Security	Date	Code	Shares	Price	A/D	Owned after	D/I	Nature of ownership
Common Stock, par value $0.001 ("Commn Stock")^F1	Jul 31, 2015	S	75,000	$92.00	D	1,757,969	I	See footnote
Common Stock^F1	Aug 3, 2015	S	10,000	$91.38	D	1,747,969	I	See footnote
Common Stock^F1	Aug 3, 2015	S	5,000	$90.02	D	1,742,969	I	See footnote
Common Stock^F1	Aug 3, 2015	S	800	$90.12	D	1,742,169	I	See footnote
Common Stock^F1	Aug 3, 2015	S	10,000	$90.08	D	1,732,169	I	See footnote
Common Stock^F1	Aug 3, 2015	S	9,200	$90.03	D	1,722,969	I	See footnote

Table II — derivative securities

No Table II lines on this filing.

Explanation of responses

F1The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. ACPGP, ACA, Robert Atchinson and Phillip Gross disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein.