F1Distribution of shares in kind by Domain Partners VII, L.P. to its partners, including 29,269 shares to One Palmer Square Associates VII, LLC, the sole general partner of Domain Partners VII, L.P.
F2The securities reported as directly beneficially owned by the designated Reporting Person may be deemed to be indirectly beneficially owned by each of the Reporting Owners listed below, each of whom is a managing member of One Palmer Square Associates VII, LLC, the sole general partner of the designated Reporting Person.
F3As managing members of the sole general partner of DP VII Associates, L.P., each Reporting Owner listed below may also be deemed to indirectly beneficially own 35,253 shares of Common Stock held by DP VII Associates, L.P.
F4As managing members of Domain Associates, LLC, each Reporting Owner listed below may also be deemed to indirectly beneficially own 21,471 shares of Common Stock held by Domain Associates, LLC.
F5As managing members of One Palmer Square Associates VII, LLC, each Reporting Owner listed below may also be deemed to indirectly beneficially own 29,269 shares of Common Stock held by One Palmer Square Associates VII, LLC.
F6Pursuant to Instruction 4(b)(iv) of Form 4, each Reporting Owner listed below has elected to report as indirectly beneficially owned the entire number of securities owned by Domain Partners VII, L.P., DP VII Associates, L.P., One Palmer Square Associates VII, LLC and Domain Associates, LLC , however he or she disclaims beneficial ownership of any securities, and any proceeds thereof, that exceed his or her pecuniary interest therein and/or that are not actually distributed to him or her.