Security	Date	Code	Shares	A/D	Owned after	D/I	Nature of ownership
Common Stock, $0.0001 par value^F1,F2	holding	—	—	—	2,798,795	D
Common Stock, $0.0001 par value^F1,F3	holding	—	—	—	2,219,858	D
Common Stock, $0.0001 par value^F1,F4	holding	—	—	—	353,412	D
Common Stock, $0.0001 par value^F1,F5	holding	—	—	—	130,645	I	See footnote

Table II — derivative securities

Security	Conv. / exercise price	Date	Code	Shares	A/D	Exercisable	Expires	Underlying	Underlying shares	Owned after	D/I
Stock Option (Right to Buy)^F6,F7	$99.87	Jun 24, 2026	A	6,068	A	—	Jun 23, 2036	Common Stock, $0.0001 par value	6,068	6,068	I
Pre-Funded Warrants to Purchase Common Stock^F1,F2,F8	$0.0001	holding	—	—	—	—	—	Common Stock, $0.0001 par value	201,546	201,546	D
Pre-Funded Warrants to Purchase Common Stock^F1,F3,F8	$0.0001	holding	—	—	—	—	—	Common Stock, $0.0001 par value	156,742	156,742	D
Pre-Funded Warrants to Purchase Common Stock^F1,F2,F8	$0.0001	holding	—	—	—	—	—	Common Stock, $0.0001 par value	550,425	550,425	D
Pre-Funded Warrants to Purchase Common Stock^F1,F3,F8	$0.0001	holding	—	—	—	—	—	Common Stock, $0.0001 par value	375,856	375,856	D
Pre-Funded Warrants to Purchase Common Stock^F1,F4,F8	$0.0001	holding	—	—	—	—	—	Common Stock, $0.0001 par value	52,733	52,733	D
Pre-Funded Warrants to Purchase Common Stock^F1,F5,F8	$0.0001	holding	—	—	—	—	—	Common Stock, $0.0001 par value	27,797	27,797	I
Stock Option (Right to Buy)^F6,F9	$20.00	holding	—	—	—	—	Aug 19, 2030	Common Stock, $0.0001 par value	40,127	40,127	I
Stock Option (Right to Buy)^F6,F9	$49.10	holding	—	—	—	—	Jun 15, 2031	Common Stock, $0.0001 par value	20,063	20,063	I
Stock Option (Right to Buy)^F6,F9	$14.18	holding	—	—	—	—	Jun 14, 2032	Common Stock, $0.0001 par value	12,000	12,000	I
Stock Option (Right to Buy)^F6,F9	$27.67	holding	—	—	—	—	Jun 14, 2033	Common Stock, $0.0001 par value	12,000	12,000	I
Stock Option (Right to Buy)^F6,F9	$31.20	holding	—	—	—	—	Jun 17, 2034	Common Stock, $0.0001 par value	16,000	16,000	I
Stock Option (Right to Buy)^F6,F9	$46.47	holding	—	—	—	—	Jun 24, 2035	Common Stock, $0.0001 par value	16,000	16,000	I

Explanation of responses

F1This Form 4 is filed jointly by Biotechnology Value Fund, L.P. ("BVF"), Biotechnology Value Fund II, L.P. ("BVF2"), Biotechnology Value Trading Fund OS LP ("Trading Fund OS"), BVF Partners OS Ltd. ("Partners OS"), BVF I GP LLC ("BVF GP"), BVF II GP LLC ("BVF2 GP"), BVF GP Holdings LLC ("BVF GPH"), BVF Partners L.P. ("Partners"), BVF Inc. and Mark N. Lampert (collectively, the "Reporting Persons"). Each of the Reporting Persons is a member of a Section 13(d) group. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein except to the extent of his or its pecuniary interest therein.
F2Securities owned directly by BVF. As the general partner of BVF, BVF GP may be deemed to beneficially own the securities owned directly by BVF. As the sole member of BVF GP, BVF GPH may be deemed to beneficially own the securities owned directly by BVF. As the investment manager of BVF, Partners may be deemed to beneficially own the securities owned directly by BVF. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF.
F3Securities owned directly by BVF2. As the general partner of BVF2, BVF2 GP may be deemed to beneficially own the securities owned directly by BVF2. As the sole member of BVF2 GP, BVF GPH may be deemed to beneficially own the securities owned directly by BVF2. As the investment manager of BVF2, Partners may be deemed to beneficially own the securities owned directly by BVF2. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF2. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF2.
F4Securities owned directly by Trading Fund OS. As the general partner of Trading Fund OS, Partners OS may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the investment manager of Trading Fund OS and the sole member of Partners OS, Partners may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by Trading Fund OS. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by Trading Fund OS.
F5Securities held in a certain Partners managed account (the "Partners Managed Account"). Partners may be deemed to have indirect beneficial ownership of the securities of the Issuer held by the Partners Managed Account for purposes of Rule 16a-1(a)(2) because the securities account for more than 10% of the market value of the portfolio of the Partners Managed Account as of the reporting date. Partners, as the investment manager of the Partners Managed Account, may be deemed to beneficially own the securities held by the Partners Managed Account. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities held by the Partners Managed Account. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities held by the Partners Managed Account.
F6Partners, BVF Inc. and Mr. Lampert may be deemed to have a pecuniary interest in the securities reported owned herein due to a certain agreement between Partners and Gorjan Hrustanovic, who serves on the Issuer's board of directors and as a member of Partners, pursuant to which Mr. Hrustanovic is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the securities reported owned herein to Partners. As such, Mr. Hrustanovic disclaims beneficial ownership of the securities reported herein except to the extent of his pecuniary interest therein.
F7The shares underlying this stock option shall vest in full upon the earlier to occur of (i) June 24, 2027 and (ii) the date of the next annual meeting of the Issuer's stockholders.
F8The Pre-Funded Warrants are exercisable at any time after the date of issuance, subject to certain conditions and limitations, and do not expire.
F9The shares subject to the option have fully vested.

Remarks

For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each of the Reporting Persons may be deemed to be a director by deputization of the Issuer due to a member of Partners, Gorjan Hrustanovic, serving on the Board of Directors of the Issuer, and his agreement to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the securities reported owned herein to Partners.