Security	Date	Code	Shares	Price	A/D	Owned after	D/I	Nature of ownership
Common Stock^F1,F3	Jun 30, 2015	C	2,868,959	—	A	2,868,959	I	Through Versant Venture Capital I, L.P.
Common Stock^F1,F3	Jun 30, 2015	M	27,612	—	A	2,896,571	I	Through Versant Venture Capital I, L.P.
Common Stock^F3	Jun 30, 2015	F	11,736	$18.00	D	2,884,835	I	Through Versant Venture Capital I, L.P.
Common Stock^F1,F4	Jun 30, 2015	C	61,886	—	A	61,886	I	Through Versant Affiliates Fund I-A, L.P.
Common Stock^F1,F4	Jun 30, 2015	M	577	—	A	62,463	I	Through Versant Affiliates Fund I-A, L.P.
Common Stock^F4	Jun 30, 2015	F	246	$18.00	D	62,217	I	Through Versant Affiliates Fund I-A, L.P.
Common Stock^F1,F5	Jun 30, 2015	C	131,738	—	A	131,738	I	Through Versant Affiliates Fund I-B L.P.
Common Stock^F1,F5	Jun 30, 2015	M	1,296	—	A	133,034	I	Through Versant Affiliates Fund I-B L.P.
Common Stock^F5	Jun 30, 2015	F	551	$18.00	D	132,483	I	Through Versant Affiliates Fund I-B L.P.
Common Stock^F1,F6	Jun 30, 2015	C	56,379	—	A	56,379	I	Through Versant Side Fund I, L.P.
Common Stock^F1,F6	Jun 30, 2015	M	552	—	A	56,931	I	Through Versant Side Fund I, L.P.
Common Stock^F6	Jun 30, 2015	F	235	$18.00	D	56,696	I	Through Versant Side Fund I, L.P.

Table II — derivative securities

Security	Conv. / exercise price	Date	Code	Shares	A/D	Exercisable	Expires	Underlying	Underlying shares	D/I
Series A Convertible Preferred Stock^F1,F3	—	Jun 30, 2015	C	552,000	D	—	—	Common Stock	552,000	I
Series A Convertible Preferred Stock^F1,F4	—	Jun 30, 2015	C	12,000	D	—	—	Common Stock	12,000	I
Series A Convertible Preferred Stock^F1,F5	—	Jun 30, 2015	C	25,200	D	—	—	Common Stock	25,200	I
Series A Convertible Preferred Stock^F1,F6	—	Jun 30, 2015	C	10,800	D	—	—	Common Stock	10,800	I
Series B Convertible Preferred Stock^F1,F3	—	Jun 30, 2015	C	851,852	D	—	—	Common Stock	851,852	I
Series B Convertible Preferred Stock^F1,F4	—	Jun 30, 2015	C	18,518	D	—	—	Common Stock	18,518	I
Series B Convertible Preferred Stock^F1,F5	—	Jun 30, 2015	C	38,888	D	—	—	Common Stock	38,888	I
Series B Convertible Preferred Stock^F1,F6	—	Jun 30, 2015	C	16,666	D	—	—	Common Stock	16,666	I
Series C Convertible Preferred Stock^F1,F3	—	Jun 30, 2015	C	479,714	D	—	—	Common Stock	479,714	I
Series C Convertible Preferred Stock^F1,F4	—	Jun 30, 2015	C	10,428	D	—	—	Common Stock	10,428	I
Series C Convertible Preferred Stock^F1,F5	—	Jun 30, 2015	C	21,900	D	—	—	Common Stock	21,900	I
Series C Convertible Preferred Stock^F1,F6	—	Jun 30, 2015	C	9,386	D	—	—	Common Stock	9,386	I
Series D Convertible Preferred Stock^F1,F3	—	Jun 30, 2015	C	548,464	D	—	—	Common Stock	548,464	I
Series D Convertible Preferred Stock^F1,F4	—	Jun 30, 2015	C	11,805	D	—	—	Common Stock	11,805	I
Series D Convertible Preferred Stock^F1,F5	—	Jun 30, 2015	C	25,226	D	—	—	Common Stock	25,226	I
Series D Convertible Preferred Stock^F1,F6	—	Jun 30, 2015	C	10,791	D	—	—	Common Stock	10,791	I
Series E Convertible Preferred Stock^F1,F3	—	Jun 30, 2015	C	163,592	D	—	—	Common Stock	163,592	I
Series E Convertible Preferred Stock^F1,F4	—	Jun 30, 2015	C	3,420	D	—	—	Common Stock	3,420	I
Series E Convertible Preferred Stock^F1,F5	—	Jun 30, 2015	C	7,684	D	—	—	Common Stock	7,684	I
Series E Convertible Preferred Stock^F1,F6	—	Jun 30, 2015	C	3,271	D	—	—	Common Stock	3,271	I
Series F Convertible Preferred Stock^F1,F3	—	Jun 30, 2015	C	273,337	D	—	—	Common Stock	273,337	I
Series F Convertible Preferred Stock^F1,F4	—	Jun 30, 2015	C	5,715	D	—	—	Common Stock	5,715	I
Series F Convertible Preferred Stock^F1,F5	—	Jun 30, 2015	C	12,840	D	—	—	Common Stock	12,840	I
Series F Convertible Preferred Stock^F1,F6	—	Jun 30, 2015	C	5,465	D	—	—	Common Stock	5,465	I
Series D Convertible Preferred Stock Warrant (right to buy)^F2,F3	$7.65	Jun 30, 2015	M	27,612	D	—	—	Common Stock	27,612	I
Series D Convertible Preferred Stock Warrant (right to buy)^F2,F4	$7.65	Jun 30, 2015	M	577	D	—	—	Common Stock	577	I
Series D Convertible Preferred Stock Warrant (right to buy)^F2,F5	$7.65	Jun 30, 2015	M	1,296	D	—	—	Common Stock	1,296	I
Series D Convertible Preferred Stock Warrant (right to buy)^F2,F6	$7.65	Jun 30, 2015	M	552	D	—	—	Common Stock	552	I

