Security	Conv. / exercise price	Date	Code	Shares	A/D	Exercisable	Expires	Underlying	Underlying shares	Owned after	D/I
Series D Convertible Preferred Stock^F2,F1	—	Jun 26, 2015	X	24,705	A	—	—	Common Stock	24,705	674,510	D
Series D Convertible Preferred Stock Warrant (right to buy)^F2,F3	$7.65	Jun 26, 2015	X	24,705	D	Sep 15, 2010	Sep 15, 2017	Common Stock	24,705	0	D

Explanation of responses

F1The shares of Series D Convertible Preferred Stock, will automatically convert into shares of common stock on a 1:1 basis immediately prior to the consummation of Issuer's initial public offering ("IPO") and have no expiration date.
F2This report is filed jointly by Frazier Healthcare V, L.P., a Delaware limited partnership ("FH-V''), FHM V, L.P., a Delaware limited partnership ("FHM V L.P.''), FHM V LLC a Delaware limited liability company ("FHM V LLC''), Nathan Every, Alan Frazier, Nader Naini, Patrick Heron and James Topper. Shares and warrants are held directly by FH-V. FHM V, L.P. serves as the sole general partner of FH-V and owns no shares directly. FHM V LLC serves as the sole general partner of FHM V, L.P. and owns no shares directly. Nathan Every, Alan Frazier, Nader Naini, Patrick Heron and James Topper are members of FHM V, LLC and share voting and dispositive power over the shares held by FH-V; however, they disclaim beneficial ownership of the shares held by FH-V except to the extent of their pecuniary interests therein.
F3If not exercised prior to the IPO, the warrants would have automatically net exercised immediately prior to the IPO at the IPO price per share.