Security	Date	Code	Shares	Price	A/D	Owned after	D/I	Nature of ownership
Common Stock, par value $0.0001 ("Common Stock")^F1,F2	Jun 1, 2017	S	164,325	$82.4112	D	4,286,643	I	See footnote
Common Stock^F3,F2	Jun 1, 2017	S	5,200	$83.5454	D	4,281,443	I	See footnote
Common Stock^F4,F2	Jun 2, 2017	S	30,475	$83.0611	D	4,250,968	I	See footnote
Common Stock^F5,F2	Jun 5, 2017	S	1,100	$85.3182	D	4,249,868	I	See footnote
Common Stock^F6,F2	Jun 5, 2017	S	63,227	$88.1235	D	4,186,641	I	See footnote
Common Stock^F7,F2	Jun 5, 2017	S	152,762	$90.2132	D	4,033,879	I	See footnote
Common Stock^F8,F2	Jun 5, 2017	S	23,272	$91.3138	D	4,010,607	I	See footnote
Common Stock^F2	Jun 5, 2017	S	3,083	$92.00	D	4,007,524	I	See footnote
Common Stock^F9,F2	Jun 5, 2017	S	52,016	$96.6144	D	3,955,508	I	See footnote
Common Stock^F10,F2	Jun 5, 2017	S	11,668	$99.0798	D	3,943,840	I	See footnote

Table II — derivative securities

No Table II lines on this filing.

Explanation of responses

F1The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $81.75 to $82.625, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth herein.
F10The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $99 to $99.45, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth herein.
F2The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except as to such extent of the reporting person's pecuniary interest in the securities.
F3The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $83.2 to $84, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth herein.
F4The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $83 to $83.45, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth herein.
F5The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $85.25 to $85.45, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth herein.
F6The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $87.625 to $88.6, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth herein.
F7The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $90 to $90.75, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth herein
F8The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $91 to $91.65, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth herein.
F9The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $96.5 to $97, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth herein.