Security	Date	Code	Shares	Price	A/D	Owned after	D/I
Common Stock^F1,F2	Oct 5, 2015	C	1,244,269	—	A	1,244,269	D
Common Stock^F1,F2	Oct 5, 2015	C	583,559	—	A	1,827,828	D
Common Stock^F3,F2	Oct 6, 2015	J	289,841	$0.00	A	2,117,669	D
Common Stock^F2	Oct 6, 2015	P	857,142	$7.00	A	2,974,811	D

Table II — derivative securities

Security	Conv. / exercise price	Date	Code	Shares	A/D	Exercisable	Expires	Underlying	Underlying shares	Owned after	D/I
Series C Preferred Stock^F5,F2,F1,F4	—	Oct 5, 2015	C	1,244,269	D	—	—	Common Stock	1,244,269	0	D
Series D Preferred Stock^F2,F1,F4	—	Oct 5, 2015	C	583,559	D	—	—	Common Stock	583,559	0	D

Explanation of responses

F1Each share of Series C and Series D Preferred Stock automatically converted on a one-to-one basis into Common Stock immediately prior to the consummation of the Issuer's initial public offering.
F2The shares are held by Sofinnova Venture Partners VIII, L.P. ("SVP VIII"). Sofinnova Management VIII, L.L.C. ("SM VIII") is the general partner of SVP VIII. The individual Managers, or the Managing Members, of SM VIII are Michael Powell, James Healy, Srinivas Akkaraju and Anand Mehra. The Managers share voting and dispositive power with regard to the shares held directly by SVP VIII. Such persons and entities disclaim beneficial ownership over the shares owned by SVP VIII except to the extent of any pecuniary interest therein.
F3The shares were issued for no additional consideration pursuant to an accruing paid-in-kind dividend on shares of Series C and Series D Preferred Stock of the Company.
F4The expiration date is not relevant to the conversion of the securities.
F5Due to a clerical error, the Reporting Persons' Form 3 which previously reported the holding of these shares understated his total by one (1) share.