F1Represents shares held by Frazier Healthcare VI, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.
F2Represents shares held by Frazier Life Sciences VIII, L.P., an affiliate of Frazier Healthcare Partners. Each of the Reporting Persons disclaims beneficial ownership of the shares except to the extent of their pecuniary interest therein, if any.

Remarks

This statement is filed by: (i) Frazier Healthcare VI, L.P. ("Frazier VI") and Frazier Life Sciences VIII, L.P. ("Frazier VIII"), each a Delaware limited partnership and direct owners of the shares of Common Stock (together, the "Shares"); (ii) FHM VI, L.P., a Delaware limited partnership and general partner to Frazier VI; FHM VI, LLC a Delaware limited liability company and general partner of FHM VI, L.P.; FHM Life Sciences VIII, L.P., a Delaware limited partnership and general partner to Frazier VIII; and FHM Life Sciences VIII, LLC, a Delaware limited liability company and general partner of FHM Life Sciences VIII, L.P.;and (iii) Alan Frazier, Nader Naini, Nathan Every and Patrick Heron, each of who are members of FHM VI, LLC and may be deemed to share voting and investment power with respect to shares held by Frazier VI and Patrick Heron, who is a member of FHM Life Sciences VIII, LLC and may be deemed to share voting and investment power with respect to shares held by Frazier VIII.