SEC Form 4 · accession 0001628280-26-061581

MADRIGAL PHARMACEUTICALS, INC. · MDGL

Statement of changes in beneficial ownership, as filed. Original on EDGAR ↗

Reporting owner

William John Sibold

Officer — President and CEO · Director

Period of report

Sep 9, 2026

Accepted (ET)

Sep 11, 2026 · 4:57 pm EDT

Rule 10b5-1 plan

yes — trade under a plan

Issuer CIK

0001157601

Table I — non-derivative securities

Security	Date	Code	Shares	Price	A/D	Owned after	D/I
Common Stock^F2	Sep 9, 2026	S	131	$527.8783	D	209,198	D
Common Stock^F3	Sep 9, 2026	S	347	$529.2671	D	208,851	D
Common Stock^F4	Sep 9, 2026	S	522	$530.2311	D	208,329	D
Common Stock^F5	Sep 9, 2026	S	368	$531.9897	D	207,961	D
Common Stock^F6	Sep 9, 2026	S	512	$533.0932	D	207,449	D
Common Stock^F7	Sep 9, 2026	S	396	$534.1964	D	207,053	D
Common Stock^F8	Sep 9, 2026	S	644	$535.2719	D	206,409	D
Common Stock^F9	Sep 9, 2026	S	1,040	$536.1123	D	205,369	D
Common Stock^F10	Sep 9, 2026	S	640	$537.1738	D	204,729	D
Common Stock^F11	Sep 9, 2026	S	520	$538.2971	D	204,209	D
Common Stock^F12	Sep 9, 2026	S	215	$539.0281	D	203,994	D
Common Stock^F13	Sep 9, 2026	S	505	$540.1909	D	203,489	D
Common Stock^F14	Sep 9, 2026	S	362	$541.6538	D	203,127	D
Common Stock^F15	Sep 9, 2026	S	160	$542.5475	D	202,967	D
Common Stock^F17	Sep 11, 2026	S	60	$533.0913	D	202,907	D
Common Stock^F18	Sep 11, 2026	S	106	$534.063	D	202,801	D
Common Stock^F19	Sep 11, 2026	S	218	$535.9435	D	202,583	D
Common Stock^F20	Sep 11, 2026	S	160	$537.6175	D	202,423	D
Common Stock^F21	Sep 11, 2026	S	687	$540.5857	D	201,736	D
Common Stock^F22	Sep 11, 2026	S	368	$541.6423	D	201,368	D
Common Stock^F23	Sep 11, 2026	S	1,202	$542.6032	D	200,166	D
Common Stock^F24	Sep 11, 2026	S	1,539	$544.024	D	198,627	D
Common Stock^F25	Sep 11, 2026	S	761	$544.8307	D	197,866	D
Common Stock^F26	Sep 11, 2026	S	120	$546.3767	D	197,746	D

Table II — derivative securities

No Table II lines on this filing.

Explanation of responses

F1This sale represents the number of shares sold by the Issuer on behalf of the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. This sale was automatic and not at the discretion of the Reporting Person.
F10The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $536.64 to $537.56, inclusive.
F11The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $537.70 to $538.65, inclusive.
F12The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $538.86 to $539.83, inclusive.
F13The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $539.86 to $540.47, inclusive.
F14The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $541.29 to $542.27, inclusive.
F15The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $542.42 to $542.68, inclusive.
F16These sales were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 5, 2026.
F17The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $532.76 to $533.64, inclusive.
F18The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $533.76 to $534.48, inclusive.
F19The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $535.52 to $536.02, inclusive.
F2The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $527.49 to $528.27, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and the footnotes below.
F20The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $537.235 to $538.00, inclusive.
F21The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $539.97 to $540.90, inclusive.
F22The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $541.00 to $541.73, inclusive.
F23The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $542.11 to $543.02, inclusive.
F24The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $543.27 to $544.20, inclusive.
F25The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $544.38 to $545.32, inclusive.
F26The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $546.28 to $546.56, inclusive.
F3The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $528.54 to $529.51, inclusive.
F4The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $529.64 to $530.48, inclusive.
F5The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $531.57 to $532.28, inclusive.
F6The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $532.57 to $533.29, inclusive.
F7The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $533.58 to $534.57, inclusive.
F8The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $534.63 to $535.62, inclusive.
F9The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $535.64 to $536.45, inclusive.