Security	Conv. / exercise price	Date	Code	Shares	A/D	Exercisable	Expires	Underlying	Underlying shares	Owned after	D/I
Convertible Preferred Stock^F2,F1	—	Apr 20, 2015	C	1,764,195	D	—	—	Common Stock	1,764,195	0	I
Convertible Preferred Stock^F3,F1	—	Apr 20, 2015	C	45,467	D	—	—	Common Stock	45,467	0	I

Explanation of responses

F1In connection with the Issuer's initial public offering, the preferred stock automatically converted into shares of the Issuer's common stock at the rate of 1 share of common stock for each 25.4 shares of preferred stock. The preferred stock had no expiration date.
F2Shares are held by 5AM Ventures III, L.P. 5AM Partners III, LLC ("5AM Partners") is the general partner of 5AM Ventures III, L.P. and 5AM Co-Investors III, L.P. and may be deemed to have solevoting and investment power over the shares beneficially owned by 5AM Ventures III, L.P. and 5AM Co-Investors III, L.P. Dr. John Diekman, Andrew Schwab and Dr. Scott Rocklage, themanaging members of 5AM Partners, may be deemed to have shared voting and investment power over the shares beneficially owned by 5AM Ventures III, L.P. and 5AM Co-Investors III, L.P.Each of 5AM Partners, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaim beneficial ownership of such shares except to the extent of its or his pecuniary interest therein.
F3Shares are held by 5AM Co-Investors III, L.P. 5AM Partners is the general partner of 5AM Ventures III, L.P. and 5AM Co-Investors III, L.P. and may be deemed to have sole voting andinvestment power over the shares beneficially owned by 5AM Ventures III, L.P. and 5AM Co-Investors III, L.P. Dr. John Diekman, Andrew Schwab and Dr. Scott Rocklage, the managingmembers of 5AM Partners, may be deemed to have shared voting and investment power over the shares beneficially owned by 5AM Ventures III, L.P. and 5AM Co-Investors III, L.P. Each of5AM Partners, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaim beneficial ownership of such shares except to the extent of its or his pecuniary interest therein.