Security	Date	Code	Shares	Price	A/D	Owned after	D/I	Nature of ownership
Common Stock^{F3,F4,F19,F20,F21}	Nov 1, 2016	P	9,347	$54.9253	A	4,725,245	I	See footnote
Common Stock^{F3,F5,F19,F20,F21}	Nov 1, 2016	P	85,353	$54.9253	A	39,517,849	I	See footnote
Common Stock^{F6,F4,F19,F20,F21}	Nov 1, 2016	P	197	$54.6063	A	4,725,442	I	See footnote
Common Stock^{F6,F5,F19,F20,F21}	Nov 1, 2016	P	1,803	$54.6063	A	39,519,652	I	See footnote
Common Stock^{F7,F4,F19,F20,F21}	Nov 1, 2016	P	101	$54.5079	A	4,725,543	I	See footnote
Common Stock^{F7,F5,F19,F20,F21}	Nov 1, 2016	P	924	$54.5079	A	39,520,576	I	See Footnote
Common Stock^{F8,F4,F19,F20,F21}	Nov 1, 2016	P	4,417	$54.3731	A	4,729,960	I	See Footnote
Common Stock^{F8,F5,F19,F20,F21}	Nov 1, 2016	P	40,332	$54.3731	A	39,560,908	I	See Footnote
Common Stock^{F9,F4,F19,F20,F21}	Nov 1, 2016	P	3,583	$53.6595	A	4,733,543	I	See Footnote
Common Stock^{F9,F5,F19,F20,F21}	Nov 1, 2016	P	32,717	$53.6595	A	39,593,625	I	See Footnote
Common Stock^{F10,F4,F19,F20,F21}	Nov 1, 2016	P	266	$53.3339	A	4,733,809	I	See Footnote
Common Stock^{F10,F5,F19,F20,F21}	Nov 1, 2016	P	2,434	$53.3339	A	39,596,059	I	See Footnote
Common Stock^{F11,F4,F19,F20,F21}	Nov 1, 2016	P	316	$51.8303	A	4,734,125	I	See Footnote
Common Stock^{F11,F5,F19,F20,F21}	Nov 1, 2016	P	2,884	$51.8303	A	39,598,943	I	See Footnote
Common Stock^{F12,F4,F19,F20,F21}	Nov 2, 2016	P	31,679	$56.258	A	4,765,804	I	See Footnote
Common Stock^{F12,F5,F19,F20,F21}	Nov 2, 2016	P	289,278	$56.258	A	39,888,221	I	See Footnote
Common Stock^{F13,F4,F19,F20,F21}	Nov 2, 2016	P	2,889	$56.1297	A	4,768,693	I	See Footnote
Common Stock^{F13,F5,F19,F20,F21}	Nov 2, 2016	P	26,381	$56.1297	A	39,914,602	I	See Footnote
Common Stock^{F14,F4,F19,F20,F21}	Nov 2, 2016	P	689	$56.1162	A	4,769,382	I	See Footnote
Common Stock^{F14,F5,F19,F20,F21}	Nov 2, 2016	P	6,289	$56.1162	A	39,920,891	I	See Footnote
Common Stock^{F15,F4,F19,F20,F21}	Nov 2, 2016	P	365	$55.873	A	4,769,747	I	See Footnote
Common Stock^{F15,F5,F19,F20,F21}	Nov 2, 2016	P	3,335	$55.873	A	39,924,226	I	See Footnote
Common Stock^{F16,F4,F19,F20,F21}	Nov 2, 2016	P	10,434	$55.8425	A	4,780,181	I	See Footnote
Common Stock^{F16,F5,F19,F20,F21}	Nov 2, 2016	P	95,280	$55.8425	A	40,019,506	I	See Footnote
Common Stock^{F17,F4,F19,F20,F21}	Nov 3, 2016	P	37,392	$56.9075	A	4,817,573	I	See Footnote
Common Stock^{F17,F5,F19,F20,F21}	Nov 3, 2016	P	341,438	$56.9075	A	40,360,944	I	See Footnote
Common Stock^{F18,F4,F19,F20,F21}	Nov 3, 2016	P	50	$56.553	A	4,817,623	I	See Footnote
Common Stock^{F18,F5,F19,F20,F21}	Nov 3, 2016	P	456	$56.553	A	40,361,400	I	See Footnote
Common Stock^F1	holding	—	—		—	107,511	D
Common Stock^F2	holding	—	—		—	107,504	D

Table II — derivative securities

No Table II lines on this filing.

