Security	Date	Code	Shares	Price	A/D	Owned after	D/I	Nature of ownership
Common Stock^F1,F2	Sep 28, 2015	S	288,726	$1.8019	D	7,490,126	I	Through Deerfield International Master Fund, L.P.
Common Stock^F1,F2	Sep 28, 2015	S	226,857	$1.8019	D	5,885,100	I	Through Deerfield Partners, L.P.
Common Stock^F1,F2	Sep 28, 2015	S	469,224	$1.8147	D	7,020,902	I	Through Deerfield International Master Fund, L.P.
Common Stock^F1,F2	Sep 28, 2015	S	368,676	$1.8147	D	5,516,424	I	Through Deerfield Partners, L.P.
Common Stock^F1,F2	Sep 29, 2015	S	42,728	$1.81	D	6,978,174	I	Through Deerfield International Master Fund, L.P.
Common Stock^F1,F2	Sep 29, 2015	S	33,572	$1.81	D	5,482,852	I	Through Deerfield Partners, L.P.
Common Stock^F1,F2	Sep 29, 2015	S	23,700	$1.81	D	3,365,146	I	Through Deerfield Special Situations Fund, L.P.
Common Stock^F1,F2	Sep 29, 2015	S	19,976	$1.8208	D	6,958,198	I	Through Deerfield International Master Fund, L.P.
Common Stock^F1,F2	Sep 29, 2015	S	15,696	$1.8208	D	5,467,156	I	Through Deerfield Partners, L.P.
Common Stock^F1,F2	Sep 29, 2015	S	11,081	$1.8208	D	3,354,065	I	Through Deerfield Special Situations Fund, L.P.
Common Stock^F1,F2	Sep 29, 2015	S	43,845	$1.83	D	6,914,353	I	Through Deerfield International Master Fund, L.P.
Common Stock^F1,F2	Sep 29, 2015	S	34,450	$1.83	D	5,432,706	I	Through Deerfield Partners, L.P.
Common Stock^F1,F2	Sep 30, 2015	S	59,248	$1.6921	D	3,294,817	I	Through Deerfield Special Situations Fund, L.P.
Common Stock^F1,F2	Sep 30, 2015	S	106,820	$1.6921	D	6,807,533	I	Through Deerfield International Master Fund, L.P.
Common Stock^F1,F2	Sep 30, 2015	S	83,930	$1.6921	D	5,348,776	I	Through Deerfield Partners, L.P.

Table II — derivative securities

No Table II lines on this filing.

Explanation of responses

F1This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the "Reporting Persons"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P., Deerfield Special Situations Fund, L.P. and Deerfield International Master Fund, L.P. (collectively, the "Funds"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P.
F2In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise.

Remarks

Jonathan Isler, Attorney-in-Fact: Power of Attorney, which is hereby incorporated by reference to Exhibit 24 to a Form 3 with regard to Avalanche Biotechnologies, Inc. filed with the Securities and Exchange Commission on July 30, 2014 by Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P., Deerfield Management Company, L.P., Deerfield Special Situations Fund, L.P., Deerfield Special Situations International Master Fund, L.P., Deerfield Private Design Fund III, L.P. and James E. Flynn.