Security	Date	Code	Shares	Price	A/D	Owned after	D/I	Nature of ownership
Common Stock^F1	Aug 20, 2018	P	465,116	$2.35	A	1,937,983	I	Directly owned by LVP III
Common Stock^F1	Aug 20, 2018	P	23,256	$2.35	A	96,897	I	Directly owned by Associates
Common Stock^F1	Aug 20, 2018	P	11,628	$2.35	A	48,449	I	Directly owned by Partners
Common Stock^F1	holding	—	—		—	5,250	I	Directly owned by LVPMC

Table II — derivative securities

No Table II lines on this filing.

Explanation of responses

F1The reported securities are owned directly by each of LVPMC, LLC ("LVPMC"), LVP Life Science Ventures III, L.P. ("LVP III"), LVP III Associates, L.P. ("Associates") and LVP III Partners, L.P. ("Partners"). LVP GP III, LLC ("GP III") is the general partner of LVP III, Associates and Partners. GP III may be deemed to have sole voting power and dispositive power over the shares held by LVP III, Associates and Partners. Each of GP III and Patrick Latterell, the managing member of GP III and the manager of LVPMC, may be deemed to share voting and dispositive power over the reported securities and disclaim beneficial ownership of the reported securities held by LVPMC, LVP III, Associates and Partners except to the extent of any pecuniary interest therein.