Security	Date	Code	Shares	Price	A/D	Owned after	D/I	Nature of ownership
Common Stock^F2	Mar 24, 2015	J	900,383	$0.00	D	1,672,140	I	See Footnote
Common Stock^F4,F5	Mar 24, 2015	J	20,357	$0.00	A	32,584	I	See Footnote
Common Stock^F7,F8	Mar 24, 2015	J	20,357	$0.00	A	28,237	I	See Footnote
Common Stock^F9	holding	—	—		—	395,799	I	See Footnote
Common Stock^F10,F11	holding	—	—		—	0	I	See Footnote
Common Stock^F12,F13	holding	—	—		—	0	I	See Footnote

Table II — derivative securities

No Table II lines on this filing.

Explanation of responses

F1Represents a pro rata distribution without additional consideration by Prospect Venture Partners II, L.P. ("PVP II").
F10The shares previously reported as held by PVP, as Nominee are now being held directly in each of the Beneficial Owners' names.
F11The reportable securities are owned by PVP, as Nominee. PMC is the general partner of PVP. Schnell is the managing member of PMC. Each of PMC and Schnell disclaim beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein.
F12The shares previously reported as held by PVP II, as Nominee are now being held directly in each of the Beneficial Owners' names.
F13The reportable securities are owned by PVP II, as Nominee. PMC II is the general partner of PVP II. Hirsch and Schnell are the managing members of PMC II. Each of PMC II, Hirsch and Schnell disclaim beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein.
F2The reportable securities are owned by PVP II. Prospect Management Co. II, L.L.C. ("PMC II") is the general partner of PVP II. Russell Hirsch ("Hirsch") and David Schnell ("Schnell") are the managing members of PMC II. Each of PMC II, Hirsch and Schnell disclaim beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein.
F3Acquisition by The Hirsch Living Trust Dated 9/22/2000 ("Hirsch Trust") pursuant to a pro rata distribution without additional consideration by PVP II.
F4Includes 4,347 shares previously held through Prospect Venture Partner, L.P. ("PVP"), as Nominee and 7,880 shares previously held through PVP II, as Nominee that are now held directly by Hirsch Trust.
F5The reportable securities are owned directly by Hirsch Trust. Hirsch is a trustee of Hirsch Trust.
F6Acquisition by David Schnell, Trust 2000 U/L DTD May 26, 2000 ("Schnell Trust") pursuant to a pro rata distribution without additional consideration by PVP II.
F7Includes 7,880 shares previously held through PVP II, as Nominee that are now held directly by Schnell Trust.
F8The reportable securities are owned directly by Schnell Trust. Schnell is a trustee of Schnell Trust.
F9The reportable securities are owned by PVP. Prospect Management Co., L.L.C. ("PMC") is the general partner of PVP. Schnell is the managing member of PMC. Each of PMC and Schnell disclaim beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein.