2016 AForm 4 →	Mar 9, 5:14 pm EST	Maria E CantorSVP, Corporate Affairs	66,300	$6.51	$332,010	15,300	—
Mar 7, 2016 AForm 4 →	Mar 9, 5:14 pm EST	Frank HaluskaSVP, Clinical R&D, CMO	78,000	$6.51	$390,600	18,000	—
Mar 7, 2016 AForm 4 →	Mar 9, 5:14 pm EST	Timothy P ClacksonPresident, R&D, CSO	113,305	—	—	26,180	—
Mar 7, 2016 AForm 4 →	Mar 9, 5:14 pm EST	Thomas DesRosierEVP, General Counsel	133,300	—	—	30,800	—
Mar 7, 2016 AForm 4 →	Mar 9, 5:13 pm EST	Martin J DuvallEVP, CCO	113,305	—	—	26,180	—
Mar 7, 2016 AForm 4 →	Mar 9, 5:13 pm EST	Hugh M ColeSVP, Chief Business Officer	101,400	$6.51	$507,780	23,400	—
Mar 7, 2016 AForm 4 →	Mar 9, 5:13 pm EST	Edward M FitzgeraldExecutive VP, CFO	113,305	$6.51	$567,184	26,180	—
Mar 7, 2016 AForm 4 →	Mar 9, 5:08 pm EST	Daniel M BollagSr. VP, Reg. Affairs & Quality	78,000	—	—	18,000	—
Mar 1, 2016 AMForm 4 →	Mar 3, 8:12 pm EST	Edward M FitzgeraldExecutive VP, CFO	57,750	—	—	38,500	—
Mar 1, 2016 AMForm 4 →	Mar 3, 8:08 pm EST	David L BersteinSVP, Chief IP Counsel	57,750	—	—	38,500	—
Mar 1, 2016 AMForm 4 →	Mar 3, 8:07 pm EST	Martin J DuvallEVP, CCO	57,750	—	—	38,500	—
Mar 1, 2016 AMForm 4 →	Mar 3, 8:00 pm EST	Maria E CantorSVP, Corporate Affairs	57,750	—	—	38,500	—
Mar 1, 2016 AMForm 4 →	Mar 3, 8:00 pm EST	Timothy P ClacksonPresident, R&D, CSO	57,750	—	—	38,500	—
Mar 1, 2016 AMForm 4 →	Mar 3, 7:59 pm EST	Daniel M BollagSr. VP, Reg. Affairs & Quality	57,750	—	—	38,500	—
Mar 1, 2016 AMForm 4 →	Mar 3, 7:58 pm EST	Frank HaluskaSVP, Clinical R&D, CMO	57,750	—	—	38,500	—
Feb 18, 2016 MForm 4 →	Mar 30, 5:04 pm EDT	Thomas DesRosierEVP, General Counsel	55,000	—	—	55,000	—	late
Feb 1, 2016 AForm 4/A →	Feb 9, 5:31 pm EST	Jay R LamarcheDirector	25,000	$4.91	$122,750	25,000	—
Feb 1, 2016 AForm 4 →	Feb 3, 5:31 pm EST	Alexander J DennerDirector	25,000	$4.91	$122,750	25,000	—
Feb 1, 2016 AForm 4 →	Feb 3, 5:17 pm EST	Jay R LamarcheDirector	25,000	$4.91	$122,750	25,000	—	amended
Feb 1, 2016 AForm 4 →	Feb 3, 5:15 pm EST	Wayne WilsonDirector	25,000	$4.91	$122,750	25,000	—
Feb 1, 2016 AForm 4 →	Feb 3, 5:08 pm EST	Athanese LavidasDirector	25,000	$4.91	$122,750	25,000	—
Feb 1, 2016 AForm 4 →	Feb 3, 4:56 pm EST	Anna ProtopapasDirector	25,000	$4.91	$122,750	25,000	—
Feb 1, 2016 AForm 4 →	Feb 3, 4:54 pm EST	Massimo RadaelliDirector	25,000	$4.91	$122,750	25,000	—
Feb 1, 2016 AForm 4 →	Feb 3, 4:50 pm EST	Sarah J. SchlesingerDirector	25,000	$4.91	$122,750	25,000	—
Feb 1, 2016 AForm 4 →	Feb 3, 4:47 pm EST	Norbert G RiedelDirector	25,000	$4.91	$122,750	25,000	—
Feb 1, 2016 MForm 4 →	Feb 3, 4:46 pm EST	Martin J DuvallEVP, CCO	29,333	—	—	29,333	—
Feb 1, 2016 MForm 4 →	Feb 3, 4:43 pm EST	Timothy P ClacksonPresident, R&D, CSO	29,333	—	—	29,333	—
Feb 1, 2016 MForm 4 →	Feb 3, 4:41 pm EST	Daniel M BollagSr. VP, Reg. Affairs & Quality	29,333	—	—	29,333	—
Feb 1, 2016 MForm 4 →	Feb 3, 4:39 pm EST	Frank HaluskaSVP, Clinical R&D, CMO	29,333	—	—	29,333	—
Feb 1, 2016 MForm 4 →	Feb 3, 4:38 pm EST	David L BersteinSVP, Chief IP Counsel	29,333	—	—	29,333	—
Feb 1, 2016 MForm 4 →	Feb 3, 4:37 pm EST	Edward M FitzgeraldExecutive VP, CFO	29,333	—	—	29,333	—
Feb 1, 2016 MForm 4 →	Feb 3, 4:35 pm EST	Maria E CantorSVP, Corporate Affairs	29,333	—	—	29,333	—
Jan 13, 2016 AForm 4 →	Jan 15, 4:35 pm EST	Paris PanayiotopoulosPresident and CEO, Director	1,700,000	$5.34	$8,010,000	200,000	—
Dec 31, 2015 MForm 4 →	Jan 5, 2016, 5:41 pm EST	Harvey J M D BergerChairman & CEO, Director	602,500	—	—	0	—
Sep 24, 2015 AMForm 4/A →	Sep 30, 4:14 pm EDT	David L BersteinSVP, Chief IP Counsel	30,000	—	—	20,000	—
Sep 24, 2015 AMForm 4/A →	Sep 28, 6:35 pm EDT	Daniel M BollagSr. VP, Reg. Affairs & Quality	30,000	—	—	20,000	—
Sep 24, 2015 AMForm 4 →	Sep 28, 6:14 pm EDT	Daniel M BollagSr. VP, Reg. Affairs & Quality	30,000	—	—	20,000	—
Sep 24, 2015 AMForm 4 →	Sep 28, 6:09 pm EDT	Martin J DuvallEVP, CCO	30,000	—	—	20,000	—
Sep 24, 2015 AMForm 4 →	Sep 28, 5:57 pm EDT	Maria E CantorSVP, Corporate Affairs	30,000	—	—	20,000	—
Sep 24, 2015 AMForm 4 →	Sep 28, 5:50 pm EDT	Edward M FitzgeraldExecutive VP, CFO	52,500	—	—	35,000	—