SEC Form 4 · accession 0001298709-26-000011

Krystal Biotech, Inc. · KRYS

Statement of changes in beneficial ownership, as filed. Original on EDGAR ↗

Reporting owner

Krish S Krishnan

Officer — President and CEO · Director · 10% Owner

Period of report

Sep 4, 2026

Accepted (ET)

Sep 4, 2026 · 7:14 pm EDT

Rule 10b5-1 plan

yes — trade under a plan

Issuer CIK

0001711279

Table I — non-derivative securities

Security	Date	Code	Shares	Price	A/D	Owned after	D/I	Nature of ownership
Common Stock^F2,F3	Sep 4, 2026	S	520	$354.54	D	1,372,023	D
Common Stock^F4	Sep 4, 2026	S	2,029	$355.5719	D	1,369,994	D
Common Stock^F5	Sep 4, 2026	S	3,297	$356.3687	D	1,366,697	D
Common Stock^F6	Sep 4, 2026	S	3,981	$357.5738	D	1,362,716	D
Common Stock^F7	Sep 4, 2026	S	3,143	$358.4182	D	1,359,573	D
Common Stock^F8	Sep 4, 2026	S	3,357	$359.3861	D	1,356,216	D
Common Stock^F9	Sep 4, 2026	S	2,266	$360.463	D	1,353,950	D
Common Stock^F10	Sep 4, 2026	S	1,214	$361.6091	D	1,352,736	D
Common Stock^F11	Sep 4, 2026	S	2,010	$362.6504	D	1,350,726	D
Common Stock^F12	Sep 4, 2026	S	573	$363.3424	D	1,350,153	D
Common Stock^F13	Sep 4, 2026	S	1,358	$364.4794	D	1,348,795	D
Common Stock^F14	Sep 4, 2026	S	847	$365.4163	D	1,347,948	D
Common Stock^F15	Sep 4, 2026	S	405	$366.5567	D	1,347,543	D
Common Stock^F16	holding	—	—		—	90,000	I	By SMK Trust FBO KSK
Common Stock^F17	holding	—	—		—	77,710	I	By Krish Srinivas Krishnan Trust
Common Stock^F18	holding	—	—		—	50,000	I	By Krishnan Family Trust

Table II — derivative securities

No Table II lines on this filing.

Explanation of responses

F1The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Suma M. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by his spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein.
F10The transaction was executed in multiple trades ranging from $361.02 to $362.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
F11The transaction was executed in multiple trades ranging from $362.02 to $363.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
F12The transaction was executed in multiple trades ranging from $363.05 to $364.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
F13The transaction was executed in multiple trades ranging from $364.07 to $365.05. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
F14The transaction was executed in multiple trades ranging from $365.07 to $366.03. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
F15The transaction was executed in multiple trades ranging from $366.39 to $366.91. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
F16Held by SMK Trust FBO KSK, an irrevocable trust established by Mrs. Krishnan for the benefit of Mr. Krishnan who serves as a co-trustee and shares voting and investment power with a 3rd party co-trustee.
F17Held by the Krish Srinivas Krishnan Trust dated July 7, 2026. The Reporting Person is the grantor and trustee of the trust, has the power to revoke the trust, and has voting and investment power with respect to the shares held by the trust.
F18Held by the Krishnan Family Trust. The Reporting Person and his spouse are each joint beneficial owners of the trust with joint voting and investment control.
F2The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.
F3The transaction was executed in multiple trades ranging from $353.98 to $354.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
F4The transaction was executed in multiple trades ranging from $354.98 to $355.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
F5The transaction was executed in multiple trades ranging from $355.98 to $356.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
F6The transaction was executed in multiple trades ranging from $356.99 to $357.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
F7The transaction was executed in multiple trades ranging from $357.99 to $358.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
F8The transaction was executed in multiple trades ranging from $358.99 to $359.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
F9The transaction was executed in multiple trades ranging from $360.01 to $361.005. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.