SEC Form 4 · accession 0001214659-26-009655

Twist Bioscience Corp · TWST

Statement of changes in beneficial ownership, as filed. Original on EDGAR ↗

Reporting owner

Emily M. Leproust

Officer — Chief Executive Officer · Director

Period of report

Aug 3, 2026

Accepted (ET)

Aug 5, 2026 · 4:05 pm EDT

Rule 10b5-1 plan

box not checked

Issuer CIK

0001581280

Table I — non-derivative securities

Security	Date	Code	Shares	Price	A/D	Owned after	D/I	Nature of ownership
Common Stock^F1	Aug 3, 2026	S	5,101	$85.3212	D	818,938	D

Table II — derivative securities

Security	Conv. / exercise price	Date	Code	Shares	A/D	Exercisable	Expires	Underlying	Underlying shares	Owned after	D/I
Employee Stock Option (right to buy)^F2	$5.95	holding	—	—	—	—	Sep 28, 2025	Common Stock	0	0	D
Employee Stock Option (right to buy)^F3	$8.82	holding	—	—	—	—	Sep 28, 2027	Common Stock	0	75,439	D
Employee Stock Option (right to buy)^F4	$26.66	holding	—	—	—	—	Nov 18, 2028	Common Stock	0	266,539	D
Employee Stock Option (right to buy)^F5	$23.33	holding	—	—	—	—	Oct 23, 2029	Common Stock	0	131,290	D
Employee Stock Option (right to buy)^F6	$67.85	holding	—	—	—	Dec 19, 2022	Aug 31, 2030	Common Stock	64,950	64,950	D

Explanation of responses

F1Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of Restricted Stock Units. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.
F2The option is immediately exercisable. 25% of the shares subject to the option vested on September 1, 2016 and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.
F3The option is immediately exercisable. 10% of the shares subject to the option vested on September 28, 2017, 15% of the shares subject to the option vested on September 28, 2018, and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.
F420% of the shares subject to the option vested and became exercisable on October 31, 2019 and 1/60th of the shares subject to the option vest and become exercisable on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.
F525% of the shares subject to the option vested on October 24, 2020, and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.
F6Represents performance stock options granted to the reporting person on September 1, 2020, that vested and became exercisable on December 19, 2022 as a result of the reporting person having met the applicable performance criteria.