Security	Date	Code	Shares	Price	A/D	Owned after	D/I	Nature of ownership
Common Stock^F3	Jan 6, 2015	J	6,952	$0.00	D	7,812	I	See Footnote
Common Stock^F5	Jan 6, 2015	J	778,272	$0.00	D	1,263,716	I	See Footnote
Common Stock^F6	Jan 6, 2015	J	136,039	$0.00	A	136,039	I	See Footnote
Common Stock^F6	Jan 7, 2015	J	136,039	$0.00	D	0	I	See Footnote
Common Stock^F8,F9	Jan 7, 2015	J	17,834	$0.00	A	17,834	I	By Lubash Moses LLC and Evan Michael Moses Trust
Common Stock^F10	Jan 7, 2015	J	8,916	$0.00	A	13,196	I	By Robertson Family Trust
Common Stock^F11	Jan 6, 2015	J	486	$0.00	A	13,682	I	By Robertson Family Trust
Common Stock^F12	Jan 7, 2015	J	17,539	$0.00	A	52,985	D
Common Stock^F13	Jan 7, 2015	J	4,682	$0.00	A	4,682	D
Common Stock^F1	holding	—	—		—	31,334	I	See Footnote

Table II — derivative securities

No Table II lines on this filing.

Explanation of responses

F1The shares are held by Versant Affiliates Fund II-A, L.P. ("VAF II-A"). Versant Ventures II, LLC ("VV II") serves as the sole general partner of VAF II-A. Brian G. Atwood, Samuel D. Colella, Ross A. Jaffe, William J. Link, Ph.D., Donald B. Milder, Rebecca B. Robertson, Bradley J. Bolzon, Charles M. Warden, and Barbara N. Lubash are directors and/or members of VV II and share voting and dispositive power over the shares held by VAF II-A, however, each disclaim beneficial ownership of these shares, except to the extent of their pecuniary interest in such shares.
F10The shares are held by the Robertson Family Trust (the "Trust") for the benefit of Rebecca B. Robertson. Rebecca B. Robertson is a trustee of the Trust.
F11The shares are held by the Robertson Family Trust (the "Trust") for the benefit of Rebecca Robertson. Rebecca Robertson is a trustee of the Trust. The Reporting Person disclaims beneficial ownership of the shares except to the extent of her proportionate pecuniary interest therein.
F12The shares are held by Bradley J. Bolzon.
F13The shares are held by Charles M. Warden.
F2Represents a pro-rata in-kind distribution of Common Stock of the Issuer for no consideration by Versant Side Fund II, L.P. ("VSF II") to its partners.
F3The shares are held by VSF II. VV II serves as the sole general partner of VSF II. Brian G. Atwood, Samuel D. Colella, Ross A. Jaffe, William J. Link, Ph.D., Donald B. Milder, Rebecca B. Robertson, Bradley J. Bolzon, Charles M. Warden, and Barbara N. Lubash are directors and/or members of VV II and share voting and dispositive power over the shares held by VSF II, however, each disclaim beneficial ownership of these shares, except to the extent of their pecuniary interest in such shares.
F4Represents a pro-rata in-kind distribution of Common Stock of the Issuer for no consideration by Versant Venture Capital II, L.P. ("VVC II") to its partners.
F5The shares are held by VVC II. VV II serves as the sole general partner of VVC II. Brian G. Atwood, Samuel D. Colella, Ross A. Jaffe, William J. Link, Ph.D., Donald B. Milder, Rebecca B. Robertson, Bradley J. Bolzon, Charles M. Warden, and Barbara N. Lubash are directors and/or members of VV II and share voting and dispositive power over the shares held by VVC II, however, each disclaim beneficial ownership of these shares, except to the extent of their pecuniary interest in such shares.
F6The shares are held by VV II. Brian G. Atwood, Samuel D. Colella, Ross A. Jaffe, William J. Link, Ph.D., Donald B. Milder, Rebecca B. Robertson, Bradley J. Bolzon, Charles M. Warden, and Barbara N. Lubash are directors and/or members of VV II and share voting and dispositive power over the shares, however, each disclaim beneficial ownership of these shares, except to the extent of their pecuniary interest in such shares.
F7Represents a pro-rata in-kind distribution of Common Stock of the Issuer by VV II without consideration to its members.
F8The shares are held by Lubash Moses LLC (the "LLC") for the benefit of Barbara N. Lubash. Barbara N. Lubash is a manager of the LLC.
F9The shares are held by the Evan Michael Moses Trust for the benefit of one or more family member of Barbara Lubash.

Remarks

Filing 2 of 2