Explanation of responses

F1The shares of Series A Convertible Preferred Stock, Series B Convertible Preferred Stock, Series C Convertible Preferred Stock, Series D Convertible Preferred Stock, Series E Convertible Preferred Stock and Series F Convertible Preferred Stock automatically converted into shares of common stock on a 1:1 basis immediately prior to the consummation of the Issuer's initial public offering ("IPO") and had no expiration date.
F2The warrants to acquire Series D Convertible Preferred Stock automatically net exercised immediately prior to consummation of the IPO at the IPO price per share and the shares of Series D Convertible Preferred Stock received thereupon automatically converted into shares of common stock as described in footnote (1).
F3The shares are held by Versant Venture Capital I, L.P., a Delaware limited partnership ("VVC I"). Versant Ventures I, LLC, a Delaware limited liability company ("VV I") serves as the sole general partner of VVC I. Brian G. Atwood, Samuel D. Colella, Ross A. Jaffe, William J. Link, Ph.D., Donald B. Milder, Rebecca B. Robertson and Barbara N. Lubash are directors and/or members of VV I and share voting and dispositive power over the shares held by VVC I; however, they disclaim beneficial ownership of the shares held by such entities except to the extent of their pecuniary interests therein. William J. Link, Ph.D. is a director of the Issuer and, accordingly, files separate Section 16 reports.
F4The shares are held by Versant Affiliates Fund I-A, L.P., a Delaware limited partnership ("VAF I-A"). VV I serves as the sole general partner of VAF I-A. Brian G. Atwood, Samuel D. Colella, Ross A. Jaffe, William J. Link, Ph.D., Donald B. Milder, Rebecca B. Robertson and Barbara N. Lubash are directors and/or members of VV I and share voting and dispositive power over the shares held by VAF I-A; however, they disclaim beneficial ownership of the shares held by such entities except to the extent of their pecuniary interests therein. William J. Link, Ph.D. is a director of the Issuer and, accordingly, files separate Section 16 reports.
F5The shares are held by Versant Affiliates Fund I-B, L.P., a Delaware limited partnership ("VAF I-B"). VV I serves as the sole general partner of VAF I-B. Brian G. Atwood, Samuel D. Colella, Ross A. Jaffe, William J. Link, Ph.D., Donald B. Milder, Rebecca B. Robertson and Barbara N. Lubash are directors and/or members of VV I and share voting and dispositive power over the shares held by VAF I-B; however, they disclaim beneficial ownership of the shares held by such entities except to the extent of their pecuniary interests therein. William J. Link, Ph.D. is a director of the Issuer and, accordingly, files separate Section 16 reports.
F6The shares are held by Versant Side Fund I, L.P., a Delaware limited partnership ("VSF I"). VV I serves as the sole general partner of VSF I. Brian G. Atwood, Samuel D. Colella, Ross A. Jaffe, William J. Link, Ph.D., Donald B. Milder, Rebecca B. Robertson and Barbara N. Lubash are directors and/or members of VV I and share voting and dispositive power over the shares held by VSF I; however, they disclaim beneficial ownership of the shares held by such entities except to the extent of their pecuniary interests therein. William J. Link, Ph.D. is a director of the Issuer and, accordingly, files separate Section 16 reports.

Remarks

Form 1 of 2