Security	Date	Code	Shares	Price	A/D	Owned after	D/I	Nature of ownership
Ordinary Shares^F1,F2	May 30, 2018	C	495,370	—	A	495,370	I	By Frazier Healthcare VII, L.P.
Ordinary Shares^F3,F2	May 30, 2018	C	189,141	—	A	684,511	I	By Frazier Healthcare VII, L.P.
Ordinary Shares^F4,F2	May 30, 2018	C	157,701	—	A	842,212	I	By Frazier Healthcare VII, L.P.
Ordinary Shares^F2	May 30, 2018	P	354,949	$13.00	A	1,197,161	I	By Frazier Healthcare VII, L.P.
Ordinary Shares^F1,F5	May 30, 2018	C	141,166	—	A	141,166	I	By Frazier Healthcare VII-A, L.P.
Ordinary Shares^F3,F5	May 30, 2018	C	53,899	—	A	195,065	I	By Frazier Healthcare VII-A, L.P.
Ordinary Shares^F4,F5	May 30, 2018	C	44,940	—	A	240,005	I	By Frazier Healthcare VII-A, L.P.
Ordinary Shares^F5	May 30, 2018	P	101,150	$13.00	A	341,155	I	By Frazier Healthcare VII-A, L.P.

Table II — derivative securities

Security	Conv. / exercise price	Date	Code	Shares	A/D	Exercisable	Expires	Underlying	Underlying shares	D/I
Series A Preferred Shares^F2,F1,F6	—	May 30, 2018	C	495,370	D	—	—	Ordinary Shares	495,370	I
Series B-1 Preferred Shares^F2,F3,F6	—	May 30, 2018	C	189,141	D	—	—	Ordinary Shares	189,141	I
Series B-2 Preferred Shares^F2,F4,F6	—	May 30, 2018	C	157,701	D	—	—	Ordinary Shares	157,701	I
Series A Preferred Shares^F5,F1,F6	—	May 30, 2018	C	141,166	D	—	—	Ordinary Shares	141,166	I
Series B-1 Preferred Shares^F5,F3,F6	—	May 30, 2018	C	53,899	D	—	—	Ordinary Shares	53,899	I
Series B-2 Preferred Shares^F5,F4,F6	—	May 30, 2018	C	44,940	D	—	—	Ordinary Shares	44,940	I

Explanation of responses

F1The Series A Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.
F2These shares are held directly by Frazier Healthcare VII, L.P. ("FH VII"). The sole general partner of FH VII is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VII. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VII, except to the extent of his or its pecuniary interest therein, if any.
F3The Series B-1 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.
F4The Series B-2 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.
F5These shares are held directly by Frazier Healthcare VII-A, L.P. ("FH VIIA"). The sole general partner of FH VIIA is FHM VII, L.P. and the general partner of FHM VII, L.P. is FHM VII, L.L.C., and each may be deemed to have sole voting, investment and dispositive power with respect to the shares held by FH VIIA. The Reporting Person is one of six members of FHM VII, L.L.C. The Reporting Person, FHM VII, L.P. and FHM VII, L.L.C. disclaims Section 16 beneficial ownership of the securities held by FH VIIA, except to the extent of his or its pecuniary interest therein, if any.
F6Not applicable.