Explanation of responses

F1Reflects shares of common stock of Seattle Genetics, Inc. (the "Issuer") held directly by Felix J. Baker.
F10The price reported in Column 4 is a weighted average price. These shares were traded by 667 and Life Sciences in multiple transactions at prices ranging from $53.19 to $53.59, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares traded at each separate price within the range set forth in this footnote.
F11The price reported in Column 4 is a weighted average price. These shares were traded by 667 and Life Sciences in multiple transactions at prices ranging from $51.78 to $51.94, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares traded at each separate price within the range set forth in this footnote.
F12The price reported in Column 4 is a weighted average price. These shares were traded by 667 and Life Sciences in multiple transactions at prices ranging from $55.78 to $56.37, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares traded at each separate price within the range set forth in this footnote.
F13The price reported in Column 4 is a weighted average price. These shares were traded by 667 and Life Sciences in multiple transactions at prices ranging from $55.50 to $56.35, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares traded at each separate price within the range set forth in this footnote.
F14The price reported in Column 4 is a weighted average price. These shares were traded by 667 and Life Sciences in multiple transactions at prices ranging from $55.96 to $56.25, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares traded at each separate price within the range set forth in this footnote.
F15The price reported in Column 4 is a weighted average price. These shares were traded by 667 and Life Sciences in multiple transactions at prices ranging from $55.74 to $55.90, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares traded at each separate price within the range set forth in this footnote.
F16The price reported in Column 4 is a weighted average price. These shares were traded by 667 and Life Sciences in multiple transactions at prices ranging from $55.45 to $56.20, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares traded at each separate price within the range set forth in this footnote.
F17The price reported in Column 4 is a weighted average price. These shares were traded by 667 and Life Sciences in multiple transactions at prices ranging from $56.50 to $57.00, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares traded at each separate price within the range set forth in this footnote.
F18The price reported in Column 4 is a weighted average price. These shares were traded by 667 and Life Sciences in multiple transactions at prices ranging from $56.51 to $56.60, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares traded at each separate price within the range set forth in this footnote.
F19Includes beneficial ownership of 14,400 previously issued restricted stock units payable solely in common shares issued to Felix Baker in his capacity as a director of the Issuer pursuant to the Amended and Restated 2007 Equity Incentive Plan of which the fund may be deemed to own a portion and 30,000 shares received previously from exercise of 30,000 stock options of the Issuer that were issued to Felix J. Baker in his capacity as a director of the Issuer, of which the fund may be deemed to own a portion.
F2Reflects shares of common stock of the Issuer held directly by Julian C. Baker.
F20Baker Bros. Advisors LP (the "Adviser") serves as the Investment Adviser to Life Sciences and 667 (collectively the "Funds"). In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held by the Funds. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are principals of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds.
F21Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.
F3The price reported in Column 4 is a weighted average price. These shares were traded by 667, L.P. ("667") and Baker Brothers Life Sciences, L.P. ("Life Sciences") in multiple transactions at prices ranging from $54.35 to $54.99, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares traded at each separate price within the range set forth in this footnote.
F4After giving effect to the transactions reported herein and as a result of their ownership interest in Baker Biotech Capital (GP), LLC, Felix J. Baker and Julian C. Baker each may be deemed to have an indirect pecuniary interest in the Issuer's shares of Common Stock reported in column 5 of Table I directly held by 667, a limited partnership of which the sole general partner is Baker Biotech Capital, L.P., a limited partnership of which the sole general partner is Baker Biotech Capital (GP), LLC, due to Baker Biotech Capital, L.P.'s right to receive an allocation of a portion of the profits from 667.
F5After giving effect to the transactions reported herein and as a result of their ownership interest in Baker Brothers Life Sciences Capital (GP), LLC, Julian C. Baker and Felix J. Baker each may be deemed to have an indirect pecuniary interest in the Issuer's shares of Common Stock reported in column 5 of Table I directly held by Life Sciences, a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital, L.P., a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital (GP), LLC, due to Baker Brothers Life Sciences Capital, L.P.'s right to receive an allocation of a portion of the profits from Life Sciences
F6The price reported in Column 4 is a weighted average price. These shares were traded by 667 and Life Sciences in multiple transactions at prices ranging from $54.60 to $54.62, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares traded at each separate price within the range set forth in this footnote.
F7The price reported in Column 4 is a weighted average price. These shares were traded by 667 and Life Sciences in multiple transactions at prices ranging from $54.39 to $54.63, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares traded at each separate price within the range set forth in this footnote.
F8The price reported in Column 4 is a weighted average price. These shares were traded by 667 and Life Sciences in multiple transactions at prices ranging from $54.32 to $54.72, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares traded at each separate price within the range set forth in this footnote.
F9The price reported in Column 4 is a weighted average price. These shares were traded by 667 and Life Sciences in multiple transactions at prices ranging from $53.62 to $53.77, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares traded at each separate price within the range set forth in this footnote.

Remarks

Felix J. Baker is a director of Seattle Genetics, Inc. (the "Issuer"). By virtue of his representation on the Board of Directors of the Issuer, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, the reporting persons are deemed directors by deputization of the Issuer. This is the first of two Form 4's reporting changes in beneficial ownership. Due to space limitations in Form 4 we are thus filing these two Forms 4.